                         SEQUENCE LISTING

<110>  Bionomics Limited
 
<120>  P12

<130>  SMEI Diagnostic

<160>  58    

<170>  PatentIn version 3.2

<210>  1
<211>  8381
<212>  DNA
<213>  Homo sapiens

<400>  1
atactgcaga ggtctctggt gcatgtgtgt atgtgtgcgt ttgtgtgtgt ttgtgtgtct     60

gtgtgttctg ccccagtgag actgcagccc ttgtaaatac tttgacacct tttgcaagaa    120

ggaatctgaa caattgcaac tgaaggcaca ttgttatcat ctcgtctttg ggtgatgctg    180

ttcctcactg cagatggata attttccttt taatcaggaa tttcatatgc agaataaatg    240

gtaattaaaa tgtgcaggat gacaagatgg agcaaacagt gcttgtacca ccaggacctg    300

acagcttcaa cttcttcacc agagaatctc ttgcggctat tgaaagacgc attgcagaag    360

aaaaggcaaa gaatcccaaa ccagacaaaa aagatgacga cgaaaatggc ccaaagccaa    420

atagtgactt ggaagctgga aagaaccttc catttattta tggagacatt cctccagaga    480

tggtgtcaga gcccctggag gacctggacc cctactgtat caataagaaa acttttatag    540

tattgaataa attgaaggcc atcttccggt tcagtgccac ctctgccctg tacattttaa    600

ctcccttcaa tcctcttagg aaaatagcta ttaagatttt ggtacattca ttattcagca    660

tgctaattat gtgcactatt ttgacaaact gtgtgtttat gacaatgagt aaccctcctg    720

attggacaaa gaatgtagaa tacaccttca caggaatata tacttttgaa tcacttataa    780

aaattattgc aaggggattc tgtttagaag attttacttt ccttcgggat ccatggaact    840

ggctcgattt cactgtcatt acatttgcgt acgtcacaga gtttgtggac ctgggcaatg    900

tctcggcatt gagaacattc agagttctcc gagcattgaa gacgatttca gtcattccag    960

gcctgaaaac cattgtggga gccctgatcc agtctgtgaa gaagctctca gatgtaatga   1020

tcctgactgt gttctgtctg agcgtatttg ctctaattgg gctgcagctg ttcatgggca   1080

acctgaggaa taaatgtata caatggcctc ccaccaatgc ttccttggag gaacatagta   1140

tagaaaagaa tataactgtg aattataatg gtacacttat aaatgaaact gtctttgagt   1200

ttgactggaa gtcatatatt caagattcaa gatatcatta tttcctggag ggttttttag   1260

atgcactact atgtggaaat agctctgatg caggccaatg tccagaggga tatatgtgtg   1320

tgaaagctgg tagaaatccc aattatggct acacaagctt tgataccttc agttgggctt   1380

ttttgtcctt gtttcgacta atgactcagg acttctggga aaatctttat caactgacat   1440

tacgtgctgc tgggaaaacg tacatgatat tttttgtatt ggtcattttc ttgggctcat   1500

tctacctaat aaatttgatc ctggctgtgg tggccatggc ctacgaggaa cagaatcagg   1560

ccaccttgga agaagcagaa cagaaagagg ccgaatttca gcagatgatt gaacagctta   1620

aaaagcaaca ggaggcagct cagcaggcag caacggcaac tgcctcagaa cattccagag   1680

agcccagtgc agcaggcagg ctctcagaca gctcatctga agcctctaag ttgagttcca   1740

agagtgctaa ggaaagaaga aatcggagga agaaaagaaa acagaaagag cagtctggtg   1800

gggaagagaa agatgaggat gaattccaaa aatctgaatc tgaggacagc atcaggagga   1860

aaggttttcg cttctccatt gaagggaacc gattgacata tgaaaagagg tactcctccc   1920

cacaccagtc tttgttgagc atccgtggct ccctattttc accaaggcga aatagcagaa   1980

caagcctttt cagctttaga gggcgagcaa aggatgtggg atctgagaac gacttcgcag   2040

atgatgagca cagcaccttt gaggataacg agagccgtag agattccttg tttgtgcccc   2100

gacgacacgg agagagacgc aacagcaacc tgagtcagac cagtaggtca tcccggatgc   2160

tggcagtgtt tccagcgaat gggaagatgc acagcactgt ggattgcaat ggtgtggttt   2220

ccttggttgg tggaccttca gttcctacat cgcctgttgg acagcttctg ccagaggtga   2280

taatagataa gccagctact gatgacaatg gaacaaccac tgaaactgaa atgagaaaga   2340

gaaggtcaag ttctttccac gtttccatgg actttctaga agatccttcc caaaggcaac   2400

gagcaatgag tatagccagc attctaacaa atacagtaga agaacttgaa gaatccaggc   2460

agaaatgccc accctgttgg tataaatttt ccaacatatt cttaatctgg gactgttctc   2520

catattggtt aaaagtgaaa catgttgtca acctggttgt gatggaccca tttgttgacc   2580

tggccatcac catctgtatt gtcttaaata ctcttttcat ggccatggag cactatccaa   2640

tgacggacca tttcaataat gtgcttacag taggaaactt ggttttcact gggatcttta   2700

cagcagaaat gtttctgaaa attattgcca tggatcctta ctattatttc caagaaggct   2760

ggaatatctt tgacggtttt attgtgacgc ttagcctggt agaacttgga ctcgccaatg   2820

tggaaggatt atctgttctc cgttcatttc gattgctgcg agttttcaag ttggcaaaat   2880

cttggccaac gttaaatatg ctaataaaga tcatcggcaa ttccgtgggg gctctgggaa   2940

atttaaccct cgtcttggcc atcatcgtct tcatttttgc cgtggtcggc atgcagctct   3000

ttggtaaaag ctacaaagat tgtgtctgca agatcgccag tgattgtcaa ctcccacgct   3060

ggcacatgaa tgacttcttc cactccttcc tgattgtgtt ccgcgtgctg tgtggggagt   3120

ggatagagac catgtgggac tgtatggagg ttgctggtca agccatgtgc cttactgtct   3180

tcatgatggt catggtgatt ggaaacctag tggtcctgaa tctctttctg gccttgcttc   3240

tgagctcatt tagtgcagac aaccttgcag ccactgatga tgataatgaa atgaataatc   3300

tccaaattgc tgtggatagg atgcacaaag gagtagctta tgtgaaaaga aaaatatatg   3360

aatttattca acagtccttc attaggaaac aaaagatttt agatgaaatt aaaccacttg   3420

atgatctaaa caacaagaaa gacagttgta tgtccaatca tacaacagaa attgggaaag   3480

atcttgacta tcttaaagat gtaaatggaa ctacaagtgg tataggaact ggcagcagtg   3540

ttgaaaaata cattattgat gaaagtgatt acatgtcatt cataaacaac cccagtctta   3600

ctgtgactgt accaattgct gtaggagaat ctgactttga aaatttaaac acggaagact   3660

ttagtagtga atcggatctg gaagaaagca aagagaaact gaatgaaagc agtagctcat   3720

cagaaggtag cactgtggac atcggcgcac ctgtagaaga acagcccgta gtggaacctg   3780

aagaaactct tgaaccagaa gcttgtttca ctgaaggctg tgtacaaaga ttcaagtgtt   3840

gtcaaatcaa tgtggaagaa ggcagaggaa aacaatggtg gaacctgaga aggacgtgtt   3900

tccgaatagt tgaacataac tggtttgaga ccttcattgt tttcatgatt ctccttagta   3960

gtggtgctct ggcatttgaa gatatatata ttgatcagcg aaagacgatt aagacgatgt   4020

tggaatatgc tgacaaggtt ttcacttaca ttttcattct ggaaatgctt ctaaaatggg   4080

tggcatatgg ctatcaaaca tatttcacca atgcctggtg ttggctggac ttcttaattg   4140

ttgatgtttc attggtcagt ttaacagcaa atgccttggg ttactcagaa cttggagcca   4200

tcaaatctct caggacacta agagctctga gacctctaag agccttatct cgatttgaag   4260

ggatgagggt ggttgtgaat gcccttttag gagcaattcc atccatcatg aatgtgcttc   4320

tggtttgtct tatattctgg ctaattttca gcatcatggg cgtaaatttg tttgctggca   4380

aattctacca ctgtattaac accacaactg gtgacaggtt tgacatcgaa gacgtgaata   4440

atcatactga ttgcctaaaa ctaatagaaa gaaatgagac tgctcgatgg aaaaatgtga   4500

aagtaaactt tgataatgta ggatttgggt atctctcttt gcttcaagtt gccacattca   4560

aaggatggat ggatataatg tatgcagcag ttgattccag aaatgtggaa ctccagccta   4620

agtatgaaaa aagtctgtac atgtatcttt actttgttat tttcatcatc tttgggtcct   4680

tcttcacctt gaacctgttt attggtgtca tcatagataa tttcaaccag cagaaaaaga   4740

agtttggagg tcaagacatc tttatgacag aagaacagaa gaaatactat aatgcaatga   4800

aaaaattagg atcgaaaaaa ccgcaaaagc ctatacctcg accaggaaac aaatttcaag   4860

gaatggtctt tgacttcgta accagacaag tttttgacat aagcatcatg attctcatct   4920

gtcttaacat ggtcacaatg atggtggaaa cagatgacca gagtgaatat gtgactacca   4980

ttttgtcacg catcaatctg gtgttcattg tgctatttac tggagagtgt gtactgaaac   5040

tcatctctct acgccattat tattttacca ttggatggaa tatttttgat tttgtggttg   5100

tcattctctc cattgtaggt atgtttcttg ccgagctgat agaaaagtat ttcgtgtccc   5160

ctaccctgtt ccgagtgatc cgtcttgcta ggattggccg aatcctacgt ctgatcaaag   5220

gagcaaaggg gatccgcacg ctgctctttg ctttgatgat gtcccttcct gcgttgttta   5280

acatcggcct cctactcttc ctagtcatgt tcatctacgc catctttggg atgtccaact   5340

ttgcctatgt taagagggaa gttgggatcg atgacatgtt caactttgag acctttggca   5400

acagcatgat ctgcctattc caaattacaa cctctgctgg ctgggatgga ttgctagcac   5460

ccattctcaa cagtaagcca cccgactgtg accctaataa agttaaccct ggaagctcag   5520

ttaagggaga ctgtgggaac ccatctgttg gaattttctt ttttgtcagt tacatcatca   5580

tatccttcct ggttgtggtg aacatgtaca tcgcggtcat cctggagaac ttcagtgttg   5640

ctactgaaga aagtgcagag cctctgagtg aggatgactt tgagatgttc tatgaggttt   5700

gggagaagtt tgatcccgat gcaactcagt tcatggaatt tgaaaaatta tctcagtttg   5760

cagctgcgct tgaaccgcct ctcaatctgc cacaaccaaa caaactccag ctcattgcca   5820

tggatttgcc catggtgagt ggtgaccgga tccactgtct tgatatctta tttgctttta   5880

caaagcgggt tctaggagag agtggagaga tggatgctct acgaatacag atggaagagc   5940

gattcatggc ttccaatcct tccaaggtct cctatcagcc aatcactact actttaaaac   6000

gaaaacaaga ggaagtatct gctgtcatta ttcagcgtgc ttacagacgc caccttttaa   6060

agcgaactgt aaaacaagct tcctttacgt acaataaaaa caaaatcaaa ggtggggcta   6120

atcttcttat aaaagaagac atgataattg acagaataaa tgaaaactct attacagaaa   6180

aaactgatct gaccatgtcc actgcagctt gtccaccttc ctatgaccgg gtgacaaagc   6240

caattgtgga aaaacatgag caagaaggca aagatgaaaa agccaaaggg aaataaatga   6300

aaataaataa aaataattgg gtgacaaatt gtttacagcc tgtgaaggtg atgtattttt   6360

atcaacagga ctcctttagg aggtcaatgc caaactgact gtttttacac aaatctcctt   6420

aaggtcagtg cctacaataa gacagtgacc ccttgtcagc aaactgtgac tctgtgtaaa   6480

ggggagatga ccttgacagg aggttactgt tctcactacc agctgacact gctgaagata   6540

agatgcacaa tggctagtca gactgtaggg accagtttca aggggtgcaa acctgtgatt   6600

ttggggttgt ttaacatgaa acactttagt gtagtaattg tatccactgt ttgcatttca   6660

actgccacat ttgtcacatt tttatggaat ctgttagtgg attcatcttt ttgttaatcc   6720

atgtgtttat tatatgtgac tatttttgta aacgaagttt ctgttgagaa ataggctaag   6780

gacctctata acaggtatgc cacctggggg gtatggcaac cacatggccc tcccagctac   6840

acaaagtcgt ggtttgcatg agggcatgct gcacttagag atcatgcatg agaaaaagtc   6900

acaagaaaaa caaattctta aatttcacca tatttctggg aggggtaatt gggtgataag   6960

tggaggtgct ttgttgatct tgttttgcga aatccagccc ctagaccaag tagattattt   7020

gtgggtaggc cagtaaatct tagcaggtgc aaacttcatt caaatgtttg gagtcataaa   7080

tgttatgttt ctttttgttg tattaaaaaa aaaacctgaa tagtgaatat tgcccctcac   7140

cctccaccgc cagaagactg aattgaccaa aattactctt tataaatttc tgctttttcc   7200

tgcactttgt ttagccatct ttgggctctc agcaaggttg acactgtata tgttaatgaa   7260

atgctattta ttatgtaaat agtcatttta ccctgtggtg cacgtttgag caaacaaata   7320

atgacctaag cacagtattt attgcatcaa atatgtacca caagaaatgt agagtgcaag   7380

ctttacacag gtaataaaat gtattctgta ccatttatag atagtttgga tgctatcaat   7440

gcatgtttat attaccatgc tgctgtatct ggtttctctc actgctcaga atctcattta   7500

tgagaaacca tatgtcagtg gtaaagtcaa ggaaattgtt caacagatct catttattta   7560

agtcattaag caatagtttg cagcacttta acagcttttt ggttattttt acattttaag   7620

tggataacat atggtatata gccagactgt acagacatgt ttaaaaaaac acactgctta   7680

acctattaaa tatgtgttta gaattttata agcaaatata aatactgtaa aaagtcactt   7740

tattttattt ttcagcatta tgtacataaa tatgaagagg aaattatctt caggttgata   7800

tcacaatcac ttttcttact ttctgtccat agtacttttt catgaaagaa atttgctaaa   7860

taagacatga aaacaagact gggtagttgt agatttctgc tttttaaatt acatttgcta   7920

attttagatt atttcacaat tttaaggagc aaaataggtt cacgattcat atccaaatta   7980

tgctttgcaa ttggaaaagg gtttaaaatt ttatttatat ttctggtagt acctgtacta   8040

actgaattga aggtagtgct tatgttattt ttgttctttt tttctgactt cggtttatgt   8100

tttcatttct ttggagtaat gctgctctag attgttctaa atagaatgtg ggcttcataa   8160

tttttttttc cacaaaaaca gagtagtcaa cttatatagt caattacatc aggacatttt   8220

gtgtttctta cagaagcaaa ccataggctc ctcttttcct taaaactact tagataaact   8280

gtattcgtga actgcatgct ggaaaatgct actattatgc taaataatgc taaccaacat   8340

ttaaaatgtg caaaactaat aaagattaca ttttttattt t                       8381


<210>  2
<211>  8381
<212>  DNA
<213>  Homo sapiens

<400>  2
atactgcaga ggtctctggt gcatgtgtgt atgtgtgcgt ttgtgtgtgt ttgtgtgtct     60

gtgtgttctg ccccagtgag actgcagccc ttgtaaatac tttgacacct tttgcaagaa    120

ggaatctgaa caattgcaac tgaaggcaca ttgttatcat ctcgtctttg ggtgatgctg    180

ttcctcactg cagatggata attttccttt taatcaggaa tttcatatgc agaataaatg    240

gtaattaaaa tgtgcaggat gacaagatgg agcaaacagt gcttgtacca ccaggacctg    300

acagcttcaa cttcttcacc agagaatctc ttgcggctat tgaaagacgc attgcagaag    360

aaaaggcaaa gaatcccaaa ccagacaaaa aagatgacga cgaaaatggc ccaaagccaa    420

atagtgactt ggaagctgga aagaaccttc catttattta tggagacatt cctccagaga    480

tggtgtcaga gcccctggag gacctggacc cctactatat caataagaaa acttttatag    540

tattgaataa attgaaggcc atcttctggt tcagtgccac ctctgccctg tacattttaa    600

ctcccttcaa tcctcttagg aaaatagcta ttaagatttt ggtacattca ttattcagca    660

tgctaattat gtgcactatt ttgacaaact gtgtgtttat gacaatgagt aaccctcctg    720

attggacaaa gaatgtagaa tacaccttca caggaatata tacttttgaa tcacttataa    780

aaattattgc aaggggattc tgtttagaag attttacttt ccttcgggat ccatggaact    840

ggctcgattt cactgtcatt acatttgcgt acgtcacaga gtttgtggac ctgggcaatg    900

tctcggcatt gagaacattc agagttctcc gagcattgaa gacgatttca gtcattccag    960

gcctgaaaac cattgtggga gccctgatcc agtctgtgaa gaagctctca gatgtaatga   1020

tcctgactgt gttctgtctg agcgtatttg ctctaattgg gctgcagctg ttcatgggca   1080

acctgaggaa taaatgtata caatggcctc ccaccaatgc ttccttggag gaacatagta   1140

tagaaaagaa tataactgtg aattataatg gtacacttat aaatgaaact gtctttgagt   1200

ttgactggaa gtcatatatt caagattcaa gatatcatta tttcctggag ggttttttag   1260

atgcactact atgtggaaat agctctgatg caggccaatg tccagaggga tatatgtgtg   1320

tgaaagctgg tagaaatccc aattatggct acacaagctt tgataccttc agttgggctt   1380

ttttgtcctt gtttcgacta atgactcagg acttctggga aaatctttat caactgacat   1440

tacgtgctgc tgggaaaacg tacatgatat tttttgtatt ggtcattttc ttgggctcat   1500

tctacctaat aaatttgatc ctggctgtgg tggccatggc ctacgaggaa cagaatcagg   1560

ccaccttgga agaagcagaa cagaaagagg ccgaatttca gcagatgatt gaacagctta   1620

aaaagcaaca ggaggcagct cagcaggcag caacggcaac tgcctcagaa cattccagag   1680

agcccagtgc agcaggcagg ctctcagaca gctcatctga agcctctaag ttgagttcca   1740

agagtgctaa ggaaagaaga aatcggagga agaaaagaaa acagaaagag cagtctggtg   1800

gggaagagaa agatgaggat gaattccaaa aatctgaatc tgaggacagc atcaggagga   1860

aaggttttcg cttctccatt gaagggaacc gattgacata tgaaaagagg tactcctccc   1920

cacaccagtc tttgttgagc atccgtggct ccctattttc accaaggcga aatagcagaa   1980

caagcctttt cagctttaga gggcgagcaa aggatgtggg atctgagaac gacttcgcag   2040

atgatgagca cagcaccttt gaggataacg agagccgtag agattccttg tttgtgcccc   2100

gacgacacgg agagagacgc aacagcaacc tgagtcagac cagtaggtca tcccggatgc   2160

tggcagtgtt tccagcgaat gggaagatgc acagcactgt ggattgcaat ggtgtggttt   2220

ccttggttgg tggaccttca gttcctacat cgcctgttgg acagcttctg ccagaggtga   2280

taatagataa gccagctact gatgacaatg gaacaaccac tgaaactgaa atgagaaaga   2340

gaaggtcaag ttctttccac gtttccatgg actttctaga agatccttcc caaaggcaac   2400

gagcaatgag tatagccagc attctaacaa atacagtaga agaacttgaa gaatccaggc   2460

agaaatgccc accctgttgg tataaatttt ccaacatatt cttaatctgg gactgttctc   2520

catattggtt aaaagtgaaa catgttgtca acctggttgt gatggaccca tttgttgacc   2580

tggccatcac catctgtatt gtcttaaata ctcttttcat ggccatggag cactatccaa   2640

tgacggacca tttcaataat gtgcttacag taggaaactt ggttttcact gggatcttta   2700

cagcagaaat gtttctgaaa attattgcca tggatcctta ctattatttc caagaaggct   2760

ggaatatctt tgacggtttt attgtgacgc ttagcctggt agaacttgga ctcgccaatg   2820

tggaaggatt atctgttctc cgttcatttc gattgctgcg agttttcaag ttggcaaaat   2880

cttggccaac gttaaatatg ctaataaaga tcatcggcaa ttccgtgggg gctctgggaa   2940

atttaaccct cgtcttggcc atcatcgtct tcatttttgc cgtggtcggc atgcagctct   3000

ttggtaaaag ctacaaagat tgtgtctgca agatcgccag tgattgtcaa ctcccacgct   3060

ggcacatgaa tgacttcttc cactccttcc tgattgtgtt ccgcgtgctg tgtggggagt   3120

ggatagagac catgtgggac tgtatggagg ttgctggtca agccatgtgc cttactgtct   3180

tcatgatggt catggtgatt ggaaacctag tggtcctgaa tctctttctg gccttgcttc   3240

tgagctcatt tagtgcagac aaccttgcag ccactgatga tgataatgaa atgaataatc   3300

tccaaattgc tgtggatagg atgcacaaag gagtagctta tgtgaaaaga aaaatatatg   3360

aatttattca acagtccttc attaggaaac aaaagatttt agatgaaatt aaaccacttg   3420

atgatctaaa caacaagaaa gacagttgta tgtccaatca tacaacagaa attgggaaag   3480

atcttgacta tcttaaagat gtaaatggaa ctacaagtgg tataggaact ggcagcagtg   3540

ttgaaaaata cattattgat gaaagtgatt acatgtcatt cataaacaac cccagtctta   3600

ctgtgactgt accaattgct gtaggagaat ctgactttga aaatttaaac acggaagact   3660

ttagtagtga atcggatctg gaagaaagca aagagaaact gaatgaaagc agtagctcat   3720

cagaaggtag cactgtggac atcggcgcac ctgtagaaga acagcccgta gtggaacctg   3780

aagaaactct tgaaccagaa gcttgtttca ctgaaggctg tgtacaaaga ttcaagtgtt   3840

gtcaaatcaa tgtggaagaa ggcagaggaa aacaatggtg gaacctgaga aggacgtgtt   3900

tccgaatagt tgaacataac tggtttgaga ccttcattgt tttcatgatt ctccttagta   3960

gtggtgctct ggcatttgaa gatatatata ttgatcagcg aaagacgatt aagacgatgt   4020

tggaatatgc tgacaaggtt ttcacttaca ttttcattct ggaaatgctt ctaaaatggg   4080

tggcatatgg ctatcaaaca tatttcacca atgcctggtg ttggctggac ttcttaattg   4140

ttgatgtttc attggtcagt ttaacagcaa atgccttggg ttactcagaa cttggagcca   4200

tcaaatctct caggacacta agagctctga gacctctaag agccttatct cgatttgaag   4260

ggatgagggt ggttgtgaat gcccttttag gagcaattcc atccatcatg aatgtgcttc   4320

tggtttgtct tatattctgg ctaattttca gcatcatggg cgtaaatttg tttgctggca   4380

aattctacca ctgtattaac accacaactg gtgacaggtt tgacatcgaa gacgtgaata   4440

atcatactga ttgcctaaaa ctaatagaaa gaaatgagac tgctcgatgg aaaaatgtga   4500

aagtaaactt tgataatgta ggatttgggt atctctcttt gcttcaagtt gccacattca   4560

aaggatggat ggatataatg tatgcagcag ttgattccag aaatgtggaa ctccagccta   4620

agtatgaaaa aagtctgtac atgtatcttt actttgttat tttcatcatc tttgggtcct   4680

tcttcacctt gaacctgttt attggtgtca tcatagataa tttcaaccag cagaaaaaga   4740

agtttggagg tcaagacatc tttatgacag aagaacagaa gaaatactat aatgcaatga   4800

aaaaattagg atcgaaaaaa ccgcaaaagc ctatacctcg accaggaaac aaatttcaag   4860

gaatggtctt tgacttcgta accagacaag tttttgacat aagcatcatg attctcatct   4920

gtcttaacat ggtcacaatg atggtggaaa cagatgacca gagtgaatat gtgactacca   4980

ttttgtcacg catcaatctg gtgttcattg tgctatttac tggagagtgt gtactgaaac   5040

tcatctctct acgccattat tattttacca ttggatggaa tatttttgat tttgtggttg   5100

tcattctctc cattgtaggt atgtttcttg ccgagctgat agaaaagtat ttcgtgtccc   5160

ctaccctgtt ccgagtgatc cgtcttgcta ggattggccg aatcctacgt ctgatcaaag   5220

gagcaaaggg gatccgcacg ctgctctttg ctttgatgat gtcccttcct gcgttgttta   5280

acatcggcct cctactcttc ctagtcatgt tcatctacgc catctttggg atgtccaact   5340

ttgcctatgt taagagggaa gttgggatcg atgacatgtt caactttgag acctttggca   5400

acagcatgat ctgcctattc caaattacaa cctctgctgg ctgggatgga ttgctagcac   5460

ccattctcaa cagtaagcca cccgactgtg accctaataa agttaaccct ggaagctcag   5520

ttaagggaga ctgtgggaac ccatctgttg gaattttctt ttttgtcagt tacatcatca   5580

tatccttcct ggttgtggtg aacatgtaca tcgcggtcat cctggagaac ttcagtgttg   5640

ctactgaaga aagtgcagag cctctgagtg aggatgactt tgagatgttc tatgaggttt   5700

gggagaagtt tgatcccgat gcaactcagt tcatggaatt tgaaaaatta tctcagtttg   5760

cagctgcgct tgaaccgcct ctcaatctgc cacaaccaaa caaactccag ctcattgcca   5820

tggatttgcc catggtgagt ggtgaccgga tccactgtct tgatatctta tttgctttta   5880

caaagcgggt tctaggagag agtggagaga tggatgctct acgaatacag atggaagagc   5940

gattcatggc ttccaatcct tccaaggtct cctatcagcc aatcactact actttaaaac   6000

gaaaacaaga ggaagtatct gctgtcatta ttcagcgtgc ttacagacgc caccttttaa   6060

agcgaactgt aaaacaagct tcctttacgt acaataaaaa caaaatcaaa ggtggggcta   6120

atcttcttat aaaagaagac atgataattg acagaataaa tgaaaactct attacagaaa   6180

aaactgatct gaccatgtcc actgcagctt gtccaccttc ctatgaccgg gtgacaaagc   6240

caattgtgga aaaacatgag caagaaggca aagatgaaaa agccaaaggg aaataaatga   6300

aaataaataa aaataattgg gtgacaaatt gtttacagcc tgtgaaggtg atgtattttt   6360

atcaacagga ctcctttagg aggtcaatgc caaactgact gtttttacac aaatctcctt   6420

aaggtcagtg cctacaataa gacagtgacc ccttgtcagc aaactgtgac tctgtgtaaa   6480

ggggagatga ccttgacagg aggttactgt tctcactacc agctgacact gctgaagata   6540

agatgcacaa tggctagtca gactgtaggg accagtttca aggggtgcaa acctgtgatt   6600

ttggggttgt ttaacatgaa acactttagt gtagtaattg tatccactgt ttgcatttca   6660

actgccacat ttgtcacatt tttatggaat ctgttagtgg attcatcttt ttgttaatcc   6720

atgtgtttat tatatgtgac tatttttgta aacgaagttt ctgttgagaa ataggctaag   6780

gacctctata acaggtatgc cacctggggg gtatggcaac cacatggccc tcccagctac   6840

acaaagtcgt ggtttgcatg agggcatgct gcacttagag atcatgcatg agaaaaagtc   6900

acaagaaaaa caaattctta aatttcacca tatttctggg aggggtaatt gggtgataag   6960

tggaggtgct ttgttgatct tgttttgcga aatccagccc ctagaccaag tagattattt   7020

gtgggtaggc cagtaaatct tagcaggtgc aaacttcatt caaatgtttg gagtcataaa   7080

tgttatgttt ctttttgttg tattaaaaaa aaaacctgaa tagtgaatat tgcccctcac   7140

cctccaccgc cagaagactg aattgaccaa aattactctt tataaatttc tgctttttcc   7200

tgcactttgt ttagccatct ttgggctctc agcaaggttg acactgtata tgttaatgaa   7260

atgctattta ttatgtaaat agtcatttta ccctgtggtg cacgtttgag caaacaaata   7320

atgacctaag cacagtattt attgcatcaa atatgtacca caagaaatgt agagtgcaag   7380

ctttacacag gtaataaaat gtattctgta ccatttatag atagtttgga tgctatcaat   7440

gcatgtttat attaccatgc tgctgtatct ggtttctctc actgctcaga atctcattta   7500

tgagaaacca tatgtcagtg gtaaagtcaa ggaaattgtt caacagatct catttattta   7560

agtcattaag caatagtttg cagcacttta acagcttttt ggttattttt acattttaag   7620

tggataacat atggtatata gccagactgt acagacatgt ttaaaaaaac acactgctta   7680

acctattaaa tatgtgttta gaattttata agcaaatata aatactgtaa aaagtcactt   7740

tattttattt ttcagcatta tgtacataaa tatgaagagg aaattatctt caggttgata   7800

tcacaatcac ttttcttact ttctgtccat agtacttttt catgaaagaa atttgctaaa   7860

taagacatga aaacaagact gggtagttgt agatttctgc tttttaaatt acatttgcta   7920

attttagatt atttcacaat tttaaggagc aaaataggtt cacgattcat atccaaatta   7980

tgctttgcaa ttggaaaagg gtttaaaatt ttatttatat ttctggtagt acctgtacta   8040

actgaattga aggtagtgct tatgttattt ttgttctttt tttctgactt cggtttatgt   8100

tttcatttct ttggagtaat gctgctctag attgttctaa atagaatgtg ggcttcataa   8160

tttttttttc cacaaaaaca gagtagtcaa cttatatagt caattacatc aggacatttt   8220

gtgtttctta cagaagcaaa ccataggctc ctcttttcct taaaactact tagataaact   8280

gtattcgtga actgcatgct ggaaaatgct actattatgc taaataatgc taaccaacat   8340

ttaaaatgtg caaaactaat aaagattaca ttttttattt t                       8381


<210>  3
<211>  8381
<212>  DNA
<213>  Homo sapiens

<400>  3
atactgcaga ggtctctggt gcatgtgtgt atgtgtgcgt ttgtgtgtgt ttgtgtgtct     60

gtgtgttctg ccccagtgag actgcagccc ttgtaaatac tttgacacct tttgcaagaa    120

ggaatctgaa caattgcaac tgaaggcaca ttgttatcat ctcgtctttg ggtgatgctg    180

ttcctcactg cagatggata attttccttt taatcaggaa tttcatatgc agaataaatg    240

gtaattaaaa tgtgcaggat gacaagatgg agcaaacagt gcttgtacca ccaggacctg    300

acagcttcaa cttcttcacc agagaatctc ttgcggctat tgaaagacgc attgcagaag    360

aaaaggcaaa gaatcccaaa ccagacaaaa aagatgacga cgaaaatggc ccaaagccaa    420

atagtgactt ggaagctgga aagaaccttc catttattta tggagacatt cctccagaga    480

tggtgtcaga gcccctggag gacctggacc cctactatat caataagaaa acttttatag    540

tattgaataa attgaaggcc atcttccggt tcagtgccac ctctgccctg tacattttaa    600

ctcccttcaa tcctcttagg aaaatagcta ttaagatttt ggtacattca ttattcagca    660

tgctaattat gtgcactatt ttgacaaact gtgtgtttat gacaatgagt aaccctcctg    720

attggacaaa gaatgtagaa tacaccttca caggaatata tacttttgaa tcacttaaaa    780

aaattattgc aaggggattc tgtttagaag attttacttt ccttcgggat ccatggaact    840

ggctcgattt cactgtcatt acatttgcgt acgtcacaga gtttgtggac ctgggcaatg    900

tctcggcatt gagaacattc agagttctcc gagcattgaa gacgatttca gtcattccag    960

gcctgaaaac cattgtggga gccctgatcc agtctgtgaa gaagctctca gatgtaatga   1020

tcctgactgt gttctgtctg agcgtatttg ctctaattgg gctgcagctg ttcatgggca   1080

acctgaggaa taaatgtata caatggcctc ccaccaatgc ttccttggag gaacatagta   1140

tagaaaagaa tataactgtg aattataatg gtacacttat aaatgaaact gtctttgagt   1200

ttgactggaa gtcatatatt caagattcaa gatatcatta tttcctggag ggttttttag   1260

atgcactact atgtggaaat agctctgatg caggccaatg tccagaggga tatatgtgtg   1320

tgaaagctgg tagaaatccc aattatggct acacaagctt tgataccttc agttgggctt   1380

ttttgtcctt gtttcgacta atgactcagg acttctggga aaatctttat caactgacat   1440

tacgtgctgc tgggaaaacg tacatgatat tttttgtatt ggtcattttc ttgggctcat   1500

tctacctaat aaatttgatc ctggctgtgg tggccatggc ctacgaggaa cagaatcagg   1560

ccaccttgga agaagcagaa cagaaagagg ccgaatttca gcagatgatt gaacagctta   1620

aaaagcaaca ggaggcagct cagcaggcag caacggcaac tgcctcagaa cattccagag   1680

agcccagtgc agcaggcagg ctctcagaca gctcatctga agcctctaag ttgagttcca   1740

agagtgctaa ggaaagaaga aatcggagga agaaaagaaa acagaaagag cagtctggtg   1800

gggaagagaa agatgaggat gaattccaaa aatctgaatc tgaggacagc atcaggagga   1860

aaggttttcg cttctccatt gaagggaacc gattgacata tgaaaagagg tactcctccc   1920

cacaccagtc tttgttgagc atccgtggct ccctattttc accaaggcga aatagcagaa   1980

caagcctttt cagctttaga gggcgagcaa aggatgtggg atctgagaac gacttcgcag   2040

atgatgagca cagcaccttt gaggataacg agagccgtag agattccttg tttgtgcccc   2100

gacgacacgg agagagacgc aacagcaacc tgagtcagac cagtaggtca tcccggatgc   2160

tggcagtgtt tccagcgaat gggaagatgc acagcactgt ggattgcaat ggtgtggttt   2220

ccttggttgg tggaccttca gttcctacat cgcctgttgg acagcttctg ccagaggtga   2280

taatagataa gccagctact gatgacaatg gaacaaccac tgaaactgaa atgagaaaga   2340

gaaggtcaag ttctttccac gtttccatgg actttctaga agatccttcc caaaggcaac   2400

gagcaatgag tatagccagc attctaacaa atacagtaga agaacttgaa gaatccaggc   2460

agaaatgccc accctgttgg tataaatttt ccaacatatt cttaatctgg gactgttctc   2520

catattggtt aaaagtgaaa catgttgtca acctggttgt gatggaccca tttgttgacc   2580

tggccatcac catctgtatt gtcttaaata ctcttttcat ggccatggag cactatccaa   2640

tgacggacca tttcaataat gtgcttacag taggaaactt ggttttcact gggatcttta   2700

cagcagaaat gtttctgaaa attattgcca tggatcctta ctattatttc caagaaggct   2760

ggaatatctt tgacggtttt attgtgacgc ttagcctggt agaacttgga ctcgccaatg   2820

tggaaggatt atctgttctc cgttcatttc gattgctgcg agttttcaag ttggcaaaat   2880

cttggccaac gttaaatatg ctaataaaga tcatcggcaa ttccgtgggg gctctgggaa   2940

atttaaccct cgtcttggcc atcatcgtct tcatttttgc cgtggtcggc atgcagctct   3000

ttggtaaaag ctacaaagat tgtgtctgca agatcgccag tgattgtcaa ctcccacgct   3060

ggcacatgaa tgacttcttc cactccttcc tgattgtgtt ccgcgtgctg tgtggggagt   3120

ggatagagac catgtgggac tgtatggagg ttgctggtca agccatgtgc cttactgtct   3180

tcatgatggt catggtgatt ggaaacctag tggtcctgaa tctctttctg gccttgcttc   3240

tgagctcatt tagtgcagac aaccttgcag ccactgatga tgataatgaa atgaataatc   3300

tccaaattgc tgtggatagg atgcacaaag gagtagctta tgtgaaaaga aaaatatatg   3360

aatttattca acagtccttc attaggaaac aaaagatttt agatgaaatt aaaccacttg   3420

atgatctaaa caacaagaaa gacagttgta tgtccaatca tacaacagaa attgggaaag   3480

atcttgacta tcttaaagat gtaaatggaa ctacaagtgg tataggaact ggcagcagtg   3540

ttgaaaaata cattattgat gaaagtgatt acatgtcatt cataaacaac cccagtctta   3600

ctgtgactgt accaattgct gtaggagaat ctgactttga aaatttaaac acggaagact   3660

ttagtagtga atcggatctg gaagaaagca aagagaaact gaatgaaagc agtagctcat   3720

cagaaggtag cactgtggac atcggcgcac ctgtagaaga acagcccgta gtggaacctg   3780

aagaaactct tgaaccagaa gcttgtttca ctgaaggctg tgtacaaaga ttcaagtgtt   3840

gtcaaatcaa tgtggaagaa ggcagaggaa aacaatggtg gaacctgaga aggacgtgtt   3900

tccgaatagt tgaacataac tggtttgaga ccttcattgt tttcatgatt ctccttagta   3960

gtggtgctct ggcatttgaa gatatatata ttgatcagcg aaagacgatt aagacgatgt   4020

tggaatatgc tgacaaggtt ttcacttaca ttttcattct ggaaatgctt ctaaaatggg   4080

tggcatatgg ctatcaaaca tatttcacca atgcctggtg ttggctggac ttcttaattg   4140

ttgatgtttc attggtcagt ttaacagcaa atgccttggg ttactcagaa cttggagcca   4200

tcaaatctct caggacacta agagctctga gacctctaag agccttatct cgatttgaag   4260

ggatgagggt ggttgtgaat gcccttttag gagcaattcc atccatcatg aatgtgcttc   4320

tggtttgtct tatattctgg ctaattttca gcatcatggg cgtaaatttg tttgctggca   4380

aattctacca ctgtattaac accacaactg gtgacaggtt tgacatcgaa gacgtgaata   4440

atcatactga ttgcctaaaa ctaatagaaa gaaatgagac tgctcgatgg aaaaatgtga   4500

aagtaaactt tgataatgta ggatttgggt atctctcttt gcttcaagtt gccacattca   4560

aaggatggat ggatataatg tatgcagcag ttgattccag aaatgtggaa ctccagccta   4620

agtatgaaaa aagtctgtac atgtatcttt actttgttat tttcatcatc tttgggtcct   4680

tcttcacctt gaacctgttt attggtgtca tcatagataa tttcaaccag cagaaaaaga   4740

agtttggagg tcaagacatc tttatgacag aagaacagaa gaaatactat aatgcaatga   4800

aaaaattagg atcgaaaaaa ccgcaaaagc ctatacctcg accaggaaac aaatttcaag   4860

gaatggtctt tgacttcgta accagacaag tttttgacat aagcatcatg attctcatct   4920

gtcttaacat ggtcacaatg atggtggaaa cagatgacca gagtgaatat gtgactacca   4980

ttttgtcacg catcaatctg gtgttcattg tgctatttac tggagagtgt gtactgaaac   5040

tcatctctct acgccattat tattttacca ttggatggaa tatttttgat tttgtggttg   5100

tcattctctc cattgtaggt atgtttcttg ccgagctgat agaaaagtat ttcgtgtccc   5160

ctaccctgtt ccgagtgatc cgtcttgcta ggattggccg aatcctacgt ctgatcaaag   5220

gagcaaaggg gatccgcacg ctgctctttg ctttgatgat gtcccttcct gcgttgttta   5280

acatcggcct cctactcttc ctagtcatgt tcatctacgc catctttggg atgtccaact   5340

ttgcctatgt taagagggaa gttgggatcg atgacatgtt caactttgag acctttggca   5400

acagcatgat ctgcctattc caaattacaa cctctgctgg ctgggatgga ttgctagcac   5460

ccattctcaa cagtaagcca cccgactgtg accctaataa agttaaccct ggaagctcag   5520

ttaagggaga ctgtgggaac ccatctgttg gaattttctt ttttgtcagt tacatcatca   5580

tatccttcct ggttgtggtg aacatgtaca tcgcggtcat cctggagaac ttcagtgttg   5640

ctactgaaga aagtgcagag cctctgagtg aggatgactt tgagatgttc tatgaggttt   5700

gggagaagtt tgatcccgat gcaactcagt tcatggaatt tgaaaaatta tctcagtttg   5760

cagctgcgct tgaaccgcct ctcaatctgc cacaaccaaa caaactccag ctcattgcca   5820

tggatttgcc catggtgagt ggtgaccgga tccactgtct tgatatctta tttgctttta   5880

caaagcgggt tctaggagag agtggagaga tggatgctct acgaatacag atggaagagc   5940

gattcatggc ttccaatcct tccaaggtct cctatcagcc aatcactact actttaaaac   6000

gaaaacaaga ggaagtatct gctgtcatta ttcagcgtgc ttacagacgc caccttttaa   6060

agcgaactgt aaaacaagct tcctttacgt acaataaaaa caaaatcaaa ggtggggcta   6120

atcttcttat aaaagaagac atgataattg acagaataaa tgaaaactct attacagaaa   6180

aaactgatct gaccatgtcc actgcagctt gtccaccttc ctatgaccgg gtgacaaagc   6240

caattgtgga aaaacatgag caagaaggca aagatgaaaa agccaaaggg aaataaatga   6300

aaataaataa aaataattgg gtgacaaatt gtttacagcc tgtgaaggtg atgtattttt   6360

atcaacagga ctcctttagg aggtcaatgc caaactgact gtttttacac aaatctcctt   6420

aaggtcagtg cctacaataa gacagtgacc ccttgtcagc aaactgtgac tctgtgtaaa   6480

ggggagatga ccttgacagg aggttactgt tctcactacc agctgacact gctgaagata   6540

agatgcacaa tggctagtca gactgtaggg accagtttca aggggtgcaa acctgtgatt   6600

ttggggttgt ttaacatgaa acactttagt gtagtaattg tatccactgt ttgcatttca   6660

actgccacat ttgtcacatt tttatggaat ctgttagtgg attcatcttt ttgttaatcc   6720

atgtgtttat tatatgtgac tatttttgta aacgaagttt ctgttgagaa ataggctaag   6780

gacctctata acaggtatgc cacctggggg gtatggcaac cacatggccc tcccagctac   6840

acaaagtcgt ggtttgcatg agggcatgct gcacttagag atcatgcatg agaaaaagtc   6900

acaagaaaaa caaattctta aatttcacca tatttctggg aggggtaatt gggtgataag   6960

tggaggtgct ttgttgatct tgttttgcga aatccagccc ctagaccaag tagattattt   7020

gtgggtaggc cagtaaatct tagcaggtgc aaacttcatt caaatgtttg gagtcataaa   7080

tgttatgttt ctttttgttg tattaaaaaa aaaacctgaa tagtgaatat tgcccctcac   7140

cctccaccgc cagaagactg aattgaccaa aattactctt tataaatttc tgctttttcc   7200

tgcactttgt ttagccatct ttgggctctc agcaaggttg acactgtata tgttaatgaa   7260

atgctattta ttatgtaaat agtcatttta ccctgtggtg cacgtttgag caaacaaata   7320

atgacctaag cacagtattt attgcatcaa atatgtacca caagaaatgt agagtgcaag   7380

ctttacacag gtaataaaat gtattctgta ccatttatag atagtttgga tgctatcaat   7440

gcatgtttat attaccatgc tgctgtatct ggtttctctc actgctcaga atctcattta   7500

tgagaaacca tatgtcagtg gtaaagtcaa ggaaattgtt caacagatct catttattta   7560

agtcattaag caatagtttg cagcacttta acagcttttt ggttattttt acattttaag   7620

tggataacat atggtatata gccagactgt acagacatgt ttaaaaaaac acactgctta   7680

acctattaaa tatgtgttta gaattttata agcaaatata aatactgtaa aaagtcactt   7740

tattttattt ttcagcatta tgtacataaa tatgaagagg aaattatctt caggttgata   7800

tcacaatcac ttttcttact ttctgtccat agtacttttt catgaaagaa atttgctaaa   7860

taagacatga aaacaagact gggtagttgt agatttctgc tttttaaatt acatttgcta   7920

attttagatt atttcacaat tttaaggagc aaaataggtt cacgattcat atccaaatta   7980

tgctttgcaa ttggaaaagg gtttaaaatt ttatttatat ttctggtagt acctgtacta   8040

actgaattga aggtagtgct tatgttattt ttgttctttt tttctgactt cggtttatgt   8100

tttcatttct ttggagtaat gctgctctag attgttctaa atagaatgtg ggcttcataa   8160

tttttttttc cacaaaaaca gagtagtcaa cttatatagt caattacatc aggacatttt   8220

gtgtttctta cagaagcaaa ccataggctc ctcttttcct taaaactact tagataaact   8280

gtattcgtga actgcatgct ggaaaatgct actattatgc taaataatgc taaccaacat   8340

ttaaaatgtg caaaactaat aaagattaca ttttttattt t                       8381


<210>  4
<211>  8381
<212>  DNA
<213>  Homo sapiens

<400>  4
atactgcaga ggtctctggt gcatgtgtgt atgtgtgcgt ttgtgtgtgt ttgtgtgtct     60

gtgtgttctg ccccagtgag actgcagccc ttgtaaatac tttgacacct tttgcaagaa    120

ggaatctgaa caattgcaac tgaaggcaca ttgttatcat ctcgtctttg ggtgatgctg    180

ttcctcactg cagatggata attttccttt taatcaggaa tttcatatgc agaataaatg    240

gtaattaaaa tgtgcaggat gacaagatgg agcaaacagt gcttgtacca ccaggacctg    300

acagcttcaa cttcttcacc agagaatctc ttgcggctat tgaaagacgc attgcagaag    360

aaaaggcaaa gaatcccaaa ccagacaaaa aagatgacga cgaaaatggc ccaaagccaa    420

atagtgactt ggaagctgga aagaaccttc catttattta tggagacatt cctccagaga    480

tggtgtcaga gcccctggag gacctggacc cctactatat caataagaaa acttttatag    540

tattgaataa attgaaggcc atcttccggt tcagtgccac ctctgccctg tacattttaa    600

ctcccttcaa tcctcttagg aaaatagcta ttaagatttt ggtacattca ttattcagca    660

tgctaattat gtgcactatt ttgacaaact gtgtgtttat gacaatgagt aaccctcctg    720

attggacaaa gaatgtagaa tacaccttca caggaatata tacttttgaa tcacttataa    780

aaattattgc aaggggattc tgtttagaag attttacttt ccttcgggat ccatggaact    840

ggctcgattt cactgtcatt agatttgcgt acgtcacaga gtttgtggac ctgggcaatg    900

tctcggcatt gagaacattc agagttctcc gagcattgaa gacgatttca gtcattccag    960

gcctgaaaac cattgtggga gccctgatcc agtctgtgaa gaagctctca gatgtaatga   1020

tcctgactgt gttctgtctg agcgtatttg ctctaattgg gctgcagctg ttcatgggca   1080

acctgaggaa taaatgtata caatggcctc ccaccaatgc ttccttggag gaacatagta   1140

tagaaaagaa tataactgtg aattataatg gtacacttat aaatgaaact gtctttgagt   1200

ttgactggaa gtcatatatt caagattcaa gatatcatta tttcctggag ggttttttag   1260

atgcactact atgtggaaat agctctgatg caggccaatg tccagaggga tatatgtgtg   1320

tgaaagctgg tagaaatccc aattatggct acacaagctt tgataccttc agttgggctt   1380

ttttgtcctt gtttcgacta atgactcagg acttctggga aaatctttat caactgacat   1440

tacgtgctgc tgggaaaacg tacatgatat tttttgtatt ggtcattttc ttgggctcat   1500

tctacctaat aaatttgatc ctggctgtgg tggccatggc ctacgaggaa cagaatcagg   1560

ccaccttgga agaagcagaa cagaaagagg ccgaatttca gcagatgatt gaacagctta   1620

aaaagcaaca ggaggcagct cagcaggcag caacggcaac tgcctcagaa cattccagag   1680

agcccagtgc agcaggcagg ctctcagaca gctcatctga agcctctaag ttgagttcca   1740

agagtgctaa ggaaagaaga aatcggagga agaaaagaaa acagaaagag cagtctggtg   1800

gggaagagaa agatgaggat gaattccaaa aatctgaatc tgaggacagc atcaggagga   1860

aaggttttcg cttctccatt gaagggaacc gattgacata tgaaaagagg tactcctccc   1920

cacaccagtc tttgttgagc atccgtggct ccctattttc accaaggcga aatagcagaa   1980

caagcctttt cagctttaga gggcgagcaa aggatgtggg atctgagaac gacttcgcag   2040

atgatgagca cagcaccttt gaggataacg agagccgtag agattccttg tttgtgcccc   2100

gacgacacgg agagagacgc aacagcaacc tgagtcagac cagtaggtca tcccggatgc   2160

tggcagtgtt tccagcgaat gggaagatgc acagcactgt ggattgcaat ggtgtggttt   2220

ccttggttgg tggaccttca gttcctacat cgcctgttgg acagcttctg ccagaggtga   2280

taatagataa gccagctact gatgacaatg gaacaaccac tgaaactgaa atgagaaaga   2340

gaaggtcaag ttctttccac gtttccatgg actttctaga agatccttcc caaaggcaac   2400

gagcaatgag tatagccagc attctaacaa atacagtaga agaacttgaa gaatccaggc   2460

agaaatgccc accctgttgg tataaatttt ccaacatatt cttaatctgg gactgttctc   2520

catattggtt aaaagtgaaa catgttgtca acctggttgt gatggaccca tttgttgacc   2580

tggccatcac catctgtatt gtcttaaata ctcttttcat ggccatggag cactatccaa   2640

tgacggacca tttcaataat gtgcttacag taggaaactt ggttttcact gggatcttta   2700

cagcagaaat gtttctgaaa attattgcca tggatcctta ctattatttc caagaaggct   2760

ggaatatctt tgacggtttt attgtgacgc ttagcctggt agaacttgga ctcgccaatg   2820

tggaaggatt atctgttctc cgttcatttc gattgctgcg agttttcaag ttggcaaaat   2880

cttggccaac gttaaatatg ctaataaaga tcatcggcaa ttccgtgggg gctctgggaa   2940

atttaaccct cgtcttggcc atcatcgtct tcatttttgc cgtggtcggc atgcagctct   3000

ttggtaaaag ctacaaagat tgtgtctgca agatcgccag tgattgtcaa ctcccacgct   3060

ggcacatgaa tgacttcttc cactccttcc tgattgtgtt ccgcgtgctg tgtggggagt   3120

ggatagagac catgtgggac tgtatggagg ttgctggtca agccatgtgc cttactgtct   3180

tcatgatggt catggtgatt ggaaacctag tggtcctgaa tctctttctg gccttgcttc   3240

tgagctcatt tagtgcagac aaccttgcag ccactgatga tgataatgaa atgaataatc   3300

tccaaattgc tgtggatagg atgcacaaag gagtagctta tgtgaaaaga aaaatatatg   3360

aatttattca acagtccttc attaggaaac aaaagatttt agatgaaatt aaaccacttg   3420

atgatctaaa caacaagaaa gacagttgta tgtccaatca tacaacagaa attgggaaag   3480

atcttgacta tcttaaagat gtaaatggaa ctacaagtgg tataggaact ggcagcagtg   3540

ttgaaaaata cattattgat gaaagtgatt acatgtcatt cataaacaac cccagtctta   3600

ctgtgactgt accaattgct gtaggagaat ctgactttga aaatttaaac acggaagact   3660

ttagtagtga atcggatctg gaagaaagca aagagaaact gaatgaaagc agtagctcat   3720

cagaaggtag cactgtggac atcggcgcac ctgtagaaga acagcccgta gtggaacctg   3780

aagaaactct tgaaccagaa gcttgtttca ctgaaggctg tgtacaaaga ttcaagtgtt   3840

gtcaaatcaa tgtggaagaa ggcagaggaa aacaatggtg gaacctgaga aggacgtgtt   3900

tccgaatagt tgaacataac tggtttgaga ccttcattgt tttcatgatt ctccttagta   3960

gtggtgctct ggcatttgaa gatatatata ttgatcagcg aaagacgatt aagacgatgt   4020

tggaatatgc tgacaaggtt ttcacttaca ttttcattct ggaaatgctt ctaaaatggg   4080

tggcatatgg ctatcaaaca tatttcacca atgcctggtg ttggctggac ttcttaattg   4140

ttgatgtttc attggtcagt ttaacagcaa atgccttggg ttactcagaa cttggagcca   4200

tcaaatctct caggacacta agagctctga gacctctaag agccttatct cgatttgaag   4260

ggatgagggt ggttgtgaat gcccttttag gagcaattcc atccatcatg aatgtgcttc   4320

tggtttgtct tatattctgg ctaattttca gcatcatggg cgtaaatttg tttgctggca   4380

aattctacca ctgtattaac accacaactg gtgacaggtt tgacatcgaa gacgtgaata   4440

atcatactga ttgcctaaaa ctaatagaaa gaaatgagac tgctcgatgg aaaaatgtga   4500

aagtaaactt tgataatgta ggatttgggt atctctcttt gcttcaagtt gccacattca   4560

aaggatggat ggatataatg tatgcagcag ttgattccag aaatgtggaa ctccagccta   4620

agtatgaaaa aagtctgtac atgtatcttt actttgttat tttcatcatc tttgggtcct   4680

tcttcacctt gaacctgttt attggtgtca tcatagataa tttcaaccag cagaaaaaga   4740

agtttggagg tcaagacatc tttatgacag aagaacagaa gaaatactat aatgcaatga   4800

aaaaattagg atcgaaaaaa ccgcaaaagc ctatacctcg accaggaaac aaatttcaag   4860

gaatggtctt tgacttcgta accagacaag tttttgacat aagcatcatg attctcatct   4920

gtcttaacat ggtcacaatg atggtggaaa cagatgacca gagtgaatat gtgactacca   4980

ttttgtcacg catcaatctg gtgttcattg tgctatttac tggagagtgt gtactgaaac   5040

tcatctctct acgccattat tattttacca ttggatggaa tatttttgat tttgtggttg   5100

tcattctctc cattgtaggt atgtttcttg ccgagctgat agaaaagtat ttcgtgtccc   5160

ctaccctgtt ccgagtgatc cgtcttgcta ggattggccg aatcctacgt ctgatcaaag   5220

gagcaaaggg gatccgcacg ctgctctttg ctttgatgat gtcccttcct gcgttgttta   5280

acatcggcct cctactcttc ctagtcatgt tcatctacgc catctttggg atgtccaact   5340

ttgcctatgt taagagggaa gttgggatcg atgacatgtt caactttgag acctttggca   5400

acagcatgat ctgcctattc caaattacaa cctctgctgg ctgggatgga ttgctagcac   5460

ccattctcaa cagtaagcca cccgactgtg accctaataa agttaaccct ggaagctcag   5520

ttaagggaga ctgtgggaac ccatctgttg gaattttctt ttttgtcagt tacatcatca   5580

tatccttcct ggttgtggtg aacatgtaca tcgcggtcat cctggagaac ttcagtgttg   5640

ctactgaaga aagtgcagag cctctgagtg aggatgactt tgagatgttc tatgaggttt   5700

gggagaagtt tgatcccgat gcaactcagt tcatggaatt tgaaaaatta tctcagtttg   5760

cagctgcgct tgaaccgcct ctcaatctgc cacaaccaaa caaactccag ctcattgcca   5820

tggatttgcc catggtgagt ggtgaccgga tccactgtct tgatatctta tttgctttta   5880

caaagcgggt tctaggagag agtggagaga tggatgctct acgaatacag atggaagagc   5940

gattcatggc ttccaatcct tccaaggtct cctatcagcc aatcactact actttaaaac   6000

gaaaacaaga ggaagtatct gctgtcatta ttcagcgtgc ttacagacgc caccttttaa   6060

agcgaactgt aaaacaagct tcctttacgt acaataaaaa caaaatcaaa ggtggggcta   6120

atcttcttat aaaagaagac atgataattg acagaataaa tgaaaactct attacagaaa   6180

aaactgatct gaccatgtcc actgcagctt gtccaccttc ctatgaccgg gtgacaaagc   6240

caattgtgga aaaacatgag caagaaggca aagatgaaaa agccaaaggg aaataaatga   6300

aaataaataa aaataattgg gtgacaaatt gtttacagcc tgtgaaggtg atgtattttt   6360

atcaacagga ctcctttagg aggtcaatgc caaactgact gtttttacac aaatctcctt   6420

aaggtcagtg cctacaataa gacagtgacc ccttgtcagc aaactgtgac tctgtgtaaa   6480

ggggagatga ccttgacagg aggttactgt tctcactacc agctgacact gctgaagata   6540

agatgcacaa tggctagtca gactgtaggg accagtttca aggggtgcaa acctgtgatt   6600

ttggggttgt ttaacatgaa acactttagt gtagtaattg tatccactgt ttgcatttca   6660

actgccacat ttgtcacatt tttatggaat ctgttagtgg attcatcttt ttgttaatcc   6720

atgtgtttat tatatgtgac tatttttgta aacgaagttt ctgttgagaa ataggctaag   6780

gacctctata acaggtatgc cacctggggg gtatggcaac cacatggccc tcccagctac   6840

acaaagtcgt ggtttgcatg agggcatgct gcacttagag atcatgcatg agaaaaagtc   6900

acaagaaaaa caaattctta aatttcacca tatttctggg aggggtaatt gggtgataag   6960

tggaggtgct ttgttgatct tgttttgcga aatccagccc ctagaccaag tagattattt   7020

gtgggtaggc cagtaaatct tagcaggtgc aaacttcatt caaatgtttg gagtcataaa   7080

tgttatgttt ctttttgttg tattaaaaaa aaaacctgaa tagtgaatat tgcccctcac   7140

cctccaccgc cagaagactg aattgaccaa aattactctt tataaatttc tgctttttcc   7200

tgcactttgt ttagccatct ttgggctctc agcaaggttg acactgtata tgttaatgaa   7260

atgctattta ttatgtaaat agtcatttta ccctgtggtg cacgtttgag caaacaaata   7320

atgacctaag cacagtattt attgcatcaa atatgtacca caagaaatgt agagtgcaag   7380

ctttacacag gtaataaaat gtattctgta ccatttatag atagtttgga tgctatcaat   7440

gcatgtttat attaccatgc tgctgtatct ggtttctctc actgctcaga atctcattta   7500

tgagaaacca tatgtcagtg gtaaagtcaa ggaaattgtt caacagatct catttattta   7560

agtcattaag caatagtttg cagcacttta acagcttttt ggttattttt acattttaag   7620

tggataacat atggtatata gccagactgt acagacatgt ttaaaaaaac acactgctta   7680

acctattaaa tatgtgttta gaattttata agcaaatata aatactgtaa aaagtcactt   7740

tattttattt ttcagcatta tgtacataaa tatgaagagg aaattatctt caggttgata   7800

tcacaatcac ttttcttact ttctgtccat agtacttttt catgaaagaa atttgctaaa   7860

taagacatga aaacaagact gggtagttgt agatttctgc tttttaaatt acatttgcta   7920

attttagatt atttcacaat tttaaggagc aaaataggtt cacgattcat atccaaatta   7980

tgctttgcaa ttggaaaagg gtttaaaatt ttatttatat ttctggtagt acctgtacta   8040

actgaattga aggtagtgct tatgttattt ttgttctttt tttctgactt cggtttatgt   8100

tttcatttct ttggagtaat gctgctctag attgttctaa atagaatgtg ggcttcataa   8160

tttttttttc cacaaaaaca gagtagtcaa cttatatagt caattacatc aggacatttt   8220

gtgtttctta cagaagcaaa ccataggctc ctcttttcct taaaactact tagataaact   8280

gtattcgtga actgcatgct ggaaaatgct actattatgc taaataatgc taaccaacat   8340

ttaaaatgtg caaaactaat aaagattaca ttttttattt t                       8381


<210>  5
<211>  8381
<212>  DNA
<213>  Homo sapiens

<400>  5
atactgcaga ggtctctggt gcatgtgtgt atgtgtgcgt ttgtgtgtgt ttgtgtgtct     60

gtgtgttctg ccccagtgag actgcagccc ttgtaaatac tttgacacct tttgcaagaa    120

ggaatctgaa caattgcaac tgaaggcaca ttgttatcat ctcgtctttg ggtgatgctg    180

ttcctcactg cagatggata attttccttt taatcaggaa tttcatatgc agaataaatg    240

gtaattaaaa tgtgcaggat gacaagatgg agcaaacagt gcttgtacca ccaggacctg    300

acagcttcaa cttcttcacc agagaatctc ttgcggctat tgaaagacgc attgcagaag    360

aaaaggcaaa gaatcccaaa ccagacaaaa aagatgacga cgaaaatggc ccaaagccaa    420

atagtgactt ggaagctgga aagaaccttc catttattta tggagacatt cctccagaga    480

tggtgtcaga gcccctggag gacctggacc cctactatat caataagaaa acttttatag    540

tattgaataa attgaaggcc atcttccggt tcagtgccac ctctgccctg tacattttaa    600

ctcccttcaa tcctcttagg aaaatagcta ttaagatttt ggtacattca ttattcagca    660

tgctaattat gtgcactatt ttgacaaact gtgtgtttat gacaatgagt aaccctcctg    720

attggacaaa gaatgtagaa tacaccttca caggaatata tacttttgaa tcacttataa    780

aaattattgc aaggggattc tgtttagaag attttacttt ccttcgggat ccatggaact    840

ggctcgattt cactgtcatt acatttgcgt acgtcacaga gtttgtggac ctgggcaatg    900

tctcggcatt gagaacattc agagttctcc gagcattgaa gatgatttca gtcattccag    960

gcctgaaaac cattgtggga gccctgatcc agtctgtgaa gaagctctca gatgtaatga   1020

tcctgactgt gttctgtctg agcgtatttg ctctaattgg gctgcagctg ttcatgggca   1080

acctgaggaa taaatgtata caatggcctc ccaccaatgc ttccttggag gaacatagta   1140

tagaaaagaa tataactgtg aattataatg gtacacttat aaatgaaact gtctttgagt   1200

ttgactggaa gtcatatatt caagattcaa gatatcatta tttcctggag ggttttttag   1260

atgcactact atgtggaaat agctctgatg caggccaatg tccagaggga tatatgtgtg   1320

tgaaagctgg tagaaatccc aattatggct acacaagctt tgataccttc agttgggctt   1380

ttttgtcctt gtttcgacta atgactcagg acttctggga aaatctttat caactgacat   1440

tacgtgctgc tgggaaaacg tacatgatat tttttgtatt ggtcattttc ttgggctcat   1500

tctacctaat aaatttgatc ctggctgtgg tggccatggc ctacgaggaa cagaatcagg   1560

ccaccttgga agaagcagaa cagaaagagg ccgaatttca gcagatgatt gaacagctta   1620

aaaagcaaca ggaggcagct cagcaggcag caacggcaac tgcctcagaa cattccagag   1680

agcccagtgc agcaggcagg ctctcagaca gctcatctga agcctctaag ttgagttcca   1740

agagtgctaa ggaaagaaga aatcggagga agaaaagaaa acagaaagag cagtctggtg   1800

gggaagagaa agatgaggat gaattccaaa aatctgaatc tgaggacagc atcaggagga   1860

aaggttttcg cttctccatt gaagggaacc gattgacata tgaaaagagg tactcctccc   1920

cacaccagtc tttgttgagc atccgtggct ccctattttc accaaggcga aatagcagaa   1980

caagcctttt cagctttaga gggcgagcaa aggatgtggg atctgagaac gacttcgcag   2040

atgatgagca cagcaccttt gaggataacg agagccgtag agattccttg tttgtgcccc   2100

gacgacacgg agagagacgc aacagcaacc tgagtcagac cagtaggtca tcccggatgc   2160

tggcagtgtt tccagcgaat gggaagatgc acagcactgt ggattgcaat ggtgtggttt   2220

ccttggttgg tggaccttca gttcctacat cgcctgttgg acagcttctg ccagaggtga   2280

taatagataa gccagctact gatgacaatg gaacaaccac tgaaactgaa atgagaaaga   2340

gaaggtcaag ttctttccac gtttccatgg actttctaga agatccttcc caaaggcaac   2400

gagcaatgag tatagccagc attctaacaa atacagtaga agaacttgaa gaatccaggc   2460

agaaatgccc accctgttgg tataaatttt ccaacatatt cttaatctgg gactgttctc   2520

catattggtt aaaagtgaaa catgttgtca acctggttgt gatggaccca tttgttgacc   2580

tggccatcac catctgtatt gtcttaaata ctcttttcat ggccatggag cactatccaa   2640

tgacggacca tttcaataat gtgcttacag taggaaactt ggttttcact gggatcttta   2700

cagcagaaat gtttctgaaa attattgcca tggatcctta ctattatttc caagaaggct   2760

ggaatatctt tgacggtttt attgtgacgc ttagcctggt agaacttgga ctcgccaatg   2820

tggaaggatt atctgttctc cgttcatttc gattgctgcg agttttcaag ttggcaaaat   2880

cttggccaac gttaaatatg ctaataaaga tcatcggcaa ttccgtgggg gctctgggaa   2940

atttaaccct cgtcttggcc atcatcgtct tcatttttgc cgtggtcggc atgcagctct   3000

ttggtaaaag ctacaaagat tgtgtctgca agatcgccag tgattgtcaa ctcccacgct   3060

ggcacatgaa tgacttcttc cactccttcc tgattgtgtt ccgcgtgctg tgtggggagt   3120

ggatagagac catgtgggac tgtatggagg ttgctggtca agccatgtgc cttactgtct   3180

tcatgatggt catggtgatt ggaaacctag tggtcctgaa tctctttctg gccttgcttc   3240

tgagctcatt tagtgcagac aaccttgcag ccactgatga tgataatgaa atgaataatc   3300

tccaaattgc tgtggatagg atgcacaaag gagtagctta tgtgaaaaga aaaatatatg   3360

aatttattca acagtccttc attaggaaac aaaagatttt agatgaaatt aaaccacttg   3420

atgatctaaa caacaagaaa gacagttgta tgtccaatca tacaacagaa attgggaaag   3480

atcttgacta tcttaaagat gtaaatggaa ctacaagtgg tataggaact ggcagcagtg   3540

ttgaaaaata cattattgat gaaagtgatt acatgtcatt cataaacaac cccagtctta   3600

ctgtgactgt accaattgct gtaggagaat ctgactttga aaatttaaac acggaagact   3660

ttagtagtga atcggatctg gaagaaagca aagagaaact gaatgaaagc agtagctcat   3720

cagaaggtag cactgtggac atcggcgcac ctgtagaaga acagcccgta gtggaacctg   3780

aagaaactct tgaaccagaa gcttgtttca ctgaaggctg tgtacaaaga ttcaagtgtt   3840

gtcaaatcaa tgtggaagaa ggcagaggaa aacaatggtg gaacctgaga aggacgtgtt   3900

tccgaatagt tgaacataac tggtttgaga ccttcattgt tttcatgatt ctccttagta   3960

gtggtgctct ggcatttgaa gatatatata ttgatcagcg aaagacgatt aagacgatgt   4020

tggaatatgc tgacaaggtt ttcacttaca ttttcattct ggaaatgctt ctaaaatggg   4080

tggcatatgg ctatcaaaca tatttcacca atgcctggtg ttggctggac ttcttaattg   4140

ttgatgtttc attggtcagt ttaacagcaa atgccttggg ttactcagaa cttggagcca   4200

tcaaatctct caggacacta agagctctga gacctctaag agccttatct cgatttgaag   4260

ggatgagggt ggttgtgaat gcccttttag gagcaattcc atccatcatg aatgtgcttc   4320

tggtttgtct tatattctgg ctaattttca gcatcatggg cgtaaatttg tttgctggca   4380

aattctacca ctgtattaac accacaactg gtgacaggtt tgacatcgaa gacgtgaata   4440

atcatactga ttgcctaaaa ctaatagaaa gaaatgagac tgctcgatgg aaaaatgtga   4500

aagtaaactt tgataatgta ggatttgggt atctctcttt gcttcaagtt gccacattca   4560

aaggatggat ggatataatg tatgcagcag ttgattccag aaatgtggaa ctccagccta   4620

agtatgaaaa aagtctgtac atgtatcttt actttgttat tttcatcatc tttgggtcct   4680

tcttcacctt gaacctgttt attggtgtca tcatagataa tttcaaccag cagaaaaaga   4740

agtttggagg tcaagacatc tttatgacag aagaacagaa gaaatactat aatgcaatga   4800

aaaaattagg atcgaaaaaa ccgcaaaagc ctatacctcg accaggaaac aaatttcaag   4860

gaatggtctt tgacttcgta accagacaag tttttgacat aagcatcatg attctcatct   4920

gtcttaacat ggtcacaatg atggtggaaa cagatgacca gagtgaatat gtgactacca   4980

ttttgtcacg catcaatctg gtgttcattg tgctatttac tggagagtgt gtactgaaac   5040

tcatctctct acgccattat tattttacca ttggatggaa tatttttgat tttgtggttg   5100

tcattctctc cattgtaggt atgtttcttg ccgagctgat agaaaagtat ttcgtgtccc   5160

ctaccctgtt ccgagtgatc cgtcttgcta ggattggccg aatcctacgt ctgatcaaag   5220

gagcaaaggg gatccgcacg ctgctctttg ctttgatgat gtcccttcct gcgttgttta   5280

acatcggcct cctactcttc ctagtcatgt tcatctacgc catctttggg atgtccaact   5340

ttgcctatgt taagagggaa gttgggatcg atgacatgtt caactttgag acctttggca   5400

acagcatgat ctgcctattc caaattacaa cctctgctgg ctgggatgga ttgctagcac   5460

ccattctcaa cagtaagcca cccgactgtg accctaataa agttaaccct ggaagctcag   5520

ttaagggaga ctgtgggaac ccatctgttg gaattttctt ttttgtcagt tacatcatca   5580

tatccttcct ggttgtggtg aacatgtaca tcgcggtcat cctggagaac ttcagtgttg   5640

ctactgaaga aagtgcagag cctctgagtg aggatgactt tgagatgttc tatgaggttt   5700

gggagaagtt tgatcccgat gcaactcagt tcatggaatt tgaaaaatta tctcagtttg   5760

cagctgcgct tgaaccgcct ctcaatctgc cacaaccaaa caaactccag ctcattgcca   5820

tggatttgcc catggtgagt ggtgaccgga tccactgtct tgatatctta tttgctttta   5880

caaagcgggt tctaggagag agtggagaga tggatgctct acgaatacag atggaagagc   5940

gattcatggc ttccaatcct tccaaggtct cctatcagcc aatcactact actttaaaac   6000

gaaaacaaga ggaagtatct gctgtcatta ttcagcgtgc ttacagacgc caccttttaa   6060

agcgaactgt aaaacaagct tcctttacgt acaataaaaa caaaatcaaa ggtggggcta   6120

atcttcttat aaaagaagac atgataattg acagaataaa tgaaaactct attacagaaa   6180

aaactgatct gaccatgtcc actgcagctt gtccaccttc ctatgaccgg gtgacaaagc   6240

caattgtgga aaaacatgag caagaaggca aagatgaaaa agccaaaggg aaataaatga   6300

aaataaataa aaataattgg gtgacaaatt gtttacagcc tgtgaaggtg atgtattttt   6360

atcaacagga ctcctttagg aggtcaatgc caaactgact gtttttacac aaatctcctt   6420

aaggtcagtg cctacaataa gacagtgacc ccttgtcagc aaactgtgac tctgtgtaaa   6480

ggggagatga ccttgacagg aggttactgt tctcactacc agctgacact gctgaagata   6540

agatgcacaa tggctagtca gactgtaggg accagtttca aggggtgcaa acctgtgatt   6600

ttggggttgt ttaacatgaa acactttagt gtagtaattg tatccactgt ttgcatttca   6660

actgccacat ttgtcacatt tttatggaat ctgttagtgg attcatcttt ttgttaatcc   6720

atgtgtttat tatatgtgac tatttttgta aacgaagttt ctgttgagaa ataggctaag   6780

gacctctata acaggtatgc cacctggggg gtatggcaac cacatggccc tcccagctac   6840

acaaagtcgt ggtttgcatg agggcatgct gcacttagag atcatgcatg agaaaaagtc   6900

acaagaaaaa caaattctta aatttcacca tatttctggg aggggtaatt gggtgataag   6960

tggaggtgct ttgttgatct tgttttgcga aatccagccc ctagaccaag tagattattt   7020

gtgggtaggc cagtaaatct tagcaggtgc aaacttcatt caaatgtttg gagtcataaa   7080

tgttatgttt ctttttgttg tattaaaaaa aaaacctgaa tagtgaatat tgcccctcac   7140

cctccaccgc cagaagactg aattgaccaa aattactctt tataaatttc tgctttttcc   7200

tgcactttgt ttagccatct ttgggctctc agcaaggttg acactgtata tgttaatgaa   7260

atgctattta ttatgtaaat agtcatttta ccctgtggtg cacgtttgag caaacaaata   7320

atgacctaag cacagtattt attgcatcaa atatgtacca caagaaatgt agagtgcaag   7380

ctttacacag gtaataaaat gtattctgta ccatttatag atagtttgga tgctatcaat   7440

gcatgtttat attaccatgc tgctgtatct ggtttctctc actgctcaga atctcattta   7500

tgagaaacca tatgtcagtg gtaaagtcaa ggaaattgtt caacagatct catttattta   7560

agtcattaag caatagtttg cagcacttta acagcttttt ggttattttt acattttaag   7620

tggataacat atggtatata gccagactgt acagacatgt ttaaaaaaac acactgctta   7680

acctattaaa tatgtgttta gaattttata agcaaatata aatactgtaa aaagtcactt   7740

tattttattt ttcagcatta tgtacataaa tatgaagagg aaattatctt caggttgata   7800

tcacaatcac ttttcttact ttctgtccat agtacttttt catgaaagaa atttgctaaa   7860

taagacatga aaacaagact gggtagttgt agatttctgc tttttaaatt acatttgcta   7920

attttagatt atttcacaat tttaaggagc aaaataggtt cacgattcat atccaaatta   7980

tgctttgcaa ttggaaaagg gtttaaaatt ttatttatat ttctggtagt acctgtacta   8040

actgaattga aggtagtgct tatgttattt ttgttctttt tttctgactt cggtttatgt   8100

tttcatttct ttggagtaat gctgctctag attgttctaa atagaatgtg ggcttcataa   8160

tttttttttc cacaaaaaca gagtagtcaa cttatatagt caattacatc aggacatttt   8220

gtgtttctta cagaagcaaa ccataggctc ctcttttcct taaaactact tagataaact   8280

gtattcgtga actgcatgct ggaaaatgct actattatgc taaataatgc taaccaacat   8340

ttaaaatgtg caaaactaat aaagattaca ttttttattt t                       8381


<210>  6
<211>  8381
<212>  DNA
<213>  Homo sapiens

<400>  6
atactgcaga ggtctctggt gcatgtgtgt atgtgtgcgt ttgtgtgtgt ttgtgtgtct     60

gtgtgttctg ccccagtgag actgcagccc ttgtaaatac tttgacacct tttgcaagaa    120

ggaatctgaa caattgcaac tgaaggcaca ttgttatcat ctcgtctttg ggtgatgctg    180

ttcctcactg cagatggata attttccttt taatcaggaa tttcatatgc agaataaatg    240

gtaattaaaa tgtgcaggat gacaagatgg agcaaacagt gcttgtacca ccaggacctg    300

acagcttcaa cttcttcacc agagaatctc ttgcggctat tgaaagacgc attgcagaag    360

aaaaggcaaa gaatcccaaa ccagacaaaa aagatgacga cgaaaatggc ccaaagccaa    420

atagtgactt ggaagctgga aagaaccttc catttattta tggagacatt cctccagaga    480

tggtgtcaga gcccctggag gacctggacc cctactatat caataagaaa acttttatag    540

tattgaataa attgaaggcc atcttccggt tcagtgccac ctctgccctg tacattttaa    600

ctcccttcaa tcctcttagg aaaatagcta ttaagatttt ggtacattca ttattcagca    660

tgctaattat gtgcactatt ttgacaaact gtgtgtttat gacaatgagt aaccctcctg    720

attggacaaa gaatgtagaa tacaccttca caggaatata tacttttgaa tcacttataa    780

aaattattgc aaggggattc tgtttagaag attttacttt ccttcgggat ccatggaact    840

ggctcgattt cactgtcatt acatttgcgt acgtcacaga gtttgtggac ctgggcaatg    900

tctcggcatt gagaacattc agagttctcc gagcattgaa gacgatttca gtcattccag    960

gcctgaaaac cattgtggga accctgatcc agtctgtgaa gaagctctca gatgtaatga   1020

tcctgactgt gttctgtctg agcgtatttg ctctaattgg gctgcagctg ttcatgggca   1080

acctgaggaa taaatgtata caatggcctc ccaccaatgc ttccttggag gaacatagta   1140

tagaaaagaa tataactgtg aattataatg gtacacttat aaatgaaact gtctttgagt   1200

ttgactggaa gtcatatatt caagattcaa gatatcatta tttcctggag ggttttttag   1260

atgcactact atgtggaaat agctctgatg caggccaatg tccagaggga tatatgtgtg   1320

tgaaagctgg tagaaatccc aattatggct acacaagctt tgataccttc agttgggctt   1380

ttttgtcctt gtttcgacta atgactcagg acttctggga aaatctttat caactgacat   1440

tacgtgctgc tgggaaaacg tacatgatat tttttgtatt ggtcattttc ttgggctcat   1500

tctacctaat aaatttgatc ctggctgtgg tggccatggc ctacgaggaa cagaatcagg   1560

ccaccttgga agaagcagaa cagaaagagg ccgaatttca gcagatgatt gaacagctta   1620

aaaagcaaca ggaggcagct cagcaggcag caacggcaac tgcctcagaa cattccagag   1680

agcccagtgc agcaggcagg ctctcagaca gctcatctga agcctctaag ttgagttcca   1740

agagtgctaa ggaaagaaga aatcggagga agaaaagaaa acagaaagag cagtctggtg   1800

gggaagagaa agatgaggat gaattccaaa aatctgaatc tgaggacagc atcaggagga   1860

aaggttttcg cttctccatt gaagggaacc gattgacata tgaaaagagg tactcctccc   1920

cacaccagtc tttgttgagc atccgtggct ccctattttc accaaggcga aatagcagaa   1980

caagcctttt cagctttaga gggcgagcaa aggatgtggg atctgagaac gacttcgcag   2040

atgatgagca cagcaccttt gaggataacg agagccgtag agattccttg tttgtgcccc   2100

gacgacacgg agagagacgc aacagcaacc tgagtcagac cagtaggtca tcccggatgc   2160

tggcagtgtt tccagcgaat gggaagatgc acagcactgt ggattgcaat ggtgtggttt   2220

ccttggttgg tggaccttca gttcctacat cgcctgttgg acagcttctg ccagaggtga   2280

taatagataa gccagctact gatgacaatg gaacaaccac tgaaactgaa atgagaaaga   2340

gaaggtcaag ttctttccac gtttccatgg actttctaga agatccttcc caaaggcaac   2400

gagcaatgag tatagccagc attctaacaa atacagtaga agaacttgaa gaatccaggc   2460

agaaatgccc accctgttgg tataaatttt ccaacatatt cttaatctgg gactgttctc   2520

catattggtt aaaagtgaaa catgttgtca acctggttgt gatggaccca tttgttgacc   2580

tggccatcac catctgtatt gtcttaaata ctcttttcat ggccatggag cactatccaa   2640

tgacggacca tttcaataat gtgcttacag taggaaactt ggttttcact gggatcttta   2700

cagcagaaat gtttctgaaa attattgcca tggatcctta ctattatttc caagaaggct   2760

ggaatatctt tgacggtttt attgtgacgc ttagcctggt agaacttgga ctcgccaatg   2820

tggaaggatt atctgttctc cgttcatttc gattgctgcg agttttcaag ttggcaaaat   2880

cttggccaac gttaaatatg ctaataaaga tcatcggcaa ttccgtgggg gctctgggaa   2940

atttaaccct cgtcttggcc atcatcgtct tcatttttgc cgtggtcggc atgcagctct   3000

ttggtaaaag ctacaaagat tgtgtctgca agatcgccag tgattgtcaa ctcccacgct   3060

ggcacatgaa tgacttcttc cactccttcc tgattgtgtt ccgcgtgctg tgtggggagt   3120

ggatagagac catgtgggac tgtatggagg ttgctggtca agccatgtgc cttactgtct   3180

tcatgatggt catggtgatt ggaaacctag tggtcctgaa tctctttctg gccttgcttc   3240

tgagctcatt tagtgcagac aaccttgcag ccactgatga tgataatgaa atgaataatc   3300

tccaaattgc tgtggatagg atgcacaaag gagtagctta tgtgaaaaga aaaatatatg   3360

aatttattca acagtccttc attaggaaac aaaagatttt agatgaaatt aaaccacttg   3420

atgatctaaa caacaagaaa gacagttgta tgtccaatca tacaacagaa attgggaaag   3480

atcttgacta tcttaaagat gtaaatggaa ctacaagtgg tataggaact ggcagcagtg   3540

ttgaaaaata cattattgat gaaagtgatt acatgtcatt cataaacaac cccagtctta   3600

ctgtgactgt accaattgct gtaggagaat ctgactttga aaatttaaac acggaagact   3660

ttagtagtga atcggatctg gaagaaagca aagagaaact gaatgaaagc agtagctcat   3720

cagaaggtag cactgtggac atcggcgcac ctgtagaaga acagcccgta gtggaacctg   3780

aagaaactct tgaaccagaa gcttgtttca ctgaaggctg tgtacaaaga ttcaagtgtt   3840

gtcaaatcaa tgtggaagaa ggcagaggaa aacaatggtg gaacctgaga aggacgtgtt   3900

tccgaatagt tgaacataac tggtttgaga ccttcattgt tttcatgatt ctccttagta   3960

gtggtgctct ggcatttgaa gatatatata ttgatcagcg aaagacgatt aagacgatgt   4020

tggaatatgc tgacaaggtt ttcacttaca ttttcattct ggaaatgctt ctaaaatggg   4080

tggcatatgg ctatcaaaca tatttcacca atgcctggtg ttggctggac ttcttaattg   4140

ttgatgtttc attggtcagt ttaacagcaa atgccttggg ttactcagaa cttggagcca   4200

tcaaatctct caggacacta agagctctga gacctctaag agccttatct cgatttgaag   4260

ggatgagggt ggttgtgaat gcccttttag gagcaattcc atccatcatg aatgtgcttc   4320

tggtttgtct tatattctgg ctaattttca gcatcatggg cgtaaatttg tttgctggca   4380

aattctacca ctgtattaac accacaactg gtgacaggtt tgacatcgaa gacgtgaata   4440

atcatactga ttgcctaaaa ctaatagaaa gaaatgagac tgctcgatgg aaaaatgtga   4500

aagtaaactt tgataatgta ggatttgggt atctctcttt gcttcaagtt gccacattca   4560

aaggatggat ggatataatg tatgcagcag ttgattccag aaatgtggaa ctccagccta   4620

agtatgaaaa aagtctgtac atgtatcttt actttgttat tttcatcatc tttgggtcct   4680

tcttcacctt gaacctgttt attggtgtca tcatagataa tttcaaccag cagaaaaaga   4740

agtttggagg tcaagacatc tttatgacag aagaacagaa gaaatactat aatgcaatga   4800

aaaaattagg atcgaaaaaa ccgcaaaagc ctatacctcg accaggaaac aaatttcaag   4860

gaatggtctt tgacttcgta accagacaag tttttgacat aagcatcatg attctcatct   4920

gtcttaacat ggtcacaatg atggtggaaa cagatgacca gagtgaatat gtgactacca   4980

ttttgtcacg catcaatctg gtgttcattg tgctatttac tggagagtgt gtactgaaac   5040

tcatctctct acgccattat tattttacca ttggatggaa tatttttgat tttgtggttg   5100

tcattctctc cattgtaggt atgtttcttg ccgagctgat agaaaagtat ttcgtgtccc   5160

ctaccctgtt ccgagtgatc cgtcttgcta ggattggccg aatcctacgt ctgatcaaag   5220

gagcaaaggg gatccgcacg ctgctctttg ctttgatgat gtcccttcct gcgttgttta   5280

acatcggcct cctactcttc ctagtcatgt tcatctacgc catctttggg atgtccaact   5340

ttgcctatgt taagagggaa gttgggatcg atgacatgtt caactttgag acctttggca   5400

acagcatgat ctgcctattc caaattacaa cctctgctgg ctgggatgga ttgctagcac   5460

ccattctcaa cagtaagcca cccgactgtg accctaataa agttaaccct ggaagctcag   5520

ttaagggaga ctgtgggaac ccatctgttg gaattttctt ttttgtcagt tacatcatca   5580

tatccttcct ggttgtggtg aacatgtaca tcgcggtcat cctggagaac ttcagtgttg   5640

ctactgaaga aagtgcagag cctctgagtg aggatgactt tgagatgttc tatgaggttt   5700

gggagaagtt tgatcccgat gcaactcagt tcatggaatt tgaaaaatta tctcagtttg   5760

cagctgcgct tgaaccgcct ctcaatctgc cacaaccaaa caaactccag ctcattgcca   5820

tggatttgcc catggtgagt ggtgaccgga tccactgtct tgatatctta tttgctttta   5880

caaagcgggt tctaggagag agtggagaga tggatgctct acgaatacag atggaagagc   5940

gattcatggc ttccaatcct tccaaggtct cctatcagcc aatcactact actttaaaac   6000

gaaaacaaga ggaagtatct gctgtcatta ttcagcgtgc ttacagacgc caccttttaa   6060

agcgaactgt aaaacaagct tcctttacgt acaataaaaa caaaatcaaa ggtggggcta   6120

atcttcttat aaaagaagac atgataattg acagaataaa tgaaaactct attacagaaa   6180

aaactgatct gaccatgtcc actgcagctt gtccaccttc ctatgaccgg gtgacaaagc   6240

caattgtgga aaaacatgag caagaaggca aagatgaaaa agccaaaggg aaataaatga   6300

aaataaataa aaataattgg gtgacaaatt gtttacagcc tgtgaaggtg atgtattttt   6360

atcaacagga ctcctttagg aggtcaatgc caaactgact gtttttacac aaatctcctt   6420

aaggtcagtg cctacaataa gacagtgacc ccttgtcagc aaactgtgac tctgtgtaaa   6480

ggggagatga ccttgacagg aggttactgt tctcactacc agctgacact gctgaagata   6540

agatgcacaa tggctagtca gactgtaggg accagtttca aggggtgcaa acctgtgatt   6600

ttggggttgt ttaacatgaa acactttagt gtagtaattg tatccactgt ttgcatttca   6660

actgccacat ttgtcacatt tttatggaat ctgttagtgg attcatcttt ttgttaatcc   6720

atgtgtttat tatatgtgac tatttttgta aacgaagttt ctgttgagaa ataggctaag   6780

gacctctata acaggtatgc cacctggggg gtatggcaac cacatggccc tcccagctac   6840

acaaagtcgt ggtttgcatg agggcatgct gcacttagag atcatgcatg agaaaaagtc   6900

acaagaaaaa caaattctta aatttcacca tatttctggg aggggtaatt gggtgataag   6960

tggaggtgct ttgttgatct tgttttgcga aatccagccc ctagaccaag tagattattt   7020

gtgggtaggc cagtaaatct tagcaggtgc aaacttcatt caaatgtttg gagtcataaa   7080

tgttatgttt ctttttgttg tattaaaaaa aaaacctgaa tagtgaatat tgcccctcac   7140

cctccaccgc cagaagactg aattgaccaa aattactctt tataaatttc tgctttttcc   7200

tgcactttgt ttagccatct ttgggctctc agcaaggttg acactgtata tgttaatgaa   7260

atgctattta ttatgtaaat agtcatttta ccctgtggtg cacgtttgag caaacaaata   7320

atgacctaag cacagtattt attgcatcaa atatgtacca caagaaatgt agagtgcaag   7380

ctttacacag gtaataaaat gtattctgta ccatttatag atagtttgga tgctatcaat   7440

gcatgtttat attaccatgc tgctgtatct ggtttctctc actgctcaga atctcattta   7500

tgagaaacca tatgtcagtg gtaaagtcaa ggaaattgtt caacagatct catttattta   7560

agtcattaag caatagtttg cagcacttta acagcttttt ggttattttt acattttaag   7620

tggataacat atggtatata gccagactgt acagacatgt ttaaaaaaac acactgctta   7680

acctattaaa tatgtgttta gaattttata agcaaatata aatactgtaa aaagtcactt   7740

tattttattt ttcagcatta tgtacataaa tatgaagagg aaattatctt caggttgata   7800

tcacaatcac ttttcttact ttctgtccat agtacttttt catgaaagaa atttgctaaa   7860

taagacatga aaacaagact gggtagttgt agatttctgc tttttaaatt acatttgcta   7920

attttagatt atttcacaat tttaaggagc aaaataggtt cacgattcat atccaaatta   7980

tgctttgcaa ttggaaaagg gtttaaaatt ttatttatat ttctggtagt acctgtacta   8040

actgaattga aggtagtgct tatgttattt ttgttctttt tttctgactt cggtttatgt   8100

tttcatttct ttggagtaat gctgctctag attgttctaa atagaatgtg ggcttcataa   8160

tttttttttc cacaaaaaca gagtagtcaa cttatatagt caattacatc aggacatttt   8220

gtgtttctta cagaagcaaa ccataggctc ctcttttcct taaaactact tagataaact   8280

gtattcgtga actgcatgct ggaaaatgct actattatgc taaataatgc taaccaacat   8340

ttaaaatgtg caaaactaat aaagattaca ttttttattt t                       8381


<210>  7
<211>  8381
<212>  DNA
<213>  Homo sapiens

<400>  7
atactgcaga ggtctctggt gcatgtgtgt atgtgtgcgt ttgtgtgtgt ttgtgtgtct     60

gtgtgttctg ccccagtgag actgcagccc ttgtaaatac tttgacacct tttgcaagaa    120

ggaatctgaa caattgcaac tgaaggcaca ttgttatcat ctcgtctttg ggtgatgctg    180

ttcctcactg cagatggata attttccttt taatcaggaa tttcatatgc agaataaatg    240

gtaattaaaa tgtgcaggat gacaagatgg agcaaacagt gcttgtacca ccaggacctg    300

acagcttcaa cttcttcacc agagaatctc ttgcggctat tgaaagacgc attgcagaag    360

aaaaggcaaa gaatcccaaa ccagacaaaa aagatgacga cgaaaatggc ccaaagccaa    420

atagtgactt ggaagctgga aagaaccttc catttattta tggagacatt cctccagaga    480

tggtgtcaga gcccctggag gacctggacc cctactatat caataagaaa acttttatag    540

tattgaataa attgaaggcc atcttccggt tcagtgccac ctctgccctg tacattttaa    600

ctcccttcaa tcctcttagg aaaatagcta ttaagatttt ggtacattca ttattcagca    660

tgctaattat gtgcactatt ttgacaaact gtgtgtttat gacaatgagt aaccctcctg    720

attggacaaa gaatgtagaa tacaccttca caggaatata tacttttgaa tcacttataa    780

aaattattgc aaggggattc tgtttagaag attttacttt ccttcgggat ccatggaact    840

ggctcgattt cactgtcatt acatttgcgt acgtcacaga gtttgtggac ctgggcaatg    900

tctcggcatt gagaacattc agagttctcc gagcattgaa gacgatttca gtcattccag    960

gcctgaaaac cattgtggga gccctgatcc agtctgtgaa gaagctctca gatgtaatga   1020

tcctgactgt gttctgtctg agcgtatttg ctctaattgg gctgcagctg ttcatgggca   1080

acctgaggaa taaatgtata caatggcctc ccaccaatgc ttccttggag gaacatagta   1140

tagaaaagaa tataactgtg aattataatg gtacacttat aaatgaaact gtctttgagt   1200

ttgactggaa gtcatatatt caagattcaa gatatcatta tttcctggag ggttttttag   1260

atgcactact atgtggaaat agctctgatg caggccaatg tccagaggga tatatgtgtg   1320

tgaaagctgg tagaaatccc aattatggct acacaagctt tgataccttc agttgggctt   1380

ttttgtcctt gtttcgacta atgactcagg acttctggga aaatctttat caactgacat   1440

tacgtgctgc tgggaaaacg tacatgatat tttttgtatt ggtcattttc ttgggctcat   1500

tctacctaat aaatttgatc ctggctgtgg tggccatggc ctacgaggaa cagaatcagg   1560

ccaccttgga agaagcagaa cagaaagagg ccgaatttca gcagatgatt gaacagctta   1620

aaaagcaaca ggaggcagct cagcaggcag caacggcaac tgcctcagaa cattccagag   1680

agcccagtgc agcaggcagg ctctcagaca gctcatctga agcctctaag ttgagttcca   1740

agagtgctaa ggaaagaaga aatcggagga agaaaagaaa acagaaagag cagtctggtg   1800

gggaagagaa agatgaggat gaattccaaa aatctgaatc tgaggacagc atcaggagga   1860

aaggttttcg cttctccatt gaagggaacc gattgacata tgaaaagagg tactcctccc   1920

cacaccagtc tttgttgagc atccgtggct ccctattttc accaaggcga aatagcagaa   1980

caagcctttt cagctttaga gggcgagcaa aggatgtggg atctgagaac gacttcgcag   2040

atgatgagca cagcaccttt gaggataacg agagccgtag agattccttg tttgtgcccc   2100

gacgacacgg agagagacgc aacagcaacc tgagtcagac cagtaggtca tcccggatgc   2160

tggcagtgtt tccagcgaat gggaagatgc acagcactgt ggattgcaat ggtgtggttt   2220

ccttggttgg tggaccttca gttcctacat cgcctgttgg acagcttctg ccagaggtga   2280

taatagataa gccagctact gatgacaatg gaacaaccac tgaaactgaa atgagaaaga   2340

gaaggtcaag ttctttccac gtttccatgg actttctaga agatccttcc caaaggcaac   2400

gagcaatgag tatagccagc attctaacaa atacagtaga agaacttgaa gaatccaggc   2460

agaaatgccc accctgttgg tataaatttt ccaacatatt cttaatctgg gactgttctc   2520

catattggtt aaaagtgaaa catgttgtca acctggttgt gatggaccca tttgttgacc   2580

tggccatcac catctgtatt gtcttaaata ctcttttcat ggccatggag cactatccaa   2640

tgacggacca tttcaataat gtgcttacag taggaaactt ggttttcact gggatcttta   2700

cagcagaaat gtttctgaaa attattgcca tggatcctta ctattatttc caagaaggct   2760

ggaatatctt tgacggtttt attgtgacgc ttagcctggt agaacttgga ctcgccaatg   2820

tggaaggatt atctgttctc cgttcatttc gattgctgcg agttttcaag ttggcaaaat   2880

cttggccaac gttaaatatg ctaataaaga tcatcggcaa ttccgtgggg gctctgggaa   2940

atttaaccct cgtcttggcc atcatcgtct tcatttttgc cgtggtcggc atgcagctct   3000

ttggtaaaag ctacaaagat tgtgtctgca agatcgccag tgattgtcaa ctcccacgct   3060

ggcacatgaa tgacttcttc cactccttcc tgattgtgtt ccacgtgctg tgtggggagt   3120

ggatagagac catgtgggac tgtatggagg ttgctggtca agccatgtgc cttactgtct   3180

tcatgatggt catggtgatt ggaaacctag tggtcctgaa tctctttctg gccttgcttc   3240

tgagctcatt tagtgcagac aaccttgcag ccactgatga tgataatgaa atgaataatc   3300

tccaaattgc tgtggatagg atgcacaaag gagtagctta tgtgaaaaga aaaatatatg   3360

aatttattca acagtccttc attaggaaac aaaagatttt agatgaaatt aaaccacttg   3420

atgatctaaa caacaagaaa gacagttgta tgtccaatca tacaacagaa attgggaaag   3480

atcttgacta tcttaaagat gtaaatggaa ctacaagtgg tataggaact ggcagcagtg   3540

ttgaaaaata cattattgat gaaagtgatt acatgtcatt cataaacaac cccagtctta   3600

ctgtgactgt accaattgct gtaggagaat ctgactttga aaatttaaac acggaagact   3660

ttagtagtga atcggatctg gaagaaagca aagagaaact gaatgaaagc agtagctcat   3720

cagaaggtag cactgtggac atcggcgcac ctgtagaaga acagcccgta gtggaacctg   3780

aagaaactct tgaaccagaa gcttgtttca ctgaaggctg tgtacaaaga ttcaagtgtt   3840

gtcaaatcaa tgtggaagaa ggcagaggaa aacaatggtg gaacctgaga aggacgtgtt   3900

tccgaatagt tgaacataac tggtttgaga ccttcattgt tttcatgatt ctccttagta   3960

gtggtgctct ggcatttgaa gatatatata ttgatcagcg aaagacgatt aagacgatgt   4020

tggaatatgc tgacaaggtt ttcacttaca ttttcattct ggaaatgctt ctaaaatggg   4080

tggcatatgg ctatcaaaca tatttcacca atgcctggtg ttggctggac ttcttaattg   4140

ttgatgtttc attggtcagt ttaacagcaa atgccttggg ttactcagaa cttggagcca   4200

tcaaatctct caggacacta agagctctga gacctctaag agccttatct cgatttgaag   4260

ggatgagggt ggttgtgaat gcccttttag gagcaattcc atccatcatg aatgtgcttc   4320

tggtttgtct tatattctgg ctaattttca gcatcatggg cgtaaatttg tttgctggca   4380

aattctacca ctgtattaac accacaactg gtgacaggtt tgacatcgaa gacgtgaata   4440

atcatactga ttgcctaaaa ctaatagaaa gaaatgagac tgctcgatgg aaaaatgtga   4500

aagtaaactt tgataatgta ggatttgggt atctctcttt gcttcaagtt gccacattca   4560

aaggatggat ggatataatg tatgcagcag ttgattccag aaatgtggaa ctccagccta   4620

agtatgaaaa aagtctgtac atgtatcttt actttgttat tttcatcatc tttgggtcct   4680

tcttcacctt gaacctgttt attggtgtca tcatagataa tttcaaccag cagaaaaaga   4740

agtttggagg tcaagacatc tttatgacag aagaacagaa gaaatactat aatgcaatga   4800

aaaaattagg atcgaaaaaa ccgcaaaagc ctatacctcg accaggaaac aaatttcaag   4860

gaatggtctt tgacttcgta accagacaag tttttgacat aagcatcatg attctcatct   4920

gtcttaacat ggtcacaatg atggtggaaa cagatgacca gagtgaatat gtgactacca   4980

ttttgtcacg catcaatctg gtgttcattg tgctatttac tggagagtgt gtactgaaac   5040

tcatctctct acgccattat tattttacca ttggatggaa tatttttgat tttgtggttg   5100

tcattctctc cattgtaggt atgtttcttg ccgagctgat agaaaagtat ttcgtgtccc   5160

ctaccctgtt ccgagtgatc cgtcttgcta ggattggccg aatcctacgt ctgatcaaag   5220

gagcaaaggg gatccgcacg ctgctctttg ctttgatgat gtcccttcct gcgttgttta   5280

acatcggcct cctactcttc ctagtcatgt tcatctacgc catctttggg atgtccaact   5340

ttgcctatgt taagagggaa gttgggatcg atgacatgtt caactttgag acctttggca   5400

acagcatgat ctgcctattc caaattacaa cctctgctgg ctgggatgga ttgctagcac   5460

ccattctcaa cagtaagcca cccgactgtg accctaataa agttaaccct ggaagctcag   5520

ttaagggaga ctgtgggaac ccatctgttg gaattttctt ttttgtcagt tacatcatca   5580

tatccttcct ggttgtggtg aacatgtaca tcgcggtcat cctggagaac ttcagtgttg   5640

ctactgaaga aagtgcagag cctctgagtg aggatgactt tgagatgttc tatgaggttt   5700

gggagaagtt tgatcccgat gcaactcagt tcatggaatt tgaaaaatta tctcagtttg   5760

cagctgcgct tgaaccgcct ctcaatctgc cacaaccaaa caaactccag ctcattgcca   5820

tggatttgcc catggtgagt ggtgaccgga tccactgtct tgatatctta tttgctttta   5880

caaagcgggt tctaggagag agtggagaga tggatgctct acgaatacag atggaagagc   5940

gattcatggc ttccaatcct tccaaggtct cctatcagcc aatcactact actttaaaac   6000

gaaaacaaga ggaagtatct gctgtcatta ttcagcgtgc ttacagacgc caccttttaa   6060

agcgaactgt aaaacaagct tcctttacgt acaataaaaa caaaatcaaa ggtggggcta   6120

atcttcttat aaaagaagac atgataattg acagaataaa tgaaaactct attacagaaa   6180

aaactgatct gaccatgtcc actgcagctt gtccaccttc ctatgaccgg gtgacaaagc   6240

caattgtgga aaaacatgag caagaaggca aagatgaaaa agccaaaggg aaataaatga   6300

aaataaataa aaataattgg gtgacaaatt gtttacagcc tgtgaaggtg atgtattttt   6360

atcaacagga ctcctttagg aggtcaatgc caaactgact gtttttacac aaatctcctt   6420

aaggtcagtg cctacaataa gacagtgacc ccttgtcagc aaactgtgac tctgtgtaaa   6480

ggggagatga ccttgacagg aggttactgt tctcactacc agctgacact gctgaagata   6540

agatgcacaa tggctagtca gactgtaggg accagtttca aggggtgcaa acctgtgatt   6600

ttggggttgt ttaacatgaa acactttagt gtagtaattg tatccactgt ttgcatttca   6660

actgccacat ttgtcacatt tttatggaat ctgttagtgg attcatcttt ttgttaatcc   6720

atgtgtttat tatatgtgac tatttttgta aacgaagttt ctgttgagaa ataggctaag   6780

gacctctata acaggtatgc cacctggggg gtatggcaac cacatggccc tcccagctac   6840

acaaagtcgt ggtttgcatg agggcatgct gcacttagag atcatgcatg agaaaaagtc   6900

acaagaaaaa caaattctta aatttcacca tatttctggg aggggtaatt gggtgataag   6960

tggaggtgct ttgttgatct tgttttgcga aatccagccc ctagaccaag tagattattt   7020

gtgggtaggc cagtaaatct tagcaggtgc aaacttcatt caaatgtttg gagtcataaa   7080

tgttatgttt ctttttgttg tattaaaaaa aaaacctgaa tagtgaatat tgcccctcac   7140

cctccaccgc cagaagactg aattgaccaa aattactctt tataaatttc tgctttttcc   7200

tgcactttgt ttagccatct ttgggctctc agcaaggttg acactgtata tgttaatgaa   7260

atgctattta ttatgtaaat agtcatttta ccctgtggtg cacgtttgag caaacaaata   7320

atgacctaag cacagtattt attgcatcaa atatgtacca caagaaatgt agagtgcaag   7380

ctttacacag gtaataaaat gtattctgta ccatttatag atagtttgga tgctatcaat   7440

gcatgtttat attaccatgc tgctgtatct ggtttctctc actgctcaga atctcattta   7500

tgagaaacca tatgtcagtg gtaaagtcaa ggaaattgtt caacagatct catttattta   7560

agtcattaag caatagtttg cagcacttta acagcttttt ggttattttt acattttaag   7620

tggataacat atggtatata gccagactgt acagacatgt ttaaaaaaac acactgctta   7680

acctattaaa tatgtgttta gaattttata agcaaatata aatactgtaa aaagtcactt   7740

tattttattt ttcagcatta tgtacataaa tatgaagagg aaattatctt caggttgata   7800

tcacaatcac ttttcttact ttctgtccat agtacttttt catgaaagaa atttgctaaa   7860

taagacatga aaacaagact gggtagttgt agatttctgc tttttaaatt acatttgcta   7920

attttagatt atttcacaat tttaaggagc aaaataggtt cacgattcat atccaaatta   7980

tgctttgcaa ttggaaaagg gtttaaaatt ttatttatat ttctggtagt acctgtacta   8040

actgaattga aggtagtgct tatgttattt ttgttctttt tttctgactt cggtttatgt   8100

tttcatttct ttggagtaat gctgctctag attgttctaa atagaatgtg ggcttcataa   8160

tttttttttc cacaaaaaca gagtagtcaa cttatatagt caattacatc aggacatttt   8220

gtgtttctta cagaagcaaa ccataggctc ctcttttcct taaaactact tagataaact   8280

gtattcgtga actgcatgct ggaaaatgct actattatgc taaataatgc taaccaacat   8340

ttaaaatgtg caaaactaat aaagattaca ttttttattt t                       8381


<210>  8
<211>  8381
<212>  DNA
<213>  Homo sapiens

<400>  8
atactgcaga ggtctctggt gcatgtgtgt atgtgtgcgt ttgtgtgtgt ttgtgtgtct     60

gtgtgttctg ccccagtgag actgcagccc ttgtaaatac tttgacacct tttgcaagaa    120

ggaatctgaa caattgcaac tgaaggcaca ttgttatcat ctcgtctttg ggtgatgctg    180

ttcctcactg cagatggata attttccttt taatcaggaa tttcatatgc agaataaatg    240

gtaattaaaa tgtgcaggat gacaagatgg agcaaacagt gcttgtacca ccaggacctg    300

acagcttcaa cttcttcacc agagaatctc ttgcggctat tgaaagacgc attgcagaag    360

aaaaggcaaa gaatcccaaa ccagacaaaa aagatgacga cgaaaatggc ccaaagccaa    420

atagtgactt ggaagctgga aagaaccttc catttattta tggagacatt cctccagaga    480

tggtgtcaga gcccctggag gacctggacc cctactatat caataagaaa acttttatag    540

tattgaataa attgaaggcc atcttccggt tcagtgccac ctctgccctg tacattttaa    600

ctcccttcaa tcctcttagg aaaatagcta ttaagatttt ggtacattca ttattcagca    660

tgctaattat gtgcactatt ttgacaaact gtgtgtttat gacaatgagt aaccctcctg    720

attggacaaa gaatgtagaa tacaccttca caggaatata tacttttgaa tcacttataa    780

aaattattgc aaggggattc tgtttagaag attttacttt ccttcgggat ccatggaact    840

ggctcgattt cactgtcatt acatttgcgt acgtcacaga gtttgtggac ctgggcaatg    900

tctcggcatt gagaacattc agagttctcc gagcattgaa gacgatttca gtcattccag    960

gcctgaaaac cattgtggga gccctgatcc agtctgtgaa gaagctctca gatgtaatga   1020

tcctgactgt gttctgtctg agcgtatttg ctctaattgg gctgcagctg ttcatgggca   1080

acctgaggaa taaatgtata caatggcctc ccaccaatgc ttccttggag gaacatagta   1140

tagaaaagaa tataactgtg aattataatg gtacacttat aaatgaaact gtctttgagt   1200

ttgactggaa gtcatatatt caagattcaa gatatcatta tttcctggag ggttttttag   1260

atgcactact atgtggaaat agctctgatg caggccaatg tccagaggga tatatgtgtg   1320

tgaaagctgg tagaaatccc aattatggct acacaagctt tgataccttc agttgggctt   1380

ttttgtcctt gtttcgacta atgactcagg acttctggga aaatctttat caactgacat   1440

tacgtgctgc tgggaaaacg tacatgatat tttttgtatt ggtcattttc ttgggctcat   1500

tctacctaat aaatttgatc ctggctgtgg tggccatggc ctacgaggaa cagaatcagg   1560

ccaccttgga agaagcagaa cagaaagagg ccgaatttca gcagatgatt gaacagctta   1620

aaaagcaaca ggaggcagct cagcaggcag caacggcaac tgcctcagaa cattccagag   1680

agcccagtgc agcaggcagg ctctcagaca gctcatctga agcctctaag ttgagttcca   1740

agagtgctaa ggaaagaaga aatcggagga agaaaagaaa acagaaagag cagtctggtg   1800

gggaagagaa agatgaggat gaattccaaa aatctgaatc tgaggacagc atcaggagga   1860

aaggttttcg cttctccatt gaagggaacc gattgacata tgaaaagagg tactcctccc   1920

cacaccagtc tttgttgagc atccgtggct ccctattttc accaaggcga aatagcagaa   1980

caagcctttt cagctttaga gggcgagcaa aggatgtggg atctgagaac gacttcgcag   2040

atgatgagca cagcaccttt gaggataacg agagccgtag agattccttg tttgtgcccc   2100

gacgacacgg agagagacgc aacagcaacc tgagtcagac cagtaggtca tcccggatgc   2160

tggcagtgtt tccagcgaat gggaagatgc acagcactgt ggattgcaat ggtgtggttt   2220

ccttggttgg tggaccttca gttcctacat cgcctgttgg acagcttctg ccagaggtga   2280

taatagataa gccagctact gatgacaatg gaacaaccac tgaaactgaa atgagaaaga   2340

gaaggtcaag ttctttccac gtttccatgg actttctaga agatccttcc caaaggcaac   2400

gagcaatgag tatagccagc attctaacaa atacagtaga agaacttgaa gaatccaggc   2460

agaaatgccc accctgttgg tataaatttt ccaacatatt cttaatctgg gactgttctc   2520

catattggtt aaaagtgaaa catgttgtca acctggttgt gatggaccca tttgttgacc   2580

tggccatcac catctgtatt gtcttaaata ctcttttcat ggccatggag cactatccaa   2640

tgacggacca tttcaataat gtgcttacag taggaaactt ggttttcact gggatcttta   2700

cagcagaaat gtttctgaaa attattgcca tggatcctta ctattatttc caagaaggct   2760

ggaatatctt tgacggtttt attgtgacgc ttagcctggt agaacttgga ctcgccaatg   2820

tggaaggatt atctgttctc cgttcatttc gattgctgcg agttttcaag ttggcaaaat   2880

cttggccaac gttaaatatg ctaataaaga tcatcggcaa ttccgtgggg gctctgggaa   2940

atttaaccct cgtcttggcc atcatcgtct tcatttttgc cgtggtcggc atgcagctct   3000

ttggtaaaag ctacaaagat tgtgtctgca agatcgccag tgattgtcaa ctcccacgct   3060

ggcacatgaa tgacttcttc cactccttcc tgattgtgtt ccgcgtgctg tgtggggagt   3120

ggatagagac catgtgggac tgtatggagg ttgctggtca agccatgtgc cttactgtct   3180

tcatgatggt catggtgatt ggaaacctag tggtcctgaa tctctttctg gccttgcttc   3240

tgagctcatt tagtgcagac aaccttgcag ccactgatga tgataatgaa atgaataatc   3300

tccaaattgc tgtggatagg atgcacaaag gagtagctta tgtgaaaaga aaaatatatg   3360

aatttattca acagtccttc attaggaaac aaaagatttt agatgaaatt aaaccacttg   3420

atgatctaaa caacaagaaa gacagttgta tgtccaatca tacaacagaa attgggaaag   3480

atcttgacta tcttaaagat gtaaatggaa ctacaagtgg tataggaact ggcagcagtg   3540

ttgaaaaata cattattgat gaaagtgatt acatgtcatt cataaacaac cccagtctta   3600

ctgtgactgt accaattgct gtaggagaat ctgactttga aaatttaaac acggaagact   3660

ttagtagtga atcggatctg gaagaaagca aagagaaact gaatgaaagc agtagctcat   3720

cagaaggtag cactgtggac atcggcgcac ctgtagaaga acagcccgta gtggaacctg   3780

aagaaactct tgaaccagaa gcttgtttca ctgaaggctg tgtacaaaga ttcaagtgtt   3840

gtcaaatcaa tgtggaagaa ggcagaggaa aacaatggtg gaacctgaga aggacgtgtt   3900

tccgaatagt tgaacataac tggtttgaga ccttcattgt tttcatgatt ctccttagta   3960

gtggtgctct ggcatttgac gatatatata ttgatcagcg aaagacgatt aagacgatgt   4020

tggaatatgc tgacaaggtt ttcacttaca ttttcattct ggaaatgctt ctaaaatggg   4080

tggcatatgg ctatcaaaca tatttcacca atgcctggtg ttggctggac ttcttaattg   4140

ttgatgtttc attggtcagt ttaacagcaa atgccttggg ttactcagaa cttggagcca   4200

tcaaatctct caggacacta agagctctga gacctctaag agccttatct cgatttgaag   4260

ggatgagggt ggttgtgaat gcccttttag gagcaattcc atccatcatg aatgtgcttc   4320

tggtttgtct tatattctgg ctaattttca gcatcatggg cgtaaatttg tttgctggca   4380

aattctacca ctgtattaac accacaactg gtgacaggtt tgacatcgaa gacgtgaata   4440

atcatactga ttgcctaaaa ctaatagaaa gaaatgagac tgctcgatgg aaaaatgtga   4500

aagtaaactt tgataatgta ggatttgggt atctctcttt gcttcaagtt gccacattca   4560

aaggatggat ggatataatg tatgcagcag ttgattccag aaatgtggaa ctccagccta   4620

agtatgaaaa aagtctgtac atgtatcttt actttgttat tttcatcatc tttgggtcct   4680

tcttcacctt gaacctgttt attggtgtca tcatagataa tttcaaccag cagaaaaaga   4740

agtttggagg tcaagacatc tttatgacag aagaacagaa gaaatactat aatgcaatga   4800

aaaaattagg atcgaaaaaa ccgcaaaagc ctatacctcg accaggaaac aaatttcaag   4860

gaatggtctt tgacttcgta accagacaag tttttgacat aagcatcatg attctcatct   4920

gtcttaacat ggtcacaatg atggtggaaa cagatgacca gagtgaatat gtgactacca   4980

ttttgtcacg catcaatctg gtgttcattg tgctatttac tggagagtgt gtactgaaac   5040

tcatctctct acgccattat tattttacca ttggatggaa tatttttgat tttgtggttg   5100

tcattctctc cattgtaggt atgtttcttg ccgagctgat agaaaagtat ttcgtgtccc   5160

ctaccctgtt ccgagtgatc cgtcttgcta ggattggccg aatcctacgt ctgatcaaag   5220

gagcaaaggg gatccgcacg ctgctctttg ctttgatgat gtcccttcct gcgttgttta   5280

acatcggcct cctactcttc ctagtcatgt tcatctacgc catctttggg atgtccaact   5340

ttgcctatgt taagagggaa gttgggatcg atgacatgtt caactttgag acctttggca   5400

acagcatgat ctgcctattc caaattacaa cctctgctgg ctgggatgga ttgctagcac   5460

ccattctcaa cagtaagcca cccgactgtg accctaataa agttaaccct ggaagctcag   5520

ttaagggaga ctgtgggaac ccatctgttg gaattttctt ttttgtcagt tacatcatca   5580

tatccttcct ggttgtggtg aacatgtaca tcgcggtcat cctggagaac ttcagtgttg   5640

ctactgaaga aagtgcagag cctctgagtg aggatgactt tgagatgttc tatgaggttt   5700

gggagaagtt tgatcccgat gcaactcagt tcatggaatt tgaaaaatta tctcagtttg   5760

cagctgcgct tgaaccgcct ctcaatctgc cacaaccaaa caaactccag ctcattgcca   5820

tggatttgcc catggtgagt ggtgaccgga tccactgtct tgatatctta tttgctttta   5880

caaagcgggt tctaggagag agtggagaga tggatgctct acgaatacag atggaagagc   5940

gattcatggc ttccaatcct tccaaggtct cctatcagcc aatcactact actttaaaac   6000

gaaaacaaga ggaagtatct gctgtcatta ttcagcgtgc ttacagacgc caccttttaa   6060

agcgaactgt aaaacaagct tcctttacgt acaataaaaa caaaatcaaa ggtggggcta   6120

atcttcttat aaaagaagac atgataattg acagaataaa tgaaaactct attacagaaa   6180

aaactgatct gaccatgtcc actgcagctt gtccaccttc ctatgaccgg gtgacaaagc   6240

caattgtgga aaaacatgag caagaaggca aagatgaaaa agccaaaggg aaataaatga   6300

aaataaataa aaataattgg gtgacaaatt gtttacagcc tgtgaaggtg atgtattttt   6360

atcaacagga ctcctttagg aggtcaatgc caaactgact gtttttacac aaatctcctt   6420

aaggtcagtg cctacaataa gacagtgacc ccttgtcagc aaactgtgac tctgtgtaaa   6480

ggggagatga ccttgacagg aggttactgt tctcactacc agctgacact gctgaagata   6540

agatgcacaa tggctagtca gactgtaggg accagtttca aggggtgcaa acctgtgatt   6600

ttggggttgt ttaacatgaa acactttagt gtagtaattg tatccactgt ttgcatttca   6660

actgccacat ttgtcacatt tttatggaat ctgttagtgg attcatcttt ttgttaatcc   6720

atgtgtttat tatatgtgac tatttttgta aacgaagttt ctgttgagaa ataggctaag   6780

gacctctata acaggtatgc cacctggggg gtatggcaac cacatggccc tcccagctac   6840

acaaagtcgt ggtttgcatg agggcatgct gcacttagag atcatgcatg agaaaaagtc   6900

acaagaaaaa caaattctta aatttcacca tatttctggg aggggtaatt gggtgataag   6960

tggaggtgct ttgttgatct tgttttgcga aatccagccc ctagaccaag tagattattt   7020

gtgggtaggc cagtaaatct tagcaggtgc aaacttcatt caaatgtttg gagtcataaa   7080

tgttatgttt ctttttgttg tattaaaaaa aaaacctgaa tagtgaatat tgcccctcac   7140

cctccaccgc cagaagactg aattgaccaa aattactctt tataaatttc tgctttttcc   7200

tgcactttgt ttagccatct ttgggctctc agcaaggttg acactgtata tgttaatgaa   7260

atgctattta ttatgtaaat agtcatttta ccctgtggtg cacgtttgag caaacaaata   7320

atgacctaag cacagtattt attgcatcaa atatgtacca caagaaatgt agagtgcaag   7380

ctttacacag gtaataaaat gtattctgta ccatttatag atagtttgga tgctatcaat   7440

gcatgtttat attaccatgc tgctgtatct ggtttctctc actgctcaga atctcattta   7500

tgagaaacca tatgtcagtg gtaaagtcaa ggaaattgtt caacagatct catttattta   7560

agtcattaag caatagtttg cagcacttta acagcttttt ggttattttt acattttaag   7620

tggataacat atggtatata gccagactgt acagacatgt ttaaaaaaac acactgctta   7680

acctattaaa tatgtgttta gaattttata agcaaatata aatactgtaa aaagtcactt   7740

tattttattt ttcagcatta tgtacataaa tatgaagagg aaattatctt caggttgata   7800

tcacaatcac ttttcttact ttctgtccat agtacttttt catgaaagaa atttgctaaa   7860

taagacatga aaacaagact gggtagttgt agatttctgc tttttaaatt acatttgcta   7920

attttagatt atttcacaat tttaaggagc aaaataggtt cacgattcat atccaaatta   7980

tgctttgcaa ttggaaaagg gtttaaaatt ttatttatat ttctggtagt acctgtacta   8040

actgaattga aggtagtgct tatgttattt ttgttctttt tttctgactt cggtttatgt   8100

tttcatttct ttggagtaat gctgctctag attgttctaa atagaatgtg ggcttcataa   8160

tttttttttc cacaaaaaca gagtagtcaa cttatatagt caattacatc aggacatttt   8220

gtgtttctta cagaagcaaa ccataggctc ctcttttcct taaaactact tagataaact   8280

gtattcgtga actgcatgct ggaaaatgct actattatgc taaataatgc taaccaacat   8340

ttaaaatgtg caaaactaat aaagattaca ttttttattt t                       8381


<210>  9
<211>  8381
<212>  DNA
<213>  Homo sapiens

<400>  9
atactgcaga ggtctctggt gcatgtgtgt atgtgtgcgt ttgtgtgtgt ttgtgtgtct     60

gtgtgttctg ccccagtgag actgcagccc ttgtaaatac tttgacacct tttgcaagaa    120

ggaatctgaa caattgcaac tgaaggcaca ttgttatcat ctcgtctttg ggtgatgctg    180

ttcctcactg cagatggata attttccttt taatcaggaa tttcatatgc agaataaatg    240

gtaattaaaa tgtgcaggat gacaagatgg agcaaacagt gcttgtacca ccaggacctg    300

acagcttcaa cttcttcacc agagaatctc ttgcggctat tgaaagacgc attgcagaag    360

aaaaggcaaa gaatcccaaa ccagacaaaa aagatgacga cgaaaatggc ccaaagccaa    420

atagtgactt ggaagctgga aagaaccttc catttattta tggagacatt cctccagaga    480

tggtgtcaga gcccctggag gacctggacc cctactatat caataagaaa acttttatag    540

tattgaataa attgaaggcc atcttccggt tcagtgccac ctctgccctg tacattttaa    600

ctcccttcaa tcctcttagg aaaatagcta ttaagatttt ggtacattca ttattcagca    660

tgctaattat gtgcactatt ttgacaaact gtgtgtttat gacaatgagt aaccctcctg    720

attggacaaa gaatgtagaa tacaccttca caggaatata tacttttgaa tcacttataa    780

aaattattgc aaggggattc tgtttagaag attttacttt ccttcgggat ccatggaact    840

ggctcgattt cactgtcatt acatttgcgt acgtcacaga gtttgtggac ctgggcaatg    900

tctcggcatt gagaacattc agagttctcc gagcattgaa gacgatttca gtcattccag    960

gcctgaaaac cattgtggga gccctgatcc agtctgtgaa gaagctctca gatgtaatga   1020

tcctgactgt gttctgtctg agcgtatttg ctctaattgg gctgcagctg ttcatgggca   1080

acctgaggaa taaatgtata caatggcctc ccaccaatgc ttccttggag gaacatagta   1140

tagaaaagaa tataactgtg aattataatg gtacacttat aaatgaaact gtctttgagt   1200

ttgactggaa gtcatatatt caagattcaa gatatcatta tttcctggag ggttttttag   1260

atgcactact atgtggaaat agctctgatg caggccaatg tccagaggga tatatgtgtg   1320

tgaaagctgg tagaaatccc aattatggct acacaagctt tgataccttc agttgggctt   1380

ttttgtcctt gtttcgacta atgactcagg acttctggga aaatctttat caactgacat   1440

tacgtgctgc tgggaaaacg tacatgatat tttttgtatt ggtcattttc ttgggctcat   1500

tctacctaat aaatttgatc ctggctgtgg tggccatggc ctacgaggaa cagaatcagg   1560

ccaccttgga agaagcagaa cagaaagagg ccgaatttca gcagatgatt gaacagctta   1620

aaaagcaaca ggaggcagct cagcaggcag caacggcaac tgcctcagaa cattccagag   1680

agcccagtgc agcaggcagg ctctcagaca gctcatctga agcctctaag ttgagttcca   1740

agagtgctaa ggaaagaaga aatcggagga agaaaagaaa acagaaagag cagtctggtg   1800

gggaagagaa agatgaggat gaattccaaa aatctgaatc tgaggacagc atcaggagga   1860

aaggttttcg cttctccatt gaagggaacc gattgacata tgaaaagagg tactcctccc   1920

cacaccagtc tttgttgagc atccgtggct ccctattttc accaaggcga aatagcagaa   1980

caagcctttt cagctttaga gggcgagcaa aggatgtggg atctgagaac gacttcgcag   2040

atgatgagca cagcaccttt gaggataacg agagccgtag agattccttg tttgtgcccc   2100

gacgacacgg agagagacgc aacagcaacc tgagtcagac cagtaggtca tcccggatgc   2160

tggcagtgtt tccagcgaat gggaagatgc acagcactgt ggattgcaat ggtgtggttt   2220

ccttggttgg tggaccttca gttcctacat cgcctgttgg acagcttctg ccagaggtga   2280

taatagataa gccagctact gatgacaatg gaacaaccac tgaaactgaa atgagaaaga   2340

gaaggtcaag ttctttccac gtttccatgg actttctaga agatccttcc caaaggcaac   2400

gagcaatgag tatagccagc attctaacaa atacagtaga agaacttgaa gaatccaggc   2460

agaaatgccc accctgttgg tataaatttt ccaacatatt cttaatctgg gactgttctc   2520

catattggtt aaaagtgaaa catgttgtca acctggttgt gatggaccca tttgttgacc   2580

tggccatcac catctgtatt gtcttaaata ctcttttcat ggccatggag cactatccaa   2640

tgacggacca tttcaataat gtgcttacag taggaaactt ggttttcact gggatcttta   2700

cagcagaaat gtttctgaaa attattgcca tggatcctta ctattatttc caagaaggct   2760

ggaatatctt tgacggtttt attgtgacgc ttagcctggt agaacttgga ctcgccaatg   2820

tggaaggatt atctgttctc cgttcatttc gattgctgcg agttttcaag ttggcaaaat   2880

cttggccaac gttaaatatg ctaataaaga tcatcggcaa ttccgtgggg gctctgggaa   2940

atttaaccct cgtcttggcc atcatcgtct tcatttttgc cgtggtcggc atgcagctct   3000

ttggtaaaag ctacaaagat tgtgtctgca agatcgccag tgattgtcaa ctcccacgct   3060

ggcacatgaa tgacttcttc cactccttcc tgattgtgtt ccgcgtgctg tgtggggagt   3120

ggatagagac catgtgggac tgtatggagg ttgctggtca agccatgtgc cttactgtct   3180

tcatgatggt catggtgatt ggaaacctag tggtcctgaa tctctttctg gccttgcttc   3240

tgagctcatt tagtgcagac aaccttgcag ccactgatga tgataatgaa atgaataatc   3300

tccaaattgc tgtggatagg atgcacaaag gagtagctta tgtgaaaaga aaaatatatg   3360

aatttattca acagtccttc attaggaaac aaaagatttt agatgaaatt aaaccacttg   3420

atgatctaaa caacaagaaa gacagttgta tgtccaatca tacaacagaa attgggaaag   3480

atcttgacta tcttaaagat gtaaatggaa ctacaagtgg tataggaact ggcagcagtg   3540

ttgaaaaata cattattgat gaaagtgatt acatgtcatt cataaacaac cccagtctta   3600

ctgtgactgt accaattgct gtaggagaat ctgactttga aaatttaaac acggaagact   3660

ttagtagtga atcggatctg gaagaaagca aagagaaact gaatgaaagc agtagctcat   3720

cagaaggtag cactgtggac atcggcgcac ctgtagaaga acagcccgta gtggaacctg   3780

aagaaactct tgaaccagaa gcttgtttca ctgaaggctg tgtacaaaga ttcaagtgtt   3840

gtcaaatcaa tgtggaagaa ggcagaggaa aacaatggtg gaacctgaga aggacgtgtt   3900

tccgaatagt tgaacataac tggtttgaga ccttcattgt tttcatgatt ctccttagta   3960

gtggtgctct ggcatttgaa gatatatata ttgatcagcg aaagacgatt aagacgatgt   4020

tggaatatgc tgacaaggtt ttcacttaca ttttcattct ggaaatgctt ctaaaatggg   4080

tggcatatgg ctatcaaaca tatttcacca atgcctggtg ttggctggac ttcttaattg   4140

ttgatgtttc attggtcagt ttaacagcaa atgccttggg ttactcagaa cttggagcca   4200

tcaaatctct caggacacta agagctctga gacctctaag agccttatct cgatttgaag   4260

ggatgagggt ggttgtgaat gcccttttag gagcaattcc atccatcatg aatgtgcttc   4320

tggtttgtct tatattctgg ctaattttca gcatcatggg cgtaaatttg tttgctggca   4380

aattctacca ctgtattaac accacaactg gtgacaggtt tgacatcgaa gacgtgaata   4440

atcatactga tggcctaaaa ctaatagaaa gaaatgagac tgctcgatgg aaaaatgtga   4500

aagtaaactt tgataatgta ggatttgggt atctctcttt gcttcaagtt gccacattca   4560

aaggatggat ggatataatg tatgcagcag ttgattccag aaatgtggaa ctccagccta   4620

agtatgaaaa aagtctgtac atgtatcttt actttgttat tttcatcatc tttgggtcct   4680

tcttcacctt gaacctgttt attggtgtca tcatagataa tttcaaccag cagaaaaaga   4740

agtttggagg tcaagacatc tttatgacag aagaacagaa gaaatactat aatgcaatga   4800

aaaaattagg atcgaaaaaa ccgcaaaagc ctatacctcg accaggaaac aaatttcaag   4860

gaatggtctt tgacttcgta accagacaag tttttgacat aagcatcatg attctcatct   4920

gtcttaacat ggtcacaatg atggtggaaa cagatgacca gagtgaatat gtgactacca   4980

ttttgtcacg catcaatctg gtgttcattg tgctatttac tggagagtgt gtactgaaac   5040

tcatctctct acgccattat tattttacca ttggatggaa tatttttgat tttgtggttg   5100

tcattctctc cattgtaggt atgtttcttg ccgagctgat agaaaagtat ttcgtgtccc   5160

ctaccctgtt ccgagtgatc cgtcttgcta ggattggccg aatcctacgt ctgatcaaag   5220

gagcaaaggg gatccgcacg ctgctctttg ctttgatgat gtcccttcct gcgttgttta   5280

acatcggcct cctactcttc ctagtcatgt tcatctacgc catctttggg atgtccaact   5340

ttgcctatgt taagagggaa gttgggatcg atgacatgtt caactttgag acctttggca   5400

acagcatgat ctgcctattc caaattacaa cctctgctgg ctgggatgga ttgctagcac   5460

ccattctcaa cagtaagcca cccgactgtg accctaataa agttaaccct ggaagctcag   5520

ttaagggaga ctgtgggaac ccatctgttg gaattttctt ttttgtcagt tacatcatca   5580

tatccttcct ggttgtggtg aacatgtaca tcgcggtcat cctggagaac ttcagtgttg   5640

ctactgaaga aagtgcagag cctctgagtg aggatgactt tgagatgttc tatgaggttt   5700

gggagaagtt tgatcccgat gcaactcagt tcatggaatt tgaaaaatta tctcagtttg   5760

cagctgcgct tgaaccgcct ctcaatctgc cacaaccaaa caaactccag ctcattgcca   5820

tggatttgcc catggtgagt ggtgaccgga tccactgtct tgatatctta tttgctttta   5880

caaagcgggt tctaggagag agtggagaga tggatgctct acgaatacag atggaagagc   5940

gattcatggc ttccaatcct tccaaggtct cctatcagcc aatcactact actttaaaac   6000

gaaaacaaga ggaagtatct gctgtcatta ttcagcgtgc ttacagacgc caccttttaa   6060

agcgaactgt aaaacaagct tcctttacgt acaataaaaa caaaatcaaa ggtggggcta   6120

atcttcttat aaaagaagac atgataattg acagaataaa tgaaaactct attacagaaa   6180

aaactgatct gaccatgtcc actgcagctt gtccaccttc ctatgaccgg gtgacaaagc   6240

caattgtgga aaaacatgag caagaaggca aagatgaaaa agccaaaggg aaataaatga   6300

aaataaataa aaataattgg gtgacaaatt gtttacagcc tgtgaaggtg atgtattttt   6360

atcaacagga ctcctttagg aggtcaatgc caaactgact gtttttacac aaatctcctt   6420

aaggtcagtg cctacaataa gacagtgacc ccttgtcagc aaactgtgac tctgtgtaaa   6480

ggggagatga ccttgacagg aggttactgt tctcactacc agctgacact gctgaagata   6540

agatgcacaa tggctagtca gactgtaggg accagtttca aggggtgcaa acctgtgatt   6600

ttggggttgt ttaacatgaa acactttagt gtagtaattg tatccactgt ttgcatttca   6660

actgccacat ttgtcacatt tttatggaat ctgttagtgg attcatcttt ttgttaatcc   6720

atgtgtttat tatatgtgac tatttttgta aacgaagttt ctgttgagaa ataggctaag   6780

gacctctata acaggtatgc cacctggggg gtatggcaac cacatggccc tcccagctac   6840

acaaagtcgt ggtttgcatg agggcatgct gcacttagag atcatgcatg agaaaaagtc   6900

acaagaaaaa caaattctta aatttcacca tatttctggg aggggtaatt gggtgataag   6960

tggaggtgct ttgttgatct tgttttgcga aatccagccc ctagaccaag tagattattt   7020

gtgggtaggc cagtaaatct tagcaggtgc aaacttcatt caaatgtttg gagtcataaa   7080

tgttatgttt ctttttgttg tattaaaaaa aaaacctgaa tagtgaatat tgcccctcac   7140

cctccaccgc cagaagactg aattgaccaa aattactctt tataaatttc tgctttttcc   7200

tgcactttgt ttagccatct ttgggctctc agcaaggttg acactgtata tgttaatgaa   7260

atgctattta ttatgtaaat agtcatttta ccctgtggtg cacgtttgag caaacaaata   7320

atgacctaag cacagtattt attgcatcaa atatgtacca caagaaatgt agagtgcaag   7380

ctttacacag gtaataaaat gtattctgta ccatttatag atagtttgga tgctatcaat   7440

gcatgtttat attaccatgc tgctgtatct ggtttctctc actgctcaga atctcattta   7500

tgagaaacca tatgtcagtg gtaaagtcaa ggaaattgtt caacagatct catttattta   7560

agtcattaag caatagtttg cagcacttta acagcttttt ggttattttt acattttaag   7620

tggataacat atggtatata gccagactgt acagacatgt ttaaaaaaac acactgctta   7680

acctattaaa tatgtgttta gaattttata agcaaatata aatactgtaa aaagtcactt   7740

tattttattt ttcagcatta tgtacataaa tatgaagagg aaattatctt caggttgata   7800

tcacaatcac ttttcttact ttctgtccat agtacttttt catgaaagaa atttgctaaa   7860

taagacatga aaacaagact gggtagttgt agatttctgc tttttaaatt acatttgcta   7920

attttagatt atttcacaat tttaaggagc aaaataggtt cacgattcat atccaaatta   7980

tgctttgcaa ttggaaaagg gtttaaaatt ttatttatat ttctggtagt acctgtacta   8040

actgaattga aggtagtgct tatgttattt ttgttctttt tttctgactt cggtttatgt   8100

tttcatttct ttggagtaat gctgctctag attgttctaa atagaatgtg ggcttcataa   8160

tttttttttc cacaaaaaca gagtagtcaa cttatatagt caattacatc aggacatttt   8220

gtgtttctta cagaagcaaa ccataggctc ctcttttcct taaaactact tagataaact   8280

gtattcgtga actgcatgct ggaaaatgct actattatgc taaataatgc taaccaacat   8340

ttaaaatgtg caaaactaat aaagattaca ttttttattt t                       8381


<210>  10
<211>  8381
<212>  DNA
<213>  Homo sapiens

<400>  10
atactgcaga ggtctctggt gcatgtgtgt atgtgtgcgt ttgtgtgtgt ttgtgtgtct     60

gtgtgttctg ccccagtgag actgcagccc ttgtaaatac tttgacacct tttgcaagaa    120

ggaatctgaa caattgcaac tgaaggcaca ttgttatcat ctcgtctttg ggtgatgctg    180

ttcctcactg cagatggata attttccttt taatcaggaa tttcatatgc agaataaatg    240

gtaattaaaa tgtgcaggat gacaagatgg agcaaacagt gcttgtacca ccaggacctg    300

acagcttcaa cttcttcacc agagaatctc ttgcggctat tgaaagacgc attgcagaag    360

aaaaggcaaa gaatcccaaa ccagacaaaa aagatgacga cgaaaatggc ccaaagccaa    420

atagtgactt ggaagctgga aagaaccttc catttattta tggagacatt cctccagaga    480

tggtgtcaga gcccctggag gacctggacc cctactatat caataagaaa acttttatag    540

tattgaataa attgaaggcc atcttccggt tcagtgccac ctctgccctg tacattttaa    600

ctcccttcaa tcctcttagg aaaatagcta ttaagatttt ggtacattca ttattcagca    660

tgctaattat gtgcactatt ttgacaaact gtgtgtttat gacaatgagt aaccctcctg    720

attggacaaa gaatgtagaa tacaccttca caggaatata tacttttgaa tcacttataa    780

aaattattgc aaggggattc tgtttagaag attttacttt ccttcgggat ccatggaact    840

ggctcgattt cactgtcatt acatttgcgt acgtcacaga gtttgtggac ctgggcaatg    900

tctcggcatt gagaacattc agagttctcc gagcattgaa gacgatttca gtcattccag    960

gcctgaaaac cattgtggga gccctgatcc agtctgtgaa gaagctctca gatgtaatga   1020

tcctgactgt gttctgtctg agcgtatttg ctctaattgg gctgcagctg ttcatgggca   1080

acctgaggaa taaatgtata caatggcctc ccaccaatgc ttccttggag gaacatagta   1140

tagaaaagaa tataactgtg aattataatg gtacacttat aaatgaaact gtctttgagt   1200

ttgactggaa gtcatatatt caagattcaa gatatcatta tttcctggag ggttttttag   1260

atgcactact atgtggaaat agctctgatg caggccaatg tccagaggga tatatgtgtg   1320

tgaaagctgg tagaaatccc aattatggct acacaagctt tgataccttc agttgggctt   1380

ttttgtcctt gtttcgacta atgactcagg acttctggga aaatctttat caactgacat   1440

tacgtgctgc tgggaaaacg tacatgatat tttttgtatt ggtcattttc ttgggctcat   1500

tctacctaat aaatttgatc ctggctgtgg tggccatggc ctacgaggaa cagaatcagg   1560

ccaccttgga agaagcagaa cagaaagagg ccgaatttca gcagatgatt gaacagctta   1620

aaaagcaaca ggaggcagct cagcaggcag caacggcaac tgcctcagaa cattccagag   1680

agcccagtgc agcaggcagg ctctcagaca gctcatctga agcctctaag ttgagttcca   1740

agagtgctaa ggaaagaaga aatcggagga agaaaagaaa acagaaagag cagtctggtg   1800

gggaagagaa agatgaggat gaattccaaa aatctgaatc tgaggacagc atcaggagga   1860

aaggttttcg cttctccatt gaagggaacc gattgacata tgaaaagagg tactcctccc   1920

cacaccagtc tttgttgagc atccgtggct ccctattttc accaaggcga aatagcagaa   1980

caagcctttt cagctttaga gggcgagcaa aggatgtggg atctgagaac gacttcgcag   2040

atgatgagca cagcaccttt gaggataacg agagccgtag agattccttg tttgtgcccc   2100

gacgacacgg agagagacgc aacagcaacc tgagtcagac cagtaggtca tcccggatgc   2160

tggcagtgtt tccagcgaat gggaagatgc acagcactgt ggattgcaat ggtgtggttt   2220

ccttggttgg tggaccttca gttcctacat cgcctgttgg acagcttctg ccagaggtga   2280

taatagataa gccagctact gatgacaatg gaacaaccac tgaaactgaa atgagaaaga   2340

gaaggtcaag ttctttccac gtttccatgg actttctaga agatccttcc caaaggcaac   2400

gagcaatgag tatagccagc attctaacaa atacagtaga agaacttgaa gaatccaggc   2460

agaaatgccc accctgttgg tataaatttt ccaacatatt cttaatctgg gactgttctc   2520

catattggtt aaaagtgaaa catgttgtca acctggttgt gatggaccca tttgttgacc   2580

tggccatcac catctgtatt gtcttaaata ctcttttcat ggccatggag cactatccaa   2640

tgacggacca tttcaataat gtgcttacag taggaaactt ggttttcact gggatcttta   2700

cagcagaaat gtttctgaaa attattgcca tggatcctta ctattatttc caagaaggct   2760

ggaatatctt tgacggtttt attgtgacgc ttagcctggt agaacttgga ctcgccaatg   2820

tggaaggatt atctgttctc cgttcatttc gattgctgcg agttttcaag ttggcaaaat   2880

cttggccaac gttaaatatg ctaataaaga tcatcggcaa ttccgtgggg gctctgggaa   2940

atttaaccct cgtcttggcc atcatcgtct tcatttttgc cgtggtcggc atgcagctct   3000

ttggtaaaag ctacaaagat tgtgtctgca agatcgccag tgattgtcaa ctcccacgct   3060

ggcacatgaa tgacttcttc cactccttcc tgattgtgtt ccgcgtgctg tgtggggagt   3120

ggatagagac catgtgggac tgtatggagg ttgctggtca agccatgtgc cttactgtct   3180

tcatgatggt catggtgatt ggaaacctag tggtcctgaa tctctttctg gccttgcttc   3240

tgagctcatt tagtgcagac aaccttgcag ccactgatga tgataatgaa atgaataatc   3300

tccaaattgc tgtggatagg atgcacaaag gagtagctta tgtgaaaaga aaaatatatg   3360

aatttattca acagtccttc attaggaaac aaaagatttt agatgaaatt aaaccacttg   3420

atgatctaaa caacaagaaa gacagttgta tgtccaatca tacaacagaa attgggaaag   3480

atcttgacta tcttaaagat gtaaatggaa ctacaagtgg tataggaact ggcagcagtg   3540

ttgaaaaata cattattgat gaaagtgatt acatgtcatt cataaacaac cccagtctta   3600

ctgtgactgt accaattgct gtaggagaat ctgactttga aaatttaaac acggaagact   3660

ttagtagtga atcggatctg gaagaaagca aagagaaact gaatgaaagc agtagctcat   3720

cagaaggtag cactgtggac atcggcgcac ctgtagaaga acagcccgta gtggaacctg   3780

aagaaactct tgaaccagaa gcttgtttca ctgaaggctg tgtacaaaga ttcaagtgtt   3840

gtcaaatcaa tgtggaagaa ggcagaggaa aacaatggtg gaacctgaga aggacgtgtt   3900

tccgaatagt tgaacataac tggtttgaga ccttcattgt tttcatgatt ctccttagta   3960

gtggtgctct ggcatttgaa gatatatata ttgatcagcg aaagacgatt aagacgatgt   4020

tggaatatgc tgacaaggtt ttcacttaca ttttcattct ggaaatgctt ctaaaatggg   4080

tggcatatgg ctatcaaaca tatttcacca atgcctggtg ttggctggac ttcttaattg   4140

ttgatgtttc attggtcagt ttaacagcaa atgccttggg ttactcagaa cttggagcca   4200

tcaaatctct caggacacta agagctctga gacctctaag agccttatct cgatttgaag   4260

ggatgagggt ggttgtgaat gcccttttag gagcaattcc atccatcatg aatgtgcttc   4320

tggtttgtct tatattctgg ctaattttca gcatcatggg cgtaaatttg tttgctggca   4380

aattctacca ctgtattaac accacaactg gtgacaggtt tgacatcgaa gacgtgaata   4440

atcatactga ttgcctaaaa ctaatagaaa gaaatgagac tgctcgatgg aaaaatgtga   4500

aagtaaactt tgataatgta ggatttgggt atctctcttt gcttcaagtt gccacattca   4560

aaggatggat ggatataatg tatgcaccag ttgattccag aaatgtggaa ctccagccta   4620

agtatgaaaa aagtctgtac atgtatcttt actttgttat tttcatcatc tttgggtcct   4680

tcttcacctt gaacctgttt attggtgtca tcatagataa tttcaaccag cagaaaaaga   4740

agtttggagg tcaagacatc tttatgacag aagaacagaa gaaatactat aatgcaatga   4800

aaaaattagg atcgaaaaaa ccgcaaaagc ctatacctcg accaggaaac aaatttcaag   4860

gaatggtctt tgacttcgta accagacaag tttttgacat aagcatcatg attctcatct   4920

gtcttaacat ggtcacaatg atggtggaaa cagatgacca gagtgaatat gtgactacca   4980

ttttgtcacg catcaatctg gtgttcattg tgctatttac tggagagtgt gtactgaaac   5040

tcatctctct acgccattat tattttacca ttggatggaa tatttttgat tttgtggttg   5100

tcattctctc cattgtaggt atgtttcttg ccgagctgat agaaaagtat ttcgtgtccc   5160

ctaccctgtt ccgagtgatc cgtcttgcta ggattggccg aatcctacgt ctgatcaaag   5220

gagcaaaggg gatccgcacg ctgctctttg ctttgatgat gtcccttcct gcgttgttta   5280

acatcggcct cctactcttc ctagtcatgt tcatctacgc catctttggg atgtccaact   5340

ttgcctatgt taagagggaa gttgggatcg atgacatgtt caactttgag acctttggca   5400

acagcatgat ctgcctattc caaattacaa cctctgctgg ctgggatgga ttgctagcac   5460

ccattctcaa cagtaagcca cccgactgtg accctaataa agttaaccct ggaagctcag   5520

ttaagggaga ctgtgggaac ccatctgttg gaattttctt ttttgtcagt tacatcatca   5580

tatccttcct ggttgtggtg aacatgtaca tcgcggtcat cctggagaac ttcagtgttg   5640

ctactgaaga aagtgcagag cctctgagtg aggatgactt tgagatgttc tatgaggttt   5700

gggagaagtt tgatcccgat gcaactcagt tcatggaatt tgaaaaatta tctcagtttg   5760

cagctgcgct tgaaccgcct ctcaatctgc cacaaccaaa caaactccag ctcattgcca   5820

tggatttgcc catggtgagt ggtgaccgga tccactgtct tgatatctta tttgctttta   5880

caaagcgggt tctaggagag agtggagaga tggatgctct acgaatacag atggaagagc   5940

gattcatggc ttccaatcct tccaaggtct cctatcagcc aatcactact actttaaaac   6000

gaaaacaaga ggaagtatct gctgtcatta ttcagcgtgc ttacagacgc caccttttaa   6060

agcgaactgt aaaacaagct tcctttacgt acaataaaaa caaaatcaaa ggtggggcta   6120

atcttcttat aaaagaagac atgataattg acagaataaa tgaaaactct attacagaaa   6180

aaactgatct gaccatgtcc actgcagctt gtccaccttc ctatgaccgg gtgacaaagc   6240

caattgtgga aaaacatgag caagaaggca aagatgaaaa agccaaaggg aaataaatga   6300

aaataaataa aaataattgg gtgacaaatt gtttacagcc tgtgaaggtg atgtattttt   6360

atcaacagga ctcctttagg aggtcaatgc caaactgact gtttttacac aaatctcctt   6420

aaggtcagtg cctacaataa gacagtgacc ccttgtcagc aaactgtgac tctgtgtaaa   6480

ggggagatga ccttgacagg aggttactgt tctcactacc agctgacact gctgaagata   6540

agatgcacaa tggctagtca gactgtaggg accagtttca aggggtgcaa acctgtgatt   6600

ttggggttgt ttaacatgaa acactttagt gtagtaattg tatccactgt ttgcatttca   6660

actgccacat ttgtcacatt tttatggaat ctgttagtgg attcatcttt ttgttaatcc   6720

atgtgtttat tatatgtgac tatttttgta aacgaagttt ctgttgagaa ataggctaag   6780

gacctctata acaggtatgc cacctggggg gtatggcaac cacatggccc tcccagctac   6840

acaaagtcgt ggtttgcatg agggcatgct gcacttagag atcatgcatg agaaaaagtc   6900

acaagaaaaa caaattctta aatttcacca tatttctggg aggggtaatt gggtgataag   6960

tggaggtgct ttgttgatct tgttttgcga aatccagccc ctagaccaag tagattattt   7020

gtgggtaggc cagtaaatct tagcaggtgc aaacttcatt caaatgtttg gagtcataaa   7080

tgttatgttt ctttttgttg tattaaaaaa aaaacctgaa tagtgaatat tgcccctcac   7140

cctccaccgc cagaagactg aattgaccaa aattactctt tataaatttc tgctttttcc   7200

tgcactttgt ttagccatct ttgggctctc agcaaggttg acactgtata tgttaatgaa   7260

atgctattta ttatgtaaat agtcatttta ccctgtggtg cacgtttgag caaacaaata   7320

atgacctaag cacagtattt attgcatcaa atatgtacca caagaaatgt agagtgcaag   7380

ctttacacag gtaataaaat gtattctgta ccatttatag atagtttgga tgctatcaat   7440

gcatgtttat attaccatgc tgctgtatct ggtttctctc actgctcaga atctcattta   7500

tgagaaacca tatgtcagtg gtaaagtcaa ggaaattgtt caacagatct catttattta   7560

agtcattaag caatagtttg cagcacttta acagcttttt ggttattttt acattttaag   7620

tggataacat atggtatata gccagactgt acagacatgt ttaaaaaaac acactgctta   7680

acctattaaa tatgtgttta gaattttata agcaaatata aatactgtaa aaagtcactt   7740

tattttattt ttcagcatta tgtacataaa tatgaagagg aaattatctt caggttgata   7800

tcacaatcac ttttcttact ttctgtccat agtacttttt catgaaagaa atttgctaaa   7860

taagacatga aaacaagact gggtagttgt agatttctgc tttttaaatt acatttgcta   7920

attttagatt atttcacaat tttaaggagc aaaataggtt cacgattcat atccaaatta   7980

tgctttgcaa ttggaaaagg gtttaaaatt ttatttatat ttctggtagt acctgtacta   8040

actgaattga aggtagtgct tatgttattt ttgttctttt tttctgactt cggtttatgt   8100

tttcatttct ttggagtaat gctgctctag attgttctaa atagaatgtg ggcttcataa   8160

tttttttttc cacaaaaaca gagtagtcaa cttatatagt caattacatc aggacatttt   8220

gtgtttctta cagaagcaaa ccataggctc ctcttttcct taaaactact tagataaact   8280

gtattcgtga actgcatgct ggaaaatgct actattatgc taaataatgc taaccaacat   8340

ttaaaatgtg caaaactaat aaagattaca ttttttattt t                       8381


<210>  11
<211>  8381
<212>  DNA
<213>  Homo sapiens

<400>  11
atactgcaga ggtctctggt gcatgtgtgt atgtgtgcgt ttgtgtgtgt ttgtgtgtct     60

gtgtgttctg ccccagtgag actgcagccc ttgtaaatac tttgacacct tttgcaagaa    120

ggaatctgaa caattgcaac tgaaggcaca ttgttatcat ctcgtctttg ggtgatgctg    180

ttcctcactg cagatggata attttccttt taatcaggaa tttcatatgc agaataaatg    240

gtaattaaaa tgtgcaggat gacaagatgg agcaaacagt gcttgtacca ccaggacctg    300

acagcttcaa cttcttcacc agagaatctc ttgcggctat tgaaagacgc attgcagaag    360

aaaaggcaaa gaatcccaaa ccagacaaaa aagatgacga cgaaaatggc ccaaagccaa    420

atagtgactt ggaagctgga aagaaccttc catttattta tggagacatt cctccagaga    480

tggtgtcaga gcccctggag gacctggacc cctactatat caataagaaa acttttatag    540

tattgaataa attgaaggcc atcttccggt tcagtgccac ctctgccctg tacattttaa    600

ctcccttcaa tcctcttagg aaaatagcta ttaagatttt ggtacattca ttattcagca    660

tgctaattat gtgcactatt ttgacaaact gtgtgtttat gacaatgagt aaccctcctg    720

attggacaaa gaatgtagaa tacaccttca caggaatata tacttttgaa tcacttataa    780

aaattattgc aaggggattc tgtttagaag attttacttt ccttcgggat ccatggaact    840

ggctcgattt cactgtcatt acatttgcgt acgtcacaga gtttgtggac ctgggcaatg    900

tctcggcatt gagaacattc agagttctcc gagcattgaa gacgatttca gtcattccag    960

gcctgaaaac cattgtggga gccctgatcc agtctgtgaa gaagctctca gatgtaatga   1020

tcctgactgt gttctgtctg agcgtatttg ctctaattgg gctgcagctg ttcatgggca   1080

acctgaggaa taaatgtata caatggcctc ccaccaatgc ttccttggag gaacatagta   1140

tagaaaagaa tataactgtg aattataatg gtacacttat aaatgaaact gtctttgagt   1200

ttgactggaa gtcatatatt caagattcaa gatatcatta tttcctggag ggttttttag   1260

atgcactact atgtggaaat agctctgatg caggccaatg tccagaggga tatatgtgtg   1320

tgaaagctgg tagaaatccc aattatggct acacaagctt tgataccttc agttgggctt   1380

ttttgtcctt gtttcgacta atgactcagg acttctggga aaatctttat caactgacat   1440

tacgtgctgc tgggaaaacg tacatgatat tttttgtatt ggtcattttc ttgggctcat   1500

tctacctaat aaatttgatc ctggctgtgg tggccatggc ctacgaggaa cagaatcagg   1560

ccaccttgga agaagcagaa cagaaagagg ccgaatttca gcagatgatt gaacagctta   1620

aaaagcaaca ggaggcagct cagcaggcag caacggcaac tgcctcagaa cattccagag   1680

agcccagtgc agcaggcagg ctctcagaca gctcatctga agcctctaag ttgagttcca   1740

agagtgctaa ggaaagaaga aatcggagga agaaaagaaa acagaaagag cagtctggtg   1800

gggaagagaa agatgaggat gaattccaaa aatctgaatc tgaggacagc atcaggagga   1860

aaggttttcg cttctccatt gaagggaacc gattgacata tgaaaagagg tactcctccc   1920

cacaccagtc tttgttgagc atccgtggct ccctattttc accaaggcga aatagcagaa   1980

caagcctttt cagctttaga gggcgagcaa aggatgtggg atctgagaac gacttcgcag   2040

atgatgagca cagcaccttt gaggataacg agagccgtag agattccttg tttgtgcccc   2100

gacgacacgg agagagacgc aacagcaacc tgagtcagac cagtaggtca tcccggatgc   2160

tggcagtgtt tccagcgaat gggaagatgc acagcactgt ggattgcaat ggtgtggttt   2220

ccttggttgg tggaccttca gttcctacat cgcctgttgg acagcttctg ccagaggtga   2280

taatagataa gccagctact gatgacaatg gaacaaccac tgaaactgaa atgagaaaga   2340

gaaggtcaag ttctttccac gtttccatgg actttctaga agatccttcc caaaggcaac   2400

gagcaatgag tatagccagc attctaacaa atacagtaga agaacttgaa gaatccaggc   2460

agaaatgccc accctgttgg tataaatttt ccaacatatt cttaatctgg gactgttctc   2520

catattggtt aaaagtgaaa catgttgtca acctggttgt gatggaccca tttgttgacc   2580

tggccatcac catctgtatt gtcttaaata ctcttttcat ggccatggag cactatccaa   2640

tgacggacca tttcaataat gtgcttacag taggaaactt ggttttcact gggatcttta   2700

cagcagaaat gtttctgaaa attattgcca tggatcctta ctattatttc caagaaggct   2760

ggaatatctt tgacggtttt attgtgacgc ttagcctggt agaacttgga ctcgccaatg   2820

tggaaggatt atctgttctc cgttcatttc gattgctgcg agttttcaag ttggcaaaat   2880

cttggccaac gttaaatatg ctaataaaga tcatcggcaa ttccgtgggg gctctgggaa   2940

atttaaccct cgtcttggcc atcatcgtct tcatttttgc cgtggtcggc atgcagctct   3000

ttggtaaaag ctacaaagat tgtgtctgca agatcgccag tgattgtcaa ctcccacgct   3060

ggcacatgaa tgacttcttc cactccttcc tgattgtgtt ccgcgtgctg tgtggggagt   3120

ggatagagac catgtgggac tgtatggagg ttgctggtca agccatgtgc cttactgtct   3180

tcatgatggt catggtgatt ggaaacctag tggtcctgaa tctctttctg gccttgcttc   3240

tgagctcatt tagtgcagac aaccttgcag ccactgatga tgataatgaa atgaataatc   3300

tccaaattgc tgtggatagg atgcacaaag gagtagctta tgtgaaaaga aaaatatatg   3360

aatttattca acagtccttc attaggaaac aaaagatttt agatgaaatt aaaccacttg   3420

atgatctaaa caacaagaaa gacagttgta tgtccaatca tacaacagaa attgggaaag   3480

atcttgacta tcttaaagat gtaaatggaa ctacaagtgg tataggaact ggcagcagtg   3540

ttgaaaaata cattattgat gaaagtgatt acatgtcatt cataaacaac cccagtctta   3600

ctgtgactgt accaattgct gtaggagaat ctgactttga aaatttaaac acggaagact   3660

ttagtagtga atcggatctg gaagaaagca aagagaaact gaatgaaagc agtagctcat   3720

cagaaggtag cactgtggac atcggcgcac ctgtagaaga acagcccgta gtggaacctg   3780

aagaaactct tgaaccagaa gcttgtttca ctgaaggctg tgtacaaaga ttcaagtgtt   3840

gtcaaatcaa tgtggaagaa ggcagaggaa aacaatggtg gaacctgaga aggacgtgtt   3900

tccgaatagt tgaacataac tggtttgaga ccttcattgt tttcatgatt ctccttagta   3960

gtggtgctct ggcatttgaa gatatatata ttgatcagcg aaagacgatt aagacgatgt   4020

tggaatatgc tgacaaggtt ttcacttaca ttttcattct ggaaatgctt ctaaaatggg   4080

tggcatatgg ctatcaaaca tatttcacca atgcctggtg ttggctggac ttcttaattg   4140

ttgatgtttc attggtcagt ttaacagcaa atgccttggg ttactcagaa cttggagcca   4200

tcaaatctct caggacacta agagctctga gacctctaag agccttatct cgatttgaag   4260

ggatgagggt ggttgtgaat gcccttttag gagcaattcc atccatcatg aatgtgcttc   4320

tggtttgtct tatattctgg ctaattttca gcatcatggg cgtaaatttg tttgctggca   4380

aattctacca ctgtattaac accacaactg gtgacaggtt tgacatcgaa gacgtgaata   4440

atcatactga ttgcctaaaa ctaatagaaa gaaatgagac tgctcgatgg aaaaatgtga   4500

aagtaaactt tgataatgta ggatttgggt atctctcttt gcttcaagtt gccacattca   4560

aaggatggat ggatataatg tatgcagcag ttgattccag aaatgtggaa ctccagccta   4620

agtatgaaaa aagtctgtac atgtatcttt actttgttat tttcatcatc tttgggtcct   4680

tcttcacctt gaacctgttt attggtgtca tcatagataa tttcaaccag cagaaaaaga   4740

agtttggagg tcaagacatc tttatgacag aagaacagaa gaaatactat aatgcaatga   4800

aaaaattagg atcgaaaaaa ccgcaaaagc ctatacctcg accaggaaac aaatttcaag   4860

gaatggtctt tgacttcgta accagacaag tttttgacgt aagcatcatg attctcatct   4920

gtcttaacat ggtcacaatg atggtggaaa cagatgacca gagtgaatat gtgactacca   4980

ttttgtcacg catcaatctg gtgttcattg tgctatttac tggagagtgt gtactgaaac   5040

tcatctctct acgccattat tattttacca ttggatggaa tatttttgat tttgtggttg   5100

tcattctctc cattgtaggt atgtttcttg ccgagctgat agaaaagtat ttcgtgtccc   5160

ctaccctgtt ccgagtgatc cgtcttgcta ggattggccg aatcctacgt ctgatcaaag   5220

gagcaaaggg gatccgcacg ctgctctttg ctttgatgat gtcccttcct gcgttgttta   5280

acatcggcct cctactcttc ctagtcatgt tcatctacgc catctttggg atgtccaact   5340

ttgcctatgt taagagggaa gttgggatcg atgacatgtt caactttgag acctttggca   5400

acagcatgat ctgcctattc caaattacaa cctctgctgg ctgggatgga ttgctagcac   5460

ccattctcaa cagtaagcca cccgactgtg accctaataa agttaaccct ggaagctcag   5520

ttaagggaga ctgtgggaac ccatctgttg gaattttctt ttttgtcagt tacatcatca   5580

tatccttcct ggttgtggtg aacatgtaca tcgcggtcat cctggagaac ttcagtgttg   5640

ctactgaaga aagtgcagag cctctgagtg aggatgactt tgagatgttc tatgaggttt   5700

gggagaagtt tgatcccgat gcaactcagt tcatggaatt tgaaaaatta tctcagtttg   5760

cagctgcgct tgaaccgcct ctcaatctgc cacaaccaaa caaactccag ctcattgcca   5820

tggatttgcc catggtgagt ggtgaccgga tccactgtct tgatatctta tttgctttta   5880

caaagcgggt tctaggagag agtggagaga tggatgctct acgaatacag atggaagagc   5940

gattcatggc ttccaatcct tccaaggtct cctatcagcc aatcactact actttaaaac   6000

gaaaacaaga ggaagtatct gctgtcatta ttcagcgtgc ttacagacgc caccttttaa   6060

agcgaactgt aaaacaagct tcctttacgt acaataaaaa caaaatcaaa ggtggggcta   6120

atcttcttat aaaagaagac atgataattg acagaataaa tgaaaactct attacagaaa   6180

aaactgatct gaccatgtcc actgcagctt gtccaccttc ctatgaccgg gtgacaaagc   6240

caattgtgga aaaacatgag caagaaggca aagatgaaaa agccaaaggg aaataaatga   6300

aaataaataa aaataattgg gtgacaaatt gtttacagcc tgtgaaggtg atgtattttt   6360

atcaacagga ctcctttagg aggtcaatgc caaactgact gtttttacac aaatctcctt   6420

aaggtcagtg cctacaataa gacagtgacc ccttgtcagc aaactgtgac tctgtgtaaa   6480

ggggagatga ccttgacagg aggttactgt tctcactacc agctgacact gctgaagata   6540

agatgcacaa tggctagtca gactgtaggg accagtttca aggggtgcaa acctgtgatt   6600

ttggggttgt ttaacatgaa acactttagt gtagtaattg tatccactgt ttgcatttca   6660

actgccacat ttgtcacatt tttatggaat ctgttagtgg attcatcttt ttgttaatcc   6720

atgtgtttat tatatgtgac tatttttgta aacgaagttt ctgttgagaa ataggctaag   6780

gacctctata acaggtatgc cacctggggg gtatggcaac cacatggccc tcccagctac   6840

acaaagtcgt ggtttgcatg agggcatgct gcacttagag atcatgcatg agaaaaagtc   6900

acaagaaaaa caaattctta aatttcacca tatttctggg aggggtaatt gggtgataag   6960

tggaggtgct ttgttgatct tgttttgcga aatccagccc ctagaccaag tagattattt   7020

gtgggtaggc cagtaaatct tagcaggtgc aaacttcatt caaatgtttg gagtcataaa   7080

tgttatgttt ctttttgttg tattaaaaaa aaaacctgaa tagtgaatat tgcccctcac   7140

cctccaccgc cagaagactg aattgaccaa aattactctt tataaatttc tgctttttcc   7200

tgcactttgt ttagccatct ttgggctctc agcaaggttg acactgtata tgttaatgaa   7260

atgctattta ttatgtaaat agtcatttta ccctgtggtg cacgtttgag caaacaaata   7320

atgacctaag cacagtattt attgcatcaa atatgtacca caagaaatgt agagtgcaag   7380

ctttacacag gtaataaaat gtattctgta ccatttatag atagtttgga tgctatcaat   7440

gcatgtttat attaccatgc tgctgtatct ggtttctctc actgctcaga atctcattta   7500

tgagaaacca tatgtcagtg gtaaagtcaa ggaaattgtt caacagatct catttattta   7560

agtcattaag caatagtttg cagcacttta acagcttttt ggttattttt acattttaag   7620

tggataacat atggtatata gccagactgt acagacatgt ttaaaaaaac acactgctta   7680

acctattaaa tatgtgttta gaattttata agcaaatata aatactgtaa aaagtcactt   7740

tattttattt ttcagcatta tgtacataaa tatgaagagg aaattatctt caggttgata   7800

tcacaatcac ttttcttact ttctgtccat agtacttttt catgaaagaa atttgctaaa   7860

taagacatga aaacaagact gggtagttgt agatttctgc tttttaaatt acatttgcta   7920

attttagatt atttcacaat tttaaggagc aaaataggtt cacgattcat atccaaatta   7980

tgctttgcaa ttggaaaagg gtttaaaatt ttatttatat ttctggtagt acctgtacta   8040

actgaattga aggtagtgct tatgttattt ttgttctttt tttctgactt cggtttatgt   8100

tttcatttct ttggagtaat gctgctctag attgttctaa atagaatgtg ggcttcataa   8160

tttttttttc cacaaaaaca gagtagtcaa cttatatagt caattacatc aggacatttt   8220

gtgtttctta cagaagcaaa ccataggctc ctcttttcct taaaactact tagataaact   8280

gtattcgtga actgcatgct ggaaaatgct actattatgc taaataatgc taaccaacat   8340

ttaaaatgtg caaaactaat aaagattaca ttttttattt t                       8381


<210>  12
<211>  8381
<212>  DNA
<213>  Homo sapiens

<400>  12
atactgcaga ggtctctggt gcatgtgtgt atgtgtgcgt ttgtgtgtgt ttgtgtgtct     60

gtgtgttctg ccccagtgag actgcagccc ttgtaaatac tttgacacct tttgcaagaa    120

ggaatctgaa caattgcaac tgaaggcaca ttgttatcat ctcgtctttg ggtgatgctg    180

ttcctcactg cagatggata attttccttt taatcaggaa tttcatatgc agaataaatg    240

gtaattaaaa tgtgcaggat gacaagatgg agcaaacagt gcttgtacca ccaggacctg    300

acagcttcaa cttcttcacc agagaatctc ttgcggctat tgaaagacgc attgcagaag    360

aaaaggcaaa gaatcccaaa ccagacaaaa aagatgacga cgaaaatggc ccaaagccaa    420

atagtgactt ggaagctgga aagaaccttc catttattta tggagacatt cctccagaga    480

tggtgtcaga gcccctggag gacctggacc cctactatat caataagaaa acttttatag    540

tattgaataa attgaaggcc atcttccggt tcagtgccac ctctgccctg tacattttaa    600

ctcccttcaa tcctcttagg aaaatagcta ttaagatttt ggtacattca ttattcagca    660

tgctaattat gtgcactatt ttgacaaact gtgtgtttat gacaatgagt aaccctcctg    720

attggacaaa gaatgtagaa tacaccttca caggaatata tacttttgaa tcacttataa    780

aaattattgc aaggggattc tgtttagaag attttacttt ccttcgggat ccatggaact    840

ggctcgattt cactgtcatt acatttgcgt acgtcacaga gtttgtggac ctgggcaatg    900

tctcggcatt gagaacattc agagttctcc gagcattgaa gacgatttca gtcattccag    960

gcctgaaaac cattgtggga gccctgatcc agtctgtgaa gaagctctca gatgtaatga   1020

tcctgactgt gttctgtctg agcgtatttg ctctaattgg gctgcagctg ttcatgggca   1080

acctgaggaa taaatgtata caatggcctc ccaccaatgc ttccttggag gaacatagta   1140

tagaaaagaa tataactgtg aattataatg gtacacttat aaatgaaact gtctttgagt   1200

ttgactggaa gtcatatatt caagattcaa gatatcatta tttcctggag ggttttttag   1260

atgcactact atgtggaaat agctctgatg caggccaatg tccagaggga tatatgtgtg   1320

tgaaagctgg tagaaatccc aattatggct acacaagctt tgataccttc agttgggctt   1380

ttttgtcctt gtttcgacta atgactcagg acttctggga aaatctttat caactgacat   1440

tacgtgctgc tgggaaaacg tacatgatat tttttgtatt ggtcattttc ttgggctcat   1500

tctacctaat aaatttgatc ctggctgtgg tggccatggc ctacgaggaa cagaatcagg   1560

ccaccttgga agaagcagaa cagaaagagg ccgaatttca gcagatgatt gaacagctta   1620

aaaagcaaca ggaggcagct cagcaggcag caacggcaac tgcctcagaa cattccagag   1680

agcccagtgc agcaggcagg ctctcagaca gctcatctga agcctctaag ttgagttcca   1740

agagtgctaa ggaaagaaga aatcggagga agaaaagaaa acagaaagag cagtctggtg   1800

gggaagagaa agatgaggat gaattccaaa aatctgaatc tgaggacagc atcaggagga   1860

aaggttttcg cttctccatt gaagggaacc gattgacata tgaaaagagg tactcctccc   1920

cacaccagtc tttgttgagc atccgtggct ccctattttc accaaggcga aatagcagaa   1980

caagcctttt cagctttaga gggcgagcaa aggatgtggg atctgagaac gacttcgcag   2040

atgatgagca cagcaccttt gaggataacg agagccgtag agattccttg tttgtgcccc   2100

gacgacacgg agagagacgc aacagcaacc tgagtcagac cagtaggtca tcccggatgc   2160

tggcagtgtt tccagcgaat gggaagatgc acagcactgt ggattgcaat ggtgtggttt   2220

ccttggttgg tggaccttca gttcctacat cgcctgttgg acagcttctg ccagaggtga   2280

taatagataa gccagctact gatgacaatg gaacaaccac tgaaactgaa atgagaaaga   2340

gaaggtcaag ttctttccac gtttccatgg actttctaga agatccttcc caaaggcaac   2400

gagcaatgag tatagccagc attctaacaa atacagtaga agaacttgaa gaatccaggc   2460

agaaatgccc accctgttgg tataaatttt ccaacatatt cttaatctgg gactgttctc   2520

catattggtt aaaagtgaaa catgttgtca acctggttgt gatggaccca tttgttgacc   2580

tggccatcac catctgtatt gtcttaaata ctcttttcat ggccatggag cactatccaa   2640

tgacggacca tttcaataat gtgcttacag taggaaactt ggttttcact gggatcttta   2700

cagcagaaat gtttctgaaa attattgcca tggatcctta ctattatttc caagaaggct   2760

ggaatatctt tgacggtttt attgtgacgc ttagcctggt agaacttgga ctcgccaatg   2820

tggaaggatt atctgttctc cgttcatttc gattgctgcg agttttcaag ttggcaaaat   2880

cttggccaac gttaaatatg ctaataaaga tcatcggcaa ttccgtgggg gctctgggaa   2940

atttaaccct cgtcttggcc atcatcgtct tcatttttgc cgtggtcggc atgcagctct   3000

ttggtaaaag ctacaaagat tgtgtctgca agatcgccag tgattgtcaa ctcccacgct   3060

ggcacatgaa tgacttcttc cactccttcc tgattgtgtt ccgcgtgctg tgtggggagt   3120

ggatagagac catgtgggac tgtatggagg ttgctggtca agccatgtgc cttactgtct   3180

tcatgatggt catggtgatt ggaaacctag tggtcctgaa tctctttctg gccttgcttc   3240

tgagctcatt tagtgcagac aaccttgcag ccactgatga tgataatgaa atgaataatc   3300

tccaaattgc tgtggatagg atgcacaaag gagtagctta tgtgaaaaga aaaatatatg   3360

aatttattca acagtccttc attaggaaac aaaagatttt agatgaaatt aaaccacttg   3420

atgatctaaa caacaagaaa gacagttgta tgtccaatca tacaacagaa attgggaaag   3480

atcttgacta tcttaaagat gtaaatggaa ctacaagtgg tataggaact ggcagcagtg   3540

ttgaaaaata cattattgat gaaagtgatt acatgtcatt cataaacaac cccagtctta   3600

ctgtgactgt accaattgct gtaggagaat ctgactttga aaatttaaac acggaagact   3660

ttagtagtga atcggatctg gaagaaagca aagagaaact gaatgaaagc agtagctcat   3720

cagaaggtag cactgtggac atcggcgcac ctgtagaaga acagcccgta gtggaacctg   3780

aagaaactct tgaaccagaa gcttgtttca ctgaaggctg tgtacaaaga ttcaagtgtt   3840

gtcaaatcaa tgtggaagaa ggcagaggaa aacaatggtg gaacctgaga aggacgtgtt   3900

tccgaatagt tgaacataac tggtttgaga ccttcattgt tttcatgatt ctccttagta   3960

gtggtgctct ggcatttgaa gatatatata ttgatcagcg aaagacgatt aagacgatgt   4020

tggaatatgc tgacaaggtt ttcacttaca ttttcattct ggaaatgctt ctaaaatggg   4080

tggcatatgg ctatcaaaca tatttcacca atgcctggtg ttggctggac ttcttaattg   4140

ttgatgtttc attggtcagt ttaacagcaa atgccttggg ttactcagaa cttggagcca   4200

tcaaatctct caggacacta agagctctga gacctctaag agccttatct cgatttgaag   4260

ggatgagggt ggttgtgaat gcccttttag gagcaattcc atccatcatg aatgtgcttc   4320

tggtttgtct tatattctgg ctaattttca gcatcatggg cgtaaatttg tttgctggca   4380

aattctacca ctgtattaac accacaactg gtgacaggtt tgacatcgaa gacgtgaata   4440

atcatactga ttgcctaaaa ctaatagaaa gaaatgagac tgctcgatgg aaaaatgtga   4500

aagtaaactt tgataatgta ggatttgggt atctctcttt gcttcaagtt gccacattca   4560

aaggatggat ggatataatg tatgcagcag ttgattccag aaatgtggaa ctccagccta   4620

agtatgaaaa aagtctgtac atgtatcttt actttgttat tttcatcatc tttgggtcct   4680

tcttcacctt gaacctgttt attggtgtca tcatagataa tttcaaccag cagaaaaaga   4740

agtttggagg tcaagacatc tttatgacag aagaacagaa gaaatactat aatgcaatga   4800

aaaaattagg atcgaaaaaa ccgcaaaagc ctatacctcg accaggaaac aaatttcaag   4860

gaatggtctt tgacttcgta accagacaag tttttgacat aagcatcatg attctcatct   4920

gtcttaacat ggtcacaatg atggtggaaa cagatgacca gagtgaatat gtgactacca   4980

ttttgtcacg catcaatctg gtgttcattg tgctatttac tggagagtgt gtactgaaac   5040

tcatctctct acgccattat tattttacca ttggatggaa tatttttgat tttgtggttg   5100

tcattctctc cattgtaggt atgtttcttg ccgagctgat agaaaagtat ttcgtgtccc   5160

ctaccctgtt ccgagtgatc cgtcttgcta ggattggcca aatcctacgt ctgatcaaag   5220

gagcaaaggg gatccgcacg ctgctctttg ctttgatgat gtcccttcct gcgttgttta   5280

acatcggcct cctactcttc ctagtcatgt tcatctacgc catctttggg atgtccaact   5340

ttgcctatgt taagagggaa gttgggatcg atgacatgtt caactttgag acctttggca   5400

acagcatgat ctgcctattc caaattacaa cctctgctgg ctgggatgga ttgctagcac   5460

ccattctcaa cagtaagcca cccgactgtg accctaataa agttaaccct ggaagctcag   5520

ttaagggaga ctgtgggaac ccatctgttg gaattttctt ttttgtcagt tacatcatca   5580

tatccttcct ggttgtggtg aacatgtaca tcgcggtcat cctggagaac ttcagtgttg   5640

ctactgaaga aagtgcagag cctctgagtg aggatgactt tgagatgttc tatgaggttt   5700

gggagaagtt tgatcccgat gcaactcagt tcatggaatt tgaaaaatta tctcagtttg   5760

cagctgcgct tgaaccgcct ctcaatctgc cacaaccaaa caaactccag ctcattgcca   5820

tggatttgcc catggtgagt ggtgaccgga tccactgtct tgatatctta tttgctttta   5880

caaagcgggt tctaggagag agtggagaga tggatgctct acgaatacag atggaagagc   5940

gattcatggc ttccaatcct tccaaggtct cctatcagcc aatcactact actttaaaac   6000

gaaaacaaga ggaagtatct gctgtcatta ttcagcgtgc ttacagacgc caccttttaa   6060

agcgaactgt aaaacaagct tcctttacgt acaataaaaa caaaatcaaa ggtggggcta   6120

atcttcttat aaaagaagac atgataattg acagaataaa tgaaaactct attacagaaa   6180

aaactgatct gaccatgtcc actgcagctt gtccaccttc ctatgaccgg gtgacaaagc   6240

caattgtgga aaaacatgag caagaaggca aagatgaaaa agccaaaggg aaataaatga   6300

aaataaataa aaataattgg gtgacaaatt gtttacagcc tgtgaaggtg atgtattttt   6360

atcaacagga ctcctttagg aggtcaatgc caaactgact gtttttacac aaatctcctt   6420

aaggtcagtg cctacaataa gacagtgacc ccttgtcagc aaactgtgac tctgtgtaaa   6480

ggggagatga ccttgacagg aggttactgt tctcactacc agctgacact gctgaagata   6540

agatgcacaa tggctagtca gactgtaggg accagtttca aggggtgcaa acctgtgatt   6600

ttggggttgt ttaacatgaa acactttagt gtagtaattg tatccactgt ttgcatttca   6660

actgccacat ttgtcacatt tttatggaat ctgttagtgg attcatcttt ttgttaatcc   6720

atgtgtttat tatatgtgac tatttttgta aacgaagttt ctgttgagaa ataggctaag   6780

gacctctata acaggtatgc cacctggggg gtatggcaac cacatggccc tcccagctac   6840

acaaagtcgt ggtttgcatg agggcatgct gcacttagag atcatgcatg agaaaaagtc   6900

acaagaaaaa caaattctta aatttcacca tatttctggg aggggtaatt gggtgataag   6960

tggaggtgct ttgttgatct tgttttgcga aatccagccc ctagaccaag tagattattt   7020

gtgggtaggc cagtaaatct tagcaggtgc aaacttcatt caaatgtttg gagtcataaa   7080

tgttatgttt ctttttgttg tattaaaaaa aaaacctgaa tagtgaatat tgcccctcac   7140

cctccaccgc cagaagactg aattgaccaa aattactctt tataaatttc tgctttttcc   7200

tgcactttgt ttagccatct ttgggctctc agcaaggttg acactgtata tgttaatgaa   7260

atgctattta ttatgtaaat agtcatttta ccctgtggtg cacgtttgag caaacaaata   7320

atgacctaag cacagtattt attgcatcaa atatgtacca caagaaatgt agagtgcaag   7380

ctttacacag gtaataaaat gtattctgta ccatttatag atagtttgga tgctatcaat   7440

gcatgtttat attaccatgc tgctgtatct ggtttctctc actgctcaga atctcattta   7500

tgagaaacca tatgtcagtg gtaaagtcaa ggaaattgtt caacagatct catttattta   7560

agtcattaag caatagtttg cagcacttta acagcttttt ggttattttt acattttaag   7620

tggataacat atggtatata gccagactgt acagacatgt ttaaaaaaac acactgctta   7680

acctattaaa tatgtgttta gaattttata agcaaatata aatactgtaa aaagtcactt   7740

tattttattt ttcagcatta tgtacataaa tatgaagagg aaattatctt caggttgata   7800

tcacaatcac ttttcttact ttctgtccat agtacttttt catgaaagaa atttgctaaa   7860

taagacatga aaacaagact gggtagttgt agatttctgc tttttaaatt acatttgcta   7920

attttagatt atttcacaat tttaaggagc aaaataggtt cacgattcat atccaaatta   7980

tgctttgcaa ttggaaaagg gtttaaaatt ttatttatat ttctggtagt acctgtacta   8040

actgaattga aggtagtgct tatgttattt ttgttctttt tttctgactt cggtttatgt   8100

tttcatttct ttggagtaat gctgctctag attgttctaa atagaatgtg ggcttcataa   8160

tttttttttc cacaaaaaca gagtagtcaa cttatatagt caattacatc aggacatttt   8220

gtgtttctta cagaagcaaa ccataggctc ctcttttcct taaaactact tagataaact   8280

gtattcgtga actgcatgct ggaaaatgct actattatgc taaataatgc taaccaacat   8340

ttaaaatgtg caaaactaat aaagattaca ttttttattt t                       8381


<210>  13
<211>  8381
<212>  DNA
<213>  Homo sapiens

<400>  13
atactgcaga ggtctctggt gcatgtgtgt atgtgtgcgt ttgtgtgtgt ttgtgtgtct     60

gtgtgttctg ccccagtgag actgcagccc ttgtaaatac tttgacacct tttgcaagaa    120

ggaatctgaa caattgcaac tgaaggcaca ttgttatcat ctcgtctttg ggtgatgctg    180

ttcctcactg cagatggata attttccttt taatcaggaa tttcatatgc agaataaatg    240

gtaattaaaa tgtgcaggat gacaagatgg agcaaacagt gcttgtacca ccaggacctg    300

acagcttcaa cttcttcacc agagaatctc ttgcggctat tgaaagacgc attgcagaag    360

aaaaggcaaa gaatcccaaa ccagacaaaa aagatgacga cgaaaatggc ccaaagccaa    420

atagtgactt ggaagctgga aagaaccttc catttattta tggagacatt cctccagaga    480

tggtgtcaga gcccctggag gacctggacc cctactatat caataagaaa acttttatag    540

tattgaataa attgaaggcc atcttccggt tcagtgccac ctctgccctg tacattttaa    600

ctcccttcaa tcctcttagg aaaatagcta ttaagatttt ggtacattca ttattcagca    660

tgctaattat gtgcactatt ttgacaaact gtgtgtttat gacaatgagt aaccctcctg    720

attggacaaa gaatgtagaa tacaccttca caggaatata tacttttgaa tcacttataa    780

aaattattgc aaggggattc tgtttagaag attttacttt ccttcgggat ccatggaact    840

ggctcgattt cactgtcatt acatttgcgt acgtcacaga gtttgtggac ctgggcaatg    900

tctcggcatt gagaacattc agagttctcc gagcattgaa gacgatttca gtcattccag    960

gcctgaaaac cattgtggga gccctgatcc agtctgtgaa gaagctctca gatgtaatga   1020

tcctgactgt gttctgtctg agcgtatttg ctctaattgg gctgcagctg ttcatgggca   1080

acctgaggaa taaatgtata caatggcctc ccaccaatgc ttccttggag gaacatagta   1140

tagaaaagaa tataactgtg aattataatg gtacacttat aaatgaaact gtctttgagt   1200

ttgactggaa gtcatatatt caagattcaa gatatcatta tttcctggag ggttttttag   1260

atgcactact atgtggaaat agctctgatg caggccaatg tccagaggga tatatgtgtg   1320

tgaaagctgg tagaaatccc aattatggct acacaagctt tgataccttc agttgggctt   1380

ttttgtcctt gtttcgacta atgactcagg acttctggga aaatctttat caactgacat   1440

tacgtgctgc tgggaaaacg tacatgatat tttttgtatt ggtcattttc ttgggctcat   1500

tctacctaat aaatttgatc ctggctgtgg tggccatggc ctacgaggaa cagaatcagg   1560

ccaccttgga agaagcagaa cagaaagagg ccgaatttca gcagatgatt gaacagctta   1620

aaaagcaaca ggaggcagct cagcaggcag caacggcaac tgcctcagaa cattccagag   1680

agcccagtgc agcaggcagg ctctcagaca gctcatctga agcctctaag ttgagttcca   1740

agagtgctaa ggaaagaaga aatcggagga agaaaagaaa acagaaagag cagtctggtg   1800

gggaagagaa agatgaggat gaattccaaa aatctgaatc tgaggacagc atcaggagga   1860

aaggttttcg cttctccatt gaagggaacc gattgacata tgaaaagagg tactcctccc   1920

cacaccagtc tttgttgagc atccgtggct ccctattttc accaaggcga aatagcagaa   1980

caagcctttt cagctttaga gggcgagcaa aggatgtggg atctgagaac gacttcgcag   2040

atgatgagca cagcaccttt gaggataacg agagccgtag agattccttg tttgtgcccc   2100

gacgacacgg agagagacgc aacagcaacc tgagtcagac cagtaggtca tcccggatgc   2160

tggcagtgtt tccagcgaat gggaagatgc acagcactgt ggattgcaat ggtgtggttt   2220

ccttggttgg tggaccttca gttcctacat cgcctgttgg acagcttctg ccagaggtga   2280

taatagataa gccagctact gatgacaatg gaacaaccac tgaaactgaa atgagaaaga   2340

gaaggtcaag ttctttccac gtttccatgg actttctaga agatccttcc caaaggcaac   2400

gagcaatgag tatagccagc attctaacaa atacagtaga agaacttgaa gaatccaggc   2460

agaaatgccc accctgttgg tataaatttt ccaacatatt cttaatctgg gactgttctc   2520

catattggtt aaaagtgaaa catgttgtca acctggttgt gatggaccca tttgttgacc   2580

tggccatcac catctgtatt gtcttaaata ctcttttcat ggccatggag cactatccaa   2640

tgacggacca tttcaataat gtgcttacag taggaaactt ggttttcact gggatcttta   2700

cagcagaaat gtttctgaaa attattgcca tggatcctta ctattatttc caagaaggct   2760

ggaatatctt tgacggtttt attgtgacgc ttagcctggt agaacttgga ctcgccaatg   2820

tggaaggatt atctgttctc cgttcatttc gattgctgcg agttttcaag ttggcaaaat   2880

cttggccaac gttaaatatg ctaataaaga tcatcggcaa ttccgtgggg gctctgggaa   2940

atttaaccct cgtcttggcc atcatcgtct tcatttttgc cgtggtcggc atgcagctct   3000

ttggtaaaag ctacaaagat tgtgtctgca agatcgccag tgattgtcaa ctcccacgct   3060

ggcacatgaa tgacttcttc cactccttcc tgattgtgtt ccgcgtgctg tgtggggagt   3120

ggatagagac catgtgggac tgtatggagg ttgctggtca agccatgtgc cttactgtct   3180

tcatgatggt catggtgatt ggaaacctag tggtcctgaa tctctttctg gccttgcttc   3240

tgagctcatt tagtgcagac aaccttgcag ccactgatga tgataatgaa atgaataatc   3300

tccaaattgc tgtggatagg atgcacaaag gagtagctta tgtgaaaaga aaaatatatg   3360

aatttattca acagtccttc attaggaaac aaaagatttt agatgaaatt aaaccacttg   3420

atgatctaaa caacaagaaa gacagttgta tgtccaatca tacaacagaa attgggaaag   3480

atcttgacta tcttaaagat gtaaatggaa ctacaagtgg tataggaact ggcagcagtg   3540

ttgaaaaata cattattgat gaaagtgatt acatgtcatt cataaacaac cccagtctta   3600

ctgtgactgt accaattgct gtaggagaat ctgactttga aaatttaaac acggaagact   3660

ttagtagtga atcggatctg gaagaaagca aagagaaact gaatgaaagc agtagctcat   3720

cagaaggtag cactgtggac atcggcgcac ctgtagaaga acagcccgta gtggaacctg   3780

aagaaactct tgaaccagaa gcttgtttca ctgaaggctg tgtacaaaga ttcaagtgtt   3840

gtcaaatcaa tgtggaagaa ggcagaggaa aacaatggtg gaacctgaga aggacgtgtt   3900

tccgaatagt tgaacataac tggtttgaga ccttcattgt tttcatgatt ctccttagta   3960

gtggtgctct ggcatttgaa gatatatata ttgatcagcg aaagacgatt aagacgatgt   4020

tggaatatgc tgacaaggtt ttcacttaca ttttcattct ggaaatgctt ctaaaatggg   4080

tggcatatgg ctatcaaaca tatttcacca atgcctggtg ttggctggac ttcttaattg   4140

ttgatgtttc attggtcagt ttaacagcaa atgccttggg ttactcagaa cttggagcca   4200

tcaaatctct caggacacta agagctctga gacctctaag agccttatct cgatttgaag   4260

ggatgagggt ggttgtgaat gcccttttag gagcaattcc atccatcatg aatgtgcttc   4320

tggtttgtct tatattctgg ctaattttca gcatcatggg cgtaaatttg tttgctggca   4380

aattctacca ctgtattaac accacaactg gtgacaggtt tgacatcgaa gacgtgaata   4440

atcatactga ttgcctaaaa ctaatagaaa gaaatgagac tgctcgatgg aaaaatgtga   4500

aagtaaactt tgataatgta ggatttgggt atctctcttt gcttcaagtt gccacattca   4560

aaggatggat ggatataatg tatgcagcag ttgattccag aaatgtggaa ctccagccta   4620

agtatgaaaa aagtctgtac atgtatcttt actttgttat tttcatcatc tttgggtcct   4680

tcttcacctt gaacctgttt attggtgtca tcatagataa tttcaaccag cagaaaaaga   4740

agtttggagg tcaagacatc tttatgacag aagaacagaa gaaatactat aatgcaatga   4800

aaaaattagg atcgaaaaaa ccgcaaaagc ctatacctcg accaggaaac aaatttcaag   4860

gaatggtctt tgacttcgta accagacaag tttttgacat aagcatcatg attctcatct   4920

gtcttaacat ggtcacaatg atggtggaaa cagatgacca gagtgaatat gtgactacca   4980

ttttgtcacg catcaatctg gtgttcattg tgctatttac tggagagtgt gtactgaaac   5040

tcatctctct acgccattat tattttacca ttggatggaa tatttttgat tttgtggttg   5100

tcattctctc cattgtaggt atgtttcttg ccgagctgat agaaaagtat ttcgtgtccc   5160

ctaccctgtt ccgagtgatc cgtcttgcta ggattggccg aatcctacgt ctgatcaaag   5220

gagcaaaggg gatccgcacg ctgctctttg ctttgatgat gtcccttcct gcgttgttta   5280

acatcggcct cctactcttc ctagtcatgt tcatctacgc catctttggg atgtccaact   5340

ttgcctatgt taagagggaa gttgggatcg atgacatgtt caacgttgag acctttggca   5400

acagcatgat ctgcctattc caaattacaa cctctgctgg ctgggatgga ttgctagcac   5460

ccattctcaa cagtaagcca cccgactgtg accctaataa agttaaccct ggaagctcag   5520

ttaagggaga ctgtgggaac ccatctgttg gaattttctt ttttgtcagt tacatcatca   5580

tatccttcct ggttgtggtg aacatgtaca tcgcggtcat cctggagaac ttcagtgttg   5640

ctactgaaga aagtgcagag cctctgagtg aggatgactt tgagatgttc tatgaggttt   5700

gggagaagtt tgatcccgat gcaactcagt tcatggaatt tgaaaaatta tctcagtttg   5760

cagctgcgct tgaaccgcct ctcaatctgc cacaaccaaa caaactccag ctcattgcca   5820

tggatttgcc catggtgagt ggtgaccgga tccactgtct tgatatctta tttgctttta   5880

caaagcgggt tctaggagag agtggagaga tggatgctct acgaatacag atggaagagc   5940

gattcatggc ttccaatcct tccaaggtct cctatcagcc aatcactact actttaaaac   6000

gaaaacaaga ggaagtatct gctgtcatta ttcagcgtgc ttacagacgc caccttttaa   6060

agcgaactgt aaaacaagct tcctttacgt acaataaaaa caaaatcaaa ggtggggcta   6120

atcttcttat aaaagaagac atgataattg acagaataaa tgaaaactct attacagaaa   6180

aaactgatct gaccatgtcc actgcagctt gtccaccttc ctatgaccgg gtgacaaagc   6240

caattgtgga aaaacatgag caagaaggca aagatgaaaa agccaaaggg aaataaatga   6300

aaataaataa aaataattgg gtgacaaatt gtttacagcc tgtgaaggtg atgtattttt   6360

atcaacagga ctcctttagg aggtcaatgc caaactgact gtttttacac aaatctcctt   6420

aaggtcagtg cctacaataa gacagtgacc ccttgtcagc aaactgtgac tctgtgtaaa   6480

ggggagatga ccttgacagg aggttactgt tctcactacc agctgacact gctgaagata   6540

agatgcacaa tggctagtca gactgtaggg accagtttca aggggtgcaa acctgtgatt   6600

ttggggttgt ttaacatgaa acactttagt gtagtaattg tatccactgt ttgcatttca   6660

actgccacat ttgtcacatt tttatggaat ctgttagtgg attcatcttt ttgttaatcc   6720

atgtgtttat tatatgtgac tatttttgta aacgaagttt ctgttgagaa ataggctaag   6780

gacctctata acaggtatgc cacctggggg gtatggcaac cacatggccc tcccagctac   6840

acaaagtcgt ggtttgcatg agggcatgct gcacttagag atcatgcatg agaaaaagtc   6900

acaagaaaaa caaattctta aatttcacca tatttctggg aggggtaatt gggtgataag   6960

tggaggtgct ttgttgatct tgttttgcga aatccagccc ctagaccaag tagattattt   7020

gtgggtaggc cagtaaatct tagcaggtgc aaacttcatt caaatgtttg gagtcataaa   7080

tgttatgttt ctttttgttg tattaaaaaa aaaacctgaa tagtgaatat tgcccctcac   7140

cctccaccgc cagaagactg aattgaccaa aattactctt tataaatttc tgctttttcc   7200

tgcactttgt ttagccatct ttgggctctc agcaaggttg acactgtata tgttaatgaa   7260

atgctattta ttatgtaaat agtcatttta ccctgtggtg cacgtttgag caaacaaata   7320

atgacctaag cacagtattt attgcatcaa atatgtacca caagaaatgt agagtgcaag   7380

ctttacacag gtaataaaat gtattctgta ccatttatag atagtttgga tgctatcaat   7440

gcatgtttat attaccatgc tgctgtatct ggtttctctc actgctcaga atctcattta   7500

tgagaaacca tatgtcagtg gtaaagtcaa ggaaattgtt caacagatct catttattta   7560

agtcattaag caatagtttg cagcacttta acagcttttt ggttattttt acattttaag   7620

tggataacat atggtatata gccagactgt acagacatgt ttaaaaaaac acactgctta   7680

acctattaaa tatgtgttta gaattttata agcaaatata aatactgtaa aaagtcactt   7740

tattttattt ttcagcatta tgtacataaa tatgaagagg aaattatctt caggttgata   7800

tcacaatcac ttttcttact ttctgtccat agtacttttt catgaaagaa atttgctaaa   7860

taagacatga aaacaagact gggtagttgt agatttctgc tttttaaatt acatttgcta   7920

attttagatt atttcacaat tttaaggagc aaaataggtt cacgattcat atccaaatta   7980

tgctttgcaa ttggaaaagg gtttaaaatt ttatttatat ttctggtagt acctgtacta   8040

actgaattga aggtagtgct tatgttattt ttgttctttt tttctgactt cggtttatgt   8100

tttcatttct ttggagtaat gctgctctag attgttctaa atagaatgtg ggcttcataa   8160

tttttttttc cacaaaaaca gagtagtcaa cttatatagt caattacatc aggacatttt   8220

gtgtttctta cagaagcaaa ccataggctc ctcttttcct taaaactact tagataaact   8280

gtattcgtga actgcatgct ggaaaatgct actattatgc taaataatgc taaccaacat   8340

ttaaaatgtg caaaactaat aaagattaca ttttttattt t                       8381


<210>  14
<211>  8381
<212>  DNA
<213>  Homo sapiens

<400>  14
atactgcaga ggtctctggt gcatgtgtgt atgtgtgcgt ttgtgtgtgt ttgtgtgtct     60

gtgtgttctg ccccagtgag actgcagccc ttgtaaatac tttgacacct tttgcaagaa    120

ggaatctgaa caattgcaac tgaaggcaca ttgttatcat ctcgtctttg ggtgatgctg    180

ttcctcactg cagatggata attttccttt taatcaggaa tttcatatgc agaataaatg    240

gtaattaaaa tgtgcaggat gacaagatgg agcaaacagt gcttgtacca ccaggacctg    300

acagcttcaa cttcttcacc agagaatctc ttgcggctat tgaaagacgc attgcagaag    360

aaaaggcaaa gaatcccaaa ccagacaaaa aagatgacga cgaaaatggc ccaaagccaa    420

atagtgactt ggaagctgga aagaaccttc catttattta tggagacatt cctccagaga    480

tggtgtcaga gcccctggag gacctggacc cctactatat caataagaaa acttttatag    540

tattgaataa attgaaggcc atcttccggt tcagtgccac ctctgccctg tacattttaa    600

ctcccttcaa tcctcttagg aaaatagcta ttaagatttt ggtacattca ttattcagca    660

tgctaattat gtgcactatt ttgacaaact gtgtgtttat gacaatgagt aaccctcctg    720

attggacaaa gaatgtagaa tacaccttca caggaatata tacttttgaa tcacttataa    780

aaattattgc aaggggattc tgtttagaag attttacttt ccttcgggat ccatggaact    840

ggctcgattt cactgtcatt acatttgcgt acgtcacaga gtttgtggac ctgggcaatg    900

tctcggcatt gagaacattc agagttctcc gagcattgaa gacgatttca gtcattccag    960

gcctgaaaac cattgtggga gccctgatcc agtctgtgaa gaagctctca gatgtaatga   1020

tcctgactgt gttctgtctg agcgtatttg ctctaattgg gctgcagctg ttcatgggca   1080

acctgaggaa taaatgtata caatggcctc ccaccaatgc ttccttggag gaacatagta   1140

tagaaaagaa tataactgtg aattataatg gtacacttat aaatgaaact gtctttgagt   1200

ttgactggaa gtcatatatt caagattcaa gatatcatta tttcctggag ggttttttag   1260

atgcactact atgtggaaat agctctgatg caggccaatg tccagaggga tatatgtgtg   1320

tgaaagctgg tagaaatccc aattatggct acacaagctt tgataccttc agttgggctt   1380

ttttgtcctt gtttcgacta atgactcagg acttctggga aaatctttat caactgacat   1440

tacgtgctgc tgggaaaacg tacatgatat tttttgtatt ggtcattttc ttgggctcat   1500

tctacctaat aaatttgatc ctggctgtgg tggccatggc ctacgaggaa cagaatcagg   1560

ccaccttgga agaagcagaa cagaaagagg ccgaatttca gcagatgatt gaacagctta   1620

aaaagcaaca ggaggcagct cagcaggcag caacggcaac tgcctcagaa cattccagag   1680

agcccagtgc agcaggcagg ctctcagaca gctcatctga agcctctaag ttgagttcca   1740

agagtgctaa ggaaagaaga aatcggagga agaaaagaaa acagaaagag cagtctggtg   1800

gggaagagaa agatgaggat gaattccaaa aatctgaatc tgaggacagc atcaggagga   1860

aaggttttcg cttctccatt gaagggaacc gattgacata tgaaaagagg tactcctccc   1920

cacaccagtc tttgttgagc atccgtggct ccctattttc accaaggcga aatagcagaa   1980

caagcctttt cagctttaga gggcgagcaa aggatgtggg atctgagaac gacttcgcag   2040

atgatgagca cagcaccttt gaggataacg agagccgtag agattccttg tttgtgcccc   2100

gacgacacgg agagagacgc aacagcaacc tgagtcagac cagtaggtca tcccggatgc   2160

tggcagtgtt tccagcgaat gggaagatgc acagcactgt ggattgcaat ggtgtggttt   2220

ccttggttgg tggaccttca gttcctacat cgcctgttgg acagcttctg ccagaggtga   2280

taatagataa gccagctact gatgacaatg gaacaaccac tgaaactgaa atgagaaaga   2340

gaaggtcaag ttctttccac gtttccatgg actttctaga agatccttcc caaaggcaac   2400

gagcaatgag tatagccagc attctaacaa atacagtaga agaacttgaa gaatccaggc   2460

agaaatgccc accctgttgg tataaatttt ccaacatatt cttaatctgg gactgttctc   2520

catattggtt aaaagtgaaa catgttgtca acctggttgt gatggaccca tttgttgacc   2580

tggccatcac catctgtatt gtcttaaata ctcttttcat ggccatggag cactatccaa   2640

tgacggacca tttcaataat gtgcttacag taggaaactt ggttttcact gggatcttta   2700

cagcagaaat gtttctgaaa attattgcca tggatcctta ctattatttc caagaaggct   2760

ggaatatctt tgacggtttt attgtgacgc ttagcctggt agaacttgga ctcgccaatg   2820

tggaaggatt atctgttctc cgttcatttc gattgctgcg agttttcaag ttggcaaaat   2880

cttggccaac gttaaatatg ctaataaaga tcatcggcaa ttccgtgggg gctctgggaa   2940

atttaaccct cgtcttggcc atcatcgtct tcatttttgc cgtggtcggc atgcagctct   3000

ttggtaaaag ctacaaagat tgtgtctgca agatcgccag tgattgtcaa ctcccacgct   3060

ggcacatgaa tgacttcttc cactccttcc tgattgtgtt ccgcgtgctg tgtggggagt   3120

ggatagagac catgtgggac tgtatggagg ttgctggtca agccatgtgc cttactgtct   3180

tcatgatggt catggtgatt ggaaacctag tggtcctgaa tctctttctg gccttgcttc   3240

tgagctcatt tagtgcagac aaccttgcag ccactgatga tgataatgaa atgaataatc   3300

tccaaattgc tgtggatagg atgcacaaag gagtagctta tgtgaaaaga aaaatatatg   3360

aatttattca acagtccttc attaggaaac aaaagatttt agatgaaatt aaaccacttg   3420

atgatctaaa caacaagaaa gacagttgta tgtccaatca tacaacagaa attgggaaag   3480

atcttgacta tcttaaagat gtaaatggaa ctacaagtgg tataggaact ggcagcagtg   3540

ttgaaaaata cattattgat gaaagtgatt acatgtcatt cataaacaac cccagtctta   3600

ctgtgactgt accaattgct gtaggagaat ctgactttga aaatttaaac acggaagact   3660

ttagtagtga atcggatctg gaagaaagca aagagaaact gaatgaaagc agtagctcat   3720

cagaaggtag cactgtggac atcggcgcac ctgtagaaga acagcccgta gtggaacctg   3780

aagaaactct tgaaccagaa gcttgtttca ctgaaggctg tgtacaaaga ttcaagtgtt   3840

gtcaaatcaa tgtggaagaa ggcagaggaa aacaatggtg gaacctgaga aggacgtgtt   3900

tccgaatagt tgaacataac tggtttgaga ccttcattgt tttcatgatt ctccttagta   3960

gtggtgctct ggcatttgaa gatatatata ttgatcagcg aaagacgatt aagacgatgt   4020

tggaatatgc tgacaaggtt ttcacttaca ttttcattct ggaaatgctt ctaaaatggg   4080

tggcatatgg ctatcaaaca tatttcacca atgcctggtg ttggctggac ttcttaattg   4140

ttgatgtttc attggtcagt ttaacagcaa atgccttggg ttactcagaa cttggagcca   4200

tcaaatctct caggacacta agagctctga gacctctaag agccttatct cgatttgaag   4260

ggatgagggt ggttgtgaat gcccttttag gagcaattcc atccatcatg aatgtgcttc   4320

tggtttgtct tatattctgg ctaattttca gcatcatggg cgtaaatttg tttgctggca   4380

aattctacca ctgtattaac accacaactg gtgacaggtt tgacatcgaa gacgtgaata   4440

atcatactga ttgcctaaaa ctaatagaaa gaaatgagac tgctcgatgg aaaaatgtga   4500

aagtaaactt tgataatgta ggatttgggt atctctcttt gcttcaagtt gccacattca   4560

aaggatggat ggatataatg tatgcagcag ttgattccag aaatgtggaa ctccagccta   4620

agtatgaaaa aagtctgtac atgtatcttt actttgttat tttcatcatc tttgggtcct   4680

tcttcacctt gaacctgttt attggtgtca tcatagataa tttcaaccag cagaaaaaga   4740

agtttggagg tcaagacatc tttatgacag aagaacagaa gaaatactat aatgcaatga   4800

aaaaattagg atcgaaaaaa ccgcaaaagc ctatacctcg accaggaaac aaatttcaag   4860

gaatggtctt tgacttcgta accagacaag tttttgacat aagcatcatg attctcatct   4920

gtcttaacat ggtcacaatg atggtggaaa cagatgacca gagtgaatat gtgactacca   4980

ttttgtcacg catcaatctg gtgttcattg tgctatttac tggagagtgt gtactgaaac   5040

tcatctctct acgccattat tattttacca ttggatggaa tatttttgat tttgtggttg   5100

tcattctctc cattgtaggt atgtttcttg ccgagctgat agaaaagtat ttcgtgtccc   5160

ctaccctgtt ccgagtgatc cgtcttgcta ggattggccg aatcctacgt ctgatcaaag   5220

gagcaaaggg gatccgcacg ctgctctttg ctttgatgat gtcccttcct gcgttgttta   5280

acatcggcct cctactcttc ctagtcatgt tcatctacgc catctttggg atgtccaact   5340

ttgcctatgt taagagggaa gttgggatcg atgacatgtt caactttgag acctttggca   5400

acagcatgat ctgcctattc caaattacaa cctctgctgg ctgggatgga ttgctagcac   5460

ccattctcaa cagtaagcca cccgactgtg accctaataa agttaaccct ggaagctcag   5520

ttaagggaga ctgtgggaac ccatctgttg gaattttctt ttttgtcagt tacatcatca   5580

tatccttcct ggttgtggtg aacatgtaca tcacggtcat cctggagaac ttcagtgttg   5640

ctactgaaga aagtgcagag cctctgagtg aggatgactt tgagatgttc tatgaggttt   5700

gggagaagtt tgatcccgat gcaactcagt tcatggaatt tgaaaaatta tctcagtttg   5760

cagctgcgct tgaaccgcct ctcaatctgc cacaaccaaa caaactccag ctcattgcca   5820

tggatttgcc catggtgagt ggtgaccgga tccactgtct tgatatctta tttgctttta   5880

caaagcgggt tctaggagag agtggagaga tggatgctct acgaatacag atggaagagc   5940

gattcatggc ttccaatcct tccaaggtct cctatcagcc aatcactact actttaaaac   6000

gaaaacaaga ggaagtatct gctgtcatta ttcagcgtgc ttacagacgc caccttttaa   6060

agcgaactgt aaaacaagct tcctttacgt acaataaaaa caaaatcaaa ggtggggcta   6120

atcttcttat aaaagaagac atgataattg acagaataaa tgaaaactct attacagaaa   6180

aaactgatct gaccatgtcc actgcagctt gtccaccttc ctatgaccgg gtgacaaagc   6240

caattgtgga aaaacatgag caagaaggca aagatgaaaa agccaaaggg aaataaatga   6300

aaataaataa aaataattgg gtgacaaatt gtttacagcc tgtgaaggtg atgtattttt   6360

atcaacagga ctcctttagg aggtcaatgc caaactgact gtttttacac aaatctcctt   6420

aaggtcagtg cctacaataa gacagtgacc ccttgtcagc aaactgtgac tctgtgtaaa   6480

ggggagatga ccttgacagg aggttactgt tctcactacc agctgacact gctgaagata   6540

agatgcacaa tggctagtca gactgtaggg accagtttca aggggtgcaa acctgtgatt   6600

ttggggttgt ttaacatgaa acactttagt gtagtaattg tatccactgt ttgcatttca   6660

actgccacat ttgtcacatt tttatggaat ctgttagtgg attcatcttt ttgttaatcc   6720

atgtgtttat tatatgtgac tatttttgta aacgaagttt ctgttgagaa ataggctaag   6780

gacctctata acaggtatgc cacctggggg gtatggcaac cacatggccc tcccagctac   6840

acaaagtcgt ggtttgcatg agggcatgct gcacttagag atcatgcatg agaaaaagtc   6900

acaagaaaaa caaattctta aatttcacca tatttctggg aggggtaatt gggtgataag   6960

tggaggtgct ttgttgatct tgttttgcga aatccagccc ctagaccaag tagattattt   7020

gtgggtaggc cagtaaatct tagcaggtgc aaacttcatt caaatgtttg gagtcataaa   7080

tgttatgttt ctttttgttg tattaaaaaa aaaacctgaa tagtgaatat tgcccctcac   7140

cctccaccgc cagaagactg aattgaccaa aattactctt tataaatttc tgctttttcc   7200

tgcactttgt ttagccatct ttgggctctc agcaaggttg acactgtata tgttaatgaa   7260

atgctattta ttatgtaaat agtcatttta ccctgtggtg cacgtttgag caaacaaata   7320

atgacctaag cacagtattt attgcatcaa atatgtacca caagaaatgt agagtgcaag   7380

ctttacacag gtaataaaat gtattctgta ccatttatag atagtttgga tgctatcaat   7440

gcatgtttat attaccatgc tgctgtatct ggtttctctc actgctcaga atctcattta   7500

tgagaaacca tatgtcagtg gtaaagtcaa ggaaattgtt caacagatct catttattta   7560

agtcattaag caatagtttg cagcacttta acagcttttt ggttattttt acattttaag   7620

tggataacat atggtatata gccagactgt acagacatgt ttaaaaaaac acactgctta   7680

acctattaaa tatgtgttta gaattttata agcaaatata aatactgtaa aaagtcactt   7740

tattttattt ttcagcatta tgtacataaa tatgaagagg aaattatctt caggttgata   7800

tcacaatcac ttttcttact ttctgtccat agtacttttt catgaaagaa atttgctaaa   7860

taagacatga aaacaagact gggtagttgt agatttctgc tttttaaatt acatttgcta   7920

attttagatt atttcacaat tttaaggagc aaaataggtt cacgattcat atccaaatta   7980

tgctttgcaa ttggaaaagg gtttaaaatt ttatttatat ttctggtagt acctgtacta   8040

actgaattga aggtagtgct tatgttattt ttgttctttt tttctgactt cggtttatgt   8100

tttcatttct ttggagtaat gctgctctag attgttctaa atagaatgtg ggcttcataa   8160

tttttttttc cacaaaaaca gagtagtcaa cttatatagt caattacatc aggacatttt   8220

gtgtttctta cagaagcaaa ccataggctc ctcttttcct taaaactact tagataaact   8280

gtattcgtga actgcatgct ggaaaatgct actattatgc taaataatgc taaccaacat   8340

ttaaaatgtg caaaactaat aaagattaca ttttttattt t                       8381


<210>  15
<211>  8380
<212>  DNA
<213>  Homo sapiens

<400>  15
atactgcaga ggtctctggt gcatgtgtgt atgtgtgcgt ttgtgtgtgt ttgtgtgtct     60

gtgtgttctg ccccagtgag actgcagccc ttgtaaatac tttgacacct tttgcaagaa    120

ggaatctgaa caattgcaac tgaaggcaca ttgttatcat ctcgtctttg ggtgatgctg    180

ttcctcactg cagatggata attttccttt taatcaggaa tttcatatgc agaataaatg    240

gtaattaaaa tgtgcaggat gacaagatgg agcaaacagt gcttgtacca ccaggacctg    300

acagctcaac ttcttcacca gagaatctct tgcggctatt gaaagacgca ttgcagaaga    360

aaaggcaaag aatcccaaac cagacaaaaa agatgacgac gaaaatggcc caaagccaaa    420

tagtgacttg gaagctggaa agaaccttcc atttatttat ggagacattc ctccagagat    480

ggtgtcagag cccctggagg acctggaccc ctactatatc aataagaaaa cttttatagt    540

attgaataaa ttgaaggcca tcttccggtt cagtgccacc tctgccctgt acattttaac    600

tcccttcaat cctcttagga aaatagctat taagattttg gtacattcat tattcagcat    660

gctaattatg tgcactattt tgacaaactg tgtgtttatg acaatgagta accctcctga    720

ttggacaaag aatgtagaat acaccttcac aggaatatat acttttgaat cacttataaa    780

aattattgca aggggattct gtttagaaga ttttactttc cttcgggatc catggaactg    840

gctcgatttc actgtcatta catttgcgta cgtcacagag tttgtggacc tgggcaatgt    900

ctcggcattg agaacattca gagttctccg agcattgaag acgatttcag tcattccagg    960

cctgaaaacc attgtgggag ccctgatcca gtctgtgaag aagctctcag atgtaatgat   1020

cctgactgtg ttctgtctga gcgtatttgc tctaattggg ctgcagctgt tcatgggcaa   1080

cctgaggaat aaatgtatac aatggcctcc caccaatgct tccttggagg aacatagtat   1140

agaaaagaat ataactgtga attataatgg tacacttata aatgaaactg tctttgagtt   1200

tgactggaag tcatatattc aagattcaag atatcattat ttcctggagg gttttttaga   1260

tgcactacta tgtggaaata gctctgatgc aggccaatgt ccagagggat atatgtgtgt   1320

gaaagctggt agaaatccca attatggcta cacaagcttt gataccttca gttgggcttt   1380

tttgtccttg tttcgactaa tgactcagga cttctgggaa aatctttatc aactgacatt   1440

acgtgctgct gggaaaacgt acatgatatt ttttgtattg gtcattttct tgggctcatt   1500

ctacctaata aatttgatcc tggctgtggt ggccatggcc tacgaggaac agaatcaggc   1560

caccttggaa gaagcagaac agaaagaggc cgaatttcag cagatgattg aacagcttaa   1620

aaagcaacag gaggcagctc agcaggcagc aacggcaact gcctcagaac attccagaga   1680

gcccagtgca gcaggcaggc tctcagacag ctcatctgaa gcctctaagt tgagttccaa   1740

gagtgctaag gaaagaagaa atcggaggaa gaaaagaaaa cagaaagagc agtctggtgg   1800

ggaagagaaa gatgaggatg aattccaaaa atctgaatct gaggacagca tcaggaggaa   1860

aggttttcgc ttctccattg aagggaaccg attgacatat gaaaagaggt actcctcccc   1920

acaccagtct ttgttgagca tccgtggctc cctattttca ccaaggcgaa atagcagaac   1980

aagccttttc agctttagag ggcgagcaaa ggatgtggga tctgagaacg acttcgcaga   2040

tgatgagcac agcacctttg aggataacga gagccgtaga gattccttgt ttgtgccccg   2100

acgacacgga gagagacgca acagcaacct gagtcagacc agtaggtcat cccggatgct   2160

ggcagtgttt ccagcgaatg ggaagatgca cagcactgtg gattgcaatg gtgtggtttc   2220

cttggttggt ggaccttcag ttcctacatc gcctgttgga cagcttctgc cagaggtgat   2280

aatagataag ccagctactg atgacaatgg aacaaccact gaaactgaaa tgagaaagag   2340

aaggtcaagt tctttccacg tttccatgga ctttctagaa gatccttccc aaaggcaacg   2400

agcaatgagt atagccagca ttctaacaaa tacagtagaa gaacttgaag aatccaggca   2460

gaaatgccca ccctgttggt ataaattttc caacatattc ttaatctggg actgttctcc   2520

atattggtta aaagtgaaac atgttgtcaa cctggttgtg atggacccat ttgttgacct   2580

ggccatcacc atctgtattg tcttaaatac tcttttcatg gccatggagc actatccaat   2640

gacggaccat ttcaataatg tgcttacagt aggaaacttg gttttcactg ggatctttac   2700

agcagaaatg tttctgaaaa ttattgccat ggatccttac tattatttcc aagaaggctg   2760

gaatatcttt gacggtttta ttgtgacgct tagcctggta gaacttggac tcgccaatgt   2820

ggaaggatta tctgttctcc gttcatttcg attgctgcga gttttcaagt tggcaaaatc   2880

ttggccaacg ttaaatatgc taataaagat catcggcaat tccgtggggg ctctgggaaa   2940

tttaaccctc gtcttggcca tcatcgtctt catttttgcc gtggtcggca tgcagctctt   3000

tggtaaaagc tacaaagatt gtgtctgcaa gatcgccagt gattgtcaac tcccacgctg   3060

gcacatgaat gacttcttcc actccttcct gattgtgttc cgcgtgctgt gtggggagtg   3120

gatagagacc atgtgggact gtatggaggt tgctggtcaa gccatgtgcc ttactgtctt   3180

catgatggtc atggtgattg gaaacctagt ggtcctgaat ctctttctgg ccttgcttct   3240

gagctcattt agtgcagaca accttgcagc cactgatgat gataatgaaa tgaataatct   3300

ccaaattgct gtggatagga tgcacaaagg agtagcttat gtgaaaagaa aaatatatga   3360

atttattcaa cagtccttca ttaggaaaca aaagatttta gatgaaatta aaccacttga   3420

tgatctaaac aacaagaaag acagttgtat gtccaatcat acaacagaaa ttgggaaaga   3480

tcttgactat cttaaagatg taaatggaac tacaagtggt ataggaactg gcagcagtgt   3540

tgaaaaatac attattgatg aaagtgatta catgtcattc ataaacaacc ccagtcttac   3600

tgtgactgta ccaattgctg taggagaatc tgactttgaa aatttaaaca cggaagactt   3660

tagtagtgaa tcggatctgg aagaaagcaa agagaaactg aatgaaagca gtagctcatc   3720

agaaggtagc actgtggaca tcggcgcacc tgtagaagaa cagcccgtag tggaacctga   3780

agaaactctt gaaccagaag cttgtttcac tgaaggctgt gtacaaagat tcaagtgttg   3840

tcaaatcaat gtggaagaag gcagaggaaa acaatggtgg aacctgagaa ggacgtgttt   3900

ccgaatagtt gaacataact ggtttgagac cttcattgtt ttcatgattc tccttagtag   3960

tggtgctctg gcatttgaag atatatatat tgatcagcga aagacgatta agacgatgtt   4020

ggaatatgct gacaaggttt tcacttacat tttcattctg gaaatgcttc taaaatgggt   4080

ggcatatggc tatcaaacat atttcaccaa tgcctggtgt tggctggact tcttaattgt   4140

tgatgtttca ttggtcagtt taacagcaaa tgccttgggt tactcagaac ttggagccat   4200

caaatctctc aggacactaa gagctctgag acctctaaga gccttatctc gatttgaagg   4260

gatgagggtg gttgtgaatg cccttttagg agcaattcca tccatcatga atgtgcttct   4320

ggtttgtctt atattctggc taattttcag catcatgggc gtaaatttgt ttgctggcaa   4380

attctaccac tgtattaaca ccacaactgg tgacaggttt gacatcgaag acgtgaataa   4440

tcatactgat tgcctaaaac taatagaaag aaatgagact gctcgatgga aaaatgtgaa   4500

agtaaacttt gataatgtag gatttgggta tctctctttg cttcaagttg ccacattcaa   4560

aggatggatg gatataatgt atgcagcagt tgattccaga aatgtggaac tccagcctaa   4620

gtatgaaaaa agtctgtaca tgtatcttta ctttgttatt ttcatcatct ttgggtcctt   4680

cttcaccttg aacctgttta ttggtgtcat catagataat ttcaaccagc agaaaaagaa   4740

gtttggaggt caagacatct ttatgacaga agaacagaag aaatactata atgcaatgaa   4800

aaaattagga tcgaaaaaac cgcaaaagcc tatacctcga ccaggaaaca aatttcaagg   4860

aatggtcttt gacttcgtaa ccagacaagt ttttgacata agcatcatga ttctcatctg   4920

tcttaacatg gtcacaatga tggtggaaac agatgaccag agtgaatatg tgactaccat   4980

tttgtcacgc atcaatctgg tgttcattgt gctatttact ggagagtgtg tactgaaact   5040

catctctcta cgccattatt attttaccat tggatggaat atttttgatt ttgtggttgt   5100

cattctctcc attgtaggta tgtttcttgc cgagctgata gaaaagtatt tcgtgtcccc   5160

taccctgttc cgagtgatcc gtcttgctag gattggccga atcctacgtc tgatcaaagg   5220

agcaaagggg atccgcacgc tgctctttgc tttgatgatg tcccttcctg cgttgtttaa   5280

catcggcctc ctactcttcc tagtcatgtt catctacgcc atctttggga tgtccaactt   5340

tgcctatgtt aagagggaag ttgggatcga tgacatgttc aactttgaga cctttggcaa   5400

cagcatgatc tgcctattcc aaattacaac ctctgctggc tgggatggat tgctagcacc   5460

cattctcaac agtaagccac ccgactgtga ccctaataaa gttaaccctg gaagctcagt   5520

taagggagac tgtgggaacc catctgttgg aattttcttt tttgtcagtt acatcatcat   5580

atccttcctg gttgtggtga acatgtacat cgcggtcatc ctggagaact tcagtgttgc   5640

tactgaagaa agtgcagagc ctctgagtga ggatgacttt gagatgttct atgaggtttg   5700

ggagaagttt gatcccgatg caactcagtt catggaattt gaaaaattat ctcagtttgc   5760

agctgcgctt gaaccgcctc tcaatctgcc acaaccaaac aaactccagc tcattgccat   5820

ggatttgccc atggtgagtg gtgaccggat ccactgtctt gatatcttat ttgcttttac   5880

aaagcgggtt ctaggagaga gtggagagat ggatgctcta cgaatacaga tggaagagcg   5940

attcatggct tccaatcctt ccaaggtctc ctatcagcca atcactacta ctttaaaacg   6000

aaaacaagag gaagtatctg ctgtcattat tcagcgtgct tacagacgcc accttttaaa   6060

gcgaactgta aaacaagctt cctttacgta caataaaaac aaaatcaaag gtggggctaa   6120

tcttcttata aaagaagaca tgataattga cagaataaat gaaaactcta ttacagaaaa   6180

aactgatctg accatgtcca ctgcagcttg tccaccttcc tatgaccggg tgacaaagcc   6240

aattgtggaa aaacatgagc aagaaggcaa agatgaaaaa gccaaaggga aataaatgaa   6300

aataaataaa aataattggg tgacaaattg tttacagcct gtgaaggtga tgtattttta   6360

tcaacaggac tcctttagga ggtcaatgcc aaactgactg tttttacaca aatctcctta   6420

aggtcagtgc ctacaataag acagtgaccc cttgtcagca aactgtgact ctgtgtaaag   6480

gggagatgac cttgacagga ggttactgtt ctcactacca gctgacactg ctgaagataa   6540

gatgcacaat ggctagtcag actgtaggga ccagtttcaa ggggtgcaaa cctgtgattt   6600

tggggttgtt taacatgaaa cactttagtg tagtaattgt atccactgtt tgcatttcaa   6660

ctgccacatt tgtcacattt ttatggaatc tgttagtgga ttcatctttt tgttaatcca   6720

tgtgtttatt atatgtgact atttttgtaa acgaagtttc tgttgagaaa taggctaagg   6780

acctctataa caggtatgcc acctgggggg tatggcaacc acatggccct cccagctaca   6840

caaagtcgtg gtttgcatga gggcatgctg cacttagaga tcatgcatga gaaaaagtca   6900

caagaaaaac aaattcttaa atttcaccat atttctggga ggggtaattg ggtgataagt   6960

ggaggtgctt tgttgatctt gttttgcgaa atccagcccc tagaccaagt agattatttg   7020

tgggtaggcc agtaaatctt agcaggtgca aacttcattc aaatgtttgg agtcataaat   7080

gttatgtttc tttttgttgt attaaaaaaa aaacctgaat agtgaatatt gcccctcacc   7140

ctccaccgcc agaagactga attgaccaaa attactcttt ataaatttct gctttttcct   7200

gcactttgtt tagccatctt tgggctctca gcaaggttga cactgtatat gttaatgaaa   7260

tgctatttat tatgtaaata gtcattttac cctgtggtgc acgtttgagc aaacaaataa   7320

tgacctaagc acagtattta ttgcatcaaa tatgtaccac aagaaatgta gagtgcaagc   7380

tttacacagg taataaaatg tattctgtac catttataga tagtttggat gctatcaatg   7440

catgtttata ttaccatgct gctgtatctg gtttctctca ctgctcagaa tctcatttat   7500

gagaaaccat atgtcagtgg taaagtcaag gaaattgttc aacagatctc atttatttaa   7560

gtcattaagc aatagtttgc agcactttaa cagctttttg gttattttta cattttaagt   7620

ggataacata tggtatatag ccagactgta cagacatgtt taaaaaaaca cactgcttaa   7680

cctattaaat atgtgtttag aattttataa gcaaatataa atactgtaaa aagtcacttt   7740

attttatttt tcagcattat gtacataaat atgaagagga aattatcttc aggttgatat   7800

cacaatcact tttcttactt tctgtccata gtactttttc atgaaagaaa tttgctaaat   7860

aagacatgaa aacaagactg ggtagttgta gatttctgct ttttaaatta catttgctaa   7920

ttttagatta tttcacaatt ttaaggagca aaataggttc acgattcata tccaaattat   7980

gctttgcaat tggaaaaggg tttaaaattt tatttatatt tctggtagta cctgtactaa   8040

ctgaattgaa ggtagtgctt atgttatttt tgttcttttt ttctgacttc ggtttatgtt   8100

ttcatttctt tggagtaatg ctgctctaga ttgttctaaa tagaatgtgg gcttcataat   8160

ttttttttcc acaaaaacag agtagtcaac ttatatagtc aattacatca ggacattttg   8220

tgtttcttac agaagcaaac cataggctcc tcttttcctt aaaactactt agataaactg   8280

tattcgtgaa ctgcatgctg gaaaatgcta ctattatgct aaataatgct aaccaacatt   8340

taaaatgtgc aaaactaata aagattacat tttttatttt                         8380


<210>  16
<211>  8388
<212>  DNA
<213>  Homo sapiens

<400>  16
atactgcaga ggtctctggt gcatgtgtgt atgtgtgcgt ttgtgtgtgt ttgtgtgtct     60

gtgtgttctg ccccagtgag actgcagccc ttgtaaatac tttgacacct tttgcaagaa    120

ggaatctgaa caattgcaac tgaaggcaca ttgttatcat ctcgtctttg ggtgatgctg    180

ttcctcactg cagatggata attttccttt taatcaggaa tttcatatgc agaataaatg    240

gtaattaaaa tgtgcaggat gacaagatgg agcaaacagt gcttgtacca ccaggacctg    300

acagcttcaa cttcttcacc agagaatctc ttgcggctat tgaaagacgc attgcagaag    360

aaaaggcaaa gaatcccaaa ccagacaaaa aagatgacga cgaaaatggc ccaaagccaa    420

atagtgactt ggaagctgga aagaaccttc catttattta tggagacatt cctccagaga    480

tggtgtcaga gcccctggag gacctggacc cctactatat caataagaaa acttttatag    540

tattgaataa attgaaggcc atcttccggt tcagtgccac ctctgccctg tacattttaa    600

ctcccttcaa tcctcttagg aaaatagcta ttaagatttt ggtacattca ttattcagca    660

tgctaattat gtgcactatt ttgacaaact gtgtgtttat gacaatgagt aaccctcctg    720

attggacaaa gaatgtagaa tacaccttca caggaatata tagtgaatcc ttttgaatca    780

cttataaaaa ttattgcaag gggattctgt ttagaagatt ttactttcct tcgggatcca    840

tggaactggc tcgatttcac tgtcattaca tttgcgtacg tcacagagtt tgtggacctg    900

ggcaatgtct cggcattgag aacattcaga gttctccgag cattgaagac gatttcagtc    960

attccaggcc tgaaaaccat tgtgggagcc ctgatccagt ctgtgaagaa gctctcagat   1020

gtaatgatcc tgactgtgtt ctgtctgagc gtatttgctc taattgggct gcagctgttc   1080

atgggcaacc tgaggaataa atgtatacaa tggcctccca ccaatgcttc cttggaggaa   1140

catagtatag aaaagaatat aactgtgaat tataatggta cacttataaa tgaaactgtc   1200

tttgagtttg actggaagtc atatattcaa gattcaagat atcattattt cctggagggt   1260

tttttagatg cactactatg tggaaatagc tctgatgcag gccaatgtcc agagggatat   1320

atgtgtgtga aagctggtag aaatcccaat tatggctaca caagctttga taccttcagt   1380

tgggcttttt tgtccttgtt tcgactaatg actcaggact tctgggaaaa tctttatcaa   1440

ctgacattac gtgctgctgg gaaaacgtac atgatatttt ttgtattggt cattttcttg   1500

ggctcattct acctaataaa tttgatcctg gctgtggtgg ccatggccta cgaggaacag   1560

aatcaggcca ccttggaaga agcagaacag aaagaggccg aatttcagca gatgattgaa   1620

cagcttaaaa agcaacagga ggcagctcag caggcagcaa cggcaactgc ctcagaacat   1680

tccagagagc ccagtgcagc aggcaggctc tcagacagct catctgaagc ctctaagttg   1740

agttccaaga gtgctaagga aagaagaaat cggaggaaga aaagaaaaca gaaagagcag   1800

tctggtgggg aagagaaaga tgaggatgaa ttccaaaaat ctgaatctga ggacagcatc   1860

aggaggaaag gttttcgctt ctccattgaa gggaaccgat tgacatatga aaagaggtac   1920

tcctccccac accagtcttt gttgagcatc cgtggctccc tattttcacc aaggcgaaat   1980

agcagaacaa gccttttcag ctttagaggg cgagcaaagg atgtgggatc tgagaacgac   2040

ttcgcagatg atgagcacag cacctttgag gataacgaga gccgtagaga ttccttgttt   2100

gtgccccgac gacacggaga gagacgcaac agcaacctga gtcagaccag taggtcatcc   2160

cggatgctgg cagtgtttcc agcgaatggg aagatgcaca gcactgtgga ttgcaatggt   2220

gtggtttcct tggttggtgg accttcagtt cctacatcgc ctgttggaca gcttctgcca   2280

gaggtgataa tagataagcc agctactgat gacaatggaa caaccactga aactgaaatg   2340

agaaagagaa ggtcaagttc tttccacgtt tccatggact ttctagaaga tccttcccaa   2400

aggcaacgag caatgagtat agccagcatt ctaacaaata cagtagaaga acttgaagaa   2460

tccaggcaga aatgcccacc ctgttggtat aaattttcca acatattctt aatctgggac   2520

tgttctccat attggttaaa agtgaaacat gttgtcaacc tggttgtgat ggacccattt   2580

gttgacctgg ccatcaccat ctgtattgtc ttaaatactc ttttcatggc catggagcac   2640

tatccaatga cggaccattt caataatgtg cttacagtag gaaacttggt tttcactggg   2700

atctttacag cagaaatgtt tctgaaaatt attgccatgg atccttacta ttatttccaa   2760

gaaggctgga atatctttga cggttttatt gtgacgctta gcctggtaga acttggactc   2820

gccaatgtgg aaggattatc tgttctccgt tcatttcgat tgctgcgagt tttcaagttg   2880

gcaaaatctt ggccaacgtt aaatatgcta ataaagatca tcggcaattc cgtgggggct   2940

ctgggaaatt taaccctcgt cttggccatc atcgtcttca tttttgccgt ggtcggcatg   3000

cagctctttg gtaaaagcta caaagattgt gtctgcaaga tcgccagtga ttgtcaactc   3060

ccacgctggc acatgaatga cttcttccac tccttcctga ttgtgttccg cgtgctgtgt   3120

ggggagtgga tagagaccat gtgggactgt atggaggttg ctggtcaagc catgtgcctt   3180

actgtcttca tgatggtcat ggtgattgga aacctagtgg tcctgaatct ctttctggcc   3240

ttgcttctga gctcatttag tgcagacaac cttgcagcca ctgatgatga taatgaaatg   3300

aataatctcc aaattgctgt ggataggatg cacaaaggag tagcttatgt gaaaagaaaa   3360

atatatgaat ttattcaaca gtccttcatt aggaaacaaa agattttaga tgaaattaaa   3420

ccacttgatg atctaaacaa caagaaagac agttgtatgt ccaatcatac aacagaaatt   3480

gggaaagatc ttgactatct taaagatgta aatggaacta caagtggtat aggaactggc   3540

agcagtgttg aaaaatacat tattgatgaa agtgattaca tgtcattcat aaacaacccc   3600

agtcttactg tgactgtacc aattgctgta ggagaatctg actttgaaaa tttaaacacg   3660

gaagacttta gtagtgaatc ggatctggaa gaaagcaaag agaaactgaa tgaaagcagt   3720

agctcatcag aaggtagcac tgtggacatc ggcgcacctg tagaagaaca gcccgtagtg   3780

gaacctgaag aaactcttga accagaagct tgtttcactg aaggctgtgt acaaagattc   3840

aagtgttgtc aaatcaatgt ggaagaaggc agaggaaaac aatggtggaa cctgagaagg   3900

acgtgtttcc gaatagttga acataactgg tttgagacct tcattgtttt catgattctc   3960

cttagtagtg gtgctctggc atttgaagat atatatattg atcagcgaaa gacgattaag   4020

acgatgttgg aatatgctga caaggttttc acttacattt tcattctgga aatgcttcta   4080

aaatgggtgg catatggcta tcaaacatat ttcaccaatg cctggtgttg gctggacttc   4140

ttaattgttg atgtttcatt ggtcagttta acagcaaatg ccttgggtta ctcagaactt   4200

ggagccatca aatctctcag gacactaaga gctctgagac ctctaagagc cttatctcga   4260

tttgaaggga tgagggtggt tgtgaatgcc cttttaggag caattccatc catcatgaat   4320

gtgcttctgg tttgtcttat attctggcta attttcagca tcatgggcgt aaatttgttt   4380

gctggcaaat tctaccactg tattaacacc acaactggtg acaggtttga catcgaagac   4440

gtgaataatc atactgattg cctaaaacta atagaaagaa atgagactgc tcgatggaaa   4500

aatgtgaaag taaactttga taatgtagga tttgggtatc tctctttgct tcaagttgcc   4560

acattcaaag gatggatgga tataatgtat gcagcagttg attccagaaa tgtggaactc   4620

cagcctaagt atgaaaaaag tctgtacatg tatctttact ttgttatttt catcatcttt   4680

gggtccttct tcaccttgaa cctgtttatt ggtgtcatca tagataattt caaccagcag   4740

aaaaagaagt ttggaggtca agacatcttt atgacagaag aacagaagaa atactataat   4800

gcaatgaaaa aattaggatc gaaaaaaccg caaaagccta tacctcgacc aggaaacaaa   4860

tttcaaggaa tggtctttga cttcgtaacc agacaagttt ttgacataag catcatgatt   4920

ctcatctgtc ttaacatggt cacaatgatg gtggaaacag atgaccagag tgaatatgtg   4980

actaccattt tgtcacgcat caatctggtg ttcattgtgc tatttactgg agagtgtgta   5040

ctgaaactca tctctctacg ccattattat tttaccattg gatggaatat ttttgatttt   5100

gtggttgtca ttctctccat tgtaggtatg tttcttgccg agctgataga aaagtatttc   5160

gtgtccccta ccctgttccg agtgatccgt cttgctagga ttggccgaat cctacgtctg   5220

atcaaaggag caaaggggat ccgcacgctg ctctttgctt tgatgatgtc ccttcctgcg   5280

ttgtttaaca tcggcctcct actcttccta gtcatgttca tctacgccat ctttgggatg   5340

tccaactttg cctatgttaa gagggaagtt gggatcgatg acatgttcaa ctttgagacc   5400

tttggcaaca gcatgatctg cctattccaa attacaacct ctgctggctg ggatggattg   5460

ctagcaccca ttctcaacag taagccaccc gactgtgacc ctaataaagt taaccctgga   5520

agctcagtta agggagactg tgggaaccca tctgttggaa ttttcttttt tgtcagttac   5580

atcatcatat ccttcctggt tgtggtgaac atgtacatcg cggtcatcct ggagaacttc   5640

agtgttgcta ctgaagaaag tgcagagcct ctgagtgagg atgactttga gatgttctat   5700

gaggtttggg agaagtttga tcccgatgca actcagttca tggaatttga aaaattatct   5760

cagtttgcag ctgcgcttga accgcctctc aatctgccac aaccaaacaa actccagctc   5820

attgccatgg atttgcccat ggtgagtggt gaccggatcc actgtcttga tatcttattt   5880

gcttttacaa agcgggttct aggagagagt ggagagatgg atgctctacg aatacagatg   5940

gaagagcgat tcatggcttc caatccttcc aaggtctcct atcagccaat cactactact   6000

ttaaaacgaa aacaagagga agtatctgct gtcattattc agcgtgctta cagacgccac   6060

cttttaaagc gaactgtaaa acaagcttcc tttacgtaca ataaaaacaa aatcaaaggt   6120

ggggctaatc ttcttataaa agaagacatg ataattgaca gaataaatga aaactctatt   6180

acagaaaaaa ctgatctgac catgtccact gcagcttgtc caccttccta tgaccgggtg   6240

acaaagccaa ttgtggaaaa acatgagcaa gaaggcaaag atgaaaaagc caaagggaaa   6300

taaatgaaaa taaataaaaa taattgggtg acaaattgtt tacagcctgt gaaggtgatg   6360

tatttttatc aacaggactc ctttaggagg tcaatgccaa actgactgtt tttacacaaa   6420

tctccttaag gtcagtgcct acaataagac agtgacccct tgtcagcaaa ctgtgactct   6480

gtgtaaaggg gagatgacct tgacaggagg ttactgttct cactaccagc tgacactgct   6540

gaagataaga tgcacaatgg ctagtcagac tgtagggacc agtttcaagg ggtgcaaacc   6600

tgtgattttg gggttgttta acatgaaaca ctttagtgta gtaattgtat ccactgtttg   6660

catttcaact gccacatttg tcacattttt atggaatctg ttagtggatt catctttttg   6720

ttaatccatg tgtttattat atgtgactat ttttgtaaac gaagtttctg ttgagaaata   6780

ggctaaggac ctctataaca ggtatgccac ctggggggta tggcaaccac atggccctcc   6840

cagctacaca aagtcgtggt ttgcatgagg gcatgctgca cttagagatc atgcatgaga   6900

aaaagtcaca agaaaaacaa attcttaaat ttcaccatat ttctgggagg ggtaattggg   6960

tgataagtgg aggtgctttg ttgatcttgt tttgcgaaat ccagccccta gaccaagtag   7020

attatttgtg ggtaggccag taaatcttag caggtgcaaa cttcattcaa atgtttggag   7080

tcataaatgt tatgtttctt tttgttgtat taaaaaaaaa acctgaatag tgaatattgc   7140

ccctcaccct ccaccgccag aagactgaat tgaccaaaat tactctttat aaatttctgc   7200

tttttcctgc actttgttta gccatctttg ggctctcagc aaggttgaca ctgtatatgt   7260

taatgaaatg ctatttatta tgtaaatagt cattttaccc tgtggtgcac gtttgagcaa   7320

acaaataatg acctaagcac agtatttatt gcatcaaata tgtaccacaa gaaatgtaga   7380

gtgcaagctt tacacaggta ataaaatgta ttctgtacca tttatagata gtttggatgc   7440

tatcaatgca tgtttatatt accatgctgc tgtatctggt ttctctcact gctcagaatc   7500

tcatttatga gaaaccatat gtcagtggta aagtcaagga aattgttcaa cagatctcat   7560

ttatttaagt cattaagcaa tagtttgcag cactttaaca gctttttggt tatttttaca   7620

ttttaagtgg ataacatatg gtatatagcc agactgtaca gacatgttta aaaaaacaca   7680

ctgcttaacc tattaaatat gtgtttagaa ttttataagc aaatataaat actgtaaaaa   7740

gtcactttat tttatttttc agcattatgt acataaatat gaagaggaaa ttatcttcag   7800

gttgatatca caatcacttt tcttactttc tgtccatagt actttttcat gaaagaaatt   7860

tgctaaataa gacatgaaaa caagactggg tagttgtaga tttctgcttt ttaaattaca   7920

tttgctaatt ttagattatt tcacaatttt aaggagcaaa ataggttcac gattcatatc   7980

caaattatgc tttgcaattg gaaaagggtt taaaatttta tttatatttc tggtagtacc   8040

tgtactaact gaattgaagg tagtgcttat gttatttttg ttcttttttt ctgacttcgg   8100

tttatgtttt catttctttg gagtaatgct gctctagatt gttctaaata gaatgtgggc   8160

ttcataattt ttttttccac aaaaacagag tagtcaactt atatagtcaa ttacatcagg   8220

acattttgtg tttcttacag aagcaaacca taggctcctc ttttccttaa aactacttag   8280

ataaactgta ttcgtgaact gcatgctgga aaatgctact attatgctaa ataatgctaa   8340

ccaacattta aaatgtgcaa aactaataaa gattacattt tttatttt                8388


<210>  17
<211>  8380
<212>  DNA
<213>  Homo sapiens

<400>  17
atactgcaga ggtctctggt gcatgtgtgt atgtgtgcgt ttgtgtgtgt ttgtgtgtct     60

gtgtgttctg ccccagtgag actgcagccc ttgtaaatac tttgacacct tttgcaagaa    120

ggaatctgaa caattgcaac tgaaggcaca ttgttatcat ctcgtctttg ggtgatgctg    180

ttcctcactg cagatggata attttccttt taatcaggaa tttcatatgc agaataaatg    240

gtaattaaaa tgtgcaggat gacaagatgg agcaaacagt gcttgtacca ccaggacctg    300

acagcttcaa cttcttcacc agagaatctc ttgcggctat tgaaagacgc attgcagaag    360

aaaaggcaaa gaatcccaaa ccagacaaaa aagatgacga cgaaaatggc ccaaagccaa    420

atagtgactt ggaagctgga aagaaccttc catttattta tggagacatt cctccagaga    480

tggtgtcaga gcccctggag gacctggacc cctactatat caataagaaa acttttatag    540

tattgaataa attgaaggcc atcttccggt tcagtgccac ctctgccctg tacattttaa    600

ctcccttcaa tcctcttagg aaaatagcta ttaagatttt ggtacattca ttattcagca    660

tgctaattat gtgcactatt ttgacaaact gtgtgtttat gacaatgagt aaccctcctg    720

attggacaaa gaatgtagaa tacaccttca caggaatata tacttttgaa tcacttataa    780

aaattattgc aaggggattc tgtttagaag attttacttt ccttcgggat ccatggaact    840

ggctcgattt cactgtcatt acatttgcgt acgtcacaga gtttgtggac ctgggcaatg    900

tctcggcatt gagaacattc agagttctcc gagcattgaa gacgatttca gtcattccag    960

gcctgaaaac cattgtggga gccctgatcc agtctgtgaa gaagctctca gatgtaatga   1020

tcctgactgt gttctgtctg agcgtatttg ctctaattgg gctgcagctg ttcatgggca   1080

acctgaggaa taaatgtata caatggcctc ccaccaatgc ttccttggag gaacatagta   1140

tagaaaagaa tataactgtg aattataatg gtacacttat aaatgaaact gtctttgagt   1200

ttgactggaa gtcatatatt caagattcaa gatatcatta tttcctggag ggttttttag   1260

atgcactact atgtggaaat agctctgatg caggccaatg tccagaggga tatatgtgtg   1320

tgaaagctgg tagaaatccc aattatggct acacaagctt tgataccttc agttgggctt   1380

ttttgtcctt gtttcgacta atgactcagg acttctggga aaatctttat caactgacat   1440

tacgtgctgc tgggaaaacg tacatgatat tttttgtatt ggtcattttc ttgggctcat   1500

tctacctaat aaatttgatc ctggctgtgg tggccatggc ctacgaggaa cagaatcagg   1560

ccaccttgga agaagcagaa cagaaagagg ccgaatttca gcagatgatt gaacagctta   1620

aaaagcaaca ggaggcagct cagcaggcag caacggcaac tgcctcagaa cattccagag   1680

agcccagtgc agcaggcagg ctctcagaca gctcatctga agcctctaag ttgagttcca   1740

agagtgctaa ggaaagaaga aatcggagga agaaaagaaa acagaaagag cagtctggtg   1800

gggaagagaa agatgaggat gaattccaaa aatctgaatc tgaggacagc atcaggagga   1860

aaggttttcg cttctccatt gaagggaacc gattgacata tgaaaagagg tactcctccc   1920

cacaccagtc tttgttgagc atccgtggct cctattttca ccaaggcgaa atagcagaac   1980

aagccttttc agctttagag ggcgagcaaa ggatgtggga tctgagaacg acttcgcaga   2040

tgatgagcac agcacctttg aggataacga gagccgtaga gattccttgt ttgtgccccg   2100

acgacacgga gagagacgca acagcaacct gagtcagacc agtaggtcat cccggatgct   2160

ggcagtgttt ccagcgaatg ggaagatgca cagcactgtg gattgcaatg gtgtggtttc   2220

cttggttggt ggaccttcag ttcctacatc gcctgttgga cagcttctgc cagaggtgat   2280

aatagataag ccagctactg atgacaatgg aacaaccact gaaactgaaa tgagaaagag   2340

aaggtcaagt tctttccacg tttccatgga ctttctagaa gatccttccc aaaggcaacg   2400

agcaatgagt atagccagca ttctaacaaa tacagtagaa gaacttgaag aatccaggca   2460

gaaatgccca ccctgttggt ataaattttc caacatattc ttaatctggg actgttctcc   2520

atattggtta aaagtgaaac atgttgtcaa cctggttgtg atggacccat ttgttgacct   2580

ggccatcacc atctgtattg tcttaaatac tcttttcatg gccatggagc actatccaat   2640

gacggaccat ttcaataatg tgcttacagt aggaaacttg gttttcactg ggatctttac   2700

agcagaaatg tttctgaaaa ttattgccat ggatccttac tattatttcc aagaaggctg   2760

gaatatcttt gacggtttta ttgtgacgct tagcctggta gaacttggac tcgccaatgt   2820

ggaaggatta tctgttctcc gttcatttcg attgctgcga gttttcaagt tggcaaaatc   2880

ttggccaacg ttaaatatgc taataaagat catcggcaat tccgtggggg ctctgggaaa   2940

tttaaccctc gtcttggcca tcatcgtctt catttttgcc gtggtcggca tgcagctctt   3000

tggtaaaagc tacaaagatt gtgtctgcaa gatcgccagt gattgtcaac tcccacgctg   3060

gcacatgaat gacttcttcc actccttcct gattgtgttc cgcgtgctgt gtggggagtg   3120

gatagagacc atgtgggact gtatggaggt tgctggtcaa gccatgtgcc ttactgtctt   3180

catgatggtc atggtgattg gaaacctagt ggtcctgaat ctctttctgg ccttgcttct   3240

gagctcattt agtgcagaca accttgcagc cactgatgat gataatgaaa tgaataatct   3300

ccaaattgct gtggatagga tgcacaaagg agtagcttat gtgaaaagaa aaatatatga   3360

atttattcaa cagtccttca ttaggaaaca aaagatttta gatgaaatta aaccacttga   3420

tgatctaaac aacaagaaag acagttgtat gtccaatcat acaacagaaa ttgggaaaga   3480

tcttgactat cttaaagatg taaatggaac tacaagtggt ataggaactg gcagcagtgt   3540

tgaaaaatac attattgatg aaagtgatta catgtcattc ataaacaacc ccagtcttac   3600

tgtgactgta ccaattgctg taggagaatc tgactttgaa aatttaaaca cggaagactt   3660

tagtagtgaa tcggatctgg aagaaagcaa agagaaactg aatgaaagca gtagctcatc   3720

agaaggtagc actgtggaca tcggcgcacc tgtagaagaa cagcccgtag tggaacctga   3780

agaaactctt gaaccagaag cttgtttcac tgaaggctgt gtacaaagat tcaagtgttg   3840

tcaaatcaat gtggaagaag gcagaggaaa acaatggtgg aacctgagaa ggacgtgttt   3900

ccgaatagtt gaacataact ggtttgagac cttcattgtt ttcatgattc tccttagtag   3960

tggtgctctg gcatttgaag atatatatat tgatcagcga aagacgatta agacgatgtt   4020

ggaatatgct gacaaggttt tcacttacat tttcattctg gaaatgcttc taaaatgggt   4080

ggcatatggc tatcaaacat atttcaccaa tgcctggtgt tggctggact tcttaattgt   4140

tgatgtttca ttggtcagtt taacagcaaa tgccttgggt tactcagaac ttggagccat   4200

caaatctctc aggacactaa gagctctgag acctctaaga gccttatctc gatttgaagg   4260

gatgagggtg gttgtgaatg cccttttagg agcaattcca tccatcatga atgtgcttct   4320

ggtttgtctt atattctggc taattttcag catcatgggc gtaaatttgt ttgctggcaa   4380

attctaccac tgtattaaca ccacaactgg tgacaggttt gacatcgaag acgtgaataa   4440

tcatactgat tgcctaaaac taatagaaag aaatgagact gctcgatgga aaaatgtgaa   4500

agtaaacttt gataatgtag gatttgggta tctctctttg cttcaagttg ccacattcaa   4560

aggatggatg gatataatgt atgcagcagt tgattccaga aatgtggaac tccagcctaa   4620

gtatgaaaaa agtctgtaca tgtatcttta ctttgttatt ttcatcatct ttgggtcctt   4680

cttcaccttg aacctgttta ttggtgtcat catagataat ttcaaccagc agaaaaagaa   4740

gtttggaggt caagacatct ttatgacaga agaacagaag aaatactata atgcaatgaa   4800

aaaattagga tcgaaaaaac cgcaaaagcc tatacctcga ccaggaaaca aatttcaagg   4860

aatggtcttt gacttcgtaa ccagacaagt ttttgacata agcatcatga ttctcatctg   4920

tcttaacatg gtcacaatga tggtggaaac agatgaccag agtgaatatg tgactaccat   4980

tttgtcacgc atcaatctgg tgttcattgt gctatttact ggagagtgtg tactgaaact   5040

catctctcta cgccattatt attttaccat tggatggaat atttttgatt ttgtggttgt   5100

cattctctcc attgtaggta tgtttcttgc cgagctgata gaaaagtatt tcgtgtcccc   5160

taccctgttc cgagtgatcc gtcttgctag gattggccga atcctacgtc tgatcaaagg   5220

agcaaagggg atccgcacgc tgctctttgc tttgatgatg tcccttcctg cgttgtttaa   5280

catcggcctc ctactcttcc tagtcatgtt catctacgcc atctttggga tgtccaactt   5340

tgcctatgtt aagagggaag ttgggatcga tgacatgttc aactttgaga cctttggcaa   5400

cagcatgatc tgcctattcc aaattacaac ctctgctggc tgggatggat tgctagcacc   5460

cattctcaac agtaagccac ccgactgtga ccctaataaa gttaaccctg gaagctcagt   5520

taagggagac tgtgggaacc catctgttgg aattttcttt tttgtcagtt acatcatcat   5580

atccttcctg gttgtggtga acatgtacat cgcggtcatc ctggagaact tcagtgttgc   5640

tactgaagaa agtgcagagc ctctgagtga ggatgacttt gagatgttct atgaggtttg   5700

ggagaagttt gatcccgatg caactcagtt catggaattt gaaaaattat ctcagtttgc   5760

agctgcgctt gaaccgcctc tcaatctgcc acaaccaaac aaactccagc tcattgccat   5820

ggatttgccc atggtgagtg gtgaccggat ccactgtctt gatatcttat ttgcttttac   5880

aaagcgggtt ctaggagaga gtggagagat ggatgctcta cgaatacaga tggaagagcg   5940

attcatggct tccaatcctt ccaaggtctc ctatcagcca atcactacta ctttaaaacg   6000

aaaacaagag gaagtatctg ctgtcattat tcagcgtgct tacagacgcc accttttaaa   6060

gcgaactgta aaacaagctt cctttacgta caataaaaac aaaatcaaag gtggggctaa   6120

tcttcttata aaagaagaca tgataattga cagaataaat gaaaactcta ttacagaaaa   6180

aactgatctg accatgtcca ctgcagcttg tccaccttcc tatgaccggg tgacaaagcc   6240

aattgtggaa aaacatgagc aagaaggcaa agatgaaaaa gccaaaggga aataaatgaa   6300

aataaataaa aataattggg tgacaaattg tttacagcct gtgaaggtga tgtattttta   6360

tcaacaggac tcctttagga ggtcaatgcc aaactgactg tttttacaca aatctcctta   6420

aggtcagtgc ctacaataag acagtgaccc cttgtcagca aactgtgact ctgtgtaaag   6480

gggagatgac cttgacagga ggttactgtt ctcactacca gctgacactg ctgaagataa   6540

gatgcacaat ggctagtcag actgtaggga ccagtttcaa ggggtgcaaa cctgtgattt   6600

tggggttgtt taacatgaaa cactttagtg tagtaattgt atccactgtt tgcatttcaa   6660

ctgccacatt tgtcacattt ttatggaatc tgttagtgga ttcatctttt tgttaatcca   6720

tgtgtttatt atatgtgact atttttgtaa acgaagtttc tgttgagaaa taggctaagg   6780

acctctataa caggtatgcc acctgggggg tatggcaacc acatggccct cccagctaca   6840

caaagtcgtg gtttgcatga gggcatgctg cacttagaga tcatgcatga gaaaaagtca   6900

caagaaaaac aaattcttaa atttcaccat atttctggga ggggtaattg ggtgataagt   6960

ggaggtgctt tgttgatctt gttttgcgaa atccagcccc tagaccaagt agattatttg   7020

tgggtaggcc agtaaatctt agcaggtgca aacttcattc aaatgtttgg agtcataaat   7080

gttatgtttc tttttgttgt attaaaaaaa aaacctgaat agtgaatatt gcccctcacc   7140

ctccaccgcc agaagactga attgaccaaa attactcttt ataaatttct gctttttcct   7200

gcactttgtt tagccatctt tgggctctca gcaaggttga cactgtatat gttaatgaaa   7260

tgctatttat tatgtaaata gtcattttac cctgtggtgc acgtttgagc aaacaaataa   7320

tgacctaagc acagtattta ttgcatcaaa tatgtaccac aagaaatgta gagtgcaagc   7380

tttacacagg taataaaatg tattctgtac catttataga tagtttggat gctatcaatg   7440

catgtttata ttaccatgct gctgtatctg gtttctctca ctgctcagaa tctcatttat   7500

gagaaaccat atgtcagtgg taaagtcaag gaaattgttc aacagatctc atttatttaa   7560

gtcattaagc aatagtttgc agcactttaa cagctttttg gttattttta cattttaagt   7620

ggataacata tggtatatag ccagactgta cagacatgtt taaaaaaaca cactgcttaa   7680

cctattaaat atgtgtttag aattttataa gcaaatataa atactgtaaa aagtcacttt   7740

attttatttt tcagcattat gtacataaat atgaagagga aattatcttc aggttgatat   7800

cacaatcact tttcttactt tctgtccata gtactttttc atgaaagaaa tttgctaaat   7860

aagacatgaa aacaagactg ggtagttgta gatttctgct ttttaaatta catttgctaa   7920

ttttagatta tttcacaatt ttaaggagca aaataggttc acgattcata tccaaattat   7980

gctttgcaat tggaaaaggg tttaaaattt tatttatatt tctggtagta cctgtactaa   8040

ctgaattgaa ggtagtgctt atgttatttt tgttcttttt ttctgacttc ggtttatgtt   8100

ttcatttctt tggagtaatg ctgctctaga ttgttctaaa tagaatgtgg gcttcataat   8160

ttttttttcc acaaaaacag agtagtcaac ttatatagtc aattacatca ggacattttg   8220

tgtttcttac agaagcaaac cataggctcc tcttttcctt aaaactactt agataaactg   8280

tattcgtgaa ctgcatgctg gaaaatgcta ctattatgct aaataatgct aaccaacatt   8340

taaaatgtgc aaaactaata aagattacat tttttatttt                         8380


<210>  18
<211>  8380
<212>  DNA
<213>  Homo sapiens

<400>  18
atactgcaga ggtctctggt gcatgtgtgt atgtgtgcgt ttgtgtgtgt ttgtgtgtct     60

gtgtgttctg ccccagtgag actgcagccc ttgtaaatac tttgacacct tttgcaagaa    120

ggaatctgaa caattgcaac tgaaggcaca ttgttatcat ctcgtctttg ggtgatgctg    180

ttcctcactg cagatggata attttccttt taatcaggaa tttcatatgc agaataaatg    240

gtaattaaaa tgtgcaggat gacaagatgg agcaaacagt gcttgtacca ccaggacctg    300

acagcttcaa cttcttcacc agagaatctc ttgcggctat tgaaagacgc attgcagaag    360

aaaaggcaaa gaatcccaaa ccagacaaaa aagatgacga cgaaaatggc ccaaagccaa    420

atagtgactt ggaagctgga aagaaccttc catttattta tggagacatt cctccagaga    480

tggtgtcaga gcccctggag gacctggacc cctactatat caataagaaa acttttatag    540

tattgaataa attgaaggcc atcttccggt tcagtgccac ctctgccctg tacattttaa    600

ctcccttcaa tcctcttagg aaaatagcta ttaagatttt ggtacattca ttattcagca    660

tgctaattat gtgcactatt ttgacaaact gtgtgtttat gacaatgagt aaccctcctg    720

attggacaaa gaatgtagaa tacaccttca caggaatata tacttttgaa tcacttataa    780

aaattattgc aaggggattc tgtttagaag attttacttt ccttcgggat ccatggaact    840

ggctcgattt cactgtcatt acatttgcgt acgtcacaga gtttgtggac ctgggcaatg    900

tctcggcatt gagaacattc agagttctcc gagcattgaa gacgatttca gtcattccag    960

gcctgaaaac cattgtggga gccctgatcc agtctgtgaa gaagctctca gatgtaatga   1020

tcctgactgt gttctgtctg agcgtatttg ctctaattgg gctgcagctg ttcatgggca   1080

acctgaggaa taaatgtata caatggcctc ccaccaatgc ttccttggag gaacatagta   1140

tagaaaagaa tataactgtg aattataatg gtacacttat aaatgaaact gtctttgagt   1200

ttgactggaa gtcatatatt caagattcaa gatatcatta tttcctggag ggttttttag   1260

atgcactact atgtggaaat agctctgatg caggccaatg tccagaggga tatatgtgtg   1320

tgaaagctgg tagaaatccc aattatggct acacaagctt tgataccttc agttgggctt   1380

ttttgtcctt gtttcgacta atgactcagg acttctggga aaatctttat caactgacat   1440

tacgtgctgc tgggaaaacg tacatgatat tttttgtatt ggtcattttc ttgggctcat   1500

tctacctaat aaatttgatc ctggctgtgg tggccatggc ctacgaggaa cagaatcagg   1560

ccaccttgga agaagcagaa cagaaagagg ccgaatttca gcagatgatt gaacagctta   1620

aaaagcaaca ggaggcagct cagcaggcag caacggcaac tgcctcagaa cattccagag   1680

agcccagtgc agcaggcagg ctctcagaca gctcatctga agcctctaag ttgagttcca   1740

agagtgctaa ggaaagaaga aatcggagga agaaaagaaa acagaaagag cagtctggtg   1800

gggaagagaa agatgaggat gaattccaaa aatctgaatc tgaggacagc atcaggagga   1860

aaggttttcg cttctccatt gaagggaacc gattgacata tgaaaagagg tactcctccc   1920

cacaccagtc tttgttgagc atccgtggct ccctattttc accaaggcga aatagcagaa   1980

caagcctttt cagctttaga gggcgagcaa aggatgtggg atctgagaac gacttcgcag   2040

atgatgagca cagcaccttt gaggataacg agagccgtag agattccttg tttgtgcccc   2100

gacgacacgg agagagacgc aacagcaacc tgagtcagac cagtaggtca tcccggatgc   2160

tggcagtgtt tccagcgaat gggaagatgc acagcactgt ggattgcaat ggtgtggttt   2220

ccttggttgg tggaccttca gttcctacat cgcctgttgg acagcttctg ccagaggtga   2280

taatagataa gccagctact gatgacaatg gaacaaccac tgaaactgaa atgagaaaga   2340

gaaggtcaag ttctttccac gtttccatgg actttctaga agatccttcc caaaggcaac   2400

gagcaatgag tatagccagc attctaacaa atacagtaga agaacttgaa gaatccaggc   2460

agaaatgccc accctgttgg tataaatttt ccaacatatt cttaatctgg gactgttctc   2520

catattggtt aaaagtgaaa catgttgtca acctggttgt gatggaccca tttgttgacc   2580

tggccatcac catctgtatt gtcttaaata ctcttttcat ggccatggag cactatccaa   2640

tgacggacca tttcaataat gtgcttacag taggaaactt ggttttcact gggatcttta   2700

cagcagaaat gtttctgaaa attattgcca tggatcctta ctattatttc caagaaggct   2760

ggaatatctt tgacggtttt attgtgacgc ttagcctggt agaacttgga ctcgccaatg   2820

tggaaggatt atctgttctc cgttcatttc gattgctgcg agttttcaag ttggcaaaat   2880

cttggccaac gttaaatatg ctaataaaga tcatcggcaa ttccgtgggg gctctgggaa   2940

atttaaccct cgtcttggcc atcatcgtct tcatttttgc cgtggtcggc atgcagctct   3000

ttggtaaaag ctacaaagat tgtgtctgca agatcgccag tgattgtcaa ctcccacgct   3060

ggcacatgaa tgacttcttc cactccttcc tgattgtgtt ccgcgtgctg tgtggggagt   3120

ggatagagac catgtgggac tgtatggagg ttgctggtca agccatgtgc cttactgtct   3180

tcatgatggt catggtgatt ggaaacctag tggtcctgaa tctctttctg gccttgcttc   3240

tgagctcatt tagtgcagac aaccttgcag ccactgatga tgataatgaa atgaataatc   3300

tccaaattgc tgtggatagg atgcacaaag gagtagctta tgtgaaaaga aaaatatatg   3360

aatttattca acagtccttc attaggaaac aaaagatttt agatgaaatt aaaccacttg   3420

atgatctaaa caacaagaaa gacagttgta tgtccaatca tacaacagaa attgggaaag   3480

atcttgacta tcttaagatg taaatggaac tacaagtggt ataggaactg gcagcagtgt   3540

tgaaaaatac attattgatg aaagtgatta catgtcattc ataaacaacc ccagtcttac   3600

tgtgactgta ccaattgctg taggagaatc tgactttgaa aatttaaaca cggaagactt   3660

tagtagtgaa tcggatctgg aagaaagcaa agagaaactg aatgaaagca gtagctcatc   3720

agaaggtagc actgtggaca tcggcgcacc tgtagaagaa cagcccgtag tggaacctga   3780

agaaactctt gaaccagaag cttgtttcac tgaaggctgt gtacaaagat tcaagtgttg   3840

tcaaatcaat gtggaagaag gcagaggaaa acaatggtgg aacctgagaa ggacgtgttt   3900

ccgaatagtt gaacataact ggtttgagac cttcattgtt ttcatgattc tccttagtag   3960

tggtgctctg gcatttgaag atatatatat tgatcagcga aagacgatta agacgatgtt   4020

ggaatatgct gacaaggttt tcacttacat tttcattctg gaaatgcttc taaaatgggt   4080

ggcatatggc tatcaaacat atttcaccaa tgcctggtgt tggctggact tcttaattgt   4140

tgatgtttca ttggtcagtt taacagcaaa tgccttgggt tactcagaac ttggagccat   4200

caaatctctc aggacactaa gagctctgag acctctaaga gccttatctc gatttgaagg   4260

gatgagggtg gttgtgaatg cccttttagg agcaattcca tccatcatga atgtgcttct   4320

ggtttgtctt atattctggc taattttcag catcatgggc gtaaatttgt ttgctggcaa   4380

attctaccac tgtattaaca ccacaactgg tgacaggttt gacatcgaag acgtgaataa   4440

tcatactgat tgcctaaaac taatagaaag aaatgagact gctcgatgga aaaatgtgaa   4500

agtaaacttt gataatgtag gatttgggta tctctctttg cttcaagttg ccacattcaa   4560

aggatggatg gatataatgt atgcagcagt tgattccaga aatgtggaac tccagcctaa   4620

gtatgaaaaa agtctgtaca tgtatcttta ctttgttatt ttcatcatct ttgggtcctt   4680

cttcaccttg aacctgttta ttggtgtcat catagataat ttcaaccagc agaaaaagaa   4740

gtttggaggt caagacatct ttatgacaga agaacagaag aaatactata atgcaatgaa   4800

aaaattagga tcgaaaaaac cgcaaaagcc tatacctcga ccaggaaaca aatttcaagg   4860

aatggtcttt gacttcgtaa ccagacaagt ttttgacata agcatcatga ttctcatctg   4920

tcttaacatg gtcacaatga tggtggaaac agatgaccag agtgaatatg tgactaccat   4980

tttgtcacgc atcaatctgg tgttcattgt gctatttact ggagagtgtg tactgaaact   5040

catctctcta cgccattatt attttaccat tggatggaat atttttgatt ttgtggttgt   5100

cattctctcc attgtaggta tgtttcttgc cgagctgata gaaaagtatt tcgtgtcccc   5160

taccctgttc cgagtgatcc gtcttgctag gattggccga atcctacgtc tgatcaaagg   5220

agcaaagggg atccgcacgc tgctctttgc tttgatgatg tcccttcctg cgttgtttaa   5280

catcggcctc ctactcttcc tagtcatgtt catctacgcc atctttggga tgtccaactt   5340

tgcctatgtt aagagggaag ttgggatcga tgacatgttc aactttgaga cctttggcaa   5400

cagcatgatc tgcctattcc aaattacaac ctctgctggc tgggatggat tgctagcacc   5460

cattctcaac agtaagccac ccgactgtga ccctaataaa gttaaccctg gaagctcagt   5520

taagggagac tgtgggaacc catctgttgg aattttcttt tttgtcagtt acatcatcat   5580

atccttcctg gttgtggtga acatgtacat cgcggtcatc ctggagaact tcagtgttgc   5640

tactgaagaa agtgcagagc ctctgagtga ggatgacttt gagatgttct atgaggtttg   5700

ggagaagttt gatcccgatg caactcagtt catggaattt gaaaaattat ctcagtttgc   5760

agctgcgctt gaaccgcctc tcaatctgcc acaaccaaac aaactccagc tcattgccat   5820

ggatttgccc atggtgagtg gtgaccggat ccactgtctt gatatcttat ttgcttttac   5880

aaagcgggtt ctaggagaga gtggagagat ggatgctcta cgaatacaga tggaagagcg   5940

attcatggct tccaatcctt ccaaggtctc ctatcagcca atcactacta ctttaaaacg   6000

aaaacaagag gaagtatctg ctgtcattat tcagcgtgct tacagacgcc accttttaaa   6060

gcgaactgta aaacaagctt cctttacgta caataaaaac aaaatcaaag gtggggctaa   6120

tcttcttata aaagaagaca tgataattga cagaataaat gaaaactcta ttacagaaaa   6180

aactgatctg accatgtcca ctgcagcttg tccaccttcc tatgaccggg tgacaaagcc   6240

aattgtggaa aaacatgagc aagaaggcaa agatgaaaaa gccaaaggga aataaatgaa   6300

aataaataaa aataattggg tgacaaattg tttacagcct gtgaaggtga tgtattttta   6360

tcaacaggac tcctttagga ggtcaatgcc aaactgactg tttttacaca aatctcctta   6420

aggtcagtgc ctacaataag acagtgaccc cttgtcagca aactgtgact ctgtgtaaag   6480

gggagatgac cttgacagga ggttactgtt ctcactacca gctgacactg ctgaagataa   6540

gatgcacaat ggctagtcag actgtaggga ccagtttcaa ggggtgcaaa cctgtgattt   6600

tggggttgtt taacatgaaa cactttagtg tagtaattgt atccactgtt tgcatttcaa   6660

ctgccacatt tgtcacattt ttatggaatc tgttagtgga ttcatctttt tgttaatcca   6720

tgtgtttatt atatgtgact atttttgtaa acgaagtttc tgttgagaaa taggctaagg   6780

acctctataa caggtatgcc acctgggggg tatggcaacc acatggccct cccagctaca   6840

caaagtcgtg gtttgcatga gggcatgctg cacttagaga tcatgcatga gaaaaagtca   6900

caagaaaaac aaattcttaa atttcaccat atttctggga ggggtaattg ggtgataagt   6960

ggaggtgctt tgttgatctt gttttgcgaa atccagcccc tagaccaagt agattatttg   7020

tgggtaggcc agtaaatctt agcaggtgca aacttcattc aaatgtttgg agtcataaat   7080

gttatgtttc tttttgttgt attaaaaaaa aaacctgaat agtgaatatt gcccctcacc   7140

ctccaccgcc agaagactga attgaccaaa attactcttt ataaatttct gctttttcct   7200

gcactttgtt tagccatctt tgggctctca gcaaggttga cactgtatat gttaatgaaa   7260

tgctatttat tatgtaaata gtcattttac cctgtggtgc acgtttgagc aaacaaataa   7320

tgacctaagc acagtattta ttgcatcaaa tatgtaccac aagaaatgta gagtgcaagc   7380

tttacacagg taataaaatg tattctgtac catttataga tagtttggat gctatcaatg   7440

catgtttata ttaccatgct gctgtatctg gtttctctca ctgctcagaa tctcatttat   7500

gagaaaccat atgtcagtgg taaagtcaag gaaattgttc aacagatctc atttatttaa   7560

gtcattaagc aatagtttgc agcactttaa cagctttttg gttattttta cattttaagt   7620

ggataacata tggtatatag ccagactgta cagacatgtt taaaaaaaca cactgcttaa   7680

cctattaaat atgtgtttag aattttataa gcaaatataa atactgtaaa aagtcacttt   7740

attttatttt tcagcattat gtacataaat atgaagagga aattatcttc aggttgatat   7800

cacaatcact tttcttactt tctgtccata gtactttttc atgaaagaaa tttgctaaat   7860

aagacatgaa aacaagactg ggtagttgta gatttctgct ttttaaatta catttgctaa   7920

ttttagatta tttcacaatt ttaaggagca aaataggttc acgattcata tccaaattat   7980

gctttgcaat tggaaaaggg tttaaaattt tatttatatt tctggtagta cctgtactaa   8040

ctgaattgaa ggtagtgctt atgttatttt tgttcttttt ttctgacttc ggtttatgtt   8100

ttcatttctt tggagtaatg ctgctctaga ttgttctaaa tagaatgtgg gcttcataat   8160

ttttttttcc acaaaaacag agtagtcaac ttatatagtc aattacatca ggacattttg   8220

tgtttcttac agaagcaaac cataggctcc tcttttcctt aaaactactt agataaactg   8280

tattcgtgaa ctgcatgctg gaaaatgcta ctattatgct aaataatgct aaccaacatt   8340

taaaatgtgc aaaactaata aagattacat tttttatttt                         8380


<210>  19
<211>  8379
<212>  DNA
<213>  Homo sapiens

<400>  19
atactgcaga ggtctctggt gcatgtgtgt atgtgtgcgt ttgtgtgtgt ttgtgtgtct     60

gtgtgttctg ccccagtgag actgcagccc ttgtaaatac tttgacacct tttgcaagaa    120

ggaatctgaa caattgcaac tgaaggcaca ttgttatcat ctcgtctttg ggtgatgctg    180

ttcctcactg cagatggata attttccttt taatcaggaa tttcatatgc agaataaatg    240

gtaattaaaa tgtgcaggat gacaagatgg agcaaacagt gcttgtacca ccaggacctg    300

acagcttcaa cttcttcacc agagaatctc ttgcggctat tgaaagacgc attgcagaag    360

aaaaggcaaa gaatcccaaa ccagacaaaa aagatgacga cgaaaatggc ccaaagccaa    420

atagtgactt ggaagctgga aagaaccttc catttattta tggagacatt cctccagaga    480

tggtgtcaga gcccctggag gacctggacc cctactatat caataagaaa acttttatag    540

tattgaataa attgaaggcc atcttccggt tcagtgccac ctctgccctg tacattttaa    600

ctcccttcaa tcctcttagg aaaatagcta ttaagatttt ggtacattca ttattcagca    660

tgctaattat gtgcactatt ttgacaaact gtgtgtttat gacaatgagt aaccctcctg    720

attggacaaa gaatgtagaa tacaccttca caggaatata tacttttgaa tcacttataa    780

aaattattgc aaggggattc tgtttagaag attttacttt ccttcgggat ccatggaact    840

ggctcgattt cactgtcatt acatttgcgt acgtcacaga gtttgtggac ctgggcaatg    900

tctcggcatt gagaacattc agagttctcc gagcattgaa gacgatttca gtcattccag    960

gcctgaaaac cattgtggga gccctgatcc agtctgtgaa gaagctctca gatgtaatga   1020

tcctgactgt gttctgtctg agcgtatttg ctctaattgg gctgcagctg ttcatgggca   1080

acctgaggaa taaatgtata caatggcctc ccaccaatgc ttccttggag gaacatagta   1140

tagaaaagaa tataactgtg aattataatg gtacacttat aaatgaaact gtctttgagt   1200

ttgactggaa gtcatatatt caagattcaa gatatcatta tttcctggag ggttttttag   1260

atgcactact atgtggaaat agctctgatg caggccaatg tccagaggga tatatgtgtg   1320

tgaaagctgg tagaaatccc aattatggct acacaagctt tgataccttc agttgggctt   1380

ttttgtcctt gtttcgacta atgactcagg acttctggga aaatctttat caactgacat   1440

tacgtgctgc tgggaaaacg tacatgatat tttttgtatt ggtcattttc ttgggctcat   1500

tctacctaat aaatttgatc ctggctgtgg tggccatggc ctacgaggaa cagaatcagg   1560

ccaccttgga agaagcagaa cagaaagagg ccgaatttca gcagatgatt gaacagctta   1620

aaaagcaaca ggaggcagct cagcaggcag caacggcaac tgcctcagaa cattccagag   1680

agcccagtgc agcaggcagg ctctcagaca gctcatctga agcctctaag ttgagttcca   1740

agagtgctaa ggaaagaaga aatcggagga agaaaagaaa acagaaagag cagtctggtg   1800

gggaagagaa agatgaggat gaattccaaa aatctgaatc tgaggacagc atcaggagga   1860

aaggttttcg cttctccatt gaagggaacc gattgacata tgaaaagagg tactcctccc   1920

cacaccagtc tttgttgagc atccgtggct ccctattttc accaaggcga aatagcagaa   1980

caagcctttt cagctttaga gggcgagcaa aggatgtggg atctgagaac gacttcgcag   2040

atgatgagca cagcaccttt gaggataacg agagccgtag agattccttg tttgtgcccc   2100

gacgacacgg agagagacgc aacagcaacc tgagtcagac cagtaggtca tcccggatgc   2160

tggcagtgtt tccagcgaat gggaagatgc acagcactgt ggattgcaat ggtgtggttt   2220

ccttggttgg tggaccttca gttcctacat cgcctgttgg acagcttctg ccagaggtga   2280

taatagataa gccagctact gatgacaatg gaacaaccac tgaaactgaa atgagaaaga   2340

gaaggtcaag ttctttccac gtttccatgg actttctaga agatccttcc caaaggcaac   2400

gagcaatgag tatagccagc attctaacaa atacagtaga agaacttgaa gaatccaggc   2460

agaaatgccc accctgttgg tataaatttt ccaacatatt cttaatctgg gactgttctc   2520

catattggtt aaaagtgaaa catgttgtca acctggttgt gatggaccca tttgttgacc   2580

tggccatcac catctgtatt gtcttaaata ctcttttcat ggccatggag cactatccaa   2640

tgacggacca tttcaataat gtgcttacag taggaaactt ggttttcact gggatcttta   2700

cagcagaaat gtttctgaaa attattgcca tggatcctta ctattatttc caagaaggct   2760

ggaatatctt tgacggtttt attgtgacgc ttagcctggt agaacttgga ctcgccaatg   2820

tggaaggatt atctgttctc cgttcatttc gattgctgcg agttttcaag ttggcaaaat   2880

cttggccaac gttaaatatg ctaataaaga tcatcggcaa ttccgtgggg gctctgggaa   2940

atttaaccct cgtcttggcc atcatcgtct tcatttttgc cgtggtcggc atgcagctct   3000

ttggtaaaag ctacaaagat tgtgtctgca agatcgccag tgattgtcaa ctcccacgct   3060

ggcacatgaa tgacttcttc cactccttcc tgattgtgtt ccgcgtgctg tgtggggagt   3120

ggatagagac catgtgggac tgtatggagg ttgctggtca agccatgtgc cttactgtct   3180

tcatgatggt catggtgatt ggaaacctag tggtcctgaa tctctttctg gccttgcttc   3240

tgagctcatt tagtgcagac aaccttgcag ccactgatga tgataatgaa atgaataatc   3300

tccaaattgc tgtggatagg atgcacaaag gagtagctta tgtgaaaaga aaaatatatg   3360

aatttattca acagtccttc attaggaaac aaaagatttt agatgaaatt aaaccacttg   3420

atgatctaaa caacaagaaa gacagttgta tgtccaatca tacaacagaa attgggaaag   3480

atcttgacta tcttaaagat gtaaatggaa ctacaagtgg tataggaact ggcagcagtg   3540

ttgaaaaata cattattgat gaaagtgatt acatgtcatt cataaacaac cccagtctta   3600

ctgtgactgt accaattgct gtaggagaat ctgactttga aaatttaaac acggaagact   3660

ttagtagtga atcggatctg gaagaaagca aagagaaact gaatgaaagc agtagctcat   3720

cagaaggtag cactgtggac atcggcgcac ctgtagaaga acagcccgta gtggaacctg   3780

aagaaactct tgaaccagaa gcttgtttca ctgaaggctg tgtacagatt caagtgttgt   3840

caaatcaatg tggaagaagg cagaggaaaa caatggtgga acctgagaag gacgtgtttc   3900

cgaatagttg aacataactg gtttgagacc ttcattgttt tcatgattct ccttagtagt   3960

ggtgctctgg catttgaaga tatatatatt gatcagcgaa agacgattaa gacgatgttg   4020

gaatatgctg acaaggtttt cacttacatt ttcattctgg aaatgcttct aaaatgggtg   4080

gcatatggct atcaaacata tttcaccaat gcctggtgtt ggctggactt cttaattgtt   4140

gatgtttcat tggtcagttt aacagcaaat gccttgggtt actcagaact tggagccatc   4200

aaatctctca ggacactaag agctctgaga cctctaagag ccttatctcg atttgaaggg   4260

atgagggtgg ttgtgaatgc ccttttagga gcaattccat ccatcatgaa tgtgcttctg   4320

gtttgtctta tattctggct aattttcagc atcatgggcg taaatttgtt tgctggcaaa   4380

ttctaccact gtattaacac cacaactggt gacaggtttg acatcgaaga cgtgaataat   4440

catactgatt gcctaaaact aatagaaaga aatgagactg ctcgatggaa aaatgtgaaa   4500

gtaaactttg ataatgtagg atttgggtat ctctctttgc ttcaagttgc cacattcaaa   4560

ggatggatgg atataatgta tgcagcagtt gattccagaa atgtggaact ccagcctaag   4620

tatgaaaaaa gtctgtacat gtatctttac tttgttattt tcatcatctt tgggtccttc   4680

ttcaccttga acctgtttat tggtgtcatc atagataatt tcaaccagca gaaaaagaag   4740

tttggaggtc aagacatctt tatgacagaa gaacagaaga aatactataa tgcaatgaaa   4800

aaattaggat cgaaaaaacc gcaaaagcct atacctcgac caggaaacaa atttcaagga   4860

atggtctttg acttcgtaac cagacaagtt tttgacataa gcatcatgat tctcatctgt   4920

cttaacatgg tcacaatgat ggtggaaaca gatgaccaga gtgaatatgt gactaccatt   4980

ttgtcacgca tcaatctggt gttcattgtg ctatttactg gagagtgtgt actgaaactc   5040

atctctctac gccattatta ttttaccatt ggatggaata tttttgattt tgtggttgtc   5100

attctctcca ttgtaggtat gtttcttgcc gagctgatag aaaagtattt cgtgtcccct   5160

accctgttcc gagtgatccg tcttgctagg attggccgaa tcctacgtct gatcaaagga   5220

gcaaagggga tccgcacgct gctctttgct ttgatgatgt cccttcctgc gttgtttaac   5280

atcggcctcc tactcttcct agtcatgttc atctacgcca tctttgggat gtccaacttt   5340

gcctatgtta agagggaagt tgggatcgat gacatgttca actttgagac ctttggcaac   5400

agcatgatct gcctattcca aattacaacc tctgctggct gggatggatt gctagcaccc   5460

attctcaaca gtaagccacc cgactgtgac cctaataaag ttaaccctgg aagctcagtt   5520

aagggagact gtgggaaccc atctgttgga attttctttt ttgtcagtta catcatcata   5580

tccttcctgg ttgtggtgaa catgtacatc gcggtcatcc tggagaactt cagtgttgct   5640

actgaagaaa gtgcagagcc tctgagtgag gatgactttg agatgttcta tgaggtttgg   5700

gagaagtttg atcccgatgc aactcagttc atggaatttg aaaaattatc tcagtttgca   5760

gctgcgcttg aaccgcctct caatctgcca caaccaaaca aactccagct cattgccatg   5820

gatttgccca tggtgagtgg tgaccggatc cactgtcttg atatcttatt tgcttttaca   5880

aagcgggttc taggagagag tggagagatg gatgctctac gaatacagat ggaagagcga   5940

ttcatggctt ccaatccttc caaggtctcc tatcagccaa tcactactac tttaaaacga   6000

aaacaagagg aagtatctgc tgtcattatt cagcgtgctt acagacgcca ccttttaaag   6060

cgaactgtaa aacaagcttc ctttacgtac aataaaaaca aaatcaaagg tggggctaat   6120

cttcttataa aagaagacat gataattgac agaataaatg aaaactctat tacagaaaaa   6180

actgatctga ccatgtccac tgcagcttgt ccaccttcct atgaccgggt gacaaagcca   6240

attgtggaaa aacatgagca agaaggcaaa gatgaaaaag ccaaagggaa ataaatgaaa   6300

ataaataaaa ataattgggt gacaaattgt ttacagcctg tgaaggtgat gtatttttat   6360

caacaggact cctttaggag gtcaatgcca aactgactgt ttttacacaa atctccttaa   6420

ggtcagtgcc tacaataaga cagtgacccc ttgtcagcaa actgtgactc tgtgtaaagg   6480

ggagatgacc ttgacaggag gttactgttc tcactaccag ctgacactgc tgaagataag   6540

atgcacaatg gctagtcaga ctgtagggac cagtttcaag gggtgcaaac ctgtgatttt   6600

ggggttgttt aacatgaaac actttagtgt agtaattgta tccactgttt gcatttcaac   6660

tgccacattt gtcacatttt tatggaatct gttagtggat tcatcttttt gttaatccat   6720

gtgtttatta tatgtgacta tttttgtaaa cgaagtttct gttgagaaat aggctaagga   6780

cctctataac aggtatgcca cctggggggt atggcaacca catggccctc ccagctacac   6840

aaagtcgtgg tttgcatgag ggcatgctgc acttagagat catgcatgag aaaaagtcac   6900

aagaaaaaca aattcttaaa tttcaccata tttctgggag gggtaattgg gtgataagtg   6960

gaggtgcttt gttgatcttg ttttgcgaaa tccagcccct agaccaagta gattatttgt   7020

gggtaggcca gtaaatctta gcaggtgcaa acttcattca aatgtttgga gtcataaatg   7080

ttatgtttct ttttgttgta ttaaaaaaaa aacctgaata gtgaatattg cccctcaccc   7140

tccaccgcca gaagactgaa ttgaccaaaa ttactcttta taaatttctg ctttttcctg   7200

cactttgttt agccatcttt gggctctcag caaggttgac actgtatatg ttaatgaaat   7260

gctatttatt atgtaaatag tcattttacc ctgtggtgca cgtttgagca aacaaataat   7320

gacctaagca cagtatttat tgcatcaaat atgtaccaca agaaatgtag agtgcaagct   7380

ttacacaggt aataaaatgt attctgtacc atttatagat agtttggatg ctatcaatgc   7440

atgtttatat taccatgctg ctgtatctgg tttctctcac tgctcagaat ctcatttatg   7500

agaaaccata tgtcagtggt aaagtcaagg aaattgttca acagatctca tttatttaag   7560

tcattaagca atagtttgca gcactttaac agctttttgg ttatttttac attttaagtg   7620

gataacatat ggtatatagc cagactgtac agacatgttt aaaaaaacac actgcttaac   7680

ctattaaata tgtgtttaga attttataag caaatataaa tactgtaaaa agtcacttta   7740

ttttattttt cagcattatg tacataaata tgaagaggaa attatcttca ggttgatatc   7800

acaatcactt ttcttacttt ctgtccatag tactttttca tgaaagaaat ttgctaaata   7860

agacatgaaa acaagactgg gtagttgtag atttctgctt tttaaattac atttgctaat   7920

tttagattat ttcacaattt taaggagcaa aataggttca cgattcatat ccaaattatg   7980

ctttgcaatt ggaaaagggt ttaaaatttt atttatattt ctggtagtac ctgtactaac   8040

tgaattgaag gtagtgctta tgttattttt gttctttttt tctgacttcg gtttatgttt   8100

tcatttcttt ggagtaatgc tgctctagat tgttctaaat agaatgtggg cttcataatt   8160

tttttttcca caaaaacaga gtagtcaact tatatagtca attacatcag gacattttgt   8220

gtttcttaca gaagcaaacc ataggctcct cttttcctta aaactactta gataaactgt   8280

attcgtgaac tgcatgctgg aaaatgctac tattatgcta aataatgcta accaacattt   8340

aaaatgtgca aaactaataa agattacatt ttttatttt                          8379


<210>  20
<211>  8380
<212>  DNA
<213>  Homo sapiens

<400>  20
atactgcaga ggtctctggt gcatgtgtgt atgtgtgcgt ttgtgtgtgt ttgtgtgtct     60

gtgtgttctg ccccagtgag actgcagccc ttgtaaatac tttgacacct tttgcaagaa    120

ggaatctgaa caattgcaac tgaaggcaca ttgttatcat ctcgtctttg ggtgatgctg    180

ttcctcactg cagatggata attttccttt taatcaggaa tttcatatgc agaataaatg    240

gtaattaaaa tgtgcaggat gacaagatgg agcaaacagt gcttgtacca ccaggacctg    300

acagcttcaa cttcttcacc agagaatctc ttgcggctat tgaaagacgc attgcagaag    360

aaaaggcaaa gaatcccaaa ccagacaaaa aagatgacga cgaaaatggc ccaaagccaa    420

atagtgactt ggaagctgga aagaaccttc catttattta tggagacatt cctccagaga    480

tggtgtcaga gcccctggag gacctggacc cctactatat caataagaaa acttttatag    540

tattgaataa attgaaggcc atcttccggt tcagtgccac ctctgccctg tacattttaa    600

ctcccttcaa tcctcttagg aaaatagcta ttaagatttt ggtacattca ttattcagca    660

tgctaattat gtgcactatt ttgacaaact gtgtgtttat gacaatgagt aaccctcctg    720

attggacaaa gaatgtagaa tacaccttca caggaatata tacttttgaa tcacttataa    780

aaattattgc aaggggattc tgtttagaag attttacttt ccttcgggat ccatggaact    840

ggctcgattt cactgtcatt acatttgcgt acgtcacaga gtttgtggac ctgggcaatg    900

tctcggcatt gagaacattc agagttctcc gagcattgaa gacgatttca gtcattccag    960

gcctgaaaac cattgtggga gccctgatcc agtctgtgaa gaagctctca gatgtaatga   1020

tcctgactgt gttctgtctg agcgtatttg ctctaattgg gctgcagctg ttcatgggca   1080

acctgaggaa taaatgtata caatggcctc ccaccaatgc ttccttggag gaacatagta   1140

tagaaaagaa tataactgtg aattataatg gtacacttat aaatgaaact gtctttgagt   1200

ttgactggaa gtcatatatt caagattcaa gatatcatta tttcctggag ggttttttag   1260

atgcactact atgtggaaat agctctgatg caggccaatg tccagaggga tatatgtgtg   1320

tgaaagctgg tagaaatccc aattatggct acacaagctt tgataccttc agttgggctt   1380

ttttgtcctt gtttcgacta atgactcagg acttctggga aaatctttat caactgacat   1440

tacgtgctgc tgggaaaacg tacatgatat tttttgtatt ggtcattttc ttgggctcat   1500

tctacctaat aaatttgatc ctggctgtgg tggccatggc ctacgaggaa cagaatcagg   1560

ccaccttgga agaagcagaa cagaaagagg ccgaatttca gcagatgatt gaacagctta   1620

aaaagcaaca ggaggcagct cagcaggcag caacggcaac tgcctcagaa cattccagag   1680

agcccagtgc agcaggcagg ctctcagaca gctcatctga agcctctaag ttgagttcca   1740

agagtgctaa ggaaagaaga aatcggagga agaaaagaaa acagaaagag cagtctggtg   1800

gggaagagaa agatgaggat gaattccaaa aatctgaatc tgaggacagc atcaggagga   1860

aaggttttcg cttctccatt gaagggaacc gattgacata tgaaaagagg tactcctccc   1920

cacaccagtc tttgttgagc atccgtggct ccctattttc accaaggcga aatagcagaa   1980

caagcctttt cagctttaga gggcgagcaa aggatgtggg atctgagaac gacttcgcag   2040

atgatgagca cagcaccttt gaggataacg agagccgtag agattccttg tttgtgcccc   2100

gacgacacgg agagagacgc aacagcaacc tgagtcagac cagtaggtca tcccggatgc   2160

tggcagtgtt tccagcgaat gggaagatgc acagcactgt ggattgcaat ggtgtggttt   2220

ccttggttgg tggaccttca gttcctacat cgcctgttgg acagcttctg ccagaggtga   2280

taatagataa gccagctact gatgacaatg gaacaaccac tgaaactgaa atgagaaaga   2340

gaaggtcaag ttctttccac gtttccatgg actttctaga agatccttcc caaaggcaac   2400

gagcaatgag tatagccagc attctaacaa atacagtaga agaacttgaa gaatccaggc   2460

agaaatgccc accctgttgg tataaatttt ccaacatatt cttaatctgg gactgttctc   2520

catattggtt aaaagtgaaa catgttgtca acctggttgt gatggaccca tttgttgacc   2580

tggccatcac catctgtatt gtcttaaata ctcttttcat ggccatggag cactatccaa   2640

tgacggacca tttcaataat gtgcttacag taggaaactt ggttttcact gggatcttta   2700

cagcagaaat gtttctgaaa attattgcca tggatcctta ctattatttc caagaaggct   2760

ggaatatctt tgacggtttt attgtgacgc ttagcctggt agaacttgga ctcgccaatg   2820

tggaaggatt atctgttctc cgttcatttc gattgctgcg agttttcaag ttggcaaaat   2880

cttggccaac gttaaatatg ctaataaaga tcatcggcaa ttccgtgggg gctctgggaa   2940

atttaaccct cgtcttggcc atcatcgtct tcatttttgc cgtggtcggc atgcagctct   3000

ttggtaaaag ctacaaagat tgtgtctgca agatcgccag tgattgtcaa ctcccacgct   3060

ggcacatgaa tgacttcttc cactccttcc tgattgtgtt ccgcgtgctg tgtggggagt   3120

ggatagagac catgtgggac tgtatggagg ttgctggtca agccatgtgc cttactgtct   3180

tcatgatggt catggtgatt ggaaacctag tggtcctgaa tctctttctg gccttgcttc   3240

tgagctcatt tagtgcagac aaccttgcag ccactgatga tgataatgaa atgaataatc   3300

tccaaattgc tgtggatagg atgcacaaag gagtagctta tgtgaaaaga aaaatatatg   3360

aatttattca acagtccttc attaggaaac aaaagatttt agatgaaatt aaaccacttg   3420

atgatctaaa caacaagaaa gacagttgta tgtccaatca tacaacagaa attgggaaag   3480

atcttgacta tcttaaagat gtaaatggaa ctacaagtgg tataggaact ggcagcagtg   3540

ttgaaaaata cattattgat gaaagtgatt acatgtcatt cataaacaac cccagtctta   3600

ctgtgactgt accaattgct gtaggagaat ctgactttga aaatttaaac acggaagact   3660

ttagtagtga atcggatctg gaagaaagca aagagaaact gaatgaaagc agtagctcat   3720

cagaaggtag cactgtggac atcggcgcac ctgtagaaga acagcccgta gtggaacctg   3780

aagaaactct tgaaccagaa gcttgtttca ctgaaggctg tgtacaaaga ttcaagtgtt   3840

gtcaaatcaa tgtggaagaa ggcagaggaa aacaatggtg gaacctgaga aggacgtgtt   3900

tccgaatagt tgaacataac tggtttgaga ccttcattgt tttcatgatt ctccttagta   3960

gtggtgctct ggcatttgaa gatatatata ttgatcagcg aaagacgatt aagacgatgt   4020

tggaatatgc tgacaaggtt ttcacttaca ttttcattct ggaaatgctt ctaaaatggg   4080

tggcatatgg ctatcaaaca tatttcacca atgcctggtg ttggctggac ttcttaattg   4140

ttgatgtttc attggtcagt ttaacagcaa atgccttggg ttactcagaa cttggagcca   4200

tcaaatctct caggacacta agagctctga gacctctaag agccttatct cgatttgaag   4260

ggatgagggt ggttgtgaat gcccttttag gagcaattcc atccatcatg aatgtgcttc   4320

tggtttgctt atattctggc taattttcag catcatgggc gtaaatttgt ttgctggcaa   4380

attctaccac tgtattaaca ccacaactgg tgacaggttt gacatcgaag acgtgaataa   4440

tcatactgat tgcctaaaac taatagaaag aaatgagact gctcgatgga aaaatgtgaa   4500

agtaaacttt gataatgtag gatttgggta tctctctttg cttcaagttg ccacattcaa   4560

aggatggatg gatataatgt atgcagcagt tgattccaga aatgtggaac tccagcctaa   4620

gtatgaaaaa agtctgtaca tgtatcttta ctttgttatt ttcatcatct ttgggtcctt   4680

cttcaccttg aacctgttta ttggtgtcat catagataat ttcaaccagc agaaaaagaa   4740

gtttggaggt caagacatct ttatgacaga agaacagaag aaatactata atgcaatgaa   4800

aaaattagga tcgaaaaaac cgcaaaagcc tatacctcga ccaggaaaca aatttcaagg   4860

aatggtcttt gacttcgtaa ccagacaagt ttttgacata agcatcatga ttctcatctg   4920

tcttaacatg gtcacaatga tggtggaaac agatgaccag agtgaatatg tgactaccat   4980

tttgtcacgc atcaatctgg tgttcattgt gctatttact ggagagtgtg tactgaaact   5040

catctctcta cgccattatt attttaccat tggatggaat atttttgatt ttgtggttgt   5100

cattctctcc attgtaggta tgtttcttgc cgagctgata gaaaagtatt tcgtgtcccc   5160

taccctgttc cgagtgatcc gtcttgctag gattggccga atcctacgtc tgatcaaagg   5220

agcaaagggg atccgcacgc tgctctttgc tttgatgatg tcccttcctg cgttgtttaa   5280

catcggcctc ctactcttcc tagtcatgtt catctacgcc atctttggga tgtccaactt   5340

tgcctatgtt aagagggaag ttgggatcga tgacatgttc aactttgaga cctttggcaa   5400

cagcatgatc tgcctattcc aaattacaac ctctgctggc tgggatggat tgctagcacc   5460

cattctcaac agtaagccac ccgactgtga ccctaataaa gttaaccctg gaagctcagt   5520

taagggagac tgtgggaacc catctgttgg aattttcttt tttgtcagtt acatcatcat   5580

atccttcctg gttgtggtga acatgtacat cgcggtcatc ctggagaact tcagtgttgc   5640

tactgaagaa agtgcagagc ctctgagtga ggatgacttt gagatgttct atgaggtttg   5700

ggagaagttt gatcccgatg caactcagtt catggaattt gaaaaattat ctcagtttgc   5760

agctgcgctt gaaccgcctc tcaatctgcc acaaccaaac aaactccagc tcattgccat   5820

ggatttgccc atggtgagtg gtgaccggat ccactgtctt gatatcttat ttgcttttac   5880

aaagcgggtt ctaggagaga gtggagagat ggatgctcta cgaatacaga tggaagagcg   5940

attcatggct tccaatcctt ccaaggtctc ctatcagcca atcactacta ctttaaaacg   6000

aaaacaagag gaagtatctg ctgtcattat tcagcgtgct tacagacgcc accttttaaa   6060

gcgaactgta aaacaagctt cctttacgta caataaaaac aaaatcaaag gtggggctaa   6120

tcttcttata aaagaagaca tgataattga cagaataaat gaaaactcta ttacagaaaa   6180

aactgatctg accatgtcca ctgcagcttg tccaccttcc tatgaccggg tgacaaagcc   6240

aattgtggaa aaacatgagc aagaaggcaa agatgaaaaa gccaaaggga aataaatgaa   6300

aataaataaa aataattggg tgacaaattg tttacagcct gtgaaggtga tgtattttta   6360

tcaacaggac tcctttagga ggtcaatgcc aaactgactg tttttacaca aatctcctta   6420

aggtcagtgc ctacaataag acagtgaccc cttgtcagca aactgtgact ctgtgtaaag   6480

gggagatgac cttgacagga ggttactgtt ctcactacca gctgacactg ctgaagataa   6540

gatgcacaat ggctagtcag actgtaggga ccagtttcaa ggggtgcaaa cctgtgattt   6600

tggggttgtt taacatgaaa cactttagtg tagtaattgt atccactgtt tgcatttcaa   6660

ctgccacatt tgtcacattt ttatggaatc tgttagtgga ttcatctttt tgttaatcca   6720

tgtgtttatt atatgtgact atttttgtaa acgaagtttc tgttgagaaa taggctaagg   6780

acctctataa caggtatgcc acctgggggg tatggcaacc acatggccct cccagctaca   6840

caaagtcgtg gtttgcatga gggcatgctg cacttagaga tcatgcatga gaaaaagtca   6900

caagaaaaac aaattcttaa atttcaccat atttctggga ggggtaattg ggtgataagt   6960

ggaggtgctt tgttgatctt gttttgcgaa atccagcccc tagaccaagt agattatttg   7020

tgggtaggcc agtaaatctt agcaggtgca aacttcattc aaatgtttgg agtcataaat   7080

gttatgtttc tttttgttgt attaaaaaaa aaacctgaat agtgaatatt gcccctcacc   7140

ctccaccgcc agaagactga attgaccaaa attactcttt ataaatttct gctttttcct   7200

gcactttgtt tagccatctt tgggctctca gcaaggttga cactgtatat gttaatgaaa   7260

tgctatttat tatgtaaata gtcattttac cctgtggtgc acgtttgagc aaacaaataa   7320

tgacctaagc acagtattta ttgcatcaaa tatgtaccac aagaaatgta gagtgcaagc   7380

tttacacagg taataaaatg tattctgtac catttataga tagtttggat gctatcaatg   7440

catgtttata ttaccatgct gctgtatctg gtttctctca ctgctcagaa tctcatttat   7500

gagaaaccat atgtcagtgg taaagtcaag gaaattgttc aacagatctc atttatttaa   7560

gtcattaagc aatagtttgc agcactttaa cagctttttg gttattttta cattttaagt   7620

ggataacata tggtatatag ccagactgta cagacatgtt taaaaaaaca cactgcttaa   7680

cctattaaat atgtgtttag aattttataa gcaaatataa atactgtaaa aagtcacttt   7740

attttatttt tcagcattat gtacataaat atgaagagga aattatcttc aggttgatat   7800

cacaatcact tttcttactt tctgtccata gtactttttc atgaaagaaa tttgctaaat   7860

aagacatgaa aacaagactg ggtagttgta gatttctgct ttttaaatta catttgctaa   7920

ttttagatta tttcacaatt ttaaggagca aaataggttc acgattcata tccaaattat   7980

gctttgcaat tggaaaaggg tttaaaattt tatttatatt tctggtagta cctgtactaa   8040

ctgaattgaa ggtagtgctt atgttatttt tgttcttttt ttctgacttc ggtttatgtt   8100

ttcatttctt tggagtaatg ctgctctaga ttgttctaaa tagaatgtgg gcttcataat   8160

ttttttttcc acaaaaacag agtagtcaac ttatatagtc aattacatca ggacattttg   8220

tgtttcttac agaagcaaac cataggctcc tcttttcctt aaaactactt agataaactg   8280

tattcgtgaa ctgcatgctg gaaaatgcta ctattatgct aaataatgct aaccaacatt   8340

taaaatgtgc aaaactaata aagattacat tttttatttt                         8380


<210>  21
<211>  8380
<212>  DNA
<213>  Homo sapiens

<400>  21
atactgcaga ggtctctggt gcatgtgtgt atgtgtgcgt ttgtgtgtgt ttgtgtgtct     60

gtgtgttctg ccccagtgag actgcagccc ttgtaaatac tttgacacct tttgcaagaa    120

ggaatctgaa caattgcaac tgaaggcaca ttgttatcat ctcgtctttg ggtgatgctg    180

ttcctcactg cagatggata attttccttt taatcaggaa tttcatatgc agaataaatg    240

gtaattaaaa tgtgcaggat gacaagatgg agcaaacagt gcttgtacca ccaggacctg    300

acagcttcaa cttcttcacc agagaatctc ttgcggctat tgaaagacgc attgcagaag    360

aaaaggcaaa gaatcccaaa ccagacaaaa aagatgacga cgaaaatggc ccaaagccaa    420

atagtgactt ggaagctgga aagaaccttc catttattta tggagacatt cctccagaga    480

tggtgtcaga gcccctggag gacctggacc cctactatat caataagaaa acttttatag    540

tattgaataa attgaaggcc atcttccggt tcagtgccac ctctgccctg tacattttaa    600

ctcccttcaa tcctcttagg aaaatagcta ttaagatttt ggtacattca ttattcagca    660

tgctaattat gtgcactatt ttgacaaact gtgtgtttat gacaatgagt aaccctcctg    720

attggacaaa gaatgtagaa tacaccttca caggaatata tacttttgaa tcacttataa    780

aaattattgc aaggggattc tgtttagaag attttacttt ccttcgggat ccatggaact    840

ggctcgattt cactgtcatt acatttgcgt acgtcacaga gtttgtggac ctgggcaatg    900

tctcggcatt gagaacattc agagttctcc gagcattgaa gacgatttca gtcattccag    960

gcctgaaaac cattgtggga gccctgatcc agtctgtgaa gaagctctca gatgtaatga   1020

tcctgactgt gttctgtctg agcgtatttg ctctaattgg gctgcagctg ttcatgggca   1080

acctgaggaa taaatgtata caatggcctc ccaccaatgc ttccttggag gaacatagta   1140

tagaaaagaa tataactgtg aattataatg gtacacttat aaatgaaact gtctttgagt   1200

ttgactggaa gtcatatatt caagattcaa gatatcatta tttcctggag ggttttttag   1260

atgcactact atgtggaaat agctctgatg caggccaatg tccagaggga tatatgtgtg   1320

tgaaagctgg tagaaatccc aattatggct acacaagctt tgataccttc agttgggctt   1380

ttttgtcctt gtttcgacta atgactcagg acttctggga aaatctttat caactgacat   1440

tacgtgctgc tgggaaaacg tacatgatat tttttgtatt ggtcattttc ttgggctcat   1500

tctacctaat aaatttgatc ctggctgtgg tggccatggc ctacgaggaa cagaatcagg   1560

ccaccttgga agaagcagaa cagaaagagg ccgaatttca gcagatgatt gaacagctta   1620

aaaagcaaca ggaggcagct cagcaggcag caacggcaac tgcctcagaa cattccagag   1680

agcccagtgc agcaggcagg ctctcagaca gctcatctga agcctctaag ttgagttcca   1740

agagtgctaa ggaaagaaga aatcggagga agaaaagaaa acagaaagag cagtctggtg   1800

gggaagagaa agatgaggat gaattccaaa aatctgaatc tgaggacagc atcaggagga   1860

aaggttttcg cttctccatt gaagggaacc gattgacata tgaaaagagg tactcctccc   1920

cacaccagtc tttgttgagc atccgtggct ccctattttc accaaggcga aatagcagaa   1980

caagcctttt cagctttaga gggcgagcaa aggatgtggg atctgagaac gacttcgcag   2040

atgatgagca cagcaccttt gaggataacg agagccgtag agattccttg tttgtgcccc   2100

gacgacacgg agagagacgc aacagcaacc tgagtcagac cagtaggtca tcccggatgc   2160

tggcagtgtt tccagcgaat gggaagatgc acagcactgt ggattgcaat ggtgtggttt   2220

ccttggttgg tggaccttca gttcctacat cgcctgttgg acagcttctg ccagaggtga   2280

taatagataa gccagctact gatgacaatg gaacaaccac tgaaactgaa atgagaaaga   2340

gaaggtcaag ttctttccac gtttccatgg actttctaga agatccttcc caaaggcaac   2400

gagcaatgag tatagccagc attctaacaa atacagtaga agaacttgaa gaatccaggc   2460

agaaatgccc accctgttgg tataaatttt ccaacatatt cttaatctgg gactgttctc   2520

catattggtt aaaagtgaaa catgttgtca acctggttgt gatggaccca tttgttgacc   2580

tggccatcac catctgtatt gtcttaaata ctcttttcat ggccatggag cactatccaa   2640

tgacggacca tttcaataat gtgcttacag taggaaactt ggttttcact gggatcttta   2700

cagcagaaat gtttctgaaa attattgcca tggatcctta ctattatttc caagaaggct   2760

ggaatatctt tgacggtttt attgtgacgc ttagcctggt agaacttgga ctcgccaatg   2820

tggaaggatt atctgttctc cgttcatttc gattgctgcg agttttcaag ttggcaaaat   2880

cttggccaac gttaaatatg ctaataaaga tcatcggcaa ttccgtgggg gctctgggaa   2940

atttaaccct cgtcttggcc atcatcgtct tcatttttgc cgtggtcggc atgcagctct   3000

ttggtaaaag ctacaaagat tgtgtctgca agatcgccag tgattgtcaa ctcccacgct   3060

ggcacatgaa tgacttcttc cactccttcc tgattgtgtt ccgcgtgctg tgtggggagt   3120

ggatagagac catgtgggac tgtatggagg ttgctggtca agccatgtgc cttactgtct   3180

tcatgatggt catggtgatt ggaaacctag tggtcctgaa tctctttctg gccttgcttc   3240

tgagctcatt tagtgcagac aaccttgcag ccactgatga tgataatgaa atgaataatc   3300

tccaaattgc tgtggatagg atgcacaaag gagtagctta tgtgaaaaga aaaatatatg   3360

aatttattca acagtccttc attaggaaac aaaagatttt agatgaaatt aaaccacttg   3420

atgatctaaa caacaagaaa gacagttgta tgtccaatca tacaacagaa attgggaaag   3480

atcttgacta tcttaaagat gtaaatggaa ctacaagtgg tataggaact ggcagcagtg   3540

ttgaaaaata cattattgat gaaagtgatt acatgtcatt cataaacaac cccagtctta   3600

ctgtgactgt accaattgct gtaggagaat ctgactttga aaatttaaac acggaagact   3660

ttagtagtga atcggatctg gaagaaagca aagagaaact gaatgaaagc agtagctcat   3720

cagaaggtag cactgtggac atcggcgcac ctgtagaaga acagcccgta gtggaacctg   3780

aagaaactct tgaaccagaa gcttgtttca ctgaaggctg tgtacaaaga ttcaagtgtt   3840

gtcaaatcaa tgtggaagaa ggcagaggaa aacaatggtg gaacctgaga aggacgtgtt   3900

tccgaatagt tgaacataac tggtttgaga ccttcattgt tttcatgatt ctccttagta   3960

gtggtgctct ggcatttgaa gatatatata ttgatcagcg aaagacgatt aagacgatgt   4020

tggaatatgc tgacaaggtt ttcacttaca ttttcattct ggaaatgctt ctaaaatggg   4080

tggcatatgg ctatcaaaca tatttcacca atgcctggtg ttggctggac ttcttaattg   4140

ttgatgtttc attggtcagt ttaacagcaa atgccttggg ttactcagaa cttggagcca   4200

tcaaatctct caggacacta agagctctga gacctctaag agccttatct cgatttgaag   4260

ggatgagggt ggttgtgaat gcccttttag gagcaattcc atccatcatg aatgtgcttc   4320

tggtttgtct tatattctgg ctaattttca gcatcatggg cgtaaatttg tttgctggca   4380

aattctacca ctgtattaac accacaactg gtgacaggtt tgacatcgaa gacgtgaata   4440

atcatactga ttgcctaaaa ctaatagaaa gaaatgagac tgctcgatgg aaaaatgtga   4500

aagtaaactt tgataatgta ggatttgggt atctctcttt gcttcaagtt gccacattca   4560

aaggatggat ggatataatg tatgcagcag ttgattccag aaatgtggaa ctccagccta   4620

agtatgaaaa aagtctgtac atgtatcttt actttgttat tttcatcatc tttgggtcct   4680

tcttcacctt gaacctgttt attggtgtca tcatagataa tttcaaccag cagaaaaaga   4740

agtttggagg tcaagacatc tttatgacag aagaacagaa gaaatactat atgcaatgaa   4800

aaaattagga tcgaaaaaac cgcaaaagcc tatacctcga ccaggaaaca aatttcaagg   4860

aatggtcttt gacttcgtaa ccagacaagt ttttgacata agcatcatga ttctcatctg   4920

tcttaacatg gtcacaatga tggtggaaac agatgaccag agtgaatatg tgactaccat   4980

tttgtcacgc atcaatctgg tgttcattgt gctatttact ggagagtgtg tactgaaact   5040

catctctcta cgccattatt attttaccat tggatggaat atttttgatt ttgtggttgt   5100

cattctctcc attgtaggta tgtttcttgc cgagctgata gaaaagtatt tcgtgtcccc   5160

taccctgttc cgagtgatcc gtcttgctag gattggccga atcctacgtc tgatcaaagg   5220

agcaaagggg atccgcacgc tgctctttgc tttgatgatg tcccttcctg cgttgtttaa   5280

catcggcctc ctactcttcc tagtcatgtt catctacgcc atctttggga tgtccaactt   5340

tgcctatgtt aagagggaag ttgggatcga tgacatgttc aactttgaga cctttggcaa   5400

cagcatgatc tgcctattcc aaattacaac ctctgctggc tgggatggat tgctagcacc   5460

cattctcaac agtaagccac ccgactgtga ccctaataaa gttaaccctg gaagctcagt   5520

taagggagac tgtgggaacc catctgttgg aattttcttt tttgtcagtt acatcatcat   5580

atccttcctg gttgtggtga acatgtacat cgcggtcatc ctggagaact tcagtgttgc   5640

tactgaagaa agtgcagagc ctctgagtga ggatgacttt gagatgttct atgaggtttg   5700

ggagaagttt gatcccgatg caactcagtt catggaattt gaaaaattat ctcagtttgc   5760

agctgcgctt gaaccgcctc tcaatctgcc acaaccaaac aaactccagc tcattgccat   5820

ggatttgccc atggtgagtg gtgaccggat ccactgtctt gatatcttat ttgcttttac   5880

aaagcgggtt ctaggagaga gtggagagat ggatgctcta cgaatacaga tggaagagcg   5940

attcatggct tccaatcctt ccaaggtctc ctatcagcca atcactacta ctttaaaacg   6000

aaaacaagag gaagtatctg ctgtcattat tcagcgtgct tacagacgcc accttttaaa   6060

gcgaactgta aaacaagctt cctttacgta caataaaaac aaaatcaaag gtggggctaa   6120

tcttcttata aaagaagaca tgataattga cagaataaat gaaaactcta ttacagaaaa   6180

aactgatctg accatgtcca ctgcagcttg tccaccttcc tatgaccggg tgacaaagcc   6240

aattgtggaa aaacatgagc aagaaggcaa agatgaaaaa gccaaaggga aataaatgaa   6300

aataaataaa aataattggg tgacaaattg tttacagcct gtgaaggtga tgtattttta   6360

tcaacaggac tcctttagga ggtcaatgcc aaactgactg tttttacaca aatctcctta   6420

aggtcagtgc ctacaataag acagtgaccc cttgtcagca aactgtgact ctgtgtaaag   6480

gggagatgac cttgacagga ggttactgtt ctcactacca gctgacactg ctgaagataa   6540

gatgcacaat ggctagtcag actgtaggga ccagtttcaa ggggtgcaaa cctgtgattt   6600

tggggttgtt taacatgaaa cactttagtg tagtaattgt atccactgtt tgcatttcaa   6660

ctgccacatt tgtcacattt ttatggaatc tgttagtgga ttcatctttt tgttaatcca   6720

tgtgtttatt atatgtgact atttttgtaa acgaagtttc tgttgagaaa taggctaagg   6780

acctctataa caggtatgcc acctgggggg tatggcaacc acatggccct cccagctaca   6840

caaagtcgtg gtttgcatga gggcatgctg cacttagaga tcatgcatga gaaaaagtca   6900

caagaaaaac aaattcttaa atttcaccat atttctggga ggggtaattg ggtgataagt   6960

ggaggtgctt tgttgatctt gttttgcgaa atccagcccc tagaccaagt agattatttg   7020

tgggtaggcc agtaaatctt agcaggtgca aacttcattc aaatgtttgg agtcataaat   7080

gttatgtttc tttttgttgt attaaaaaaa aaacctgaat agtgaatatt gcccctcacc   7140

ctccaccgcc agaagactga attgaccaaa attactcttt ataaatttct gctttttcct   7200

gcactttgtt tagccatctt tgggctctca gcaaggttga cactgtatat gttaatgaaa   7260

tgctatttat tatgtaaata gtcattttac cctgtggtgc acgtttgagc aaacaaataa   7320

tgacctaagc acagtattta ttgcatcaaa tatgtaccac aagaaatgta gagtgcaagc   7380

tttacacagg taataaaatg tattctgtac catttataga tagtttggat gctatcaatg   7440

catgtttata ttaccatgct gctgtatctg gtttctctca ctgctcagaa tctcatttat   7500

gagaaaccat atgtcagtgg taaagtcaag gaaattgttc aacagatctc atttatttaa   7560

gtcattaagc aatagtttgc agcactttaa cagctttttg gttattttta cattttaagt   7620

ggataacata tggtatatag ccagactgta cagacatgtt taaaaaaaca cactgcttaa   7680

cctattaaat atgtgtttag aattttataa gcaaatataa atactgtaaa aagtcacttt   7740

attttatttt tcagcattat gtacataaat atgaagagga aattatcttc aggttgatat   7800

cacaatcact tttcttactt tctgtccata gtactttttc atgaaagaaa tttgctaaat   7860

aagacatgaa aacaagactg ggtagttgta gatttctgct ttttaaatta catttgctaa   7920

ttttagatta tttcacaatt ttaaggagca aaataggttc acgattcata tccaaattat   7980

gctttgcaat tggaaaaggg tttaaaattt tatttatatt tctggtagta cctgtactaa   8040

ctgaattgaa ggtagtgctt atgttatttt tgttcttttt ttctgacttc ggtttatgtt   8100

ttcatttctt tggagtaatg ctgctctaga ttgttctaaa tagaatgtgg gcttcataat   8160

ttttttttcc acaaaaacag agtagtcaac ttatatagtc aattacatca ggacattttg   8220

tgtttcttac agaagcaaac cataggctcc tcttttcctt aaaactactt agataaactg   8280

tattcgtgaa ctgcatgctg gaaaatgcta ctattatgct aaataatgct aaccaacatt   8340

taaaatgtgc aaaactaata aagattacat tttttatttt                         8380


<210>  22
<211>  8381
<212>  DNA
<213>  Homo sapiens

<400>  22
atactgcaga ggtctctggt gcatgtgtgt atgtgtgcgt ttgtgtgtgt ttgtgtgtct     60

gtgtgttctg ccccagtgag actgcagccc ttgtaaatac tttgacacct tttgcaagaa    120

ggaatctgaa caattgcaac tgaaggcaca ttgttatcat ctcgtctttg ggtgatgctg    180

ttcctcactg cagatggata attttccttt taatcaggaa tttcatatgc agaataaatg    240

gtaattaaaa tgtgcaggat gacaagatgg agcaaacagt gcttgtacca ccaggacctg    300

acagcttcaa cttcttcacc agagaatctc ttgcggctat tgaaagacgc attgcagaag    360

aaaaggcaaa gaatcccaaa ccagacaaaa aagatgacga cgaaaatggc ccaaagccaa    420

atagtgactt ggaagctgga aagaaccttc catttattta tggagacatt cctccagaga    480

tggtgtcaga gcccctggag gacctggacc cctactatat caataagaaa acttttatag    540

tattgaataa attgaaggcc atcttccggt tcagtgccac ctctgccctg tacattttaa    600

ctcccttcaa tcctcttagg aaaatagcta ttaagatttt ggtacattca ttattcagca    660

tgctaattat gtgcactatt ttgacaaact gtgtgtttat gacaatgagt aaccctcctg    720

attggacaaa gaatgtagaa tacaccttca caggaatata tacttttgaa tcacttataa    780

aaattattgc aaggggattc tgtttagaag attttacttt ccttcgggat ccatggaact    840

ggctcgattt cactgtcatt acatttgcgt acgtcacaga gtttgtggac ctgggcaatg    900

tctcggcatt gagaacattc agagttctcc gagcattgaa gacgatttca gtcattccag    960

gcctgaaaac cattgtggga gccctgatcc agtctgtgaa gaagctctca gatgtaatga   1020

tcctgactgt gttctgtctg agcgtatttg ctctaattgg gctgcagctg ttcatgggca   1080

acctgaggaa taaatgtata caatggcctc ccaccaatgc ttccttggag gaacatagta   1140

tagaaaagaa tataactgtg aattataatg gtacacttat aaatgaaact gtctttgagt   1200

ttgactggaa gtcatatatt caagattcaa gatatcatta tttcctggag ggttttttag   1260

atgcactact atgtggaaat agctctgatg caggccaatg tccagaggga tatatgtgtg   1320

tgaaagctgg tagaaatccc aattatggct acacaagctt tgataccttc agttgggctt   1380

ttttgtcctt gtttcgacta atgactcagg acttctggga aaatctttat caactgacat   1440

tacgtgctgc tgggaaaacg tacatgatat tttttgtatt ggtcattttc ttgggctcat   1500

tctacctaat aaatttgatc ctggctgtgg tggccatggc ctacgaggaa cagaatcagg   1560

ccaccttgga agaagcagaa cagaaagagg ccgaatttca gcagatgatt gaacagctta   1620

aaaagcaaca ggaggcagct cagcaggcag caacggcaac tgcctcagaa cattccagag   1680

agcccagtgc agcaggcagg ctctcagaca gctcatctga agcctctaag ttgagttcca   1740

agagtgctaa ggaaagaaga aatcggagga agaaaagaaa acagaaagag cagtctggtg   1800

gggaagagaa agatgaggat gaattccaaa aatctgaatc tgaggacagc atcaggagga   1860

aaggttttcg cttctccatt gaagggaacc gattgacata tgaaaagagg tactcctccc   1920

cacaccagtc tttgttgagc atccgtggct ccctattttc accaaggcga aatagcagaa   1980

caagcctttt cagctttaga gggcgagcaa aggatgtggg atctgagaac gacttcgcag   2040

atgatgagca cagcaccttt gaggataacg agagccgtag agattccttg tttgtgcccc   2100

gacgacacgg agagagacgc aacagcaacc tgagtcagac cagtaggtca tcccggatgc   2160

tggcagtgtt tccagcgaat gggaagatgc acagcactgt ggattgcaat ggtgtggttt   2220

ccttggttgg tggaccttca gttcctacat cgcctgttgg acagcttctg ccagaggtga   2280

taatagataa gccagctact gatgacaatg gaacaaccac tgaaactgaa atgagaaaga   2340

gaaggtcaag ttctttccac gtttccatgg actttctaga agatccttcc caaaggcaac   2400

gagcaatgag tatagccagc attctaacaa atacagtaga agaacttgaa gaatccaggc   2460

agaaatgccc accctgttgg tataaatttt ccaacatatt cttaatctgg gactgttctc   2520

catattggtt aaaagtgaaa catgttgtca acctggttgt gatggaccca tttgttgacc   2580

tggccatcac catctgtatt gtcttaaata ctcttttcat ggccatggag cactatccaa   2640

tgacggacca tttcaataat gtgcttacag taggaaactt ggttttcact gggatcttta   2700

cagcagaaat gtttctgaaa attattgcca tggatcctta ctattatttc caagaaggct   2760

ggaatatctt tgacggtttt attgtgacgc ttagcctggt agaacttgga ctcgccaatg   2820

tggaaggatt atctgttctc cgttcatttc gattgctgcg agttttcaag ttggcaaaat   2880

cttggccaac gttaaatatg ctaataaaga tcatcggcaa ttccgtgggg gctctgggaa   2940

atttaaccct cgtcttggcc atcatcgtct tcatttttgc cgtggtcggc atgcagctct   3000

ttggtaaaag ctacaaagat tgtgtctgca agatcgccag tgattgtcaa ctcccacgct   3060

ggcacatgaa tgacttcttc cactccttcc tgattgtgtt ccgcgtgctg tgtggggagt   3120

ggatagagac catgtgggac tgtatggagg ttgctggtca agccatgtgc cttactgtct   3180

tcatgatggt catggtgatt ggaaacctag tggtcctgaa tctctttctg gccttgcttc   3240

tgagctcatt tagtgcagac aaccttgcag ccactgatga tgataattaa atgaataatc   3300

tccaaattgc tgtggatagg atgcacaaag gagtagctta tgtgaaaaga aaaatatatg   3360

aatttattca acagtccttc attaggaaac aaaagatttt agatgaaatt aaaccacttg   3420

atgatctaaa caacaagaaa gacagttgta tgtccaatca tacaacagaa attgggaaag   3480

atcttgacta tcttaaagat gtaaatggaa ctacaagtgg tataggaact ggcagcagtg   3540

ttgaaaaata cattattgat gaaagtgatt acatgtcatt cataaacaac cccagtctta   3600

ctgtgactgt accaattgct gtaggagaat ctgactttga aaatttaaac acggaagact   3660

ttagtagtga atcggatctg gaagaaagca aagagaaact gaatgaaagc agtagctcat   3720

cagaaggtag cactgtggac atcggcgcac ctgtagaaga acagcccgta gtggaacctg   3780

aagaaactct tgaaccagaa gcttgtttca ctgaaggctg tgtacaaaga ttcaagtgtt   3840

gtcaaatcaa tgtggaagaa ggcagaggaa aacaatggtg gaacctgaga aggacgtgtt   3900

tccgaatagt tgaacataac tggtttgaga ccttcattgt tttcatgatt ctccttagta   3960

gtggtgctct ggcatttgaa gatatatata ttgatcagcg aaagacgatt aagacgatgt   4020

tggaatatgc tgacaaggtt ttcacttaca ttttcattct ggaaatgctt ctaaaatggg   4080

tggcatatgg ctatcaaaca tatttcacca atgcctggtg ttggctggac ttcttaattg   4140

ttgatgtttc attggtcagt ttaacagcaa atgccttggg ttactcagaa cttggagcca   4200

tcaaatctct caggacacta agagctctga gacctctaag agccttatct cgatttgaag   4260

ggatgagggt ggttgtgaat gcccttttag gagcaattcc atccatcatg aatgtgcttc   4320

tggtttgtct tatattctgg ctaattttca gcatcatggg cgtaaatttg tttgctggca   4380

aattctacca ctgtattaac accacaactg gtgacaggtt tgacatcgaa gacgtgaata   4440

atcatactga ttgcctaaaa ctaatagaaa gaaatgagac tgctcgatgg aaaaatgtga   4500

aagtaaactt tgataatgta ggatttgggt atctctcttt gcttcaagtt gccacattca   4560

aaggatggat ggatataatg tatgcagcag ttgattccag aaatgtggaa ctccagccta   4620

agtatgaaaa aagtctgtac atgtatcttt actttgttat tttcatcatc tttgggtcct   4680

tcttcacctt gaacctgttt attggtgtca tcatagataa tttcaaccag cagaaaaaga   4740

agtttggagg tcaagacatc tttatgacag aagaacagaa gaaatactat aatgcaatga   4800

aaaaattagg atcgaaaaaa ccgcaaaagc ctatacctcg accaggaaac aaatttcaag   4860

gaatggtctt tgacttcgta accagacaag tttttgacat aagcatcatg attctcatct   4920

gtcttaacat ggtcacaatg atggtggaaa cagatgacca gagtgaatat gtgactacca   4980

ttttgtcacg catcaatctg gtgttcattg tgctatttac tggagagtgt gtactgaaac   5040

tcatctctct acgccattat tattttacca ttggatggaa tatttttgat tttgtggttg   5100

tcattctctc cattgtaggt atgtttcttg ccgagctgat agaaaagtat ttcgtgtccc   5160

ctaccctgtt ccgagtgatc cgtcttgcta ggattggccg aatcctacgt ctgatcaaag   5220

gagcaaaggg gatccgcacg ctgctctttg ctttgatgat gtcccttcct gcgttgttta   5280

acatcggcct cctactcttc ctagtcatgt tcatctacgc catctttggg atgtccaact   5340

ttgcctatgt taagagggaa gttgggatcg atgacatgtt caactttgag acctttggca   5400

acagcatgat ctgcctattc caaattacaa cctctgctgg ctgggatgga ttgctagcac   5460

ccattctcaa cagtaagcca cccgactgtg accctaataa agttaaccct ggaagctcag   5520

ttaagggaga ctgtgggaac ccatctgttg gaattttctt ttttgtcagt tacatcatca   5580

tatccttcct ggttgtggtg aacatgtaca tcgcggtcat cctggagaac ttcagtgttg   5640

ctactgaaga aagtgcagag cctctgagtg aggatgactt tgagatgttc tatgaggttt   5700

gggagaagtt tgatcccgat gcaactcagt tcatggaatt tgaaaaatta tctcagtttg   5760

cagctgcgct tgaaccgcct ctcaatctgc cacaaccaaa caaactccag ctcattgcca   5820

tggatttgcc catggtgagt ggtgaccgga tccactgtct tgatatctta tttgctttta   5880

caaagcgggt tctaggagag agtggagaga tggatgctct acgaatacag atggaagagc   5940

gattcatggc ttccaatcct tccaaggtct cctatcagcc aatcactact actttaaaac   6000

gaaaacaaga ggaagtatct gctgtcatta ttcagcgtgc ttacagacgc caccttttaa   6060

agcgaactgt aaaacaagct tcctttacgt acaataaaaa caaaatcaaa ggtggggcta   6120

atcttcttat aaaagaagac atgataattg acagaataaa tgaaaactct attacagaaa   6180

aaactgatct gaccatgtcc actgcagctt gtccaccttc ctatgaccgg gtgacaaagc   6240

caattgtgga aaaacatgag caagaaggca aagatgaaaa agccaaaggg aaataaatga   6300

aaataaataa aaataattgg gtgacaaatt gtttacagcc tgtgaaggtg atgtattttt   6360

atcaacagga ctcctttagg aggtcaatgc caaactgact gtttttacac aaatctcctt   6420

aaggtcagtg cctacaataa gacagtgacc ccttgtcagc aaactgtgac tctgtgtaaa   6480

ggggagatga ccttgacagg aggttactgt tctcactacc agctgacact gctgaagata   6540

agatgcacaa tggctagtca gactgtaggg accagtttca aggggtgcaa acctgtgatt   6600

ttggggttgt ttaacatgaa acactttagt gtagtaattg tatccactgt ttgcatttca   6660

actgccacat ttgtcacatt tttatggaat ctgttagtgg attcatcttt ttgttaatcc   6720

atgtgtttat tatatgtgac tatttttgta aacgaagttt ctgttgagaa ataggctaag   6780

gacctctata acaggtatgc cacctggggg gtatggcaac cacatggccc tcccagctac   6840

acaaagtcgt ggtttgcatg agggcatgct gcacttagag atcatgcatg agaaaaagtc   6900

acaagaaaaa caaattctta aatttcacca tatttctggg aggggtaatt gggtgataag   6960

tggaggtgct ttgttgatct tgttttgcga aatccagccc ctagaccaag tagattattt   7020

gtgggtaggc cagtaaatct tagcaggtgc aaacttcatt caaatgtttg gagtcataaa   7080

tgttatgttt ctttttgttg tattaaaaaa aaaacctgaa tagtgaatat tgcccctcac   7140

cctccaccgc cagaagactg aattgaccaa aattactctt tataaatttc tgctttttcc   7200

tgcactttgt ttagccatct ttgggctctc agcaaggttg acactgtata tgttaatgaa   7260

atgctattta ttatgtaaat agtcatttta ccctgtggtg cacgtttgag caaacaaata   7320

atgacctaag cacagtattt attgcatcaa atatgtacca caagaaatgt agagtgcaag   7380

ctttacacag gtaataaaat gtattctgta ccatttatag atagtttgga tgctatcaat   7440

gcatgtttat attaccatgc tgctgtatct ggtttctctc actgctcaga atctcattta   7500

tgagaaacca tatgtcagtg gtaaagtcaa ggaaattgtt caacagatct catttattta   7560

agtcattaag caatagtttg cagcacttta acagcttttt ggttattttt acattttaag   7620

tggataacat atggtatata gccagactgt acagacatgt ttaaaaaaac acactgctta   7680

acctattaaa tatgtgttta gaattttata agcaaatata aatactgtaa aaagtcactt   7740

tattttattt ttcagcatta tgtacataaa tatgaagagg aaattatctt caggttgata   7800

tcacaatcac ttttcttact ttctgtccat agtacttttt catgaaagaa atttgctaaa   7860

taagacatga aaacaagact gggtagttgt agatttctgc tttttaaatt acatttgcta   7920

attttagatt atttcacaat tttaaggagc aaaataggtt cacgattcat atccaaatta   7980

tgctttgcaa ttggaaaagg gtttaaaatt ttatttatat ttctggtagt acctgtacta   8040

actgaattga aggtagtgct tatgttattt ttgttctttt tttctgactt cggtttatgt   8100

tttcatttct ttggagtaat gctgctctag attgttctaa atagaatgtg ggcttcataa   8160

tttttttttc cacaaaaaca gagtagtcaa cttatatagt caattacatc aggacatttt   8220

gtgtttctta cagaagcaaa ccataggctc ctcttttcct taaaactact tagataaact   8280

gtattcgtga actgcatgct ggaaaatgct actattatgc taaataatgc taaccaacat   8340

ttaaaatgtg caaaactaat aaagattaca ttttttattt t                       8381


<210>  23
<211>  8381
<212>  DNA
<213>  Homo sapiens

<400>  23
atactgcaga ggtctctggt gcatgtgtgt atgtgtgcgt ttgtgtgtgt ttgtgtgtct     60

gtgtgttctg ccccagtgag actgcagccc ttgtaaatac tttgacacct tttgcaagaa    120

ggaatctgaa caattgcaac tgaaggcaca ttgttatcat ctcgtctttg ggtgatgctg    180

ttcctcactg cagatggata attttccttt taatcaggaa tttcatatgc agaataaatg    240

gtaattaaaa tgtgcaggat gacaagatgg agcaaacagt gcttgtacca ccaggacctg    300

acagcttcaa cttcttcacc agagaatctc ttgcggctat tgaaagacgc attgcagaag    360

aaaaggcaaa gaatcccaaa ccagacaaaa aagatgacga cgaaaatggc ccaaagccaa    420

atagtgactt ggaagctgga aagaaccttc catttattta tggagacatt cctccagaga    480

tggtgtcaga gcccctggag gacctggacc cctactatat caataagaaa acttttatag    540

tattgaataa attgaaggcc atcttccggt tcagtgccac ctctgccctg tacattttaa    600

ctcccttcaa tcctcttagg aaaatagcta ttaagatttt ggtacattca ttattcagca    660

tgctaattat gtgcactatt ttgacaaact gtgtgtttat gacaatgagt aaccctcctg    720

attggacaaa gaatgtagaa tacaccttca caggaatata tacttttgaa tcacttataa    780

aaattattgc aaggggattc tgtttagaag attttacttt ccttcgggat ccatggaact    840

ggctcgattt cactgtcatt acatttgcgt acgtcacaga gtttgtggac ctgggcaatg    900

tctcggcatt gagaacattc agagttctcc gagcattgaa gacgatttca gtcattccag    960

gcctgaaaac cattgtggga gccctgatcc agtctgtgaa gaagctctca gatgtaatga   1020

tcctgactgt gttctgtctg agcgtatttg ctctaattgg gctgcagctg ttcatgggca   1080

acctgaggaa taaatgtata caatggcctc ccaccaatgc ttccttggag gaacatagta   1140

tagaaaagaa tataactgtg aattataatg gtacacttat aaatgaaact gtctttgagt   1200

ttgactggaa gtcatatatt caagattcaa gatatcatta tttcctggag ggttttttag   1260

atgcactact atgtggaaat agctctgatg caggccaatg tccagaggga tatatgtgtg   1320

tgaaagctgg tagaaatccc aattatggct acacaagctt tgataccttc agttgggctt   1380

ttttgtcctt gtttcgacta atgactcagg acttctggga aaatctttat caactgacat   1440

tacgtgctgc tgggaaaacg tacatgatat tttttgtatt ggtcattttc ttgggctcat   1500

tctacctaat aaatttgatc ctggctgtgg tggccatggc ctacgaggaa cagaatcagg   1560

ccaccttgga agaagcagaa cagaaagagg ccgaatttca gcagatgatt gaacagctta   1620

aaaagcaaca ggaggcagct cagcaggcag caacggcaac tgcctcagaa cattccagag   1680

agcccagtgc agcaggcagg ctctcagaca gctcatctga agcctctaag ttgagttcca   1740

agagtgctaa ggaaagaaga aatcggagga agaaaagaaa acagaaagag cagtctggtg   1800

gggaagagaa agatgaggat gaattccaaa aatctgaatc tgaggacagc atcaggagga   1860

aaggttttcg cttctccatt gaagggaacc gattgacata tgaaaagagg tactcctccc   1920

cacaccagtc tttgttgagc atccgtggct ccctattttc accaaggcga aatagcagaa   1980

caagcctttt cagctttaga gggcgagcaa aggatgtggg atctgagaac gacttcgcag   2040

atgatgagca cagcaccttt gaggataacg agagccgtag agattccttg tttgtgcccc   2100

gacgacacgg agagagacgc aacagcaacc tgagtcagac cagtaggtca tcccggatgc   2160

tggcagtgtt tccagcgaat gggaagatgc acagcactgt ggattgcaat ggtgtggttt   2220

ccttggttgg tggaccttca gttcctacat cgcctgttgg acagcttctg ccagaggtga   2280

taatagataa gccagctact gatgacaatg gaacaaccac tgaaactgaa atgagaaaga   2340

gaaggtcaag ttctttccac gtttccatgg actttctaga agatccttcc caaaggcaac   2400

gagcaatgag tatagccagc attctaacaa atacagtaga agaacttgaa gaatccaggc   2460

agaaatgccc accctgttgg tataaatttt ccaacatatt cttaatctgg gactgttctc   2520

catattggtt aaaagtgaaa catgttgtca acctggttgt gatggaccca tttgttgacc   2580

tggccatcac catctgtatt gtcttaaata ctcttttcat ggccatggag cactatccaa   2640

tgacggacca tttcaataat gtgcttacag taggaaactt ggttttcact gggatcttta   2700

cagcagaaat gtttctgaaa attattgcca tggatcctta ctattatttc caagaaggct   2760

ggaatatctt tgacggtttt attgtgacgc ttagcctggt agaacttgga ctcgccaatg   2820

tggaaggatt atctgttctc cgttcatttc gattgctgcg agttttcaag ttggcaaaat   2880

cttggccaac gttaaatatg ctaataaaga tcatcggcaa ttccgtgggg gctctgggaa   2940

atttaaccct cgtcttggcc atcatcgtct tcatttttgc cgtggtcggc atgcagctct   3000

ttggtaaaag ctacaaagat tgtgtctgca agatcgccag tgattgtcaa ctcccacgct   3060

ggcacatgaa tgacttcttc cactccttcc tgattgtgtt ccgcgtgctg tgtggggagt   3120

ggatagagac catgtgggac tgtatggagg ttgctggtca agccatgtgc cttactgtct   3180

tcatgatggt catggtgatt ggaaacctag tggtcctgaa tctctttctg gccttgcttc   3240

tgagctcatt tagtgcagac aaccttgcag ccactgatga tgataatgaa atgaataatc   3300

tccaaattgc tgtggatagg atgcacaaag gagtagctta tgtgaaaaga aaaatatatg   3360

aatttattca acagtccttc attaggaaac aaaagatttt agatgaaatt aaaccacttg   3420

atgatctaaa caacaagaaa gacagttgta tgtccaatca tacaacagaa attgggaaag   3480

atcttgacta tcttaaagat gtaaatggaa ctacaagtgg tataggaact ggcagcagtg   3540

ttgaaaaata cattattgat gaaagtgatt acatgtcatt cataaacaac cccagtctta   3600

ctgtgactgt accaattgct gtaggagaat ctgactttga aaatttaaac acggaagact   3660

ttagtagtga atcggatctg gaagaaagca aagagaaact gaatgaaagc agtagctcat   3720

cagaaggtag cactgtggac atcggcgcac ctgtagaaga acagcccgta gtggaacctg   3780

aagaaactct tgaaccagaa gcttgtttca ctgaaggctg tgtacaaaga ttcaagtgtt   3840

gtcaaatcaa tgtggaagaa ggcagaggaa aacaatggtg gaacctgaga aggacgtgtt   3900

tccgaatagt tgaacataac tggtttgaga ccttcattgt tttcatgatt ctccttagta   3960

gtggtgctct ggcatttgaa gatatatata ttgatcagcg aaagacgatt aagacgatgt   4020

tggaatatgc tgacaaggtt ttcacttaca ttttcattct ggaaatgctt ctaaaatggg   4080

tggcatatgg ctatcaaaca tatttcacca atgcctggtg ttggctggac ttcttaattg   4140

ttgatgtttc attggtcagt ttaacagcaa atgccttggg ttactcagaa cttggagcca   4200

tcaaatctct caggacacta agagctctga gacctctaag agccttatct cgatttgaag   4260

ggatgagggt ggttgtgaat gcccttttag gagcaattcc atccatcatg aatgtgcttc   4320

tggtttgtct tatattctgg ctaattttca gcatcatggg cgtaaatttg tttgctggca   4380

aattctacca ctgtattaac accacaactg gtgacaggtt tgacatcgaa gacgtgaata   4440

atcatactga ttgcctaaaa ctaatagaaa gaaatgagac tgctcgatgg aaaaatgtga   4500

aagtaaactt tgataatgta ggatttgggt atctctcttt gctttaagtt gccacattca   4560

aaggatggat ggatataatg tatgcagcag ttgattccag aaatgtggaa ctccagccta   4620

agtatgaaaa aagtctgtac atgtatcttt actttgttat tttcatcatc tttgggtcct   4680

tcttcacctt gaacctgttt attggtgtca tcatagataa tttcaaccag cagaaaaaga   4740

agtttggagg tcaagacatc tttatgacag aagaacagaa gaaatactat aatgcaatga   4800

aaaaattagg atcgaaaaaa ccgcaaaagc ctatacctcg accaggaaac aaatttcaag   4860

gaatggtctt tgacttcgta accagacaag tttttgacat aagcatcatg attctcatct   4920

gtcttaacat ggtcacaatg atggtggaaa cagatgacca gagtgaatat gtgactacca   4980

ttttgtcacg catcaatctg gtgttcattg tgctatttac tggagagtgt gtactgaaac   5040

tcatctctct acgccattat tattttacca ttggatggaa tatttttgat tttgtggttg   5100

tcattctctc cattgtaggt atgtttcttg ccgagctgat agaaaagtat ttcgtgtccc   5160

ctaccctgtt ccgagtgatc cgtcttgcta ggattggccg aatcctacgt ctgatcaaag   5220

gagcaaaggg gatccgcacg ctgctctttg ctttgatgat gtcccttcct gcgttgttta   5280

acatcggcct cctactcttc ctagtcatgt tcatctacgc catctttggg atgtccaact   5340

ttgcctatgt taagagggaa gttgggatcg atgacatgtt caactttgag acctttggca   5400

acagcatgat ctgcctattc caaattacaa cctctgctgg ctgggatgga ttgctagcac   5460

ccattctcaa cagtaagcca cccgactgtg accctaataa agttaaccct ggaagctcag   5520

ttaagggaga ctgtgggaac ccatctgttg gaattttctt ttttgtcagt tacatcatca   5580

tatccttcct ggttgtggtg aacatgtaca tcgcggtcat cctggagaac ttcagtgttg   5640

ctactgaaga aagtgcagag cctctgagtg aggatgactt tgagatgttc tatgaggttt   5700

gggagaagtt tgatcccgat gcaactcagt tcatggaatt tgaaaaatta tctcagtttg   5760

cagctgcgct tgaaccgcct ctcaatctgc cacaaccaaa caaactccag ctcattgcca   5820

tggatttgcc catggtgagt ggtgaccgga tccactgtct tgatatctta tttgctttta   5880

caaagcgggt tctaggagag agtggagaga tggatgctct acgaatacag atggaagagc   5940

gattcatggc ttccaatcct tccaaggtct cctatcagcc aatcactact actttaaaac   6000

gaaaacaaga ggaagtatct gctgtcatta ttcagcgtgc ttacagacgc caccttttaa   6060

agcgaactgt aaaacaagct tcctttacgt acaataaaaa caaaatcaaa ggtggggcta   6120

atcttcttat aaaagaagac atgataattg acagaataaa tgaaaactct attacagaaa   6180

aaactgatct gaccatgtcc actgcagctt gtccaccttc ctatgaccgg gtgacaaagc   6240

caattgtgga aaaacatgag caagaaggca aagatgaaaa agccaaaggg aaataaatga   6300

aaataaataa aaataattgg gtgacaaatt gtttacagcc tgtgaaggtg atgtattttt   6360

atcaacagga ctcctttagg aggtcaatgc caaactgact gtttttacac aaatctcctt   6420

aaggtcagtg cctacaataa gacagtgacc ccttgtcagc aaactgtgac tctgtgtaaa   6480

ggggagatga ccttgacagg aggttactgt tctcactacc agctgacact gctgaagata   6540

agatgcacaa tggctagtca gactgtaggg accagtttca aggggtgcaa acctgtgatt   6600

ttggggttgt ttaacatgaa acactttagt gtagtaattg tatccactgt ttgcatttca   6660

actgccacat ttgtcacatt tttatggaat ctgttagtgg attcatcttt ttgttaatcc   6720

atgtgtttat tatatgtgac tatttttgta aacgaagttt ctgttgagaa ataggctaag   6780

gacctctata acaggtatgc cacctggggg gtatggcaac cacatggccc tcccagctac   6840

acaaagtcgt ggtttgcatg agggcatgct gcacttagag atcatgcatg agaaaaagtc   6900

acaagaaaaa caaattctta aatttcacca tatttctggg aggggtaatt gggtgataag   6960

tggaggtgct ttgttgatct tgttttgcga aatccagccc ctagaccaag tagattattt   7020

gtgggtaggc cagtaaatct tagcaggtgc aaacttcatt caaatgtttg gagtcataaa   7080

tgttatgttt ctttttgttg tattaaaaaa aaaacctgaa tagtgaatat tgcccctcac   7140

cctccaccgc cagaagactg aattgaccaa aattactctt tataaatttc tgctttttcc   7200

tgcactttgt ttagccatct ttgggctctc agcaaggttg acactgtata tgttaatgaa   7260

atgctattta ttatgtaaat agtcatttta ccctgtggtg cacgtttgag caaacaaata   7320

atgacctaag cacagtattt attgcatcaa atatgtacca caagaaatgt agagtgcaag   7380

ctttacacag gtaataaaat gtattctgta ccatttatag atagtttgga tgctatcaat   7440

gcatgtttat attaccatgc tgctgtatct ggtttctctc actgctcaga atctcattta   7500

tgagaaacca tatgtcagtg gtaaagtcaa ggaaattgtt caacagatct catttattta   7560

agtcattaag caatagtttg cagcacttta acagcttttt ggttattttt acattttaag   7620

tggataacat atggtatata gccagactgt acagacatgt ttaaaaaaac acactgctta   7680

acctattaaa tatgtgttta gaattttata agcaaatata aatactgtaa aaagtcactt   7740

tattttattt ttcagcatta tgtacataaa tatgaagagg aaattatctt caggttgata   7800

tcacaatcac ttttcttact ttctgtccat agtacttttt catgaaagaa atttgctaaa   7860

taagacatga aaacaagact gggtagttgt agatttctgc tttttaaatt acatttgcta   7920

attttagatt atttcacaat tttaaggagc aaaataggtt cacgattcat atccaaatta   7980

tgctttgcaa ttggaaaagg gtttaaaatt ttatttatat ttctggtagt acctgtacta   8040

actgaattga aggtagtgct tatgttattt ttgttctttt tttctgactt cggtttatgt   8100

tttcatttct ttggagtaat gctgctctag attgttctaa atagaatgtg ggcttcataa   8160

tttttttttc cacaaaaaca gagtagtcaa cttatatagt caattacatc aggacatttt   8220

gtgtttctta cagaagcaaa ccataggctc ctcttttcct taaaactact tagataaact   8280

gtattcgtga actgcatgct ggaaaatgct actattatgc taaataatgc taaccaacat   8340

ttaaaatgtg caaaactaat aaagattaca ttttttattt t                       8381


<210>  24
<211>  229
<212>  DNA
<213>  Homo sapiens

<400>  24
atacaccttc acaggaatat atacttttga atcacttata aaaattattg caaggggatt     60

ctgtttagaa gattttactt tccttcggga tccatggaac tggctcgatt tcactgtcat    120

tacatttgcg taaatgcctt ttttgaaact ttaagagaga acatagtttg gttttccatc    180

agtgcttatg cttttaagaa taggtttgct ttacctgtag aatattttg                229


<210>  25
<211>  229
<212>  DNA
<213>  Homo sapiens

<400>  25
tttttagtat ttatctattc cactgatgga gtgataagaa attggtatgc tatgaaaaaa     60

cactgttact ttatcaaatt ttttggaagc ttgttttcag atacaccttc acaggaatat    120

atacttttga atcacttata aaaattattg caaggggatt ctgtttagaa gattttactt    180

tccttcggga tccatggaac tggctcgatt tcactgtcat tacatttgc                229


<210>  26
<211>  2009
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Glu Gln Thr Val Leu Val Pro Pro Gly Pro Asp Ser Phe Asn Phe 
1               5                   10                  15      


Phe Thr Arg Glu Ser Leu Ala Ala Ile Glu Arg Arg Ile Ala Glu Glu 
            20                  25                  30          


Lys Ala Lys Asn Pro Lys Pro Asp Lys Lys Asp Asp Asp Glu Asn Gly 
        35                  40                  45              


Pro Lys Pro Asn Ser Asp Leu Glu Ala Gly Lys Asn Leu Pro Phe Ile 
    50                  55                  60                  


Tyr Gly Asp Ile Pro Pro Glu Met Val Ser Glu Pro Leu Glu Asp Leu 
65                  70                  75                  80  


Asp Pro Tyr Cys Ile Asn Lys Lys Thr Phe Ile Val Leu Asn Lys Leu 
                85                  90                  95      


Lys Ala Ile Phe Arg Phe Ser Ala Thr Ser Ala Leu Tyr Ile Leu Thr 
            100                 105                 110         


Pro Phe Asn Pro Leu Arg Lys Ile Ala Ile Lys Ile Leu Val His Ser 
        115                 120                 125             


Leu Phe Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Val Phe 
    130                 135                 140                 


Met Thr Met Ser Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr Thr 
145                 150                 155                 160 


Phe Thr Gly Ile Tyr Thr Phe Glu Ser Leu Ile Lys Ile Ile Ala Arg 
                165                 170                 175     


Gly Phe Cys Leu Glu Asp Phe Thr Phe Leu Arg Asp Pro Trp Asn Trp 
            180                 185                 190         


Leu Asp Phe Thr Val Ile Thr Phe Ala Tyr Val Thr Glu Phe Val Asp 
        195                 200                 205             


Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala Leu 
    210                 215                 220                 


Lys Thr Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu 
225                 230                 235                 240 


Ile Gln Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val Phe 
                245                 250                 255     


Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly Asn 
            260                 265                 270         


Leu Arg Asn Lys Cys Ile Gln Trp Pro Pro Thr Asn Ala Ser Leu Glu 
        275                 280                 285             


Glu His Ser Ile Glu Lys Asn Ile Thr Val Asn Tyr Asn Gly Thr Leu 
    290                 295                 300                 


Ile Asn Glu Thr Val Phe Glu Phe Asp Trp Lys Ser Tyr Ile Gln Asp 
305                 310                 315                 320 


Ser Arg Tyr His Tyr Phe Leu Glu Gly Phe Leu Asp Ala Leu Leu Cys 
                325                 330                 335     


Gly Asn Ser Ser Asp Ala Gly Gln Cys Pro Glu Gly Tyr Met Cys Val 
            340                 345                 350         


Lys Ala Gly Arg Asn Pro Asn Tyr Gly Tyr Thr Ser Phe Asp Thr Phe 
        355                 360                 365             


Ser Trp Ala Phe Leu Ser Leu Phe Arg Leu Met Thr Gln Asp Phe Trp 
    370                 375                 380                 


Glu Asn Leu Tyr Gln Leu Thr Leu Arg Ala Ala Gly Lys Thr Tyr Met 
385                 390                 395                 400 


Ile Phe Phe Val Leu Val Ile Phe Leu Gly Ser Phe Tyr Leu Ile Asn 
                405                 410                 415     


Leu Ile Leu Ala Val Val Ala Met Ala Tyr Glu Glu Gln Asn Gln Ala 
            420                 425                 430         


Thr Leu Glu Glu Ala Glu Gln Lys Glu Ala Glu Phe Gln Gln Met Ile 
        435                 440                 445             


Glu Gln Leu Lys Lys Gln Gln Glu Ala Ala Gln Gln Ala Ala Thr Ala 
    450                 455                 460                 


Thr Ala Ser Glu His Ser Arg Glu Pro Ser Ala Ala Gly Arg Leu Ser 
465                 470                 475                 480 


Asp Ser Ser Ser Glu Ala Ser Lys Leu Ser Ser Lys Ser Ala Lys Glu 
                485                 490                 495     


Arg Arg Asn Arg Arg Lys Lys Arg Lys Gln Lys Glu Gln Ser Gly Gly 
            500                 505                 510         


Glu Glu Lys Asp Glu Asp Glu Phe Gln Lys Ser Glu Ser Glu Asp Ser 
        515                 520                 525             


Ile Arg Arg Lys Gly Phe Arg Phe Ser Ile Glu Gly Asn Arg Leu Thr 
    530                 535                 540                 


Tyr Glu Lys Arg Tyr Ser Ser Pro His Gln Ser Leu Leu Ser Ile Arg 
545                 550                 555                 560 


Gly Ser Leu Phe Ser Pro Arg Arg Asn Ser Arg Thr Ser Leu Phe Ser 
                565                 570                 575     


Phe Arg Gly Arg Ala Lys Asp Val Gly Ser Glu Asn Asp Phe Ala Asp 
            580                 585                 590         


Asp Glu His Ser Thr Phe Glu Asp Asn Glu Ser Arg Arg Asp Ser Leu 
        595                 600                 605             


Phe Val Pro Arg Arg His Gly Glu Arg Arg Asn Ser Asn Leu Ser Gln 
    610                 615                 620                 


Thr Ser Arg Ser Ser Arg Met Leu Ala Val Phe Pro Ala Asn Gly Lys 
625                 630                 635                 640 


Met His Ser Thr Val Asp Cys Asn Gly Val Val Ser Leu Val Gly Gly 
                645                 650                 655     


Pro Ser Val Pro Thr Ser Pro Val Gly Gln Leu Leu Pro Glu Val Ile 
            660                 665                 670         


Ile Asp Lys Pro Ala Thr Asp Asp Asn Gly Thr Thr Thr Glu Thr Glu 
        675                 680                 685             


Met Arg Lys Arg Arg Ser Ser Ser Phe His Val Ser Met Asp Phe Leu 
    690                 695                 700                 


Glu Asp Pro Ser Gln Arg Gln Arg Ala Met Ser Ile Ala Ser Ile Leu 
705                 710                 715                 720 


Thr Asn Thr Val Glu Glu Leu Glu Glu Ser Arg Gln Lys Cys Pro Pro 
                725                 730                 735     


Cys Trp Tyr Lys Phe Ser Asn Ile Phe Leu Ile Trp Asp Cys Ser Pro 
            740                 745                 750         


Tyr Trp Leu Lys Val Lys His Val Val Asn Leu Val Val Met Asp Pro 
        755                 760                 765             


Phe Val Asp Leu Ala Ile Thr Ile Cys Ile Val Leu Asn Thr Leu Phe 
    770                 775                 780                 


Met Ala Met Glu His Tyr Pro Met Thr Asp His Phe Asn Asn Val Leu 
785                 790                 795                 800 


Thr Val Gly Asn Leu Val Phe Thr Gly Ile Phe Thr Ala Glu Met Phe 
                805                 810                 815     


Leu Lys Ile Ile Ala Met Asp Pro Tyr Tyr Tyr Phe Gln Glu Gly Trp 
            820                 825                 830         


Asn Ile Phe Asp Gly Phe Ile Val Thr Leu Ser Leu Val Glu Leu Gly 
        835                 840                 845             


Leu Ala Asn Val Glu Gly Leu Ser Val Leu Arg Ser Phe Arg Leu Leu 
    850                 855                 860                 


Arg Val Phe Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Met Leu Ile 
865                 870                 875                 880 


Lys Ile Ile Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr Leu Val 
                885                 890                 895     


Leu Ala Ile Ile Val Phe Ile Phe Ala Val Val Gly Met Gln Leu Phe 
            900                 905                 910         


Gly Lys Ser Tyr Lys Asp Cys Val Cys Lys Ile Ala Ser Asp Cys Gln 
        915                 920                 925             


Leu Pro Arg Trp His Met Asn Asp Phe Phe His Ser Phe Leu Ile Val 
    930                 935                 940                 


Phe Arg Val Leu Cys Gly Glu Trp Ile Glu Thr Met Trp Asp Cys Met 
945                 950                 955                 960 


Glu Val Ala Gly Gln Ala Met Cys Leu Thr Val Phe Met Met Val Met 
                965                 970                 975     


Val Ile Gly Asn Leu Val Val Leu Asn Leu Phe Leu Ala Leu Leu Leu 
            980                 985                 990         


Ser Ser Phe Ser Ala Asp Asn Leu  Ala Ala Thr Asp Asp  Asp Asn Glu 
        995                 1000                 1005             


Met Asn  Asn Leu Gln Ile Ala  Val Asp Arg Met His  Lys Gly Val 
    1010                 1015                 1020             


Ala Tyr  Val Lys Arg Lys Ile  Tyr Glu Phe Ile Gln  Gln Ser Phe 
    1025                 1030                 1035             


Ile Arg  Lys Gln Lys Ile Leu  Asp Glu Ile Lys Pro  Leu Asp Asp 
    1040                 1045                 1050             


Leu Asn  Asn Lys Lys Asp Ser  Cys Met Ser Asn His  Thr Thr Glu 
    1055                 1060                 1065             


Ile Gly  Lys Asp Leu Asp Tyr  Leu Lys Asp Val Asn  Gly Thr Thr 
    1070                 1075                 1080             


Ser Gly  Ile Gly Thr Gly Ser  Ser Val Glu Lys Tyr  Ile Ile Asp 
    1085                 1090                 1095             


Glu Ser  Asp Tyr Met Ser Phe  Ile Asn Asn Pro Ser  Leu Thr Val 
    1100                 1105                 1110             


Thr Val  Pro Ile Ala Val Gly  Glu Ser Asp Phe Glu  Asn Leu Asn 
    1115                 1120                 1125             


Thr Glu  Asp Phe Ser Ser Glu  Ser Asp Leu Glu Glu  Ser Lys Glu 
    1130                 1135                 1140             


Lys Leu  Asn Glu Ser Ser Ser  Ser Ser Glu Gly Ser  Thr Val Asp 
    1145                 1150                 1155             


Ile Gly  Ala Pro Val Glu Glu  Gln Pro Val Val Glu  Pro Glu Glu 
    1160                 1165                 1170             


Thr Leu  Glu Pro Glu Ala Cys  Phe Thr Glu Gly Cys  Val Gln Arg 
    1175                 1180                 1185             


Phe Lys  Cys Cys Gln Ile Asn  Val Glu Glu Gly Arg  Gly Lys Gln 
    1190                 1195                 1200             


Trp Trp  Asn Leu Arg Arg Thr  Cys Phe Arg Ile Val  Glu His Asn 
    1205                 1210                 1215             


Trp Phe  Glu Thr Phe Ile Val  Phe Met Ile Leu Leu  Ser Ser Gly 
    1220                 1225                 1230             


Ala Leu  Ala Phe Glu Asp Ile  Tyr Ile Asp Gln Arg  Lys Thr Ile 
    1235                 1240                 1245             


Lys Thr  Met Leu Glu Tyr Ala  Asp Lys Val Phe Thr  Tyr Ile Phe 
    1250                 1255                 1260             


Ile Leu  Glu Met Leu Leu Lys  Trp Val Ala Tyr Gly  Tyr Gln Thr 
    1265                 1270                 1275             


Tyr Phe  Thr Asn Ala Trp Cys  Trp Leu Asp Phe Leu  Ile Val Asp 
    1280                 1285                 1290             


Val Ser  Leu Val Ser Leu Thr  Ala Asn Ala Leu Gly  Tyr Ser Glu 
    1295                 1300                 1305             


Leu Gly  Ala Ile Lys Ser Leu  Arg Thr Leu Arg Ala  Leu Arg Pro 
    1310                 1315                 1320             


Leu Arg  Ala Leu Ser Arg Phe  Glu Gly Met Arg Val  Val Val Asn 
    1325                 1330                 1335             


Ala Leu  Leu Gly Ala Ile Pro  Ser Ile Met Asn Val  Leu Leu Val 
    1340                 1345                 1350             


Cys Leu  Ile Phe Trp Leu Ile  Phe Ser Ile Met Gly  Val Asn Leu 
    1355                 1360                 1365             


Phe Ala  Gly Lys Phe Tyr His  Cys Ile Asn Thr Thr  Thr Gly Asp 
    1370                 1375                 1380             


Arg Phe  Asp Ile Glu Asp Val  Asn Asn His Thr Asp  Cys Leu Lys 
    1385                 1390                 1395             


Leu Ile  Glu Arg Asn Glu Thr  Ala Arg Trp Lys Asn  Val Lys Val 
    1400                 1405                 1410             


Asn Phe  Asp Asn Val Gly Phe  Gly Tyr Leu Ser Leu  Leu Gln Val 
    1415                 1420                 1425             


Ala Thr  Phe Lys Gly Trp Met  Asp Ile Met Tyr Ala  Ala Val Asp 
    1430                 1435                 1440             


Ser Arg  Asn Val Glu Leu Gln  Pro Lys Tyr Glu Lys  Ser Leu Tyr 
    1445                 1450                 1455             


Met Tyr  Leu Tyr Phe Val Ile  Phe Ile Ile Phe Gly  Ser Phe Phe 
    1460                 1465                 1470             


Thr Leu  Asn Leu Phe Ile Gly  Val Ile Ile Asp Asn  Phe Asn Gln 
    1475                 1480                 1485             


Gln Lys  Lys Lys Phe Gly Gly  Gln Asp Ile Phe Met  Thr Glu Glu 
    1490                 1495                 1500             


Gln Lys  Lys Tyr Tyr Asn Ala  Met Lys Lys Leu Gly  Ser Lys Lys 
    1505                 1510                 1515             


Pro Gln  Lys Pro Ile Pro Arg  Pro Gly Asn Lys Phe  Gln Gly Met 
    1520                 1525                 1530             


Val Phe  Asp Phe Val Thr Arg  Gln Val Phe Asp Ile  Ser Ile Met 
    1535                 1540                 1545             


Ile Leu  Ile Cys Leu Asn Met  Val Thr Met Met Val  Glu Thr Asp 
    1550                 1555                 1560             


Asp Gln  Ser Glu Tyr Val Thr  Thr Ile Leu Ser Arg  Ile Asn Leu 
    1565                 1570                 1575             


Val Phe  Ile Val Leu Phe Thr  Gly Glu Cys Val Leu  Lys Leu Ile 
    1580                 1585                 1590             


Ser Leu  Arg His Tyr Tyr Phe  Thr Ile Gly Trp Asn  Ile Phe Asp 
    1595                 1600                 1605             


Phe Val  Val Val Ile Leu Ser  Ile Val Gly Met Phe  Leu Ala Glu 
    1610                 1615                 1620             


Leu Ile  Glu Lys Tyr Phe Val  Ser Pro Thr Leu Phe  Arg Val Ile 
    1625                 1630                 1635             


Arg Leu  Ala Arg Ile Gly Arg  Ile Leu Arg Leu Ile  Lys Gly Ala 
    1640                 1645                 1650             


Lys Gly  Ile Arg Thr Leu Leu  Phe Ala Leu Met Met  Ser Leu Pro 
    1655                 1660                 1665             


Ala Leu  Phe Asn Ile Gly Leu  Leu Leu Phe Leu Val  Met Phe Ile 
    1670                 1675                 1680             


Tyr Ala  Ile Phe Gly Met Ser  Asn Phe Ala Tyr Val  Lys Arg Glu 
    1685                 1690                 1695             


Val Gly  Ile Asp Asp Met Phe  Asn Phe Glu Thr Phe  Gly Asn Ser 
    1700                 1705                 1710             


Met Ile  Cys Leu Phe Gln Ile  Thr Thr Ser Ala Gly  Trp Asp Gly 
    1715                 1720                 1725             


Leu Leu  Ala Pro Ile Leu Asn  Ser Lys Pro Pro Asp  Cys Asp Pro 
    1730                 1735                 1740             


Asn Lys  Val Asn Pro Gly Ser  Ser Val Lys Gly Asp  Cys Gly Asn 
    1745                 1750                 1755             


Pro Ser  Val Gly Ile Phe Phe  Phe Val Ser Tyr Ile  Ile Ile Ser 
    1760                 1765                 1770             


Phe Leu  Val Val Val Asn Met  Tyr Ile Ala Val Ile  Leu Glu Asn 
    1775                 1780                 1785             


Phe Ser  Val Ala Thr Glu Glu  Ser Ala Glu Pro Leu  Ser Glu Asp 
    1790                 1795                 1800             


Asp Phe  Glu Met Phe Tyr Glu  Val Trp Glu Lys Phe  Asp Pro Asp 
    1805                 1810                 1815             


Ala Thr  Gln Phe Met Glu Phe  Glu Lys Leu Ser Gln  Phe Ala Ala 
    1820                 1825                 1830             


Ala Leu  Glu Pro Pro Leu Asn  Leu Pro Gln Pro Asn  Lys Leu Gln 
    1835                 1840                 1845             


Leu Ile  Ala Met Asp Leu Pro  Met Val Ser Gly Asp  Arg Ile His 
    1850                 1855                 1860             


Cys Leu  Asp Ile Leu Phe Ala  Phe Thr Lys Arg Val  Leu Gly Glu 
    1865                 1870                 1875             


Ser Gly  Glu Met Asp Ala Leu  Arg Ile Gln Met Glu  Glu Arg Phe 
    1880                 1885                 1890             


Met Ala  Ser Asn Pro Ser Lys  Val Ser Tyr Gln Pro  Ile Thr Thr 
    1895                 1900                 1905             


Thr Leu  Lys Arg Lys Gln Glu  Glu Val Ser Ala Val  Ile Ile Gln 
    1910                 1915                 1920             


Arg Ala  Tyr Arg Arg His Leu  Leu Lys Arg Thr Val  Lys Gln Ala 
    1925                 1930                 1935             


Ser Phe  Thr Tyr Asn Lys Asn  Lys Ile Lys Gly Gly  Ala Asn Leu 
    1940                 1945                 1950             


Leu Ile  Lys Glu Asp Met Ile  Ile Asp Arg Ile Asn  Glu Asn Ser 
    1955                 1960                 1965             


Ile Thr  Glu Lys Thr Asp Leu  Thr Met Ser Thr Ala  Ala Cys Pro 
    1970                 1975                 1980             


Pro Ser  Tyr Asp Arg Val Thr  Lys Pro Ile Val Glu  Lys His Glu 
    1985                 1990                 1995             


Gln Glu  Gly Lys Asp Glu Lys  Ala Lys Gly Lys 
    2000                 2005                 


<210>  27
<211>  2009
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Glu Gln Thr Val Leu Val Pro Pro Gly Pro Asp Ser Phe Asn Phe 
1               5                   10                  15      


Phe Thr Arg Glu Ser Leu Ala Ala Ile Glu Arg Arg Ile Ala Glu Glu 
            20                  25                  30          


Lys Ala Lys Asn Pro Lys Pro Asp Lys Lys Asp Asp Asp Glu Asn Gly 
        35                  40                  45              


Pro Lys Pro Asn Ser Asp Leu Glu Ala Gly Lys Asn Leu Pro Phe Ile 
    50                  55                  60                  


Tyr Gly Asp Ile Pro Pro Glu Met Val Ser Glu Pro Leu Glu Asp Leu 
65                  70                  75                  80  


Asp Pro Tyr Tyr Ile Asn Lys Lys Thr Phe Ile Val Leu Asn Lys Leu 
                85                  90                  95      


Lys Ala Ile Phe Trp Phe Ser Ala Thr Ser Ala Leu Tyr Ile Leu Thr 
            100                 105                 110         


Pro Phe Asn Pro Leu Arg Lys Ile Ala Ile Lys Ile Leu Val His Ser 
        115                 120                 125             


Leu Phe Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Val Phe 
    130                 135                 140                 


Met Thr Met Ser Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr Thr 
145                 150                 155                 160 


Phe Thr Gly Ile Tyr Thr Phe Glu Ser Leu Ile Lys Ile Ile Ala Arg 
                165                 170                 175     


Gly Phe Cys Leu Glu Asp Phe Thr Phe Leu Arg Asp Pro Trp Asn Trp 
            180                 185                 190         


Leu Asp Phe Thr Val Ile Thr Phe Ala Tyr Val Thr Glu Phe Val Asp 
        195                 200                 205             


Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala Leu 
    210                 215                 220                 


Lys Thr Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu 
225                 230                 235                 240 


Ile Gln Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val Phe 
                245                 250                 255     


Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly Asn 
            260                 265                 270         


Leu Arg Asn Lys Cys Ile Gln Trp Pro Pro Thr Asn Ala Ser Leu Glu 
        275                 280                 285             


Glu His Ser Ile Glu Lys Asn Ile Thr Val Asn Tyr Asn Gly Thr Leu 
    290                 295                 300                 


Ile Asn Glu Thr Val Phe Glu Phe Asp Trp Lys Ser Tyr Ile Gln Asp 
305                 310                 315                 320 


Ser Arg Tyr His Tyr Phe Leu Glu Gly Phe Leu Asp Ala Leu Leu Cys 
                325                 330                 335     


Gly Asn Ser Ser Asp Ala Gly Gln Cys Pro Glu Gly Tyr Met Cys Val 
            340                 345                 350         


Lys Ala Gly Arg Asn Pro Asn Tyr Gly Tyr Thr Ser Phe Asp Thr Phe 
        355                 360                 365             


Ser Trp Ala Phe Leu Ser Leu Phe Arg Leu Met Thr Gln Asp Phe Trp 
    370                 375                 380                 


Glu Asn Leu Tyr Gln Leu Thr Leu Arg Ala Ala Gly Lys Thr Tyr Met 
385                 390                 395                 400 


Ile Phe Phe Val Leu Val Ile Phe Leu Gly Ser Phe Tyr Leu Ile Asn 
                405                 410                 415     


Leu Ile Leu Ala Val Val Ala Met Ala Tyr Glu Glu Gln Asn Gln Ala 
            420                 425                 430         


Thr Leu Glu Glu Ala Glu Gln Lys Glu Ala Glu Phe Gln Gln Met Ile 
        435                 440                 445             


Glu Gln Leu Lys Lys Gln Gln Glu Ala Ala Gln Gln Ala Ala Thr Ala 
    450                 455                 460                 


Thr Ala Ser Glu His Ser Arg Glu Pro Ser Ala Ala Gly Arg Leu Ser 
465                 470                 475                 480 


Asp Ser Ser Ser Glu Ala Ser Lys Leu Ser Ser Lys Ser Ala Lys Glu 
                485                 490                 495     


Arg Arg Asn Arg Arg Lys Lys Arg Lys Gln Lys Glu Gln Ser Gly Gly 
            500                 505                 510         


Glu Glu Lys Asp Glu Asp Glu Phe Gln Lys Ser Glu Ser Glu Asp Ser 
        515                 520                 525             


Ile Arg Arg Lys Gly Phe Arg Phe Ser Ile Glu Gly Asn Arg Leu Thr 
    530                 535                 540                 


Tyr Glu Lys Arg Tyr Ser Ser Pro His Gln Ser Leu Leu Ser Ile Arg 
545                 550                 555                 560 


Gly Ser Leu Phe Ser Pro Arg Arg Asn Ser Arg Thr Ser Leu Phe Ser 
                565                 570                 575     


Phe Arg Gly Arg Ala Lys Asp Val Gly Ser Glu Asn Asp Phe Ala Asp 
            580                 585                 590         


Asp Glu His Ser Thr Phe Glu Asp Asn Glu Ser Arg Arg Asp Ser Leu 
        595                 600                 605             


Phe Val Pro Arg Arg His Gly Glu Arg Arg Asn Ser Asn Leu Ser Gln 
    610                 615                 620                 


Thr Ser Arg Ser Ser Arg Met Leu Ala Val Phe Pro Ala Asn Gly Lys 
625                 630                 635                 640 


Met His Ser Thr Val Asp Cys Asn Gly Val Val Ser Leu Val Gly Gly 
                645                 650                 655     


Pro Ser Val Pro Thr Ser Pro Val Gly Gln Leu Leu Pro Glu Val Ile 
            660                 665                 670         


Ile Asp Lys Pro Ala Thr Asp Asp Asn Gly Thr Thr Thr Glu Thr Glu 
        675                 680                 685             


Met Arg Lys Arg Arg Ser Ser Ser Phe His Val Ser Met Asp Phe Leu 
    690                 695                 700                 


Glu Asp Pro Ser Gln Arg Gln Arg Ala Met Ser Ile Ala Ser Ile Leu 
705                 710                 715                 720 


Thr Asn Thr Val Glu Glu Leu Glu Glu Ser Arg Gln Lys Cys Pro Pro 
                725                 730                 735     


Cys Trp Tyr Lys Phe Ser Asn Ile Phe Leu Ile Trp Asp Cys Ser Pro 
            740                 745                 750         


Tyr Trp Leu Lys Val Lys His Val Val Asn Leu Val Val Met Asp Pro 
        755                 760                 765             


Phe Val Asp Leu Ala Ile Thr Ile Cys Ile Val Leu Asn Thr Leu Phe 
    770                 775                 780                 


Met Ala Met Glu His Tyr Pro Met Thr Asp His Phe Asn Asn Val Leu 
785                 790                 795                 800 


Thr Val Gly Asn Leu Val Phe Thr Gly Ile Phe Thr Ala Glu Met Phe 
                805                 810                 815     


Leu Lys Ile Ile Ala Met Asp Pro Tyr Tyr Tyr Phe Gln Glu Gly Trp 
            820                 825                 830         


Asn Ile Phe Asp Gly Phe Ile Val Thr Leu Ser Leu Val Glu Leu Gly 
        835                 840                 845             


Leu Ala Asn Val Glu Gly Leu Ser Val Leu Arg Ser Phe Arg Leu Leu 
    850                 855                 860                 


Arg Val Phe Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Met Leu Ile 
865                 870                 875                 880 


Lys Ile Ile Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr Leu Val 
                885                 890                 895     


Leu Ala Ile Ile Val Phe Ile Phe Ala Val Val Gly Met Gln Leu Phe 
            900                 905                 910         


Gly Lys Ser Tyr Lys Asp Cys Val Cys Lys Ile Ala Ser Asp Cys Gln 
        915                 920                 925             


Leu Pro Arg Trp His Met Asn Asp Phe Phe His Ser Phe Leu Ile Val 
    930                 935                 940                 


Phe Arg Val Leu Cys Gly Glu Trp Ile Glu Thr Met Trp Asp Cys Met 
945                 950                 955                 960 


Glu Val Ala Gly Gln Ala Met Cys Leu Thr Val Phe Met Met Val Met 
                965                 970                 975     


Val Ile Gly Asn Leu Val Val Leu Asn Leu Phe Leu Ala Leu Leu Leu 
            980                 985                 990         


Ser Ser Phe Ser Ala Asp Asn Leu  Ala Ala Thr Asp Asp  Asp Asn Glu 
        995                 1000                 1005             


Met Asn  Asn Leu Gln Ile Ala  Val Asp Arg Met His  Lys Gly Val 
    1010                 1015                 1020             


Ala Tyr  Val Lys Arg Lys Ile  Tyr Glu Phe Ile Gln  Gln Ser Phe 
    1025                 1030                 1035             


Ile Arg  Lys Gln Lys Ile Leu  Asp Glu Ile Lys Pro  Leu Asp Asp 
    1040                 1045                 1050             


Leu Asn  Asn Lys Lys Asp Ser  Cys Met Ser Asn His  Thr Thr Glu 
    1055                 1060                 1065             


Ile Gly  Lys Asp Leu Asp Tyr  Leu Lys Asp Val Asn  Gly Thr Thr 
    1070                 1075                 1080             


Ser Gly  Ile Gly Thr Gly Ser  Ser Val Glu Lys Tyr  Ile Ile Asp 
    1085                 1090                 1095             


Glu Ser  Asp Tyr Met Ser Phe  Ile Asn Asn Pro Ser  Leu Thr Val 
    1100                 1105                 1110             


Thr Val  Pro Ile Ala Val Gly  Glu Ser Asp Phe Glu  Asn Leu Asn 
    1115                 1120                 1125             


Thr Glu  Asp Phe Ser Ser Glu  Ser Asp Leu Glu Glu  Ser Lys Glu 
    1130                 1135                 1140             


Lys Leu  Asn Glu Ser Ser Ser  Ser Ser Glu Gly Ser  Thr Val Asp 
    1145                 1150                 1155             


Ile Gly  Ala Pro Val Glu Glu  Gln Pro Val Val Glu  Pro Glu Glu 
    1160                 1165                 1170             


Thr Leu  Glu Pro Glu Ala Cys  Phe Thr Glu Gly Cys  Val Gln Arg 
    1175                 1180                 1185             


Phe Lys  Cys Cys Gln Ile Asn  Val Glu Glu Gly Arg  Gly Lys Gln 
    1190                 1195                 1200             


Trp Trp  Asn Leu Arg Arg Thr  Cys Phe Arg Ile Val  Glu His Asn 
    1205                 1210                 1215             


Trp Phe  Glu Thr Phe Ile Val  Phe Met Ile Leu Leu  Ser Ser Gly 
    1220                 1225                 1230             


Ala Leu  Ala Phe Glu Asp Ile  Tyr Ile Asp Gln Arg  Lys Thr Ile 
    1235                 1240                 1245             


Lys Thr  Met Leu Glu Tyr Ala  Asp Lys Val Phe Thr  Tyr Ile Phe 
    1250                 1255                 1260             


Ile Leu  Glu Met Leu Leu Lys  Trp Val Ala Tyr Gly  Tyr Gln Thr 
    1265                 1270                 1275             


Tyr Phe  Thr Asn Ala Trp Cys  Trp Leu Asp Phe Leu  Ile Val Asp 
    1280                 1285                 1290             


Val Ser  Leu Val Ser Leu Thr  Ala Asn Ala Leu Gly  Tyr Ser Glu 
    1295                 1300                 1305             


Leu Gly  Ala Ile Lys Ser Leu  Arg Thr Leu Arg Ala  Leu Arg Pro 
    1310                 1315                 1320             


Leu Arg  Ala Leu Ser Arg Phe  Glu Gly Met Arg Val  Val Val Asn 
    1325                 1330                 1335             


Ala Leu  Leu Gly Ala Ile Pro  Ser Ile Met Asn Val  Leu Leu Val 
    1340                 1345                 1350             


Cys Leu  Ile Phe Trp Leu Ile  Phe Ser Ile Met Gly  Val Asn Leu 
    1355                 1360                 1365             


Phe Ala  Gly Lys Phe Tyr His  Cys Ile Asn Thr Thr  Thr Gly Asp 
    1370                 1375                 1380             


Arg Phe  Asp Ile Glu Asp Val  Asn Asn His Thr Asp  Cys Leu Lys 
    1385                 1390                 1395             


Leu Ile  Glu Arg Asn Glu Thr  Ala Arg Trp Lys Asn  Val Lys Val 
    1400                 1405                 1410             


Asn Phe  Asp Asn Val Gly Phe  Gly Tyr Leu Ser Leu  Leu Gln Val 
    1415                 1420                 1425             


Ala Thr  Phe Lys Gly Trp Met  Asp Ile Met Tyr Ala  Ala Val Asp 
    1430                 1435                 1440             


Ser Arg  Asn Val Glu Leu Gln  Pro Lys Tyr Glu Lys  Ser Leu Tyr 
    1445                 1450                 1455             


Met Tyr  Leu Tyr Phe Val Ile  Phe Ile Ile Phe Gly  Ser Phe Phe 
    1460                 1465                 1470             


Thr Leu  Asn Leu Phe Ile Gly  Val Ile Ile Asp Asn  Phe Asn Gln 
    1475                 1480                 1485             


Gln Lys  Lys Lys Phe Gly Gly  Gln Asp Ile Phe Met  Thr Glu Glu 
    1490                 1495                 1500             


Gln Lys  Lys Tyr Tyr Asn Ala  Met Lys Lys Leu Gly  Ser Lys Lys 
    1505                 1510                 1515             


Pro Gln  Lys Pro Ile Pro Arg  Pro Gly Asn Lys Phe  Gln Gly Met 
    1520                 1525                 1530             


Val Phe  Asp Phe Val Thr Arg  Gln Val Phe Asp Ile  Ser Ile Met 
    1535                 1540                 1545             


Ile Leu  Ile Cys Leu Asn Met  Val Thr Met Met Val  Glu Thr Asp 
    1550                 1555                 1560             


Asp Gln  Ser Glu Tyr Val Thr  Thr Ile Leu Ser Arg  Ile Asn Leu 
    1565                 1570                 1575             


Val Phe  Ile Val Leu Phe Thr  Gly Glu Cys Val Leu  Lys Leu Ile 
    1580                 1585                 1590             


Ser Leu  Arg His Tyr Tyr Phe  Thr Ile Gly Trp Asn  Ile Phe Asp 
    1595                 1600                 1605             


Phe Val  Val Val Ile Leu Ser  Ile Val Gly Met Phe  Leu Ala Glu 
    1610                 1615                 1620             


Leu Ile  Glu Lys Tyr Phe Val  Ser Pro Thr Leu Phe  Arg Val Ile 
    1625                 1630                 1635             


Arg Leu  Ala Arg Ile Gly Arg  Ile Leu Arg Leu Ile  Lys Gly Ala 
    1640                 1645                 1650             


Lys Gly  Ile Arg Thr Leu Leu  Phe Ala Leu Met Met  Ser Leu Pro 
    1655                 1660                 1665             


Ala Leu  Phe Asn Ile Gly Leu  Leu Leu Phe Leu Val  Met Phe Ile 
    1670                 1675                 1680             


Tyr Ala  Ile Phe Gly Met Ser  Asn Phe Ala Tyr Val  Lys Arg Glu 
    1685                 1690                 1695             


Val Gly  Ile Asp Asp Met Phe  Asn Phe Glu Thr Phe  Gly Asn Ser 
    1700                 1705                 1710             


Met Ile  Cys Leu Phe Gln Ile  Thr Thr Ser Ala Gly  Trp Asp Gly 
    1715                 1720                 1725             


Leu Leu  Ala Pro Ile Leu Asn  Ser Lys Pro Pro Asp  Cys Asp Pro 
    1730                 1735                 1740             


Asn Lys  Val Asn Pro Gly Ser  Ser Val Lys Gly Asp  Cys Gly Asn 
    1745                 1750                 1755             


Pro Ser  Val Gly Ile Phe Phe  Phe Val Ser Tyr Ile  Ile Ile Ser 
    1760                 1765                 1770             


Phe Leu  Val Val Val Asn Met  Tyr Ile Ala Val Ile  Leu Glu Asn 
    1775                 1780                 1785             


Phe Ser  Val Ala Thr Glu Glu  Ser Ala Glu Pro Leu  Ser Glu Asp 
    1790                 1795                 1800             


Asp Phe  Glu Met Phe Tyr Glu  Val Trp Glu Lys Phe  Asp Pro Asp 
    1805                 1810                 1815             


Ala Thr  Gln Phe Met Glu Phe  Glu Lys Leu Ser Gln  Phe Ala Ala 
    1820                 1825                 1830             


Ala Leu  Glu Pro Pro Leu Asn  Leu Pro Gln Pro Asn  Lys Leu Gln 
    1835                 1840                 1845             


Leu Ile  Ala Met Asp Leu Pro  Met Val Ser Gly Asp  Arg Ile His 
    1850                 1855                 1860             


Cys Leu  Asp Ile Leu Phe Ala  Phe Thr Lys Arg Val  Leu Gly Glu 
    1865                 1870                 1875             


Ser Gly  Glu Met Asp Ala Leu  Arg Ile Gln Met Glu  Glu Arg Phe 
    1880                 1885                 1890             


Met Ala  Ser Asn Pro Ser Lys  Val Ser Tyr Gln Pro  Ile Thr Thr 
    1895                 1900                 1905             


Thr Leu  Lys Arg Lys Gln Glu  Glu Val Ser Ala Val  Ile Ile Gln 
    1910                 1915                 1920             


Arg Ala  Tyr Arg Arg His Leu  Leu Lys Arg Thr Val  Lys Gln Ala 
    1925                 1930                 1935             


Ser Phe  Thr Tyr Asn Lys Asn  Lys Ile Lys Gly Gly  Ala Asn Leu 
    1940                 1945                 1950             


Leu Ile  Lys Glu Asp Met Ile  Ile Asp Arg Ile Asn  Glu Asn Ser 
    1955                 1960                 1965             


Ile Thr  Glu Lys Thr Asp Leu  Thr Met Ser Thr Ala  Ala Cys Pro 
    1970                 1975                 1980             


Pro Ser  Tyr Asp Arg Val Thr  Lys Pro Ile Val Glu  Lys His Glu 
    1985                 1990                 1995             


Gln Glu  Gly Lys Asp Glu Lys  Ala Lys Gly Lys 
    2000                 2005                 


<210>  28
<211>  2009
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Glu Gln Thr Val Leu Val Pro Pro Gly Pro Asp Ser Phe Asn Phe 
1               5                   10                  15      


Phe Thr Arg Glu Ser Leu Ala Ala Ile Glu Arg Arg Ile Ala Glu Glu 
            20                  25                  30          


Lys Ala Lys Asn Pro Lys Pro Asp Lys Lys Asp Asp Asp Glu Asn Gly 
        35                  40                  45              


Pro Lys Pro Asn Ser Asp Leu Glu Ala Gly Lys Asn Leu Pro Phe Ile 
    50                  55                  60                  


Tyr Gly Asp Ile Pro Pro Glu Met Val Ser Glu Pro Leu Glu Asp Leu 
65                  70                  75                  80  


Asp Pro Tyr Tyr Ile Asn Lys Lys Thr Phe Ile Val Leu Asn Lys Leu 
                85                  90                  95      


Lys Ala Ile Phe Arg Phe Ser Ala Thr Ser Ala Leu Tyr Ile Leu Thr 
            100                 105                 110         


Pro Phe Asn Pro Leu Arg Lys Ile Ala Ile Lys Ile Leu Val His Ser 
        115                 120                 125             


Leu Phe Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Val Phe 
    130                 135                 140                 


Met Thr Met Ser Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr Thr 
145                 150                 155                 160 


Phe Thr Gly Ile Tyr Thr Phe Glu Ser Leu Lys Lys Ile Ile Ala Arg 
                165                 170                 175     


Gly Phe Cys Leu Glu Asp Phe Thr Phe Leu Arg Asp Pro Trp Asn Trp 
            180                 185                 190         


Leu Asp Phe Thr Val Ile Thr Phe Ala Tyr Val Thr Glu Phe Val Asp 
        195                 200                 205             


Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala Leu 
    210                 215                 220                 


Lys Thr Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu 
225                 230                 235                 240 


Ile Gln Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val Phe 
                245                 250                 255     


Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly Asn 
            260                 265                 270         


Leu Arg Asn Lys Cys Ile Gln Trp Pro Pro Thr Asn Ala Ser Leu Glu 
        275                 280                 285             


Glu His Ser Ile Glu Lys Asn Ile Thr Val Asn Tyr Asn Gly Thr Leu 
    290                 295                 300                 


Ile Asn Glu Thr Val Phe Glu Phe Asp Trp Lys Ser Tyr Ile Gln Asp 
305                 310                 315                 320 


Ser Arg Tyr His Tyr Phe Leu Glu Gly Phe Leu Asp Ala Leu Leu Cys 
                325                 330                 335     


Gly Asn Ser Ser Asp Ala Gly Gln Cys Pro Glu Gly Tyr Met Cys Val 
            340                 345                 350         


Lys Ala Gly Arg Asn Pro Asn Tyr Gly Tyr Thr Ser Phe Asp Thr Phe 
        355                 360                 365             


Ser Trp Ala Phe Leu Ser Leu Phe Arg Leu Met Thr Gln Asp Phe Trp 
    370                 375                 380                 


Glu Asn Leu Tyr Gln Leu Thr Leu Arg Ala Ala Gly Lys Thr Tyr Met 
385                 390                 395                 400 


Ile Phe Phe Val Leu Val Ile Phe Leu Gly Ser Phe Tyr Leu Ile Asn 
                405                 410                 415     


Leu Ile Leu Ala Val Val Ala Met Ala Tyr Glu Glu Gln Asn Gln Ala 
            420                 425                 430         


Thr Leu Glu Glu Ala Glu Gln Lys Glu Ala Glu Phe Gln Gln Met Ile 
        435                 440                 445             


Glu Gln Leu Lys Lys Gln Gln Glu Ala Ala Gln Gln Ala Ala Thr Ala 
    450                 455                 460                 


Thr Ala Ser Glu His Ser Arg Glu Pro Ser Ala Ala Gly Arg Leu Ser 
465                 470                 475                 480 


Asp Ser Ser Ser Glu Ala Ser Lys Leu Ser Ser Lys Ser Ala Lys Glu 
                485                 490                 495     


Arg Arg Asn Arg Arg Lys Lys Arg Lys Gln Lys Glu Gln Ser Gly Gly 
            500                 505                 510         


Glu Glu Lys Asp Glu Asp Glu Phe Gln Lys Ser Glu Ser Glu Asp Ser 
        515                 520                 525             


Ile Arg Arg Lys Gly Phe Arg Phe Ser Ile Glu Gly Asn Arg Leu Thr 
    530                 535                 540                 


Tyr Glu Lys Arg Tyr Ser Ser Pro His Gln Ser Leu Leu Ser Ile Arg 
545                 550                 555                 560 


Gly Ser Leu Phe Ser Pro Arg Arg Asn Ser Arg Thr Ser Leu Phe Ser 
                565                 570                 575     


Phe Arg Gly Arg Ala Lys Asp Val Gly Ser Glu Asn Asp Phe Ala Asp 
            580                 585                 590         


Asp Glu His Ser Thr Phe Glu Asp Asn Glu Ser Arg Arg Asp Ser Leu 
        595                 600                 605             


Phe Val Pro Arg Arg His Gly Glu Arg Arg Asn Ser Asn Leu Ser Gln 
    610                 615                 620                 


Thr Ser Arg Ser Ser Arg Met Leu Ala Val Phe Pro Ala Asn Gly Lys 
625                 630                 635                 640 


Met His Ser Thr Val Asp Cys Asn Gly Val Val Ser Leu Val Gly Gly 
                645                 650                 655     


Pro Ser Val Pro Thr Ser Pro Val Gly Gln Leu Leu Pro Glu Val Ile 
            660                 665                 670         


Ile Asp Lys Pro Ala Thr Asp Asp Asn Gly Thr Thr Thr Glu Thr Glu 
        675                 680                 685             


Met Arg Lys Arg Arg Ser Ser Ser Phe His Val Ser Met Asp Phe Leu 
    690                 695                 700                 


Glu Asp Pro Ser Gln Arg Gln Arg Ala Met Ser Ile Ala Ser Ile Leu 
705                 710                 715                 720 


Thr Asn Thr Val Glu Glu Leu Glu Glu Ser Arg Gln Lys Cys Pro Pro 
                725                 730                 735     


Cys Trp Tyr Lys Phe Ser Asn Ile Phe Leu Ile Trp Asp Cys Ser Pro 
            740                 745                 750         


Tyr Trp Leu Lys Val Lys His Val Val Asn Leu Val Val Met Asp Pro 
        755                 760                 765             


Phe Val Asp Leu Ala Ile Thr Ile Cys Ile Val Leu Asn Thr Leu Phe 
    770                 775                 780                 


Met Ala Met Glu His Tyr Pro Met Thr Asp His Phe Asn Asn Val Leu 
785                 790                 795                 800 


Thr Val Gly Asn Leu Val Phe Thr Gly Ile Phe Thr Ala Glu Met Phe 
                805                 810                 815     


Leu Lys Ile Ile Ala Met Asp Pro Tyr Tyr Tyr Phe Gln Glu Gly Trp 
            820                 825                 830         


Asn Ile Phe Asp Gly Phe Ile Val Thr Leu Ser Leu Val Glu Leu Gly 
        835                 840                 845             


Leu Ala Asn Val Glu Gly Leu Ser Val Leu Arg Ser Phe Arg Leu Leu 
    850                 855                 860                 


Arg Val Phe Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Met Leu Ile 
865                 870                 875                 880 


Lys Ile Ile Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr Leu Val 
                885                 890                 895     


Leu Ala Ile Ile Val Phe Ile Phe Ala Val Val Gly Met Gln Leu Phe 
            900                 905                 910         


Gly Lys Ser Tyr Lys Asp Cys Val Cys Lys Ile Ala Ser Asp Cys Gln 
        915                 920                 925             


Leu Pro Arg Trp His Met Asn Asp Phe Phe His Ser Phe Leu Ile Val 
    930                 935                 940                 


Phe Arg Val Leu Cys Gly Glu Trp Ile Glu Thr Met Trp Asp Cys Met 
945                 950                 955                 960 


Glu Val Ala Gly Gln Ala Met Cys Leu Thr Val Phe Met Met Val Met 
                965                 970                 975     


Val Ile Gly Asn Leu Val Val Leu Asn Leu Phe Leu Ala Leu Leu Leu 
            980                 985                 990         


Ser Ser Phe Ser Ala Asp Asn Leu  Ala Ala Thr Asp Asp  Asp Asn Glu 
        995                 1000                 1005             


Met Asn  Asn Leu Gln Ile Ala  Val Asp Arg Met His  Lys Gly Val 
    1010                 1015                 1020             


Ala Tyr  Val Lys Arg Lys Ile  Tyr Glu Phe Ile Gln  Gln Ser Phe 
    1025                 1030                 1035             


Ile Arg  Lys Gln Lys Ile Leu  Asp Glu Ile Lys Pro  Leu Asp Asp 
    1040                 1045                 1050             


Leu Asn  Asn Lys Lys Asp Ser  Cys Met Ser Asn His  Thr Thr Glu 
    1055                 1060                 1065             


Ile Gly  Lys Asp Leu Asp Tyr  Leu Lys Asp Val Asn  Gly Thr Thr 
    1070                 1075                 1080             


Ser Gly  Ile Gly Thr Gly Ser  Ser Val Glu Lys Tyr  Ile Ile Asp 
    1085                 1090                 1095             


Glu Ser  Asp Tyr Met Ser Phe  Ile Asn Asn Pro Ser  Leu Thr Val 
    1100                 1105                 1110             


Thr Val  Pro Ile Ala Val Gly  Glu Ser Asp Phe Glu  Asn Leu Asn 
    1115                 1120                 1125             


Thr Glu  Asp Phe Ser Ser Glu  Ser Asp Leu Glu Glu  Ser Lys Glu 
    1130                 1135                 1140             


Lys Leu  Asn Glu Ser Ser Ser  Ser Ser Glu Gly Ser  Thr Val Asp 
    1145                 1150                 1155             


Ile Gly  Ala Pro Val Glu Glu  Gln Pro Val Val Glu  Pro Glu Glu 
    1160                 1165                 1170             


Thr Leu  Glu Pro Glu Ala Cys  Phe Thr Glu Gly Cys  Val Gln Arg 
    1175                 1180                 1185             


Phe Lys  Cys Cys Gln Ile Asn  Val Glu Glu Gly Arg  Gly Lys Gln 
    1190                 1195                 1200             


Trp Trp  Asn Leu Arg Arg Thr  Cys Phe Arg Ile Val  Glu His Asn 
    1205                 1210                 1215             


Trp Phe  Glu Thr Phe Ile Val  Phe Met Ile Leu Leu  Ser Ser Gly 
    1220                 1225                 1230             


Ala Leu  Ala Phe Glu Asp Ile  Tyr Ile Asp Gln Arg  Lys Thr Ile 
    1235                 1240                 1245             


Lys Thr  Met Leu Glu Tyr Ala  Asp Lys Val Phe Thr  Tyr Ile Phe 
    1250                 1255                 1260             


Ile Leu  Glu Met Leu Leu Lys  Trp Val Ala Tyr Gly  Tyr Gln Thr 
    1265                 1270                 1275             


Tyr Phe  Thr Asn Ala Trp Cys  Trp Leu Asp Phe Leu  Ile Val Asp 
    1280                 1285                 1290             


Val Ser  Leu Val Ser Leu Thr  Ala Asn Ala Leu Gly  Tyr Ser Glu 
    1295                 1300                 1305             


Leu Gly  Ala Ile Lys Ser Leu  Arg Thr Leu Arg Ala  Leu Arg Pro 
    1310                 1315                 1320             


Leu Arg  Ala Leu Ser Arg Phe  Glu Gly Met Arg Val  Val Val Asn 
    1325                 1330                 1335             


Ala Leu  Leu Gly Ala Ile Pro  Ser Ile Met Asn Val  Leu Leu Val 
    1340                 1345                 1350             


Cys Leu  Ile Phe Trp Leu Ile  Phe Ser Ile Met Gly  Val Asn Leu 
    1355                 1360                 1365             


Phe Ala  Gly Lys Phe Tyr His  Cys Ile Asn Thr Thr  Thr Gly Asp 
    1370                 1375                 1380             


Arg Phe  Asp Ile Glu Asp Val  Asn Asn His Thr Asp  Cys Leu Lys 
    1385                 1390                 1395             


Leu Ile  Glu Arg Asn Glu Thr  Ala Arg Trp Lys Asn  Val Lys Val 
    1400                 1405                 1410             


Asn Phe  Asp Asn Val Gly Phe  Gly Tyr Leu Ser Leu  Leu Gln Val 
    1415                 1420                 1425             


Ala Thr  Phe Lys Gly Trp Met  Asp Ile Met Tyr Ala  Ala Val Asp 
    1430                 1435                 1440             


Ser Arg  Asn Val Glu Leu Gln  Pro Lys Tyr Glu Lys  Ser Leu Tyr 
    1445                 1450                 1455             


Met Tyr  Leu Tyr Phe Val Ile  Phe Ile Ile Phe Gly  Ser Phe Phe 
    1460                 1465                 1470             


Thr Leu  Asn Leu Phe Ile Gly  Val Ile Ile Asp Asn  Phe Asn Gln 
    1475                 1480                 1485             


Gln Lys  Lys Lys Phe Gly Gly  Gln Asp Ile Phe Met  Thr Glu Glu 
    1490                 1495                 1500             


Gln Lys  Lys Tyr Tyr Asn Ala  Met Lys Lys Leu Gly  Ser Lys Lys 
    1505                 1510                 1515             


Pro Gln  Lys Pro Ile Pro Arg  Pro Gly Asn Lys Phe  Gln Gly Met 
    1520                 1525                 1530             


Val Phe  Asp Phe Val Thr Arg  Gln Val Phe Asp Ile  Ser Ile Met 
    1535                 1540                 1545             


Ile Leu  Ile Cys Leu Asn Met  Val Thr Met Met Val  Glu Thr Asp 
    1550                 1555                 1560             


Asp Gln  Ser Glu Tyr Val Thr  Thr Ile Leu Ser Arg  Ile Asn Leu 
    1565                 1570                 1575             


Val Phe  Ile Val Leu Phe Thr  Gly Glu Cys Val Leu  Lys Leu Ile 
    1580                 1585                 1590             


Ser Leu  Arg His Tyr Tyr Phe  Thr Ile Gly Trp Asn  Ile Phe Asp 
    1595                 1600                 1605             


Phe Val  Val Val Ile Leu Ser  Ile Val Gly Met Phe  Leu Ala Glu 
    1610                 1615                 1620             


Leu Ile  Glu Lys Tyr Phe Val  Ser Pro Thr Leu Phe  Arg Val Ile 
    1625                 1630                 1635             


Arg Leu  Ala Arg Ile Gly Arg  Ile Leu Arg Leu Ile  Lys Gly Ala 
    1640                 1645                 1650             


Lys Gly  Ile Arg Thr Leu Leu  Phe Ala Leu Met Met  Ser Leu Pro 
    1655                 1660                 1665             


Ala Leu  Phe Asn Ile Gly Leu  Leu Leu Phe Leu Val  Met Phe Ile 
    1670                 1675                 1680             


Tyr Ala  Ile Phe Gly Met Ser  Asn Phe Ala Tyr Val  Lys Arg Glu 
    1685                 1690                 1695             


Val Gly  Ile Asp Asp Met Phe  Asn Phe Glu Thr Phe  Gly Asn Ser 
    1700                 1705                 1710             


Met Ile  Cys Leu Phe Gln Ile  Thr Thr Ser Ala Gly  Trp Asp Gly 
    1715                 1720                 1725             


Leu Leu  Ala Pro Ile Leu Asn  Ser Lys Pro Pro Asp  Cys Asp Pro 
    1730                 1735                 1740             


Asn Lys  Val Asn Pro Gly Ser  Ser Val Lys Gly Asp  Cys Gly Asn 
    1745                 1750                 1755             


Pro Ser  Val Gly Ile Phe Phe  Phe Val Ser Tyr Ile  Ile Ile Ser 
    1760                 1765                 1770             


Phe Leu  Val Val Val Asn Met  Tyr Ile Ala Val Ile  Leu Glu Asn 
    1775                 1780                 1785             


Phe Ser  Val Ala Thr Glu Glu  Ser Ala Glu Pro Leu  Ser Glu Asp 
    1790                 1795                 1800             


Asp Phe  Glu Met Phe Tyr Glu  Val Trp Glu Lys Phe  Asp Pro Asp 
    1805                 1810                 1815             


Ala Thr  Gln Phe Met Glu Phe  Glu Lys Leu Ser Gln  Phe Ala Ala 
    1820                 1825                 1830             


Ala Leu  Glu Pro Pro Leu Asn  Leu Pro Gln Pro Asn  Lys Leu Gln 
    1835                 1840                 1845             


Leu Ile  Ala Met Asp Leu Pro  Met Val Ser Gly Asp  Arg Ile His 
    1850                 1855                 1860             


Cys Leu  Asp Ile Leu Phe Ala  Phe Thr Lys Arg Val  Leu Gly Glu 
    1865                 1870                 1875             


Ser Gly  Glu Met Asp Ala Leu  Arg Ile Gln Met Glu  Glu Arg Phe 
    1880                 1885                 1890             


Met Ala  Ser Asn Pro Ser Lys  Val Ser Tyr Gln Pro  Ile Thr Thr 
    1895                 1900                 1905             


Thr Leu  Lys Arg Lys Gln Glu  Glu Val Ser Ala Val  Ile Ile Gln 
    1910                 1915                 1920             


Arg Ala  Tyr Arg Arg His Leu  Leu Lys Arg Thr Val  Lys Gln Ala 
    1925                 1930                 1935             


Ser Phe  Thr Tyr Asn Lys Asn  Lys Ile Lys Gly Gly  Ala Asn Leu 
    1940                 1945                 1950             


Leu Ile  Lys Glu Asp Met Ile  Ile Asp Arg Ile Asn  Glu Asn Ser 
    1955                 1960                 1965             


Ile Thr  Glu Lys Thr Asp Leu  Thr Met Ser Thr Ala  Ala Cys Pro 
    1970                 1975                 1980             


Pro Ser  Tyr Asp Arg Val Thr  Lys Pro Ile Val Glu  Lys His Glu 
    1985                 1990                 1995             


Gln Glu  Gly Lys Asp Glu Lys  Ala Lys Gly Lys 
    2000                 2005                 


<210>  29
<211>  2009
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Glu Gln Thr Val Leu Val Pro Pro Gly Pro Asp Ser Phe Asn Phe 
1               5                   10                  15      


Phe Thr Arg Glu Ser Leu Ala Ala Ile Glu Arg Arg Ile Ala Glu Glu 
            20                  25                  30          


Lys Ala Lys Asn Pro Lys Pro Asp Lys Lys Asp Asp Asp Glu Asn Gly 
        35                  40                  45              


Pro Lys Pro Asn Ser Asp Leu Glu Ala Gly Lys Asn Leu Pro Phe Ile 
    50                  55                  60                  


Tyr Gly Asp Ile Pro Pro Glu Met Val Ser Glu Pro Leu Glu Asp Leu 
65                  70                  75                  80  


Asp Pro Tyr Tyr Ile Asn Lys Lys Thr Phe Ile Val Leu Asn Lys Leu 
                85                  90                  95      


Lys Ala Ile Phe Arg Phe Ser Ala Thr Ser Ala Leu Tyr Ile Leu Thr 
            100                 105                 110         


Pro Phe Asn Pro Leu Arg Lys Ile Ala Ile Lys Ile Leu Val His Ser 
        115                 120                 125             


Leu Phe Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Val Phe 
    130                 135                 140                 


Met Thr Met Ser Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr Thr 
145                 150                 155                 160 


Phe Thr Gly Ile Tyr Thr Phe Glu Ser Leu Ile Lys Ile Ile Ala Arg 
                165                 170                 175     


Gly Phe Cys Leu Glu Asp Phe Thr Phe Leu Arg Asp Pro Trp Asn Trp 
            180                 185                 190         


Leu Asp Phe Thr Val Ile Arg Phe Ala Tyr Val Thr Glu Phe Val Asp 
        195                 200                 205             


Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala Leu 
    210                 215                 220                 


Lys Thr Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu 
225                 230                 235                 240 


Ile Gln Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val Phe 
                245                 250                 255     


Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly Asn 
            260                 265                 270         


Leu Arg Asn Lys Cys Ile Gln Trp Pro Pro Thr Asn Ala Ser Leu Glu 
        275                 280                 285             


Glu His Ser Ile Glu Lys Asn Ile Thr Val Asn Tyr Asn Gly Thr Leu 
    290                 295                 300                 


Ile Asn Glu Thr Val Phe Glu Phe Asp Trp Lys Ser Tyr Ile Gln Asp 
305                 310                 315                 320 


Ser Arg Tyr His Tyr Phe Leu Glu Gly Phe Leu Asp Ala Leu Leu Cys 
                325                 330                 335     


Gly Asn Ser Ser Asp Ala Gly Gln Cys Pro Glu Gly Tyr Met Cys Val 
            340                 345                 350         


Lys Ala Gly Arg Asn Pro Asn Tyr Gly Tyr Thr Ser Phe Asp Thr Phe 
        355                 360                 365             


Ser Trp Ala Phe Leu Ser Leu Phe Arg Leu Met Thr Gln Asp Phe Trp 
    370                 375                 380                 


Glu Asn Leu Tyr Gln Leu Thr Leu Arg Ala Ala Gly Lys Thr Tyr Met 
385                 390                 395                 400 


Ile Phe Phe Val Leu Val Ile Phe Leu Gly Ser Phe Tyr Leu Ile Asn 
                405                 410                 415     


Leu Ile Leu Ala Val Val Ala Met Ala Tyr Glu Glu Gln Asn Gln Ala 
            420                 425                 430         


Thr Leu Glu Glu Ala Glu Gln Lys Glu Ala Glu Phe Gln Gln Met Ile 
        435                 440                 445             


Glu Gln Leu Lys Lys Gln Gln Glu Ala Ala Gln Gln Ala Ala Thr Ala 
    450                 455                 460                 


Thr Ala Ser Glu His Ser Arg Glu Pro Ser Ala Ala Gly Arg Leu Ser 
465                 470                 475                 480 


Asp Ser Ser Ser Glu Ala Ser Lys Leu Ser Ser Lys Ser Ala Lys Glu 
                485                 490                 495     


Arg Arg Asn Arg Arg Lys Lys Arg Lys Gln Lys Glu Gln Ser Gly Gly 
            500                 505                 510         


Glu Glu Lys Asp Glu Asp Glu Phe Gln Lys Ser Glu Ser Glu Asp Ser 
        515                 520                 525             


Ile Arg Arg Lys Gly Phe Arg Phe Ser Ile Glu Gly Asn Arg Leu Thr 
    530                 535                 540                 


Tyr Glu Lys Arg Tyr Ser Ser Pro His Gln Ser Leu Leu Ser Ile Arg 
545                 550                 555                 560 


Gly Ser Leu Phe Ser Pro Arg Arg Asn Ser Arg Thr Ser Leu Phe Ser 
                565                 570                 575     


Phe Arg Gly Arg Ala Lys Asp Val Gly Ser Glu Asn Asp Phe Ala Asp 
            580                 585                 590         


Asp Glu His Ser Thr Phe Glu Asp Asn Glu Ser Arg Arg Asp Ser Leu 
        595                 600                 605             


Phe Val Pro Arg Arg His Gly Glu Arg Arg Asn Ser Asn Leu Ser Gln 
    610                 615                 620                 


Thr Ser Arg Ser Ser Arg Met Leu Ala Val Phe Pro Ala Asn Gly Lys 
625                 630                 635                 640 


Met His Ser Thr Val Asp Cys Asn Gly Val Val Ser Leu Val Gly Gly 
                645                 650                 655     


Pro Ser Val Pro Thr Ser Pro Val Gly Gln Leu Leu Pro Glu Val Ile 
            660                 665                 670         


Ile Asp Lys Pro Ala Thr Asp Asp Asn Gly Thr Thr Thr Glu Thr Glu 
        675                 680                 685             


Met Arg Lys Arg Arg Ser Ser Ser Phe His Val Ser Met Asp Phe Leu 
    690                 695                 700                 


Glu Asp Pro Ser Gln Arg Gln Arg Ala Met Ser Ile Ala Ser Ile Leu 
705                 710                 715                 720 


Thr Asn Thr Val Glu Glu Leu Glu Glu Ser Arg Gln Lys Cys Pro Pro 
                725                 730                 735     


Cys Trp Tyr Lys Phe Ser Asn Ile Phe Leu Ile Trp Asp Cys Ser Pro 
            740                 745                 750         


Tyr Trp Leu Lys Val Lys His Val Val Asn Leu Val Val Met Asp Pro 
        755                 760                 765             


Phe Val Asp Leu Ala Ile Thr Ile Cys Ile Val Leu Asn Thr Leu Phe 
    770                 775                 780                 


Met Ala Met Glu His Tyr Pro Met Thr Asp His Phe Asn Asn Val Leu 
785                 790                 795                 800 


Thr Val Gly Asn Leu Val Phe Thr Gly Ile Phe Thr Ala Glu Met Phe 
                805                 810                 815     


Leu Lys Ile Ile Ala Met Asp Pro Tyr Tyr Tyr Phe Gln Glu Gly Trp 
            820                 825                 830         


Asn Ile Phe Asp Gly Phe Ile Val Thr Leu Ser Leu Val Glu Leu Gly 
        835                 840                 845             


Leu Ala Asn Val Glu Gly Leu Ser Val Leu Arg Ser Phe Arg Leu Leu 
    850                 855                 860                 


Arg Val Phe Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Met Leu Ile 
865                 870                 875                 880 


Lys Ile Ile Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr Leu Val 
                885                 890                 895     


Leu Ala Ile Ile Val Phe Ile Phe Ala Val Val Gly Met Gln Leu Phe 
            900                 905                 910         


Gly Lys Ser Tyr Lys Asp Cys Val Cys Lys Ile Ala Ser Asp Cys Gln 
        915                 920                 925             


Leu Pro Arg Trp His Met Asn Asp Phe Phe His Ser Phe Leu Ile Val 
    930                 935                 940                 


Phe Arg Val Leu Cys Gly Glu Trp Ile Glu Thr Met Trp Asp Cys Met 
945                 950                 955                 960 


Glu Val Ala Gly Gln Ala Met Cys Leu Thr Val Phe Met Met Val Met 
                965                 970                 975     


Val Ile Gly Asn Leu Val Val Leu Asn Leu Phe Leu Ala Leu Leu Leu 
            980                 985                 990         


Ser Ser Phe Ser Ala Asp Asn Leu  Ala Ala Thr Asp Asp  Asp Asn Glu 
        995                 1000                 1005             


Met Asn  Asn Leu Gln Ile Ala  Val Asp Arg Met His  Lys Gly Val 
    1010                 1015                 1020             


Ala Tyr  Val Lys Arg Lys Ile  Tyr Glu Phe Ile Gln  Gln Ser Phe 
    1025                 1030                 1035             


Ile Arg  Lys Gln Lys Ile Leu  Asp Glu Ile Lys Pro  Leu Asp Asp 
    1040                 1045                 1050             


Leu Asn  Asn Lys Lys Asp Ser  Cys Met Ser Asn His  Thr Thr Glu 
    1055                 1060                 1065             


Ile Gly  Lys Asp Leu Asp Tyr  Leu Lys Asp Val Asn  Gly Thr Thr 
    1070                 1075                 1080             


Ser Gly  Ile Gly Thr Gly Ser  Ser Val Glu Lys Tyr  Ile Ile Asp 
    1085                 1090                 1095             


Glu Ser  Asp Tyr Met Ser Phe  Ile Asn Asn Pro Ser  Leu Thr Val 
    1100                 1105                 1110             


Thr Val  Pro Ile Ala Val Gly  Glu Ser Asp Phe Glu  Asn Leu Asn 
    1115                 1120                 1125             


Thr Glu  Asp Phe Ser Ser Glu  Ser Asp Leu Glu Glu  Ser Lys Glu 
    1130                 1135                 1140             


Lys Leu  Asn Glu Ser Ser Ser  Ser Ser Glu Gly Ser  Thr Val Asp 
    1145                 1150                 1155             


Ile Gly  Ala Pro Val Glu Glu  Gln Pro Val Val Glu  Pro Glu Glu 
    1160                 1165                 1170             


Thr Leu  Glu Pro Glu Ala Cys  Phe Thr Glu Gly Cys  Val Gln Arg 
    1175                 1180                 1185             


Phe Lys  Cys Cys Gln Ile Asn  Val Glu Glu Gly Arg  Gly Lys Gln 
    1190                 1195                 1200             


Trp Trp  Asn Leu Arg Arg Thr  Cys Phe Arg Ile Val  Glu His Asn 
    1205                 1210                 1215             


Trp Phe  Glu Thr Phe Ile Val  Phe Met Ile Leu Leu  Ser Ser Gly 
    1220                 1225                 1230             


Ala Leu  Ala Phe Glu Asp Ile  Tyr Ile Asp Gln Arg  Lys Thr Ile 
    1235                 1240                 1245             


Lys Thr  Met Leu Glu Tyr Ala  Asp Lys Val Phe Thr  Tyr Ile Phe 
    1250                 1255                 1260             


Ile Leu  Glu Met Leu Leu Lys  Trp Val Ala Tyr Gly  Tyr Gln Thr 
    1265                 1270                 1275             


Tyr Phe  Thr Asn Ala Trp Cys  Trp Leu Asp Phe Leu  Ile Val Asp 
    1280                 1285                 1290             


Val Ser  Leu Val Ser Leu Thr  Ala Asn Ala Leu Gly  Tyr Ser Glu 
    1295                 1300                 1305             


Leu Gly  Ala Ile Lys Ser Leu  Arg Thr Leu Arg Ala  Leu Arg Pro 
    1310                 1315                 1320             


Leu Arg  Ala Leu Ser Arg Phe  Glu Gly Met Arg Val  Val Val Asn 
    1325                 1330                 1335             


Ala Leu  Leu Gly Ala Ile Pro  Ser Ile Met Asn Val  Leu Leu Val 
    1340                 1345                 1350             


Cys Leu  Ile Phe Trp Leu Ile  Phe Ser Ile Met Gly  Val Asn Leu 
    1355                 1360                 1365             


Phe Ala  Gly Lys Phe Tyr His  Cys Ile Asn Thr Thr  Thr Gly Asp 
    1370                 1375                 1380             


Arg Phe  Asp Ile Glu Asp Val  Asn Asn His Thr Asp  Cys Leu Lys 
    1385                 1390                 1395             


Leu Ile  Glu Arg Asn Glu Thr  Ala Arg Trp Lys Asn  Val Lys Val 
    1400                 1405                 1410             


Asn Phe  Asp Asn Val Gly Phe  Gly Tyr Leu Ser Leu  Leu Gln Val 
    1415                 1420                 1425             


Ala Thr  Phe Lys Gly Trp Met  Asp Ile Met Tyr Ala  Ala Val Asp 
    1430                 1435                 1440             


Ser Arg  Asn Val Glu Leu Gln  Pro Lys Tyr Glu Lys  Ser Leu Tyr 
    1445                 1450                 1455             


Met Tyr  Leu Tyr Phe Val Ile  Phe Ile Ile Phe Gly  Ser Phe Phe 
    1460                 1465                 1470             


Thr Leu  Asn Leu Phe Ile Gly  Val Ile Ile Asp Asn  Phe Asn Gln 
    1475                 1480                 1485             


Gln Lys  Lys Lys Phe Gly Gly  Gln Asp Ile Phe Met  Thr Glu Glu 
    1490                 1495                 1500             


Gln Lys  Lys Tyr Tyr Asn Ala  Met Lys Lys Leu Gly  Ser Lys Lys 
    1505                 1510                 1515             


Pro Gln  Lys Pro Ile Pro Arg  Pro Gly Asn Lys Phe  Gln Gly Met 
    1520                 1525                 1530             


Val Phe  Asp Phe Val Thr Arg  Gln Val Phe Asp Ile  Ser Ile Met 
    1535                 1540                 1545             


Ile Leu  Ile Cys Leu Asn Met  Val Thr Met Met Val  Glu Thr Asp 
    1550                 1555                 1560             


Asp Gln  Ser Glu Tyr Val Thr  Thr Ile Leu Ser Arg  Ile Asn Leu 
    1565                 1570                 1575             


Val Phe  Ile Val Leu Phe Thr  Gly Glu Cys Val Leu  Lys Leu Ile 
    1580                 1585                 1590             


Ser Leu  Arg His Tyr Tyr Phe  Thr Ile Gly Trp Asn  Ile Phe Asp 
    1595                 1600                 1605             


Phe Val  Val Val Ile Leu Ser  Ile Val Gly Met Phe  Leu Ala Glu 
    1610                 1615                 1620             


Leu Ile  Glu Lys Tyr Phe Val  Ser Pro Thr Leu Phe  Arg Val Ile 
    1625                 1630                 1635             


Arg Leu  Ala Arg Ile Gly Arg  Ile Leu Arg Leu Ile  Lys Gly Ala 
    1640                 1645                 1650             


Lys Gly  Ile Arg Thr Leu Leu  Phe Ala Leu Met Met  Ser Leu Pro 
    1655                 1660                 1665             


Ala Leu  Phe Asn Ile Gly Leu  Leu Leu Phe Leu Val  Met Phe Ile 
    1670                 1675                 1680             


Tyr Ala  Ile Phe Gly Met Ser  Asn Phe Ala Tyr Val  Lys Arg Glu 
    1685                 1690                 1695             


Val Gly  Ile Asp Asp Met Phe  Asn Phe Glu Thr Phe  Gly Asn Ser 
    1700                 1705                 1710             


Met Ile  Cys Leu Phe Gln Ile  Thr Thr Ser Ala Gly  Trp Asp Gly 
    1715                 1720                 1725             


Leu Leu  Ala Pro Ile Leu Asn  Ser Lys Pro Pro Asp  Cys Asp Pro 
    1730                 1735                 1740             


Asn Lys  Val Asn Pro Gly Ser  Ser Val Lys Gly Asp  Cys Gly Asn 
    1745                 1750                 1755             


Pro Ser  Val Gly Ile Phe Phe  Phe Val Ser Tyr Ile  Ile Ile Ser 
    1760                 1765                 1770             


Phe Leu  Val Val Val Asn Met  Tyr Ile Ala Val Ile  Leu Glu Asn 
    1775                 1780                 1785             


Phe Ser  Val Ala Thr Glu Glu  Ser Ala Glu Pro Leu  Ser Glu Asp 
    1790                 1795                 1800             


Asp Phe  Glu Met Phe Tyr Glu  Val Trp Glu Lys Phe  Asp Pro Asp 
    1805                 1810                 1815             


Ala Thr  Gln Phe Met Glu Phe  Glu Lys Leu Ser Gln  Phe Ala Ala 
    1820                 1825                 1830             


Ala Leu  Glu Pro Pro Leu Asn  Leu Pro Gln Pro Asn  Lys Leu Gln 
    1835                 1840                 1845             


Leu Ile  Ala Met Asp Leu Pro  Met Val Ser Gly Asp  Arg Ile His 
    1850                 1855                 1860             


Cys Leu  Asp Ile Leu Phe Ala  Phe Thr Lys Arg Val  Leu Gly Glu 
    1865                 1870                 1875             


Ser Gly  Glu Met Asp Ala Leu  Arg Ile Gln Met Glu  Glu Arg Phe 
    1880                 1885                 1890             


Met Ala  Ser Asn Pro Ser Lys  Val Ser Tyr Gln Pro  Ile Thr Thr 
    1895                 1900                 1905             


Thr Leu  Lys Arg Lys Gln Glu  Glu Val Ser Ala Val  Ile Ile Gln 
    1910                 1915                 1920             


Arg Ala  Tyr Arg Arg His Leu  Leu Lys Arg Thr Val  Lys Gln Ala 
    1925                 1930                 1935             


Ser Phe  Thr Tyr Asn Lys Asn  Lys Ile Lys Gly Gly  Ala Asn Leu 
    1940                 1945                 1950             


Leu Ile  Lys Glu Asp Met Ile  Ile Asp Arg Ile Asn  Glu Asn Ser 
    1955                 1960                 1965             


Ile Thr  Glu Lys Thr Asp Leu  Thr Met Ser Thr Ala  Ala Cys Pro 
    1970                 1975                 1980             


Pro Ser  Tyr Asp Arg Val Thr  Lys Pro Ile Val Glu  Lys His Glu 
    1985                 1990                 1995             


Gln Glu  Gly Lys Asp Glu Lys  Ala Lys Gly Lys 
    2000                 2005                 


<210>  30
<211>  2009
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Glu Gln Thr Val Leu Val Pro Pro Gly Pro Asp Ser Phe Asn Phe 
1               5                   10                  15      


Phe Thr Arg Glu Ser Leu Ala Ala Ile Glu Arg Arg Ile Ala Glu Glu 
            20                  25                  30          


Lys Ala Lys Asn Pro Lys Pro Asp Lys Lys Asp Asp Asp Glu Asn Gly 
        35                  40                  45              


Pro Lys Pro Asn Ser Asp Leu Glu Ala Gly Lys Asn Leu Pro Phe Ile 
    50                  55                  60                  


Tyr Gly Asp Ile Pro Pro Glu Met Val Ser Glu Pro Leu Glu Asp Leu 
65                  70                  75                  80  


Asp Pro Tyr Tyr Ile Asn Lys Lys Thr Phe Ile Val Leu Asn Lys Leu 
                85                  90                  95      


Lys Ala Ile Phe Arg Phe Ser Ala Thr Ser Ala Leu Tyr Ile Leu Thr 
            100                 105                 110         


Pro Phe Asn Pro Leu Arg Lys Ile Ala Ile Lys Ile Leu Val His Ser 
        115                 120                 125             


Leu Phe Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Val Phe 
    130                 135                 140                 


Met Thr Met Ser Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr Thr 
145                 150                 155                 160 


Phe Thr Gly Ile Tyr Thr Phe Glu Ser Leu Ile Lys Ile Ile Ala Arg 
                165                 170                 175     


Gly Phe Cys Leu Glu Asp Phe Thr Phe Leu Arg Asp Pro Trp Asn Trp 
            180                 185                 190         


Leu Asp Phe Thr Val Ile Thr Phe Ala Tyr Val Thr Glu Phe Val Asp 
        195                 200                 205             


Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala Leu 
    210                 215                 220                 


Lys Met Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu 
225                 230                 235                 240 


Ile Gln Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val Phe 
                245                 250                 255     


Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly Asn 
            260                 265                 270         


Leu Arg Asn Lys Cys Ile Gln Trp Pro Pro Thr Asn Ala Ser Leu Glu 
        275                 280                 285             


Glu His Ser Ile Glu Lys Asn Ile Thr Val Asn Tyr Asn Gly Thr Leu 
    290                 295                 300                 


Ile Asn Glu Thr Val Phe Glu Phe Asp Trp Lys Ser Tyr Ile Gln Asp 
305                 310                 315                 320 


Ser Arg Tyr His Tyr Phe Leu Glu Gly Phe Leu Asp Ala Leu Leu Cys 
                325                 330                 335     


Gly Asn Ser Ser Asp Ala Gly Gln Cys Pro Glu Gly Tyr Met Cys Val 
            340                 345                 350         


Lys Ala Gly Arg Asn Pro Asn Tyr Gly Tyr Thr Ser Phe Asp Thr Phe 
        355                 360                 365             


Ser Trp Ala Phe Leu Ser Leu Phe Arg Leu Met Thr Gln Asp Phe Trp 
    370                 375                 380                 


Glu Asn Leu Tyr Gln Leu Thr Leu Arg Ala Ala Gly Lys Thr Tyr Met 
385                 390                 395                 400 


Ile Phe Phe Val Leu Val Ile Phe Leu Gly Ser Phe Tyr Leu Ile Asn 
                405                 410                 415     


Leu Ile Leu Ala Val Val Ala Met Ala Tyr Glu Glu Gln Asn Gln Ala 
            420                 425                 430         


Thr Leu Glu Glu Ala Glu Gln Lys Glu Ala Glu Phe Gln Gln Met Ile 
        435                 440                 445             


Glu Gln Leu Lys Lys Gln Gln Glu Ala Ala Gln Gln Ala Ala Thr Ala 
    450                 455                 460                 


Thr Ala Ser Glu His Ser Arg Glu Pro Ser Ala Ala Gly Arg Leu Ser 
465                 470                 475                 480 


Asp Ser Ser Ser Glu Ala Ser Lys Leu Ser Ser Lys Ser Ala Lys Glu 
                485                 490                 495     


Arg Arg Asn Arg Arg Lys Lys Arg Lys Gln Lys Glu Gln Ser Gly Gly 
            500                 505                 510         


Glu Glu Lys Asp Glu Asp Glu Phe Gln Lys Ser Glu Ser Glu Asp Ser 
        515                 520                 525             


Ile Arg Arg Lys Gly Phe Arg Phe Ser Ile Glu Gly Asn Arg Leu Thr 
    530                 535                 540                 


Tyr Glu Lys Arg Tyr Ser Ser Pro His Gln Ser Leu Leu Ser Ile Arg 
545                 550                 555                 560 


Gly Ser Leu Phe Ser Pro Arg Arg Asn Ser Arg Thr Ser Leu Phe Ser 
                565                 570                 575     


Phe Arg Gly Arg Ala Lys Asp Val Gly Ser Glu Asn Asp Phe Ala Asp 
            580                 585                 590         


Asp Glu His Ser Thr Phe Glu Asp Asn Glu Ser Arg Arg Asp Ser Leu 
        595                 600                 605             


Phe Val Pro Arg Arg His Gly Glu Arg Arg Asn Ser Asn Leu Ser Gln 
    610                 615                 620                 


Thr Ser Arg Ser Ser Arg Met Leu Ala Val Phe Pro Ala Asn Gly Lys 
625                 630                 635                 640 


Met His Ser Thr Val Asp Cys Asn Gly Val Val Ser Leu Val Gly Gly 
                645                 650                 655     


Pro Ser Val Pro Thr Ser Pro Val Gly Gln Leu Leu Pro Glu Val Ile 
            660                 665                 670         


Ile Asp Lys Pro Ala Thr Asp Asp Asn Gly Thr Thr Thr Glu Thr Glu 
        675                 680                 685             


Met Arg Lys Arg Arg Ser Ser Ser Phe His Val Ser Met Asp Phe Leu 
    690                 695                 700                 


Glu Asp Pro Ser Gln Arg Gln Arg Ala Met Ser Ile Ala Ser Ile Leu 
705                 710                 715                 720 


Thr Asn Thr Val Glu Glu Leu Glu Glu Ser Arg Gln Lys Cys Pro Pro 
                725                 730                 735     


Cys Trp Tyr Lys Phe Ser Asn Ile Phe Leu Ile Trp Asp Cys Ser Pro 
            740                 745                 750         


Tyr Trp Leu Lys Val Lys His Val Val Asn Leu Val Val Met Asp Pro 
        755                 760                 765             


Phe Val Asp Leu Ala Ile Thr Ile Cys Ile Val Leu Asn Thr Leu Phe 
    770                 775                 780                 


Met Ala Met Glu His Tyr Pro Met Thr Asp His Phe Asn Asn Val Leu 
785                 790                 795                 800 


Thr Val Gly Asn Leu Val Phe Thr Gly Ile Phe Thr Ala Glu Met Phe 
                805                 810                 815     


Leu Lys Ile Ile Ala Met Asp Pro Tyr Tyr Tyr Phe Gln Glu Gly Trp 
            820                 825                 830         


Asn Ile Phe Asp Gly Phe Ile Val Thr Leu Ser Leu Val Glu Leu Gly 
        835                 840                 845             


Leu Ala Asn Val Glu Gly Leu Ser Val Leu Arg Ser Phe Arg Leu Leu 
    850                 855                 860                 


Arg Val Phe Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Met Leu Ile 
865                 870                 875                 880 


Lys Ile Ile Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr Leu Val 
                885                 890                 895     


Leu Ala Ile Ile Val Phe Ile Phe Ala Val Val Gly Met Gln Leu Phe 
            900                 905                 910         


Gly Lys Ser Tyr Lys Asp Cys Val Cys Lys Ile Ala Ser Asp Cys Gln 
        915                 920                 925             


Leu Pro Arg Trp His Met Asn Asp Phe Phe His Ser Phe Leu Ile Val 
    930                 935                 940                 


Phe Arg Val Leu Cys Gly Glu Trp Ile Glu Thr Met Trp Asp Cys Met 
945                 950                 955                 960 


Glu Val Ala Gly Gln Ala Met Cys Leu Thr Val Phe Met Met Val Met 
                965                 970                 975     


Val Ile Gly Asn Leu Val Val Leu Asn Leu Phe Leu Ala Leu Leu Leu 
            980                 985                 990         


Ser Ser Phe Ser Ala Asp Asn Leu  Ala Ala Thr Asp Asp  Asp Asn Glu 
        995                 1000                 1005             


Met Asn  Asn Leu Gln Ile Ala  Val Asp Arg Met His  Lys Gly Val 
    1010                 1015                 1020             


Ala Tyr  Val Lys Arg Lys Ile  Tyr Glu Phe Ile Gln  Gln Ser Phe 
    1025                 1030                 1035             


Ile Arg  Lys Gln Lys Ile Leu  Asp Glu Ile Lys Pro  Leu Asp Asp 
    1040                 1045                 1050             


Leu Asn  Asn Lys Lys Asp Ser  Cys Met Ser Asn His  Thr Thr Glu 
    1055                 1060                 1065             


Ile Gly  Lys Asp Leu Asp Tyr  Leu Lys Asp Val Asn  Gly Thr Thr 
    1070                 1075                 1080             


Ser Gly  Ile Gly Thr Gly Ser  Ser Val Glu Lys Tyr  Ile Ile Asp 
    1085                 1090                 1095             


Glu Ser  Asp Tyr Met Ser Phe  Ile Asn Asn Pro Ser  Leu Thr Val 
    1100                 1105                 1110             


Thr Val  Pro Ile Ala Val Gly  Glu Ser Asp Phe Glu  Asn Leu Asn 
    1115                 1120                 1125             


Thr Glu  Asp Phe Ser Ser Glu  Ser Asp Leu Glu Glu  Ser Lys Glu 
    1130                 1135                 1140             


Lys Leu  Asn Glu Ser Ser Ser  Ser Ser Glu Gly Ser  Thr Val Asp 
    1145                 1150                 1155             


Ile Gly  Ala Pro Val Glu Glu  Gln Pro Val Val Glu  Pro Glu Glu 
    1160                 1165                 1170             


Thr Leu  Glu Pro Glu Ala Cys  Phe Thr Glu Gly Cys  Val Gln Arg 
    1175                 1180                 1185             


Phe Lys  Cys Cys Gln Ile Asn  Val Glu Glu Gly Arg  Gly Lys Gln 
    1190                 1195                 1200             


Trp Trp  Asn Leu Arg Arg Thr  Cys Phe Arg Ile Val  Glu His Asn 
    1205                 1210                 1215             


Trp Phe  Glu Thr Phe Ile Val  Phe Met Ile Leu Leu  Ser Ser Gly 
    1220                 1225                 1230             


Ala Leu  Ala Phe Glu Asp Ile  Tyr Ile Asp Gln Arg  Lys Thr Ile 
    1235                 1240                 1245             


Lys Thr  Met Leu Glu Tyr Ala  Asp Lys Val Phe Thr  Tyr Ile Phe 
    1250                 1255                 1260             


Ile Leu  Glu Met Leu Leu Lys  Trp Val Ala Tyr Gly  Tyr Gln Thr 
    1265                 1270                 1275             


Tyr Phe  Thr Asn Ala Trp Cys  Trp Leu Asp Phe Leu  Ile Val Asp 
    1280                 1285                 1290             


Val Ser  Leu Val Ser Leu Thr  Ala Asn Ala Leu Gly  Tyr Ser Glu 
    1295                 1300                 1305             


Leu Gly  Ala Ile Lys Ser Leu  Arg Thr Leu Arg Ala  Leu Arg Pro 
    1310                 1315                 1320             


Leu Arg  Ala Leu Ser Arg Phe  Glu Gly Met Arg Val  Val Val Asn 
    1325                 1330                 1335             


Ala Leu  Leu Gly Ala Ile Pro  Ser Ile Met Asn Val  Leu Leu Val 
    1340                 1345                 1350             


Cys Leu  Ile Phe Trp Leu Ile  Phe Ser Ile Met Gly  Val Asn Leu 
    1355                 1360                 1365             


Phe Ala  Gly Lys Phe Tyr His  Cys Ile Asn Thr Thr  Thr Gly Asp 
    1370                 1375                 1380             


Arg Phe  Asp Ile Glu Asp Val  Asn Asn His Thr Asp  Cys Leu Lys 
    1385                 1390                 1395             


Leu Ile  Glu Arg Asn Glu Thr  Ala Arg Trp Lys Asn  Val Lys Val 
    1400                 1405                 1410             


Asn Phe  Asp Asn Val Gly Phe  Gly Tyr Leu Ser Leu  Leu Gln Val 
    1415                 1420                 1425             


Ala Thr  Phe Lys Gly Trp Met  Asp Ile Met Tyr Ala  Ala Val Asp 
    1430                 1435                 1440             


Ser Arg  Asn Val Glu Leu Gln  Pro Lys Tyr Glu Lys  Ser Leu Tyr 
    1445                 1450                 1455             


Met Tyr  Leu Tyr Phe Val Ile  Phe Ile Ile Phe Gly  Ser Phe Phe 
    1460                 1465                 1470             


Thr Leu  Asn Leu Phe Ile Gly  Val Ile Ile Asp Asn  Phe Asn Gln 
    1475                 1480                 1485             


Gln Lys  Lys Lys Phe Gly Gly  Gln Asp Ile Phe Met  Thr Glu Glu 
    1490                 1495                 1500             


Gln Lys  Lys Tyr Tyr Asn Ala  Met Lys Lys Leu Gly  Ser Lys Lys 
    1505                 1510                 1515             


Pro Gln  Lys Pro Ile Pro Arg  Pro Gly Asn Lys Phe  Gln Gly Met 
    1520                 1525                 1530             


Val Phe  Asp Phe Val Thr Arg  Gln Val Phe Asp Ile  Ser Ile Met 
    1535                 1540                 1545             


Ile Leu  Ile Cys Leu Asn Met  Val Thr Met Met Val  Glu Thr Asp 
    1550                 1555                 1560             


Asp Gln  Ser Glu Tyr Val Thr  Thr Ile Leu Ser Arg  Ile Asn Leu 
    1565                 1570                 1575             


Val Phe  Ile Val Leu Phe Thr  Gly Glu Cys Val Leu  Lys Leu Ile 
    1580                 1585                 1590             


Ser Leu  Arg His Tyr Tyr Phe  Thr Ile Gly Trp Asn  Ile Phe Asp 
    1595                 1600                 1605             


Phe Val  Val Val Ile Leu Ser  Ile Val Gly Met Phe  Leu Ala Glu 
    1610                 1615                 1620             


Leu Ile  Glu Lys Tyr Phe Val  Ser Pro Thr Leu Phe  Arg Val Ile 
    1625                 1630                 1635             


Arg Leu  Ala Arg Ile Gly Arg  Ile Leu Arg Leu Ile  Lys Gly Ala 
    1640                 1645                 1650             


Lys Gly  Ile Arg Thr Leu Leu  Phe Ala Leu Met Met  Ser Leu Pro 
    1655                 1660                 1665             


Ala Leu  Phe Asn Ile Gly Leu  Leu Leu Phe Leu Val  Met Phe Ile 
    1670                 1675                 1680             


Tyr Ala  Ile Phe Gly Met Ser  Asn Phe Ala Tyr Val  Lys Arg Glu 
    1685                 1690                 1695             


Val Gly  Ile Asp Asp Met Phe  Asn Phe Glu Thr Phe  Gly Asn Ser 
    1700                 1705                 1710             


Met Ile  Cys Leu Phe Gln Ile  Thr Thr Ser Ala Gly  Trp Asp Gly 
    1715                 1720                 1725             


Leu Leu  Ala Pro Ile Leu Asn  Ser Lys Pro Pro Asp  Cys Asp Pro 
    1730                 1735                 1740             


Asn Lys  Val Asn Pro Gly Ser  Ser Val Lys Gly Asp  Cys Gly Asn 
    1745                 1750                 1755             


Pro Ser  Val Gly Ile Phe Phe  Phe Val Ser Tyr Ile  Ile Ile Ser 
    1760                 1765                 1770             


Phe Leu  Val Val Val Asn Met  Tyr Ile Ala Val Ile  Leu Glu Asn 
    1775                 1780                 1785             


Phe Ser  Val Ala Thr Glu Glu  Ser Ala Glu Pro Leu  Ser Glu Asp 
    1790                 1795                 1800             


Asp Phe  Glu Met Phe Tyr Glu  Val Trp Glu Lys Phe  Asp Pro Asp 
    1805                 1810                 1815             


Ala Thr  Gln Phe Met Glu Phe  Glu Lys Leu Ser Gln  Phe Ala Ala 
    1820                 1825                 1830             


Ala Leu  Glu Pro Pro Leu Asn  Leu Pro Gln Pro Asn  Lys Leu Gln 
    1835                 1840                 1845             


Leu Ile  Ala Met Asp Leu Pro  Met Val Ser Gly Asp  Arg Ile His 
    1850                 1855                 1860             


Cys Leu  Asp Ile Leu Phe Ala  Phe Thr Lys Arg Val  Leu Gly Glu 
    1865                 1870                 1875             


Ser Gly  Glu Met Asp Ala Leu  Arg Ile Gln Met Glu  Glu Arg Phe 
    1880                 1885                 1890             


Met Ala  Ser Asn Pro Ser Lys  Val Ser Tyr Gln Pro  Ile Thr Thr 
    1895                 1900                 1905             


Thr Leu  Lys Arg Lys Gln Glu  Glu Val Ser Ala Val  Ile Ile Gln 
    1910                 1915                 1920             


Arg Ala  Tyr Arg Arg His Leu  Leu Lys Arg Thr Val  Lys Gln Ala 
    1925                 1930                 1935             


Ser Phe  Thr Tyr Asn Lys Asn  Lys Ile Lys Gly Gly  Ala Asn Leu 
    1940                 1945                 1950             


Leu Ile  Lys Glu Asp Met Ile  Ile Asp Arg Ile Asn  Glu Asn Ser 
    1955                 1960                 1965             


Ile Thr  Glu Lys Thr Asp Leu  Thr Met Ser Thr Ala  Ala Cys Pro 
    1970                 1975                 1980             


Pro Ser  Tyr Asp Arg Val Thr  Lys Pro Ile Val Glu  Lys His Glu 
    1985                 1990                 1995             


Gln Glu  Gly Lys Asp Glu Lys  Ala Lys Gly Lys 
    2000                 2005                 


<210>  31
<211>  2009
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Glu Gln Thr Val Leu Val Pro Pro Gly Pro Asp Ser Phe Asn Phe 
1               5                   10                  15      


Phe Thr Arg Glu Ser Leu Ala Ala Ile Glu Arg Arg Ile Ala Glu Glu 
            20                  25                  30          


Lys Ala Lys Asn Pro Lys Pro Asp Lys Lys Asp Asp Asp Glu Asn Gly 
        35                  40                  45              


Pro Lys Pro Asn Ser Asp Leu Glu Ala Gly Lys Asn Leu Pro Phe Ile 
    50                  55                  60                  


Tyr Gly Asp Ile Pro Pro Glu Met Val Ser Glu Pro Leu Glu Asp Leu 
65                  70                  75                  80  


Asp Pro Tyr Tyr Ile Asn Lys Lys Thr Phe Ile Val Leu Asn Lys Leu 
                85                  90                  95      


Lys Ala Ile Phe Arg Phe Ser Ala Thr Ser Ala Leu Tyr Ile Leu Thr 
            100                 105                 110         


Pro Phe Asn Pro Leu Arg Lys Ile Ala Ile Lys Ile Leu Val His Ser 
        115                 120                 125             


Leu Phe Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Val Phe 
    130                 135                 140                 


Met Thr Met Ser Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr Thr 
145                 150                 155                 160 


Phe Thr Gly Ile Tyr Thr Phe Glu Ser Leu Ile Lys Ile Ile Ala Arg 
                165                 170                 175     


Gly Phe Cys Leu Glu Asp Phe Thr Phe Leu Arg Asp Pro Trp Asn Trp 
            180                 185                 190         


Leu Asp Phe Thr Val Ile Thr Phe Ala Tyr Val Thr Glu Phe Val Asp 
        195                 200                 205             


Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala Leu 
    210                 215                 220                 


Lys Thr Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Thr Leu 
225                 230                 235                 240 


Ile Gln Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val Phe 
                245                 250                 255     


Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly Asn 
            260                 265                 270         


Leu Arg Asn Lys Cys Ile Gln Trp Pro Pro Thr Asn Ala Ser Leu Glu 
        275                 280                 285             


Glu His Ser Ile Glu Lys Asn Ile Thr Val Asn Tyr Asn Gly Thr Leu 
    290                 295                 300                 


Ile Asn Glu Thr Val Phe Glu Phe Asp Trp Lys Ser Tyr Ile Gln Asp 
305                 310                 315                 320 


Ser Arg Tyr His Tyr Phe Leu Glu Gly Phe Leu Asp Ala Leu Leu Cys 
                325                 330                 335     


Gly Asn Ser Ser Asp Ala Gly Gln Cys Pro Glu Gly Tyr Met Cys Val 
            340                 345                 350         


Lys Ala Gly Arg Asn Pro Asn Tyr Gly Tyr Thr Ser Phe Asp Thr Phe 
        355                 360                 365             


Ser Trp Ala Phe Leu Ser Leu Phe Arg Leu Met Thr Gln Asp Phe Trp 
    370                 375                 380                 


Glu Asn Leu Tyr Gln Leu Thr Leu Arg Ala Ala Gly Lys Thr Tyr Met 
385                 390                 395                 400 


Ile Phe Phe Val Leu Val Ile Phe Leu Gly Ser Phe Tyr Leu Ile Asn 
                405                 410                 415     


Leu Ile Leu Ala Val Val Ala Met Ala Tyr Glu Glu Gln Asn Gln Ala 
            420                 425                 430         


Thr Leu Glu Glu Ala Glu Gln Lys Glu Ala Glu Phe Gln Gln Met Ile 
        435                 440                 445             


Glu Gln Leu Lys Lys Gln Gln Glu Ala Ala Gln Gln Ala Ala Thr Ala 
    450                 455                 460                 


Thr Ala Ser Glu His Ser Arg Glu Pro Ser Ala Ala Gly Arg Leu Ser 
465                 470                 475                 480 


Asp Ser Ser Ser Glu Ala Ser Lys Leu Ser Ser Lys Ser Ala Lys Glu 
                485                 490                 495     


Arg Arg Asn Arg Arg Lys Lys Arg Lys Gln Lys Glu Gln Ser Gly Gly 
            500                 505                 510         


Glu Glu Lys Asp Glu Asp Glu Phe Gln Lys Ser Glu Ser Glu Asp Ser 
        515                 520                 525             


Ile Arg Arg Lys Gly Phe Arg Phe Ser Ile Glu Gly Asn Arg Leu Thr 
    530                 535                 540                 


Tyr Glu Lys Arg Tyr Ser Ser Pro His Gln Ser Leu Leu Ser Ile Arg 
545                 550                 555                 560 


Gly Ser Leu Phe Ser Pro Arg Arg Asn Ser Arg Thr Ser Leu Phe Ser 
                565                 570                 575     


Phe Arg Gly Arg Ala Lys Asp Val Gly Ser Glu Asn Asp Phe Ala Asp 
            580                 585                 590         


Asp Glu His Ser Thr Phe Glu Asp Asn Glu Ser Arg Arg Asp Ser Leu 
        595                 600                 605             


Phe Val Pro Arg Arg His Gly Glu Arg Arg Asn Ser Asn Leu Ser Gln 
    610                 615                 620                 


Thr Ser Arg Ser Ser Arg Met Leu Ala Val Phe Pro Ala Asn Gly Lys 
625                 630                 635                 640 


Met His Ser Thr Val Asp Cys Asn Gly Val Val Ser Leu Val Gly Gly 
                645                 650                 655     


Pro Ser Val Pro Thr Ser Pro Val Gly Gln Leu Leu Pro Glu Val Ile 
            660                 665                 670         


Ile Asp Lys Pro Ala Thr Asp Asp Asn Gly Thr Thr Thr Glu Thr Glu 
        675                 680                 685             


Met Arg Lys Arg Arg Ser Ser Ser Phe His Val Ser Met Asp Phe Leu 
    690                 695                 700                 


Glu Asp Pro Ser Gln Arg Gln Arg Ala Met Ser Ile Ala Ser Ile Leu 
705                 710                 715                 720 


Thr Asn Thr Val Glu Glu Leu Glu Glu Ser Arg Gln Lys Cys Pro Pro 
                725                 730                 735     


Cys Trp Tyr Lys Phe Ser Asn Ile Phe Leu Ile Trp Asp Cys Ser Pro 
            740                 745                 750         


Tyr Trp Leu Lys Val Lys His Val Val Asn Leu Val Val Met Asp Pro 
        755                 760                 765             


Phe Val Asp Leu Ala Ile Thr Ile Cys Ile Val Leu Asn Thr Leu Phe 
    770                 775                 780                 


Met Ala Met Glu His Tyr Pro Met Thr Asp His Phe Asn Asn Val Leu 
785                 790                 795                 800 


Thr Val Gly Asn Leu Val Phe Thr Gly Ile Phe Thr Ala Glu Met Phe 
                805                 810                 815     


Leu Lys Ile Ile Ala Met Asp Pro Tyr Tyr Tyr Phe Gln Glu Gly Trp 
            820                 825                 830         


Asn Ile Phe Asp Gly Phe Ile Val Thr Leu Ser Leu Val Glu Leu Gly 
        835                 840                 845             


Leu Ala Asn Val Glu Gly Leu Ser Val Leu Arg Ser Phe Arg Leu Leu 
    850                 855                 860                 


Arg Val Phe Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Met Leu Ile 
865                 870                 875                 880 


Lys Ile Ile Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr Leu Val 
                885                 890                 895     


Leu Ala Ile Ile Val Phe Ile Phe Ala Val Val Gly Met Gln Leu Phe 
            900                 905                 910         


Gly Lys Ser Tyr Lys Asp Cys Val Cys Lys Ile Ala Ser Asp Cys Gln 
        915                 920                 925             


Leu Pro Arg Trp His Met Asn Asp Phe Phe His Ser Phe Leu Ile Val 
    930                 935                 940                 


Phe Arg Val Leu Cys Gly Glu Trp Ile Glu Thr Met Trp Asp Cys Met 
945                 950                 955                 960 


Glu Val Ala Gly Gln Ala Met Cys Leu Thr Val Phe Met Met Val Met 
                965                 970                 975     


Val Ile Gly Asn Leu Val Val Leu Asn Leu Phe Leu Ala Leu Leu Leu 
            980                 985                 990         


Ser Ser Phe Ser Ala Asp Asn Leu  Ala Ala Thr Asp Asp  Asp Asn Glu 
        995                 1000                 1005             


Met Asn  Asn Leu Gln Ile Ala  Val Asp Arg Met His  Lys Gly Val 
    1010                 1015                 1020             


Ala Tyr  Val Lys Arg Lys Ile  Tyr Glu Phe Ile Gln  Gln Ser Phe 
    1025                 1030                 1035             


Ile Arg  Lys Gln Lys Ile Leu  Asp Glu Ile Lys Pro  Leu Asp Asp 
    1040                 1045                 1050             


Leu Asn  Asn Lys Lys Asp Ser  Cys Met Ser Asn His  Thr Thr Glu 
    1055                 1060                 1065             


Ile Gly  Lys Asp Leu Asp Tyr  Leu Lys Asp Val Asn  Gly Thr Thr 
    1070                 1075                 1080             


Ser Gly  Ile Gly Thr Gly Ser  Ser Val Glu Lys Tyr  Ile Ile Asp 
    1085                 1090                 1095             


Glu Ser  Asp Tyr Met Ser Phe  Ile Asn Asn Pro Ser  Leu Thr Val 
    1100                 1105                 1110             


Thr Val  Pro Ile Ala Val Gly  Glu Ser Asp Phe Glu  Asn Leu Asn 
    1115                 1120                 1125             


Thr Glu  Asp Phe Ser Ser Glu  Ser Asp Leu Glu Glu  Ser Lys Glu 
    1130                 1135                 1140             


Lys Leu  Asn Glu Ser Ser Ser  Ser Ser Glu Gly Ser  Thr Val Asp 
    1145                 1150                 1155             


Ile Gly  Ala Pro Val Glu Glu  Gln Pro Val Val Glu  Pro Glu Glu 
    1160                 1165                 1170             


Thr Leu  Glu Pro Glu Ala Cys  Phe Thr Glu Gly Cys  Val Gln Arg 
    1175                 1180                 1185             


Phe Lys  Cys Cys Gln Ile Asn  Val Glu Glu Gly Arg  Gly Lys Gln 
    1190                 1195                 1200             


Trp Trp  Asn Leu Arg Arg Thr  Cys Phe Arg Ile Val  Glu His Asn 
    1205                 1210                 1215             


Trp Phe  Glu Thr Phe Ile Val  Phe Met Ile Leu Leu  Ser Ser Gly 
    1220                 1225                 1230             


Ala Leu  Ala Phe Glu Asp Ile  Tyr Ile Asp Gln Arg  Lys Thr Ile 
    1235                 1240                 1245             


Lys Thr  Met Leu Glu Tyr Ala  Asp Lys Val Phe Thr  Tyr Ile Phe 
    1250                 1255                 1260             


Ile Leu  Glu Met Leu Leu Lys  Trp Val Ala Tyr Gly  Tyr Gln Thr 
    1265                 1270                 1275             


Tyr Phe  Thr Asn Ala Trp Cys  Trp Leu Asp Phe Leu  Ile Val Asp 
    1280                 1285                 1290             


Val Ser  Leu Val Ser Leu Thr  Ala Asn Ala Leu Gly  Tyr Ser Glu 
    1295                 1300                 1305             


Leu Gly  Ala Ile Lys Ser Leu  Arg Thr Leu Arg Ala  Leu Arg Pro 
    1310                 1315                 1320             


Leu Arg  Ala Leu Ser Arg Phe  Glu Gly Met Arg Val  Val Val Asn 
    1325                 1330                 1335             


Ala Leu  Leu Gly Ala Ile Pro  Ser Ile Met Asn Val  Leu Leu Val 
    1340                 1345                 1350             


Cys Leu  Ile Phe Trp Leu Ile  Phe Ser Ile Met Gly  Val Asn Leu 
    1355                 1360                 1365             


Phe Ala  Gly Lys Phe Tyr His  Cys Ile Asn Thr Thr  Thr Gly Asp 
    1370                 1375                 1380             


Arg Phe  Asp Ile Glu Asp Val  Asn Asn His Thr Asp  Cys Leu Lys 
    1385                 1390                 1395             


Leu Ile  Glu Arg Asn Glu Thr  Ala Arg Trp Lys Asn  Val Lys Val 
    1400                 1405                 1410             


Asn Phe  Asp Asn Val Gly Phe  Gly Tyr Leu Ser Leu  Leu Gln Val 
    1415                 1420                 1425             


Ala Thr  Phe Lys Gly Trp Met  Asp Ile Met Tyr Ala  Ala Val Asp 
    1430                 1435                 1440             


Ser Arg  Asn Val Glu Leu Gln  Pro Lys Tyr Glu Lys  Ser Leu Tyr 
    1445                 1450                 1455             


Met Tyr  Leu Tyr Phe Val Ile  Phe Ile Ile Phe Gly  Ser Phe Phe 
    1460                 1465                 1470             


Thr Leu  Asn Leu Phe Ile Gly  Val Ile Ile Asp Asn  Phe Asn Gln 
    1475                 1480                 1485             


Gln Lys  Lys Lys Phe Gly Gly  Gln Asp Ile Phe Met  Thr Glu Glu 
    1490                 1495                 1500             


Gln Lys  Lys Tyr Tyr Asn Ala  Met Lys Lys Leu Gly  Ser Lys Lys 
    1505                 1510                 1515             


Pro Gln  Lys Pro Ile Pro Arg  Pro Gly Asn Lys Phe  Gln Gly Met 
    1520                 1525                 1530             


Val Phe  Asp Phe Val Thr Arg  Gln Val Phe Asp Ile  Ser Ile Met 
    1535                 1540                 1545             


Ile Leu  Ile Cys Leu Asn Met  Val Thr Met Met Val  Glu Thr Asp 
    1550                 1555                 1560             


Asp Gln  Ser Glu Tyr Val Thr  Thr Ile Leu Ser Arg  Ile Asn Leu 
    1565                 1570                 1575             


Val Phe  Ile Val Leu Phe Thr  Gly Glu Cys Val Leu  Lys Leu Ile 
    1580                 1585                 1590             


Ser Leu  Arg His Tyr Tyr Phe  Thr Ile Gly Trp Asn  Ile Phe Asp 
    1595                 1600                 1605             


Phe Val  Val Val Ile Leu Ser  Ile Val Gly Met Phe  Leu Ala Glu 
    1610                 1615                 1620             


Leu Ile  Glu Lys Tyr Phe Val  Ser Pro Thr Leu Phe  Arg Val Ile 
    1625                 1630                 1635             


Arg Leu  Ala Arg Ile Gly Arg  Ile Leu Arg Leu Ile  Lys Gly Ala 
    1640                 1645                 1650             


Lys Gly  Ile Arg Thr Leu Leu  Phe Ala Leu Met Met  Ser Leu Pro 
    1655                 1660                 1665             


Ala Leu  Phe Asn Ile Gly Leu  Leu Leu Phe Leu Val  Met Phe Ile 
    1670                 1675                 1680             


Tyr Ala  Ile Phe Gly Met Ser  Asn Phe Ala Tyr Val  Lys Arg Glu 
    1685                 1690                 1695             


Val Gly  Ile Asp Asp Met Phe  Asn Phe Glu Thr Phe  Gly Asn Ser 
    1700                 1705                 1710             


Met Ile  Cys Leu Phe Gln Ile  Thr Thr Ser Ala Gly  Trp Asp Gly 
    1715                 1720                 1725             


Leu Leu  Ala Pro Ile Leu Asn  Ser Lys Pro Pro Asp  Cys Asp Pro 
    1730                 1735                 1740             


Asn Lys  Val Asn Pro Gly Ser  Ser Val Lys Gly Asp  Cys Gly Asn 
    1745                 1750                 1755             


Pro Ser  Val Gly Ile Phe Phe  Phe Val Ser Tyr Ile  Ile Ile Ser 
    1760                 1765                 1770             


Phe Leu  Val Val Val Asn Met  Tyr Ile Ala Val Ile  Leu Glu Asn 
    1775                 1780                 1785             


Phe Ser  Val Ala Thr Glu Glu  Ser Ala Glu Pro Leu  Ser Glu Asp 
    1790                 1795                 1800             


Asp Phe  Glu Met Phe Tyr Glu  Val Trp Glu Lys Phe  Asp Pro Asp 
    1805                 1810                 1815             


Ala Thr  Gln Phe Met Glu Phe  Glu Lys Leu Ser Gln  Phe Ala Ala 
    1820                 1825                 1830             


Ala Leu  Glu Pro Pro Leu Asn  Leu Pro Gln Pro Asn  Lys Leu Gln 
    1835                 1840                 1845             


Leu Ile  Ala Met Asp Leu Pro  Met Val Ser Gly Asp  Arg Ile His 
    1850                 1855                 1860             


Cys Leu  Asp Ile Leu Phe Ala  Phe Thr Lys Arg Val  Leu Gly Glu 
    1865                 1870                 1875             


Ser Gly  Glu Met Asp Ala Leu  Arg Ile Gln Met Glu  Glu Arg Phe 
    1880                 1885                 1890             


Met Ala  Ser Asn Pro Ser Lys  Val Ser Tyr Gln Pro  Ile Thr Thr 
    1895                 1900                 1905             


Thr Leu  Lys Arg Lys Gln Glu  Glu Val Ser Ala Val  Ile Ile Gln 
    1910                 1915                 1920             


Arg Ala  Tyr Arg Arg His Leu  Leu Lys Arg Thr Val  Lys Gln Ala 
    1925                 1930                 1935             


Ser Phe  Thr Tyr Asn Lys Asn  Lys Ile Lys Gly Gly  Ala Asn Leu 
    1940                 1945                 1950             


Leu Ile  Lys Glu Asp Met Ile  Ile Asp Arg Ile Asn  Glu Asn Ser 
    1955                 1960                 1965             


Ile Thr  Glu Lys Thr Asp Leu  Thr Met Ser Thr Ala  Ala Cys Pro 
    1970                 1975                 1980             


Pro Ser  Tyr Asp Arg Val Thr  Lys Pro Ile Val Glu  Lys His Glu 
    1985                 1990                 1995             


Gln Glu  Gly Lys Asp Glu Lys  Ala Lys Gly Lys 
    2000                 2005                 


<210>  32
<211>  2009
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Glu Gln Thr Val Leu Val Pro Pro Gly Pro Asp Ser Phe Asn Phe 
1               5                   10                  15      


Phe Thr Arg Glu Ser Leu Ala Ala Ile Glu Arg Arg Ile Ala Glu Glu 
            20                  25                  30          


Lys Ala Lys Asn Pro Lys Pro Asp Lys Lys Asp Asp Asp Glu Asn Gly 
        35                  40                  45              


Pro Lys Pro Asn Ser Asp Leu Glu Ala Gly Lys Asn Leu Pro Phe Ile 
    50                  55                  60                  


Tyr Gly Asp Ile Pro Pro Glu Met Val Ser Glu Pro Leu Glu Asp Leu 
65                  70                  75                  80  


Asp Pro Tyr Tyr Ile Asn Lys Lys Thr Phe Ile Val Leu Asn Lys Leu 
                85                  90                  95      


Lys Ala Ile Phe Arg Phe Ser Ala Thr Ser Ala Leu Tyr Ile Leu Thr 
            100                 105                 110         


Pro Phe Asn Pro Leu Arg Lys Ile Ala Ile Lys Ile Leu Val His Ser 
        115                 120                 125             


Leu Phe Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Val Phe 
    130                 135                 140                 


Met Thr Met Ser Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr Thr 
145                 150                 155                 160 


Phe Thr Gly Ile Tyr Thr Phe Glu Ser Leu Ile Lys Ile Ile Ala Arg 
                165                 170                 175     


Gly Phe Cys Leu Glu Asp Phe Thr Phe Leu Arg Asp Pro Trp Asn Trp 
            180                 185                 190         


Leu Asp Phe Thr Val Ile Thr Phe Ala Tyr Val Thr Glu Phe Val Asp 
        195                 200                 205             


Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala Leu 
    210                 215                 220                 


Lys Thr Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu 
225                 230                 235                 240 


Ile Gln Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val Phe 
                245                 250                 255     


Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly Asn 
            260                 265                 270         


Leu Arg Asn Lys Cys Ile Gln Trp Pro Pro Thr Asn Ala Ser Leu Glu 
        275                 280                 285             


Glu His Ser Ile Glu Lys Asn Ile Thr Val Asn Tyr Asn Gly Thr Leu 
    290                 295                 300                 


Ile Asn Glu Thr Val Phe Glu Phe Asp Trp Lys Ser Tyr Ile Gln Asp 
305                 310                 315                 320 


Ser Arg Tyr His Tyr Phe Leu Glu Gly Phe Leu Asp Ala Leu Leu Cys 
                325                 330                 335     


Gly Asn Ser Ser Asp Ala Gly Gln Cys Pro Glu Gly Tyr Met Cys Val 
            340                 345                 350         


Lys Ala Gly Arg Asn Pro Asn Tyr Gly Tyr Thr Ser Phe Asp Thr Phe 
        355                 360                 365             


Ser Trp Ala Phe Leu Ser Leu Phe Arg Leu Met Thr Gln Asp Phe Trp 
    370                 375                 380                 


Glu Asn Leu Tyr Gln Leu Thr Leu Arg Ala Ala Gly Lys Thr Tyr Met 
385                 390                 395                 400 


Ile Phe Phe Val Leu Val Ile Phe Leu Gly Ser Phe Tyr Leu Ile Asn 
                405                 410                 415     


Leu Ile Leu Ala Val Val Ala Met Ala Tyr Glu Glu Gln Asn Gln Ala 
            420                 425                 430         


Thr Leu Glu Glu Ala Glu Gln Lys Glu Ala Glu Phe Gln Gln Met Ile 
        435                 440                 445             


Glu Gln Leu Lys Lys Gln Gln Glu Ala Ala Gln Gln Ala Ala Thr Ala 
    450                 455                 460                 


Thr Ala Ser Glu His Ser Arg Glu Pro Ser Ala Ala Gly Arg Leu Ser 
465                 470                 475                 480 


Asp Ser Ser Ser Glu Ala Ser Lys Leu Ser Ser Lys Ser Ala Lys Glu 
                485                 490                 495     


Arg Arg Asn Arg Arg Lys Lys Arg Lys Gln Lys Glu Gln Ser Gly Gly 
            500                 505                 510         


Glu Glu Lys Asp Glu Asp Glu Phe Gln Lys Ser Glu Ser Glu Asp Ser 
        515                 520                 525             


Ile Arg Arg Lys Gly Phe Arg Phe Ser Ile Glu Gly Asn Arg Leu Thr 
    530                 535                 540                 


Tyr Glu Lys Arg Tyr Ser Ser Pro His Gln Ser Leu Leu Ser Ile Arg 
545                 550                 555                 560 


Gly Ser Leu Phe Ser Pro Arg Arg Asn Ser Arg Thr Ser Leu Phe Ser 
                565                 570                 575     


Phe Arg Gly Arg Ala Lys Asp Val Gly Ser Glu Asn Asp Phe Ala Asp 
            580                 585                 590         


Asp Glu His Ser Thr Phe Glu Asp Asn Glu Ser Arg Arg Asp Ser Leu 
        595                 600                 605             


Phe Val Pro Arg Arg His Gly Glu Arg Arg Asn Ser Asn Leu Ser Gln 
    610                 615                 620                 


Thr Ser Arg Ser Ser Arg Met Leu Ala Val Phe Pro Ala Asn Gly Lys 
625                 630                 635                 640 


Met His Ser Thr Val Asp Cys Asn Gly Val Val Ser Leu Val Gly Gly 
                645                 650                 655     


Pro Ser Val Pro Thr Ser Pro Val Gly Gln Leu Leu Pro Glu Val Ile 
            660                 665                 670         


Ile Asp Lys Pro Ala Thr Asp Asp Asn Gly Thr Thr Thr Glu Thr Glu 
        675                 680                 685             


Met Arg Lys Arg Arg Ser Ser Ser Phe His Val Ser Met Asp Phe Leu 
    690                 695                 700                 


Glu Asp Pro Ser Gln Arg Gln Arg Ala Met Ser Ile Ala Ser Ile Leu 
705                 710                 715                 720 


Thr Asn Thr Val Glu Glu Leu Glu Glu Ser Arg Gln Lys Cys Pro Pro 
                725                 730                 735     


Cys Trp Tyr Lys Phe Ser Asn Ile Phe Leu Ile Trp Asp Cys Ser Pro 
            740                 745                 750         


Tyr Trp Leu Lys Val Lys His Val Val Asn Leu Val Val Met Asp Pro 
        755                 760                 765             


Phe Val Asp Leu Ala Ile Thr Ile Cys Ile Val Leu Asn Thr Leu Phe 
    770                 775                 780                 


Met Ala Met Glu His Tyr Pro Met Thr Asp His Phe Asn Asn Val Leu 
785                 790                 795                 800 


Thr Val Gly Asn Leu Val Phe Thr Gly Ile Phe Thr Ala Glu Met Phe 
                805                 810                 815     


Leu Lys Ile Ile Ala Met Asp Pro Tyr Tyr Tyr Phe Gln Glu Gly Trp 
            820                 825                 830         


Asn Ile Phe Asp Gly Phe Ile Val Thr Leu Ser Leu Val Glu Leu Gly 
        835                 840                 845             


Leu Ala Asn Val Glu Gly Leu Ser Val Leu Arg Ser Phe Arg Leu Leu 
    850                 855                 860                 


Arg Val Phe Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Met Leu Ile 
865                 870                 875                 880 


Lys Ile Ile Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr Leu Val 
                885                 890                 895     


Leu Ala Ile Ile Val Phe Ile Phe Ala Val Val Gly Met Gln Leu Phe 
            900                 905                 910         


Gly Lys Ser Tyr Lys Asp Cys Val Cys Lys Ile Ala Ser Asp Cys Gln 
        915                 920                 925             


Leu Pro Arg Trp His Met Asn Asp Phe Phe His Ser Phe Leu Ile Val 
    930                 935                 940                 


Phe His Val Leu Cys Gly Glu Trp Ile Glu Thr Met Trp Asp Cys Met 
945                 950                 955                 960 


Glu Val Ala Gly Gln Ala Met Cys Leu Thr Val Phe Met Met Val Met 
                965                 970                 975     


Val Ile Gly Asn Leu Val Val Leu Asn Leu Phe Leu Ala Leu Leu Leu 
            980                 985                 990         


Ser Ser Phe Ser Ala Asp Asn Leu  Ala Ala Thr Asp Asp  Asp Asn Glu 
        995                 1000                 1005             


Met Asn  Asn Leu Gln Ile Ala  Val Asp Arg Met His  Lys Gly Val 
    1010                 1015                 1020             


Ala Tyr  Val Lys Arg Lys Ile  Tyr Glu Phe Ile Gln  Gln Ser Phe 
    1025                 1030                 1035             


Ile Arg  Lys Gln Lys Ile Leu  Asp Glu Ile Lys Pro  Leu Asp Asp 
    1040                 1045                 1050             


Leu Asn  Asn Lys Lys Asp Ser  Cys Met Ser Asn His  Thr Thr Glu 
    1055                 1060                 1065             


Ile Gly  Lys Asp Leu Asp Tyr  Leu Lys Asp Val Asn  Gly Thr Thr 
    1070                 1075                 1080             


Ser Gly  Ile Gly Thr Gly Ser  Ser Val Glu Lys Tyr  Ile Ile Asp 
    1085                 1090                 1095             


Glu Ser  Asp Tyr Met Ser Phe  Ile Asn Asn Pro Ser  Leu Thr Val 
    1100                 1105                 1110             


Thr Val  Pro Ile Ala Val Gly  Glu Ser Asp Phe Glu  Asn Leu Asn 
    1115                 1120                 1125             


Thr Glu  Asp Phe Ser Ser Glu  Ser Asp Leu Glu Glu  Ser Lys Glu 
    1130                 1135                 1140             


Lys Leu  Asn Glu Ser Ser Ser  Ser Ser Glu Gly Ser  Thr Val Asp 
    1145                 1150                 1155             


Ile Gly  Ala Pro Val Glu Glu  Gln Pro Val Val Glu  Pro Glu Glu 
    1160                 1165                 1170             


Thr Leu  Glu Pro Glu Ala Cys  Phe Thr Glu Gly Cys  Val Gln Arg 
    1175                 1180                 1185             


Phe Lys  Cys Cys Gln Ile Asn  Val Glu Glu Gly Arg  Gly Lys Gln 
    1190                 1195                 1200             


Trp Trp  Asn Leu Arg Arg Thr  Cys Phe Arg Ile Val  Glu His Asn 
    1205                 1210                 1215             


Trp Phe  Glu Thr Phe Ile Val  Phe Met Ile Leu Leu  Ser Ser Gly 
    1220                 1225                 1230             


Ala Leu  Ala Phe Glu Asp Ile  Tyr Ile Asp Gln Arg  Lys Thr Ile 
    1235                 1240                 1245             


Lys Thr  Met Leu Glu Tyr Ala  Asp Lys Val Phe Thr  Tyr Ile Phe 
    1250                 1255                 1260             


Ile Leu  Glu Met Leu Leu Lys  Trp Val Ala Tyr Gly  Tyr Gln Thr 
    1265                 1270                 1275             


Tyr Phe  Thr Asn Ala Trp Cys  Trp Leu Asp Phe Leu  Ile Val Asp 
    1280                 1285                 1290             


Val Ser  Leu Val Ser Leu Thr  Ala Asn Ala Leu Gly  Tyr Ser Glu 
    1295                 1300                 1305             


Leu Gly  Ala Ile Lys Ser Leu  Arg Thr Leu Arg Ala  Leu Arg Pro 
    1310                 1315                 1320             


Leu Arg  Ala Leu Ser Arg Phe  Glu Gly Met Arg Val  Val Val Asn 
    1325                 1330                 1335             


Ala Leu  Leu Gly Ala Ile Pro  Ser Ile Met Asn Val  Leu Leu Val 
    1340                 1345                 1350             


Cys Leu  Ile Phe Trp Leu Ile  Phe Ser Ile Met Gly  Val Asn Leu 
    1355                 1360                 1365             


Phe Ala  Gly Lys Phe Tyr His  Cys Ile Asn Thr Thr  Thr Gly Asp 
    1370                 1375                 1380             


Arg Phe  Asp Ile Glu Asp Val  Asn Asn His Thr Asp  Cys Leu Lys 
    1385                 1390                 1395             


Leu Ile  Glu Arg Asn Glu Thr  Ala Arg Trp Lys Asn  Val Lys Val 
    1400                 1405                 1410             


Asn Phe  Asp Asn Val Gly Phe  Gly Tyr Leu Ser Leu  Leu Gln Val 
    1415                 1420                 1425             


Ala Thr  Phe Lys Gly Trp Met  Asp Ile Met Tyr Ala  Ala Val Asp 
    1430                 1435                 1440             


Ser Arg  Asn Val Glu Leu Gln  Pro Lys Tyr Glu Lys  Ser Leu Tyr 
    1445                 1450                 1455             


Met Tyr  Leu Tyr Phe Val Ile  Phe Ile Ile Phe Gly  Ser Phe Phe 
    1460                 1465                 1470             


Thr Leu  Asn Leu Phe Ile Gly  Val Ile Ile Asp Asn  Phe Asn Gln 
    1475                 1480                 1485             


Gln Lys  Lys Lys Phe Gly Gly  Gln Asp Ile Phe Met  Thr Glu Glu 
    1490                 1495                 1500             


Gln Lys  Lys Tyr Tyr Asn Ala  Met Lys Lys Leu Gly  Ser Lys Lys 
    1505                 1510                 1515             


Pro Gln  Lys Pro Ile Pro Arg  Pro Gly Asn Lys Phe  Gln Gly Met 
    1520                 1525                 1530             


Val Phe  Asp Phe Val Thr Arg  Gln Val Phe Asp Ile  Ser Ile Met 
    1535                 1540                 1545             


Ile Leu  Ile Cys Leu Asn Met  Val Thr Met Met Val  Glu Thr Asp 
    1550                 1555                 1560             


Asp Gln  Ser Glu Tyr Val Thr  Thr Ile Leu Ser Arg  Ile Asn Leu 
    1565                 1570                 1575             


Val Phe  Ile Val Leu Phe Thr  Gly Glu Cys Val Leu  Lys Leu Ile 
    1580                 1585                 1590             


Ser Leu  Arg His Tyr Tyr Phe  Thr Ile Gly Trp Asn  Ile Phe Asp 
    1595                 1600                 1605             


Phe Val  Val Val Ile Leu Ser  Ile Val Gly Met Phe  Leu Ala Glu 
    1610                 1615                 1620             


Leu Ile  Glu Lys Tyr Phe Val  Ser Pro Thr Leu Phe  Arg Val Ile 
    1625                 1630                 1635             


Arg Leu  Ala Arg Ile Gly Arg  Ile Leu Arg Leu Ile  Lys Gly Ala 
    1640                 1645                 1650             


Lys Gly  Ile Arg Thr Leu Leu  Phe Ala Leu Met Met  Ser Leu Pro 
    1655                 1660                 1665             


Ala Leu  Phe Asn Ile Gly Leu  Leu Leu Phe Leu Val  Met Phe Ile 
    1670                 1675                 1680             


Tyr Ala  Ile Phe Gly Met Ser  Asn Phe Ala Tyr Val  Lys Arg Glu 
    1685                 1690                 1695             


Val Gly  Ile Asp Asp Met Phe  Asn Phe Glu Thr Phe  Gly Asn Ser 
    1700                 1705                 1710             


Met Ile  Cys Leu Phe Gln Ile  Thr Thr Ser Ala Gly  Trp Asp Gly 
    1715                 1720                 1725             


Leu Leu  Ala Pro Ile Leu Asn  Ser Lys Pro Pro Asp  Cys Asp Pro 
    1730                 1735                 1740             


Asn Lys  Val Asn Pro Gly Ser  Ser Val Lys Gly Asp  Cys Gly Asn 
    1745                 1750                 1755             


Pro Ser  Val Gly Ile Phe Phe  Phe Val Ser Tyr Ile  Ile Ile Ser 
    1760                 1765                 1770             


Phe Leu  Val Val Val Asn Met  Tyr Ile Ala Val Ile  Leu Glu Asn 
    1775                 1780                 1785             


Phe Ser  Val Ala Thr Glu Glu  Ser Ala Glu Pro Leu  Ser Glu Asp 
    1790                 1795                 1800             


Asp Phe  Glu Met Phe Tyr Glu  Val Trp Glu Lys Phe  Asp Pro Asp 
    1805                 1810                 1815             


Ala Thr  Gln Phe Met Glu Phe  Glu Lys Leu Ser Gln  Phe Ala Ala 
    1820                 1825                 1830             


Ala Leu  Glu Pro Pro Leu Asn  Leu Pro Gln Pro Asn  Lys Leu Gln 
    1835                 1840                 1845             


Leu Ile  Ala Met Asp Leu Pro  Met Val Ser Gly Asp  Arg Ile His 
    1850                 1855                 1860             


Cys Leu  Asp Ile Leu Phe Ala  Phe Thr Lys Arg Val  Leu Gly Glu 
    1865                 1870                 1875             


Ser Gly  Glu Met Asp Ala Leu  Arg Ile Gln Met Glu  Glu Arg Phe 
    1880                 1885                 1890             


Met Ala  Ser Asn Pro Ser Lys  Val Ser Tyr Gln Pro  Ile Thr Thr 
    1895                 1900                 1905             


Thr Leu  Lys Arg Lys Gln Glu  Glu Val Ser Ala Val  Ile Ile Gln 
    1910                 1915                 1920             


Arg Ala  Tyr Arg Arg His Leu  Leu Lys Arg Thr Val  Lys Gln Ala 
    1925                 1930                 1935             


Ser Phe  Thr Tyr Asn Lys Asn  Lys Ile Lys Gly Gly  Ala Asn Leu 
    1940                 1945                 1950             


Leu Ile  Lys Glu Asp Met Ile  Ile Asp Arg Ile Asn  Glu Asn Ser 
    1955                 1960                 1965             


Ile Thr  Glu Lys Thr Asp Leu  Thr Met Ser Thr Ala  Ala Cys Pro 
    1970                 1975                 1980             


Pro Ser  Tyr Asp Arg Val Thr  Lys Pro Ile Val Glu  Lys His Glu 
    1985                 1990                 1995             


Gln Glu  Gly Lys Asp Glu Lys  Ala Lys Gly Lys 
    2000                 2005                 


<210>  33
<211>  2009
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Glu Gln Thr Val Leu Val Pro Pro Gly Pro Asp Ser Phe Asn Phe 
1               5                   10                  15      


Phe Thr Arg Glu Ser Leu Ala Ala Ile Glu Arg Arg Ile Ala Glu Glu 
            20                  25                  30          


Lys Ala Lys Asn Pro Lys Pro Asp Lys Lys Asp Asp Asp Glu Asn Gly 
        35                  40                  45              


Pro Lys Pro Asn Ser Asp Leu Glu Ala Gly Lys Asn Leu Pro Phe Ile 
    50                  55                  60                  


Tyr Gly Asp Ile Pro Pro Glu Met Val Ser Glu Pro Leu Glu Asp Leu 
65                  70                  75                  80  


Asp Pro Tyr Tyr Ile Asn Lys Lys Thr Phe Ile Val Leu Asn Lys Leu 
                85                  90                  95      


Lys Ala Ile Phe Arg Phe Ser Ala Thr Ser Ala Leu Tyr Ile Leu Thr 
            100                 105                 110         


Pro Phe Asn Pro Leu Arg Lys Ile Ala Ile Lys Ile Leu Val His Ser 
        115                 120                 125             


Leu Phe Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Val Phe 
    130                 135                 140                 


Met Thr Met Ser Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr Thr 
145                 150                 155                 160 


Phe Thr Gly Ile Tyr Thr Phe Glu Ser Leu Ile Lys Ile Ile Ala Arg 
                165                 170                 175     


Gly Phe Cys Leu Glu Asp Phe Thr Phe Leu Arg Asp Pro Trp Asn Trp 
            180                 185                 190         


Leu Asp Phe Thr Val Ile Thr Phe Ala Tyr Val Thr Glu Phe Val Asp 
        195                 200                 205             


Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala Leu 
    210                 215                 220                 


Lys Thr Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu 
225                 230                 235                 240 


Ile Gln Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val Phe 
                245                 250                 255     


Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly Asn 
            260                 265                 270         


Leu Arg Asn Lys Cys Ile Gln Trp Pro Pro Thr Asn Ala Ser Leu Glu 
        275                 280                 285             


Glu His Ser Ile Glu Lys Asn Ile Thr Val Asn Tyr Asn Gly Thr Leu 
    290                 295                 300                 


Ile Asn Glu Thr Val Phe Glu Phe Asp Trp Lys Ser Tyr Ile Gln Asp 
305                 310                 315                 320 


Ser Arg Tyr His Tyr Phe Leu Glu Gly Phe Leu Asp Ala Leu Leu Cys 
                325                 330                 335     


Gly Asn Ser Ser Asp Ala Gly Gln Cys Pro Glu Gly Tyr Met Cys Val 
            340                 345                 350         


Lys Ala Gly Arg Asn Pro Asn Tyr Gly Tyr Thr Ser Phe Asp Thr Phe 
        355                 360                 365             


Ser Trp Ala Phe Leu Ser Leu Phe Arg Leu Met Thr Gln Asp Phe Trp 
    370                 375                 380                 


Glu Asn Leu Tyr Gln Leu Thr Leu Arg Ala Ala Gly Lys Thr Tyr Met 
385                 390                 395                 400 


Ile Phe Phe Val Leu Val Ile Phe Leu Gly Ser Phe Tyr Leu Ile Asn 
                405                 410                 415     


Leu Ile Leu Ala Val Val Ala Met Ala Tyr Glu Glu Gln Asn Gln Ala 
            420                 425                 430         


Thr Leu Glu Glu Ala Glu Gln Lys Glu Ala Glu Phe Gln Gln Met Ile 
        435                 440                 445             


Glu Gln Leu Lys Lys Gln Gln Glu Ala Ala Gln Gln Ala Ala Thr Ala 
    450                 455                 460                 


Thr Ala Ser Glu His Ser Arg Glu Pro Ser Ala Ala Gly Arg Leu Ser 
465                 470                 475                 480 


Asp Ser Ser Ser Glu Ala Ser Lys Leu Ser Ser Lys Ser Ala Lys Glu 
                485                 490                 495     


Arg Arg Asn Arg Arg Lys Lys Arg Lys Gln Lys Glu Gln Ser Gly Gly 
            500                 505                 510         


Glu Glu Lys Asp Glu Asp Glu Phe Gln Lys Ser Glu Ser Glu Asp Ser 
        515                 520                 525             


Ile Arg Arg Lys Gly Phe Arg Phe Ser Ile Glu Gly Asn Arg Leu Thr 
    530                 535                 540                 


Tyr Glu Lys Arg Tyr Ser Ser Pro His Gln Ser Leu Leu Ser Ile Arg 
545                 550                 555                 560 


Gly Ser Leu Phe Ser Pro Arg Arg Asn Ser Arg Thr Ser Leu Phe Ser 
                565                 570                 575     


Phe Arg Gly Arg Ala Lys Asp Val Gly Ser Glu Asn Asp Phe Ala Asp 
            580                 585                 590         


Asp Glu His Ser Thr Phe Glu Asp Asn Glu Ser Arg Arg Asp Ser Leu 
        595                 600                 605             


Phe Val Pro Arg Arg His Gly Glu Arg Arg Asn Ser Asn Leu Ser Gln 
    610                 615                 620                 


Thr Ser Arg Ser Ser Arg Met Leu Ala Val Phe Pro Ala Asn Gly Lys 
625                 630                 635                 640 


Met His Ser Thr Val Asp Cys Asn Gly Val Val Ser Leu Val Gly Gly 
                645                 650                 655     


Pro Ser Val Pro Thr Ser Pro Val Gly Gln Leu Leu Pro Glu Val Ile 
            660                 665                 670         


Ile Asp Lys Pro Ala Thr Asp Asp Asn Gly Thr Thr Thr Glu Thr Glu 
        675                 680                 685             


Met Arg Lys Arg Arg Ser Ser Ser Phe His Val Ser Met Asp Phe Leu 
    690                 695                 700                 


Glu Asp Pro Ser Gln Arg Gln Arg Ala Met Ser Ile Ala Ser Ile Leu 
705                 710                 715                 720 


Thr Asn Thr Val Glu Glu Leu Glu Glu Ser Arg Gln Lys Cys Pro Pro 
                725                 730                 735     


Cys Trp Tyr Lys Phe Ser Asn Ile Phe Leu Ile Trp Asp Cys Ser Pro 
            740                 745                 750         


Tyr Trp Leu Lys Val Lys His Val Val Asn Leu Val Val Met Asp Pro 
        755                 760                 765             


Phe Val Asp Leu Ala Ile Thr Ile Cys Ile Val Leu Asn Thr Leu Phe 
    770                 775                 780                 


Met Ala Met Glu His Tyr Pro Met Thr Asp His Phe Asn Asn Val Leu 
785                 790                 795                 800 


Thr Val Gly Asn Leu Val Phe Thr Gly Ile Phe Thr Ala Glu Met Phe 
                805                 810                 815     


Leu Lys Ile Ile Ala Met Asp Pro Tyr Tyr Tyr Phe Gln Glu Gly Trp 
            820                 825                 830         


Asn Ile Phe Asp Gly Phe Ile Val Thr Leu Ser Leu Val Glu Leu Gly 
        835                 840                 845             


Leu Ala Asn Val Glu Gly Leu Ser Val Leu Arg Ser Phe Arg Leu Leu 
    850                 855                 860                 


Arg Val Phe Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Met Leu Ile 
865                 870                 875                 880 


Lys Ile Ile Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr Leu Val 
                885                 890                 895     


Leu Ala Ile Ile Val Phe Ile Phe Ala Val Val Gly Met Gln Leu Phe 
            900                 905                 910         


Gly Lys Ser Tyr Lys Asp Cys Val Cys Lys Ile Ala Ser Asp Cys Gln 
        915                 920                 925             


Leu Pro Arg Trp His Met Asn Asp Phe Phe His Ser Phe Leu Ile Val 
    930                 935                 940                 


Phe Arg Val Leu Cys Gly Glu Trp Ile Glu Thr Met Trp Asp Cys Met 
945                 950                 955                 960 


Glu Val Ala Gly Gln Ala Met Cys Leu Thr Val Phe Met Met Val Met 
                965                 970                 975     


Val Ile Gly Asn Leu Val Val Leu Asn Leu Phe Leu Ala Leu Leu Leu 
            980                 985                 990         


Ser Ser Phe Ser Ala Asp Asn Leu  Ala Ala Thr Asp Asp  Asp Asn Glu 
        995                 1000                 1005             


Met Asn  Asn Leu Gln Ile Ala  Val Asp Arg Met His  Lys Gly Val 
    1010                 1015                 1020             


Ala Tyr  Val Lys Arg Lys Ile  Tyr Glu Phe Ile Gln  Gln Ser Phe 
    1025                 1030                 1035             


Ile Arg  Lys Gln Lys Ile Leu  Asp Glu Ile Lys Pro  Leu Asp Asp 
    1040                 1045                 1050             


Leu Asn  Asn Lys Lys Asp Ser  Cys Met Ser Asn His  Thr Thr Glu 
    1055                 1060                 1065             


Ile Gly  Lys Asp Leu Asp Tyr  Leu Lys Asp Val Asn  Gly Thr Thr 
    1070                 1075                 1080             


Ser Gly  Ile Gly Thr Gly Ser  Ser Val Glu Lys Tyr  Ile Ile Asp 
    1085                 1090                 1095             


Glu Ser  Asp Tyr Met Ser Phe  Ile Asn Asn Pro Ser  Leu Thr Val 
    1100                 1105                 1110             


Thr Val  Pro Ile Ala Val Gly  Glu Ser Asp Phe Glu  Asn Leu Asn 
    1115                 1120                 1125             


Thr Glu  Asp Phe Ser Ser Glu  Ser Asp Leu Glu Glu  Ser Lys Glu 
    1130                 1135                 1140             


Lys Leu  Asn Glu Ser Ser Ser  Ser Ser Glu Gly Ser  Thr Val Asp 
    1145                 1150                 1155             


Ile Gly  Ala Pro Val Glu Glu  Gln Pro Val Val Glu  Pro Glu Glu 
    1160                 1165                 1170             


Thr Leu  Glu Pro Glu Ala Cys  Phe Thr Glu Gly Cys  Val Gln Arg 
    1175                 1180                 1185             


Phe Lys  Cys Cys Gln Ile Asn  Val Glu Glu Gly Arg  Gly Lys Gln 
    1190                 1195                 1200             


Trp Trp  Asn Leu Arg Arg Thr  Cys Phe Arg Ile Val  Glu His Asn 
    1205                 1210                 1215             


Trp Phe  Glu Thr Phe Ile Val  Phe Met Ile Leu Leu  Ser Ser Gly 
    1220                 1225                 1230             


Ala Leu  Ala Phe Asp Asp Ile  Tyr Ile Asp Gln Arg  Lys Thr Ile 
    1235                 1240                 1245             


Lys Thr  Met Leu Glu Tyr Ala  Asp Lys Val Phe Thr  Tyr Ile Phe 
    1250                 1255                 1260             


Ile Leu  Glu Met Leu Leu Lys  Trp Val Ala Tyr Gly  Tyr Gln Thr 
    1265                 1270                 1275             


Tyr Phe  Thr Asn Ala Trp Cys  Trp Leu Asp Phe Leu  Ile Val Asp 
    1280                 1285                 1290             


Val Ser  Leu Val Ser Leu Thr  Ala Asn Ala Leu Gly  Tyr Ser Glu 
    1295                 1300                 1305             


Leu Gly  Ala Ile Lys Ser Leu  Arg Thr Leu Arg Ala  Leu Arg Pro 
    1310                 1315                 1320             


Leu Arg  Ala Leu Ser Arg Phe  Glu Gly Met Arg Val  Val Val Asn 
    1325                 1330                 1335             


Ala Leu  Leu Gly Ala Ile Pro  Ser Ile Met Asn Val  Leu Leu Val 
    1340                 1345                 1350             


Cys Leu  Ile Phe Trp Leu Ile  Phe Ser Ile Met Gly  Val Asn Leu 
    1355                 1360                 1365             


Phe Ala  Gly Lys Phe Tyr His  Cys Ile Asn Thr Thr  Thr Gly Asp 
    1370                 1375                 1380             


Arg Phe  Asp Ile Glu Asp Val  Asn Asn His Thr Asp  Cys Leu Lys 
    1385                 1390                 1395             


Leu Ile  Glu Arg Asn Glu Thr  Ala Arg Trp Lys Asn  Val Lys Val 
    1400                 1405                 1410             


Asn Phe  Asp Asn Val Gly Phe  Gly Tyr Leu Ser Leu  Leu Gln Val 
    1415                 1420                 1425             


Ala Thr  Phe Lys Gly Trp Met  Asp Ile Met Tyr Ala  Ala Val Asp 
    1430                 1435                 1440             


Ser Arg  Asn Val Glu Leu Gln  Pro Lys Tyr Glu Lys  Ser Leu Tyr 
    1445                 1450                 1455             


Met Tyr  Leu Tyr Phe Val Ile  Phe Ile Ile Phe Gly  Ser Phe Phe 
    1460                 1465                 1470             


Thr Leu  Asn Leu Phe Ile Gly  Val Ile Ile Asp Asn  Phe Asn Gln 
    1475                 1480                 1485             


Gln Lys  Lys Lys Phe Gly Gly  Gln Asp Ile Phe Met  Thr Glu Glu 
    1490                 1495                 1500             


Gln Lys  Lys Tyr Tyr Asn Ala  Met Lys Lys Leu Gly  Ser Lys Lys 
    1505                 1510                 1515             


Pro Gln  Lys Pro Ile Pro Arg  Pro Gly Asn Lys Phe  Gln Gly Met 
    1520                 1525                 1530             


Val Phe  Asp Phe Val Thr Arg  Gln Val Phe Asp Ile  Ser Ile Met 
    1535                 1540                 1545             


Ile Leu  Ile Cys Leu Asn Met  Val Thr Met Met Val  Glu Thr Asp 
    1550                 1555                 1560             


Asp Gln  Ser Glu Tyr Val Thr  Thr Ile Leu Ser Arg  Ile Asn Leu 
    1565                 1570                 1575             


Val Phe  Ile Val Leu Phe Thr  Gly Glu Cys Val Leu  Lys Leu Ile 
    1580                 1585                 1590             


Ser Leu  Arg His Tyr Tyr Phe  Thr Ile Gly Trp Asn  Ile Phe Asp 
    1595                 1600                 1605             


Phe Val  Val Val Ile Leu Ser  Ile Val Gly Met Phe  Leu Ala Glu 
    1610                 1615                 1620             


Leu Ile  Glu Lys Tyr Phe Val  Ser Pro Thr Leu Phe  Arg Val Ile 
    1625                 1630                 1635             


Arg Leu  Ala Arg Ile Gly Arg  Ile Leu Arg Leu Ile  Lys Gly Ala 
    1640                 1645                 1650             


Lys Gly  Ile Arg Thr Leu Leu  Phe Ala Leu Met Met  Ser Leu Pro 
    1655                 1660                 1665             


Ala Leu  Phe Asn Ile Gly Leu  Leu Leu Phe Leu Val  Met Phe Ile 
    1670                 1675                 1680             


Tyr Ala  Ile Phe Gly Met Ser  Asn Phe Ala Tyr Val  Lys Arg Glu 
    1685                 1690                 1695             


Val Gly  Ile Asp Asp Met Phe  Asn Phe Glu Thr Phe  Gly Asn Ser 
    1700                 1705                 1710             


Met Ile  Cys Leu Phe Gln Ile  Thr Thr Ser Ala Gly  Trp Asp Gly 
    1715                 1720                 1725             


Leu Leu  Ala Pro Ile Leu Asn  Ser Lys Pro Pro Asp  Cys Asp Pro 
    1730                 1735                 1740             


Asn Lys  Val Asn Pro Gly Ser  Ser Val Lys Gly Asp  Cys Gly Asn 
    1745                 1750                 1755             


Pro Ser  Val Gly Ile Phe Phe  Phe Val Ser Tyr Ile  Ile Ile Ser 
    1760                 1765                 1770             


Phe Leu  Val Val Val Asn Met  Tyr Ile Ala Val Ile  Leu Glu Asn 
    1775                 1780                 1785             


Phe Ser  Val Ala Thr Glu Glu  Ser Ala Glu Pro Leu  Ser Glu Asp 
    1790                 1795                 1800             


Asp Phe  Glu Met Phe Tyr Glu  Val Trp Glu Lys Phe  Asp Pro Asp 
    1805                 1810                 1815             


Ala Thr  Gln Phe Met Glu Phe  Glu Lys Leu Ser Gln  Phe Ala Ala 
    1820                 1825                 1830             


Ala Leu  Glu Pro Pro Leu Asn  Leu Pro Gln Pro Asn  Lys Leu Gln 
    1835                 1840                 1845             


Leu Ile  Ala Met Asp Leu Pro  Met Val Ser Gly Asp  Arg Ile His 
    1850                 1855                 1860             


Cys Leu  Asp Ile Leu Phe Ala  Phe Thr Lys Arg Val  Leu Gly Glu 
    1865                 1870                 1875             


Ser Gly  Glu Met Asp Ala Leu  Arg Ile Gln Met Glu  Glu Arg Phe 
    1880                 1885                 1890             


Met Ala  Ser Asn Pro Ser Lys  Val Ser Tyr Gln Pro  Ile Thr Thr 
    1895                 1900                 1905             


Thr Leu  Lys Arg Lys Gln Glu  Glu Val Ser Ala Val  Ile Ile Gln 
    1910                 1915                 1920             


Arg Ala  Tyr Arg Arg His Leu  Leu Lys Arg Thr Val  Lys Gln Ala 
    1925                 1930                 1935             


Ser Phe  Thr Tyr Asn Lys Asn  Lys Ile Lys Gly Gly  Ala Asn Leu 
    1940                 1945                 1950             


Leu Ile  Lys Glu Asp Met Ile  Ile Asp Arg Ile Asn  Glu Asn Ser 
    1955                 1960                 1965             


Ile Thr  Glu Lys Thr Asp Leu  Thr Met Ser Thr Ala  Ala Cys Pro 
    1970                 1975                 1980             


Pro Ser  Tyr Asp Arg Val Thr  Lys Pro Ile Val Glu  Lys His Glu 
    1985                 1990                 1995             


Gln Glu  Gly Lys Asp Glu Lys  Ala Lys Gly Lys 
    2000                 2005                 


<210>  34
<211>  2009
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Glu Gln Thr Val Leu Val Pro Pro Gly Pro Asp Ser Phe Asn Phe 
1               5                   10                  15      


Phe Thr Arg Glu Ser Leu Ala Ala Ile Glu Arg Arg Ile Ala Glu Glu 
            20                  25                  30          


Lys Ala Lys Asn Pro Lys Pro Asp Lys Lys Asp Asp Asp Glu Asn Gly 
        35                  40                  45              


Pro Lys Pro Asn Ser Asp Leu Glu Ala Gly Lys Asn Leu Pro Phe Ile 
    50                  55                  60                  


Tyr Gly Asp Ile Pro Pro Glu Met Val Ser Glu Pro Leu Glu Asp Leu 
65                  70                  75                  80  


Asp Pro Tyr Tyr Ile Asn Lys Lys Thr Phe Ile Val Leu Asn Lys Leu 
                85                  90                  95      


Lys Ala Ile Phe Arg Phe Ser Ala Thr Ser Ala Leu Tyr Ile Leu Thr 
            100                 105                 110         


Pro Phe Asn Pro Leu Arg Lys Ile Ala Ile Lys Ile Leu Val His Ser 
        115                 120                 125             


Leu Phe Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Val Phe 
    130                 135                 140                 


Met Thr Met Ser Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr Thr 
145                 150                 155                 160 


Phe Thr Gly Ile Tyr Thr Phe Glu Ser Leu Ile Lys Ile Ile Ala Arg 
                165                 170                 175     


Gly Phe Cys Leu Glu Asp Phe Thr Phe Leu Arg Asp Pro Trp Asn Trp 
            180                 185                 190         


Leu Asp Phe Thr Val Ile Thr Phe Ala Tyr Val Thr Glu Phe Val Asp 
        195                 200                 205             


Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala Leu 
    210                 215                 220                 


Lys Thr Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu 
225                 230                 235                 240 


Ile Gln Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val Phe 
                245                 250                 255     


Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly Asn 
            260                 265                 270         


Leu Arg Asn Lys Cys Ile Gln Trp Pro Pro Thr Asn Ala Ser Leu Glu 
        275                 280                 285             


Glu His Ser Ile Glu Lys Asn Ile Thr Val Asn Tyr Asn Gly Thr Leu 
    290                 295                 300                 


Ile Asn Glu Thr Val Phe Glu Phe Asp Trp Lys Ser Tyr Ile Gln Asp 
305                 310                 315                 320 


Ser Arg Tyr His Tyr Phe Leu Glu Gly Phe Leu Asp Ala Leu Leu Cys 
                325                 330                 335     


Gly Asn Ser Ser Asp Ala Gly Gln Cys Pro Glu Gly Tyr Met Cys Val 
            340                 345                 350         


Lys Ala Gly Arg Asn Pro Asn Tyr Gly Tyr Thr Ser Phe Asp Thr Phe 
        355                 360                 365             


Ser Trp Ala Phe Leu Ser Leu Phe Arg Leu Met Thr Gln Asp Phe Trp 
    370                 375                 380                 


Glu Asn Leu Tyr Gln Leu Thr Leu Arg Ala Ala Gly Lys Thr Tyr Met 
385                 390                 395                 400 


Ile Phe Phe Val Leu Val Ile Phe Leu Gly Ser Phe Tyr Leu Ile Asn 
                405                 410                 415     


Leu Ile Leu Ala Val Val Ala Met Ala Tyr Glu Glu Gln Asn Gln Ala 
            420                 425                 430         


Thr Leu Glu Glu Ala Glu Gln Lys Glu Ala Glu Phe Gln Gln Met Ile 
        435                 440                 445             


Glu Gln Leu Lys Lys Gln Gln Glu Ala Ala Gln Gln Ala Ala Thr Ala 
    450                 455                 460                 


Thr Ala Ser Glu His Ser Arg Glu Pro Ser Ala Ala Gly Arg Leu Ser 
465                 470                 475                 480 


Asp Ser Ser Ser Glu Ala Ser Lys Leu Ser Ser Lys Ser Ala Lys Glu 
                485                 490                 495     


Arg Arg Asn Arg Arg Lys Lys Arg Lys Gln Lys Glu Gln Ser Gly Gly 
            500                 505                 510         


Glu Glu Lys Asp Glu Asp Glu Phe Gln Lys Ser Glu Ser Glu Asp Ser 
        515                 520                 525             


Ile Arg Arg Lys Gly Phe Arg Phe Ser Ile Glu Gly Asn Arg Leu Thr 
    530                 535                 540                 


Tyr Glu Lys Arg Tyr Ser Ser Pro His Gln Ser Leu Leu Ser Ile Arg 
545                 550                 555                 560 


Gly Ser Leu Phe Ser Pro Arg Arg Asn Ser Arg Thr Ser Leu Phe Ser 
                565                 570                 575     


Phe Arg Gly Arg Ala Lys Asp Val Gly Ser Glu Asn Asp Phe Ala Asp 
            580                 585                 590         


Asp Glu His Ser Thr Phe Glu Asp Asn Glu Ser Arg Arg Asp Ser Leu 
        595                 600                 605             


Phe Val Pro Arg Arg His Gly Glu Arg Arg Asn Ser Asn Leu Ser Gln 
    610                 615                 620                 


Thr Ser Arg Ser Ser Arg Met Leu Ala Val Phe Pro Ala Asn Gly Lys 
625                 630                 635                 640 


Met His Ser Thr Val Asp Cys Asn Gly Val Val Ser Leu Val Gly Gly 
                645                 650                 655     


Pro Ser Val Pro Thr Ser Pro Val Gly Gln Leu Leu Pro Glu Val Ile 
            660                 665                 670         


Ile Asp Lys Pro Ala Thr Asp Asp Asn Gly Thr Thr Thr Glu Thr Glu 
        675                 680                 685             


Met Arg Lys Arg Arg Ser Ser Ser Phe His Val Ser Met Asp Phe Leu 
    690                 695                 700                 


Glu Asp Pro Ser Gln Arg Gln Arg Ala Met Ser Ile Ala Ser Ile Leu 
705                 710                 715                 720 


Thr Asn Thr Val Glu Glu Leu Glu Glu Ser Arg Gln Lys Cys Pro Pro 
                725                 730                 735     


Cys Trp Tyr Lys Phe Ser Asn Ile Phe Leu Ile Trp Asp Cys Ser Pro 
            740                 745                 750         


Tyr Trp Leu Lys Val Lys His Val Val Asn Leu Val Val Met Asp Pro 
        755                 760                 765             


Phe Val Asp Leu Ala Ile Thr Ile Cys Ile Val Leu Asn Thr Leu Phe 
    770                 775                 780                 


Met Ala Met Glu His Tyr Pro Met Thr Asp His Phe Asn Asn Val Leu 
785                 790                 795                 800 


Thr Val Gly Asn Leu Val Phe Thr Gly Ile Phe Thr Ala Glu Met Phe 
                805                 810                 815     


Leu Lys Ile Ile Ala Met Asp Pro Tyr Tyr Tyr Phe Gln Glu Gly Trp 
            820                 825                 830         


Asn Ile Phe Asp Gly Phe Ile Val Thr Leu Ser Leu Val Glu Leu Gly 
        835                 840                 845             


Leu Ala Asn Val Glu Gly Leu Ser Val Leu Arg Ser Phe Arg Leu Leu 
    850                 855                 860                 


Arg Val Phe Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Met Leu Ile 
865                 870                 875                 880 


Lys Ile Ile Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr Leu Val 
                885                 890                 895     


Leu Ala Ile Ile Val Phe Ile Phe Ala Val Val Gly Met Gln Leu Phe 
            900                 905                 910         


Gly Lys Ser Tyr Lys Asp Cys Val Cys Lys Ile Ala Ser Asp Cys Gln 
        915                 920                 925             


Leu Pro Arg Trp His Met Asn Asp Phe Phe His Ser Phe Leu Ile Val 
    930                 935                 940                 


Phe Arg Val Leu Cys Gly Glu Trp Ile Glu Thr Met Trp Asp Cys Met 
945                 950                 955                 960 


Glu Val Ala Gly Gln Ala Met Cys Leu Thr Val Phe Met Met Val Met 
                965                 970                 975     


Val Ile Gly Asn Leu Val Val Leu Asn Leu Phe Leu Ala Leu Leu Leu 
            980                 985                 990         


Ser Ser Phe Ser Ala Asp Asn Leu  Ala Ala Thr Asp Asp  Asp Asn Glu 
        995                 1000                 1005             


Met Asn  Asn Leu Gln Ile Ala  Val Asp Arg Met His  Lys Gly Val 
    1010                 1015                 1020             


Ala Tyr  Val Lys Arg Lys Ile  Tyr Glu Phe Ile Gln  Gln Ser Phe 
    1025                 1030                 1035             


Ile Arg  Lys Gln Lys Ile Leu  Asp Glu Ile Lys Pro  Leu Asp Asp 
    1040                 1045                 1050             


Leu Asn  Asn Lys Lys Asp Ser  Cys Met Ser Asn His  Thr Thr Glu 
    1055                 1060                 1065             


Ile Gly  Lys Asp Leu Asp Tyr  Leu Lys Asp Val Asn  Gly Thr Thr 
    1070                 1075                 1080             


Ser Gly  Ile Gly Thr Gly Ser  Ser Val Glu Lys Tyr  Ile Ile Asp 
    1085                 1090                 1095             


Glu Ser  Asp Tyr Met Ser Phe  Ile Asn Asn Pro Ser  Leu Thr Val 
    1100                 1105                 1110             


Thr Val  Pro Ile Ala Val Gly  Glu Ser Asp Phe Glu  Asn Leu Asn 
    1115                 1120                 1125             


Thr Glu  Asp Phe Ser Ser Glu  Ser Asp Leu Glu Glu  Ser Lys Glu 
    1130                 1135                 1140             


Lys Leu  Asn Glu Ser Ser Ser  Ser Ser Glu Gly Ser  Thr Val Asp 
    1145                 1150                 1155             


Ile Gly  Ala Pro Val Glu Glu  Gln Pro Val Val Glu  Pro Glu Glu 
    1160                 1165                 1170             


Thr Leu  Glu Pro Glu Ala Cys  Phe Thr Glu Gly Cys  Val Gln Arg 
    1175                 1180                 1185             


Phe Lys  Cys Cys Gln Ile Asn  Val Glu Glu Gly Arg  Gly Lys Gln 
    1190                 1195                 1200             


Trp Trp  Asn Leu Arg Arg Thr  Cys Phe Arg Ile Val  Glu His Asn 
    1205                 1210                 1215             


Trp Phe  Glu Thr Phe Ile Val  Phe Met Ile Leu Leu  Ser Ser Gly 
    1220                 1225                 1230             


Ala Leu  Ala Phe Glu Asp Ile  Tyr Ile Asp Gln Arg  Lys Thr Ile 
    1235                 1240                 1245             


Lys Thr  Met Leu Glu Tyr Ala  Asp Lys Val Phe Thr  Tyr Ile Phe 
    1250                 1255                 1260             


Ile Leu  Glu Met Leu Leu Lys  Trp Val Ala Tyr Gly  Tyr Gln Thr 
    1265                 1270                 1275             


Tyr Phe  Thr Asn Ala Trp Cys  Trp Leu Asp Phe Leu  Ile Val Asp 
    1280                 1285                 1290             


Val Ser  Leu Val Ser Leu Thr  Ala Asn Ala Leu Gly  Tyr Ser Glu 
    1295                 1300                 1305             


Leu Gly  Ala Ile Lys Ser Leu  Arg Thr Leu Arg Ala  Leu Arg Pro 
    1310                 1315                 1320             


Leu Arg  Ala Leu Ser Arg Phe  Glu Gly Met Arg Val  Val Val Asn 
    1325                 1330                 1335             


Ala Leu  Leu Gly Ala Ile Pro  Ser Ile Met Asn Val  Leu Leu Val 
    1340                 1345                 1350             


Cys Leu  Ile Phe Trp Leu Ile  Phe Ser Ile Met Gly  Val Asn Leu 
    1355                 1360                 1365             


Phe Ala  Gly Lys Phe Tyr His  Cys Ile Asn Thr Thr  Thr Gly Asp 
    1370                 1375                 1380             


Arg Phe  Asp Ile Glu Asp Val  Asn Asn His Thr Asp  Gly Leu Lys 
    1385                 1390                 1395             


Leu Ile  Glu Arg Asn Glu Thr  Ala Arg Trp Lys Asn  Val Lys Val 
    1400                 1405                 1410             


Asn Phe  Asp Asn Val Gly Phe  Gly Tyr Leu Ser Leu  Leu Gln Val 
    1415                 1420                 1425             


Ala Thr  Phe Lys Gly Trp Met  Asp Ile Met Tyr Ala  Ala Val Asp 
    1430                 1435                 1440             


Ser Arg  Asn Val Glu Leu Gln  Pro Lys Tyr Glu Lys  Ser Leu Tyr 
    1445                 1450                 1455             


Met Tyr  Leu Tyr Phe Val Ile  Phe Ile Ile Phe Gly  Ser Phe Phe 
    1460                 1465                 1470             


Thr Leu  Asn Leu Phe Ile Gly  Val Ile Ile Asp Asn  Phe Asn Gln 
    1475                 1480                 1485             


Gln Lys  Lys Lys Phe Gly Gly  Gln Asp Ile Phe Met  Thr Glu Glu 
    1490                 1495                 1500             


Gln Lys  Lys Tyr Tyr Asn Ala  Met Lys Lys Leu Gly  Ser Lys Lys 
    1505                 1510                 1515             


Pro Gln  Lys Pro Ile Pro Arg  Pro Gly Asn Lys Phe  Gln Gly Met 
    1520                 1525                 1530             


Val Phe  Asp Phe Val Thr Arg  Gln Val Phe Asp Ile  Ser Ile Met 
    1535                 1540                 1545             


Ile Leu  Ile Cys Leu Asn Met  Val Thr Met Met Val  Glu Thr Asp 
    1550                 1555                 1560             


Asp Gln  Ser Glu Tyr Val Thr  Thr Ile Leu Ser Arg  Ile Asn Leu 
    1565                 1570                 1575             


Val Phe  Ile Val Leu Phe Thr  Gly Glu Cys Val Leu  Lys Leu Ile 
    1580                 1585                 1590             


Ser Leu  Arg His Tyr Tyr Phe  Thr Ile Gly Trp Asn  Ile Phe Asp 
    1595                 1600                 1605             


Phe Val  Val Val Ile Leu Ser  Ile Val Gly Met Phe  Leu Ala Glu 
    1610                 1615                 1620             


Leu Ile  Glu Lys Tyr Phe Val  Ser Pro Thr Leu Phe  Arg Val Ile 
    1625                 1630                 1635             


Arg Leu  Ala Arg Ile Gly Arg  Ile Leu Arg Leu Ile  Lys Gly Ala 
    1640                 1645                 1650             


Lys Gly  Ile Arg Thr Leu Leu  Phe Ala Leu Met Met  Ser Leu Pro 
    1655                 1660                 1665             


Ala Leu  Phe Asn Ile Gly Leu  Leu Leu Phe Leu Val  Met Phe Ile 
    1670                 1675                 1680             


Tyr Ala  Ile Phe Gly Met Ser  Asn Phe Ala Tyr Val  Lys Arg Glu 
    1685                 1690                 1695             


Val Gly  Ile Asp Asp Met Phe  Asn Phe Glu Thr Phe  Gly Asn Ser 
    1700                 1705                 1710             


Met Ile  Cys Leu Phe Gln Ile  Thr Thr Ser Ala Gly  Trp Asp Gly 
    1715                 1720                 1725             


Leu Leu  Ala Pro Ile Leu Asn  Ser Lys Pro Pro Asp  Cys Asp Pro 
    1730                 1735                 1740             


Asn Lys  Val Asn Pro Gly Ser  Ser Val Lys Gly Asp  Cys Gly Asn 
    1745                 1750                 1755             


Pro Ser  Val Gly Ile Phe Phe  Phe Val Ser Tyr Ile  Ile Ile Ser 
    1760                 1765                 1770             


Phe Leu  Val Val Val Asn Met  Tyr Ile Ala Val Ile  Leu Glu Asn 
    1775                 1780                 1785             


Phe Ser  Val Ala Thr Glu Glu  Ser Ala Glu Pro Leu  Ser Glu Asp 
    1790                 1795                 1800             


Asp Phe  Glu Met Phe Tyr Glu  Val Trp Glu Lys Phe  Asp Pro Asp 
    1805                 1810                 1815             


Ala Thr  Gln Phe Met Glu Phe  Glu Lys Leu Ser Gln  Phe Ala Ala 
    1820                 1825                 1830             


Ala Leu  Glu Pro Pro Leu Asn  Leu Pro Gln Pro Asn  Lys Leu Gln 
    1835                 1840                 1845             


Leu Ile  Ala Met Asp Leu Pro  Met Val Ser Gly Asp  Arg Ile His 
    1850                 1855                 1860             


Cys Leu  Asp Ile Leu Phe Ala  Phe Thr Lys Arg Val  Leu Gly Glu 
    1865                 1870                 1875             


Ser Gly  Glu Met Asp Ala Leu  Arg Ile Gln Met Glu  Glu Arg Phe 
    1880                 1885                 1890             


Met Ala  Ser Asn Pro Ser Lys  Val Ser Tyr Gln Pro  Ile Thr Thr 
    1895                 1900                 1905             


Thr Leu  Lys Arg Lys Gln Glu  Glu Val Ser Ala Val  Ile Ile Gln 
    1910                 1915                 1920             


Arg Ala  Tyr Arg Arg His Leu  Leu Lys Arg Thr Val  Lys Gln Ala 
    1925                 1930                 1935             


Ser Phe  Thr Tyr Asn Lys Asn  Lys Ile Lys Gly Gly  Ala Asn Leu 
    1940                 1945                 1950             


Leu Ile  Lys Glu Asp Met Ile  Ile Asp Arg Ile Asn  Glu Asn Ser 
    1955                 1960                 1965             


Ile Thr  Glu Lys Thr Asp Leu  Thr Met Ser Thr Ala  Ala Cys Pro 
    1970                 1975                 1980             


Pro Ser  Tyr Asp Arg Val Thr  Lys Pro Ile Val Glu  Lys His Glu 
    1985                 1990                 1995             


Gln Glu  Gly Lys Asp Glu Lys  Ala Lys Gly Lys 
    2000                 2005                 


<210>  35
<211>  2009
<212>  PRT
<213>  Homo sapiens

<400>  35

Met Glu Gln Thr Val Leu Val Pro Pro Gly Pro Asp Ser Phe Asn Phe 
1               5                   10                  15      


Phe Thr Arg Glu Ser Leu Ala Ala Ile Glu Arg Arg Ile Ala Glu Glu 
            20                  25                  30          


Lys Ala Lys Asn Pro Lys Pro Asp Lys Lys Asp Asp Asp Glu Asn Gly 
        35                  40                  45              


Pro Lys Pro Asn Ser Asp Leu Glu Ala Gly Lys Asn Leu Pro Phe Ile 
    50                  55                  60                  


Tyr Gly Asp Ile Pro Pro Glu Met Val Ser Glu Pro Leu Glu Asp Leu 
65                  70                  75                  80  


Asp Pro Tyr Tyr Ile Asn Lys Lys Thr Phe Ile Val Leu Asn Lys Leu 
                85                  90                  95      


Lys Ala Ile Phe Arg Phe Ser Ala Thr Ser Ala Leu Tyr Ile Leu Thr 
            100                 105                 110         


Pro Phe Asn Pro Leu Arg Lys Ile Ala Ile Lys Ile Leu Val His Ser 
        115                 120                 125             


Leu Phe Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Val Phe 
    130                 135                 140                 


Met Thr Met Ser Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr Thr 
145                 150                 155                 160 


Phe Thr Gly Ile Tyr Thr Phe Glu Ser Leu Ile Lys Ile Ile Ala Arg 
                165                 170                 175     


Gly Phe Cys Leu Glu Asp Phe Thr Phe Leu Arg Asp Pro Trp Asn Trp 
            180                 185                 190         


Leu Asp Phe Thr Val Ile Thr Phe Ala Tyr Val Thr Glu Phe Val Asp 
        195                 200                 205             


Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala Leu 
    210                 215                 220                 


Lys Thr Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu 
225                 230                 235                 240 


Ile Gln Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val Phe 
                245                 250                 255     


Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly Asn 
            260                 265                 270         


Leu Arg Asn Lys Cys Ile Gln Trp Pro Pro Thr Asn Ala Ser Leu Glu 
        275                 280                 285             


Glu His Ser Ile Glu Lys Asn Ile Thr Val Asn Tyr Asn Gly Thr Leu 
    290                 295                 300                 


Ile Asn Glu Thr Val Phe Glu Phe Asp Trp Lys Ser Tyr Ile Gln Asp 
305                 310                 315                 320 


Ser Arg Tyr His Tyr Phe Leu Glu Gly Phe Leu Asp Ala Leu Leu Cys 
                325                 330                 335     


Gly Asn Ser Ser Asp Ala Gly Gln Cys Pro Glu Gly Tyr Met Cys Val 
            340                 345                 350         


Lys Ala Gly Arg Asn Pro Asn Tyr Gly Tyr Thr Ser Phe Asp Thr Phe 
        355                 360                 365             


Ser Trp Ala Phe Leu Ser Leu Phe Arg Leu Met Thr Gln Asp Phe Trp 
    370                 375                 380                 


Glu Asn Leu Tyr Gln Leu Thr Leu Arg Ala Ala Gly Lys Thr Tyr Met 
385                 390                 395                 400 


Ile Phe Phe Val Leu Val Ile Phe Leu Gly Ser Phe Tyr Leu Ile Asn 
                405                 410                 415     


Leu Ile Leu Ala Val Val Ala Met Ala Tyr Glu Glu Gln Asn Gln Ala 
            420                 425                 430         


Thr Leu Glu Glu Ala Glu Gln Lys Glu Ala Glu Phe Gln Gln Met Ile 
        435                 440                 445             


Glu Gln Leu Lys Lys Gln Gln Glu Ala Ala Gln Gln Ala Ala Thr Ala 
    450                 455                 460                 


Thr Ala Ser Glu His Ser Arg Glu Pro Ser Ala Ala Gly Arg Leu Ser 
465                 470                 475                 480 


Asp Ser Ser Ser Glu Ala Ser Lys Leu Ser Ser Lys Ser Ala Lys Glu 
                485                 490                 495     


Arg Arg Asn Arg Arg Lys Lys Arg Lys Gln Lys Glu Gln Ser Gly Gly 
            500                 505                 510         


Glu Glu Lys Asp Glu Asp Glu Phe Gln Lys Ser Glu Ser Glu Asp Ser 
        515                 520                 525             


Ile Arg Arg Lys Gly Phe Arg Phe Ser Ile Glu Gly Asn Arg Leu Thr 
    530                 535                 540                 


Tyr Glu Lys Arg Tyr Ser Ser Pro His Gln Ser Leu Leu Ser Ile Arg 
545                 550                 555                 560 


Gly Ser Leu Phe Ser Pro Arg Arg Asn Ser Arg Thr Ser Leu Phe Ser 
                565                 570                 575     


Phe Arg Gly Arg Ala Lys Asp Val Gly Ser Glu Asn Asp Phe Ala Asp 
            580                 585                 590         


Asp Glu His Ser Thr Phe Glu Asp Asn Glu Ser Arg Arg Asp Ser Leu 
        595                 600                 605             


Phe Val Pro Arg Arg His Gly Glu Arg Arg Asn Ser Asn Leu Ser Gln 
    610                 615                 620                 


Thr Ser Arg Ser Ser Arg Met Leu Ala Val Phe Pro Ala Asn Gly Lys 
625                 630                 635                 640 


Met His Ser Thr Val Asp Cys Asn Gly Val Val Ser Leu Val Gly Gly 
                645                 650                 655     


Pro Ser Val Pro Thr Ser Pro Val Gly Gln Leu Leu Pro Glu Val Ile 
            660                 665                 670         


Ile Asp Lys Pro Ala Thr Asp Asp Asn Gly Thr Thr Thr Glu Thr Glu 
        675                 680                 685             


Met Arg Lys Arg Arg Ser Ser Ser Phe His Val Ser Met Asp Phe Leu 
    690                 695                 700                 


Glu Asp Pro Ser Gln Arg Gln Arg Ala Met Ser Ile Ala Ser Ile Leu 
705                 710                 715                 720 


Thr Asn Thr Val Glu Glu Leu Glu Glu Ser Arg Gln Lys Cys Pro Pro 
                725                 730                 735     


Cys Trp Tyr Lys Phe Ser Asn Ile Phe Leu Ile Trp Asp Cys Ser Pro 
            740                 745                 750         


Tyr Trp Leu Lys Val Lys His Val Val Asn Leu Val Val Met Asp Pro 
        755                 760                 765             


Phe Val Asp Leu Ala Ile Thr Ile Cys Ile Val Leu Asn Thr Leu Phe 
    770                 775                 780                 


Met Ala Met Glu His Tyr Pro Met Thr Asp His Phe Asn Asn Val Leu 
785                 790                 795                 800 


Thr Val Gly Asn Leu Val Phe Thr Gly Ile Phe Thr Ala Glu Met Phe 
                805                 810                 815     


Leu Lys Ile Ile Ala Met Asp Pro Tyr Tyr Tyr Phe Gln Glu Gly Trp 
            820                 825                 830         


Asn Ile Phe Asp Gly Phe Ile Val Thr Leu Ser Leu Val Glu Leu Gly 
        835                 840                 845             


Leu Ala Asn Val Glu Gly Leu Ser Val Leu Arg Ser Phe Arg Leu Leu 
    850                 855                 860                 


Arg Val Phe Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Met Leu Ile 
865                 870                 875                 880 


Lys Ile Ile Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr Leu Val 
                885                 890                 895     


Leu Ala Ile Ile Val Phe Ile Phe Ala Val Val Gly Met Gln Leu Phe 
            900                 905                 910         


Gly Lys Ser Tyr Lys Asp Cys Val Cys Lys Ile Ala Ser Asp Cys Gln 
        915                 920                 925             


Leu Pro Arg Trp His Met Asn Asp Phe Phe His Ser Phe Leu Ile Val 
    930                 935                 940                 


Phe Arg Val Leu Cys Gly Glu Trp Ile Glu Thr Met Trp Asp Cys Met 
945                 950                 955                 960 


Glu Val Ala Gly Gln Ala Met Cys Leu Thr Val Phe Met Met Val Met 
                965                 970                 975     


Val Ile Gly Asn Leu Val Val Leu Asn Leu Phe Leu Ala Leu Leu Leu 
            980                 985                 990         


Ser Ser Phe Ser Ala Asp Asn Leu  Ala Ala Thr Asp Asp  Asp Asn Glu 
        995                 1000                 1005             


Met Asn  Asn Leu Gln Ile Ala  Val Asp Arg Met His  Lys Gly Val 
    1010                 1015                 1020             


Ala Tyr  Val Lys Arg Lys Ile  Tyr Glu Phe Ile Gln  Gln Ser Phe 
    1025                 1030                 1035             


Ile Arg  Lys Gln Lys Ile Leu  Asp Glu Ile Lys Pro  Leu Asp Asp 
    1040                 1045                 1050             


Leu Asn  Asn Lys Lys Asp Ser  Cys Met Ser Asn His  Thr Thr Glu 
    1055                 1060                 1065             


Ile Gly  Lys Asp Leu Asp Tyr  Leu Lys Asp Val Asn  Gly Thr Thr 
    1070                 1075                 1080             


Ser Gly  Ile Gly Thr Gly Ser  Ser Val Glu Lys Tyr  Ile Ile Asp 
    1085                 1090                 1095             


Glu Ser  Asp Tyr Met Ser Phe  Ile Asn Asn Pro Ser  Leu Thr Val 
    1100                 1105                 1110             


Thr Val  Pro Ile Ala Val Gly  Glu Ser Asp Phe Glu  Asn Leu Asn 
    1115                 1120                 1125             


Thr Glu  Asp Phe Ser Ser Glu  Ser Asp Leu Glu Glu  Ser Lys Glu 
    1130                 1135                 1140             


Lys Leu  Asn Glu Ser Ser Ser  Ser Ser Glu Gly Ser  Thr Val Asp 
    1145                 1150                 1155             


Ile Gly  Ala Pro Val Glu Glu  Gln Pro Val Val Glu  Pro Glu Glu 
    1160                 1165                 1170             


Thr Leu  Glu Pro Glu Ala Cys  Phe Thr Glu Gly Cys  Val Gln Arg 
    1175                 1180                 1185             


Phe Lys  Cys Cys Gln Ile Asn  Val Glu Glu Gly Arg  Gly Lys Gln 
    1190                 1195                 1200             


Trp Trp  Asn Leu Arg Arg Thr  Cys Phe Arg Ile Val  Glu His Asn 
    1205                 1210                 1215             


Trp Phe  Glu Thr Phe Ile Val  Phe Met Ile Leu Leu  Ser Ser Gly 
    1220                 1225                 1230             


Ala Leu  Ala Phe Glu Asp Ile  Tyr Ile Asp Gln Arg  Lys Thr Ile 
    1235                 1240                 1245             


Lys Thr  Met Leu Glu Tyr Ala  Asp Lys Val Phe Thr  Tyr Ile Phe 
    1250                 1255                 1260             


Ile Leu  Glu Met Leu Leu Lys  Trp Val Ala Tyr Gly  Tyr Gln Thr 
    1265                 1270                 1275             


Tyr Phe  Thr Asn Ala Trp Cys  Trp Leu Asp Phe Leu  Ile Val Asp 
    1280                 1285                 1290             


Val Ser  Leu Val Ser Leu Thr  Ala Asn Ala Leu Gly  Tyr Ser Glu 
    1295                 1300                 1305             


Leu Gly  Ala Ile Lys Ser Leu  Arg Thr Leu Arg Ala  Leu Arg Pro 
    1310                 1315                 1320             


Leu Arg  Ala Leu Ser Arg Phe  Glu Gly Met Arg Val  Val Val Asn 
    1325                 1330                 1335             


Ala Leu  Leu Gly Ala Ile Pro  Ser Ile Met Asn Val  Leu Leu Val 
    1340                 1345                 1350             


Cys Leu  Ile Phe Trp Leu Ile  Phe Ser Ile Met Gly  Val Asn Leu 
    1355                 1360                 1365             


Phe Ala  Gly Lys Phe Tyr His  Cys Ile Asn Thr Thr  Thr Gly Asp 
    1370                 1375                 1380             


Arg Phe  Asp Ile Glu Asp Val  Asn Asn His Thr Asp  Cys Leu Lys 
    1385                 1390                 1395             


Leu Ile  Glu Arg Asn Glu Thr  Ala Arg Trp Lys Asn  Val Lys Val 
    1400                 1405                 1410             


Asn Phe  Asp Asn Val Gly Phe  Gly Tyr Leu Ser Leu  Leu Gln Val 
    1415                 1420                 1425             


Ala Thr  Phe Lys Gly Trp Met  Asp Ile Met Tyr Ala  Pro Val Asp 
    1430                 1435                 1440             


Ser Arg  Asn Val Glu Leu Gln  Pro Lys Tyr Glu Lys  Ser Leu Tyr 
    1445                 1450                 1455             


Met Tyr  Leu Tyr Phe Val Ile  Phe Ile Ile Phe Gly  Ser Phe Phe 
    1460                 1465                 1470             


Thr Leu  Asn Leu Phe Ile Gly  Val Ile Ile Asp Asn  Phe Asn Gln 
    1475                 1480                 1485             


Gln Lys  Lys Lys Phe Gly Gly  Gln Asp Ile Phe Met  Thr Glu Glu 
    1490                 1495                 1500             


Gln Lys  Lys Tyr Tyr Asn Ala  Met Lys Lys Leu Gly  Ser Lys Lys 
    1505                 1510                 1515             


Pro Gln  Lys Pro Ile Pro Arg  Pro Gly Asn Lys Phe  Gln Gly Met 
    1520                 1525                 1530             


Val Phe  Asp Phe Val Thr Arg  Gln Val Phe Asp Ile  Ser Ile Met 
    1535                 1540                 1545             


Ile Leu  Ile Cys Leu Asn Met  Val Thr Met Met Val  Glu Thr Asp 
    1550                 1555                 1560             


Asp Gln  Ser Glu Tyr Val Thr  Thr Ile Leu Ser Arg  Ile Asn Leu 
    1565                 1570                 1575             


Val Phe  Ile Val Leu Phe Thr  Gly Glu Cys Val Leu  Lys Leu Ile 
    1580                 1585                 1590             


Ser Leu  Arg His Tyr Tyr Phe  Thr Ile Gly Trp Asn  Ile Phe Asp 
    1595                 1600                 1605             


Phe Val  Val Val Ile Leu Ser  Ile Val Gly Met Phe  Leu Ala Glu 
    1610                 1615                 1620             


Leu Ile  Glu Lys Tyr Phe Val  Ser Pro Thr Leu Phe  Arg Val Ile 
    1625                 1630                 1635             


Arg Leu  Ala Arg Ile Gly Arg  Ile Leu Arg Leu Ile  Lys Gly Ala 
    1640                 1645                 1650             


Lys Gly  Ile Arg Thr Leu Leu  Phe Ala Leu Met Met  Ser Leu Pro 
    1655                 1660                 1665             


Ala Leu  Phe Asn Ile Gly Leu  Leu Leu Phe Leu Val  Met Phe Ile 
    1670                 1675                 1680             


Tyr Ala  Ile Phe Gly Met Ser  Asn Phe Ala Tyr Val  Lys Arg Glu 
    1685                 1690                 1695             


Val Gly  Ile Asp Asp Met Phe  Asn Phe Glu Thr Phe  Gly Asn Ser 
    1700                 1705                 1710             


Met Ile  Cys Leu Phe Gln Ile  Thr Thr Ser Ala Gly  Trp Asp Gly 
    1715                 1720                 1725             


Leu Leu  Ala Pro Ile Leu Asn  Ser Lys Pro Pro Asp  Cys Asp Pro 
    1730                 1735                 1740             


Asn Lys  Val Asn Pro Gly Ser  Ser Val Lys Gly Asp  Cys Gly Asn 
    1745                 1750                 1755             


Pro Ser  Val Gly Ile Phe Phe  Phe Val Ser Tyr Ile  Ile Ile Ser 
    1760                 1765                 1770             


Phe Leu  Val Val Val Asn Met  Tyr Ile Ala Val Ile  Leu Glu Asn 
    1775                 1780                 1785             


Phe Ser  Val Ala Thr Glu Glu  Ser Ala Glu Pro Leu  Ser Glu Asp 
    1790                 1795                 1800             


Asp Phe  Glu Met Phe Tyr Glu  Val Trp Glu Lys Phe  Asp Pro Asp 
    1805                 1810                 1815             


Ala Thr  Gln Phe Met Glu Phe  Glu Lys Leu Ser Gln  Phe Ala Ala 
    1820                 1825                 1830             


Ala Leu  Glu Pro Pro Leu Asn  Leu Pro Gln Pro Asn  Lys Leu Gln 
    1835                 1840                 1845             


Leu Ile  Ala Met Asp Leu Pro  Met Val Ser Gly Asp  Arg Ile His 
    1850                 1855                 1860             


Cys Leu  Asp Ile Leu Phe Ala  Phe Thr Lys Arg Val  Leu Gly Glu 
    1865                 1870                 1875             


Ser Gly  Glu Met Asp Ala Leu  Arg Ile Gln Met Glu  Glu Arg Phe 
    1880                 1885                 1890             


Met Ala  Ser Asn Pro Ser Lys  Val Ser Tyr Gln Pro  Ile Thr Thr 
    1895                 1900                 1905             


Thr Leu  Lys Arg Lys Gln Glu  Glu Val Ser Ala Val  Ile Ile Gln 
    1910                 1915                 1920             


Arg Ala  Tyr Arg Arg His Leu  Leu Lys Arg Thr Val  Lys Gln Ala 
    1925                 1930                 1935             


Ser Phe  Thr Tyr Asn Lys Asn  Lys Ile Lys Gly Gly  Ala Asn Leu 
    1940                 1945                 1950             


Leu Ile  Lys Glu Asp Met Ile  Ile Asp Arg Ile Asn  Glu Asn Ser 
    1955                 1960                 1965             


Ile Thr  Glu Lys Thr Asp Leu  Thr Met Ser Thr Ala  Ala Cys Pro 
    1970                 1975                 1980             


Pro Ser  Tyr Asp Arg Val Thr  Lys Pro Ile Val Glu  Lys His Glu 
    1985                 1990                 1995             


Gln Glu  Gly Lys Asp Glu Lys  Ala Lys Gly Lys 
    2000                 2005                 


<210>  36
<211>  2009
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Glu Gln Thr Val Leu Val Pro Pro Gly Pro Asp Ser Phe Asn Phe 
1               5                   10                  15      


Phe Thr Arg Glu Ser Leu Ala Ala Ile Glu Arg Arg Ile Ala Glu Glu 
            20                  25                  30          


Lys Ala Lys Asn Pro Lys Pro Asp Lys Lys Asp Asp Asp Glu Asn Gly 
        35                  40                  45              


Pro Lys Pro Asn Ser Asp Leu Glu Ala Gly Lys Asn Leu Pro Phe Ile 
    50                  55                  60                  


Tyr Gly Asp Ile Pro Pro Glu Met Val Ser Glu Pro Leu Glu Asp Leu 
65                  70                  75                  80  


Asp Pro Tyr Tyr Ile Asn Lys Lys Thr Phe Ile Val Leu Asn Lys Leu 
                85                  90                  95      


Lys Ala Ile Phe Arg Phe Ser Ala Thr Ser Ala Leu Tyr Ile Leu Thr 
            100                 105                 110         


Pro Phe Asn Pro Leu Arg Lys Ile Ala Ile Lys Ile Leu Val His Ser 
        115                 120                 125             


Leu Phe Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Val Phe 
    130                 135                 140                 


Met Thr Met Ser Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr Thr 
145                 150                 155                 160 


Phe Thr Gly Ile Tyr Thr Phe Glu Ser Leu Ile Lys Ile Ile Ala Arg 
                165                 170                 175     


Gly Phe Cys Leu Glu Asp Phe Thr Phe Leu Arg Asp Pro Trp Asn Trp 
            180                 185                 190         


Leu Asp Phe Thr Val Ile Thr Phe Ala Tyr Val Thr Glu Phe Val Asp 
        195                 200                 205             


Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala Leu 
    210                 215                 220                 


Lys Thr Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu 
225                 230                 235                 240 


Ile Gln Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val Phe 
                245                 250                 255     


Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly Asn 
            260                 265                 270         


Leu Arg Asn Lys Cys Ile Gln Trp Pro Pro Thr Asn Ala Ser Leu Glu 
        275                 280                 285             


Glu His Ser Ile Glu Lys Asn Ile Thr Val Asn Tyr Asn Gly Thr Leu 
    290                 295                 300                 


Ile Asn Glu Thr Val Phe Glu Phe Asp Trp Lys Ser Tyr Ile Gln Asp 
305                 310                 315                 320 


Ser Arg Tyr His Tyr Phe Leu Glu Gly Phe Leu Asp Ala Leu Leu Cys 
                325                 330                 335     


Gly Asn Ser Ser Asp Ala Gly Gln Cys Pro Glu Gly Tyr Met Cys Val 
            340                 345                 350         


Lys Ala Gly Arg Asn Pro Asn Tyr Gly Tyr Thr Ser Phe Asp Thr Phe 
        355                 360                 365             


Ser Trp Ala Phe Leu Ser Leu Phe Arg Leu Met Thr Gln Asp Phe Trp 
    370                 375                 380                 


Glu Asn Leu Tyr Gln Leu Thr Leu Arg Ala Ala Gly Lys Thr Tyr Met 
385                 390                 395                 400 


Ile Phe Phe Val Leu Val Ile Phe Leu Gly Ser Phe Tyr Leu Ile Asn 
                405                 410                 415     


Leu Ile Leu Ala Val Val Ala Met Ala Tyr Glu Glu Gln Asn Gln Ala 
            420                 425                 430         


Thr Leu Glu Glu Ala Glu Gln Lys Glu Ala Glu Phe Gln Gln Met Ile 
        435                 440                 445             


Glu Gln Leu Lys Lys Gln Gln Glu Ala Ala Gln Gln Ala Ala Thr Ala 
    450                 455                 460                 


Thr Ala Ser Glu His Ser Arg Glu Pro Ser Ala Ala Gly Arg Leu Ser 
465                 470                 475                 480 


Asp Ser Ser Ser Glu Ala Ser Lys Leu Ser Ser Lys Ser Ala Lys Glu 
                485                 490                 495     


Arg Arg Asn Arg Arg Lys Lys Arg Lys Gln Lys Glu Gln Ser Gly Gly 
            500                 505                 510         


Glu Glu Lys Asp Glu Asp Glu Phe Gln Lys Ser Glu Ser Glu Asp Ser 
        515                 520                 525             


Ile Arg Arg Lys Gly Phe Arg Phe Ser Ile Glu Gly Asn Arg Leu Thr 
    530                 535                 540                 


Tyr Glu Lys Arg Tyr Ser Ser Pro His Gln Ser Leu Leu Ser Ile Arg 
545                 550                 555                 560 


Gly Ser Leu Phe Ser Pro Arg Arg Asn Ser Arg Thr Ser Leu Phe Ser 
                565                 570                 575     


Phe Arg Gly Arg Ala Lys Asp Val Gly Ser Glu Asn Asp Phe Ala Asp 
            580                 585                 590         


Asp Glu His Ser Thr Phe Glu Asp Asn Glu Ser Arg Arg Asp Ser Leu 
        595                 600                 605             


Phe Val Pro Arg Arg His Gly Glu Arg Arg Asn Ser Asn Leu Ser Gln 
    610                 615                 620                 


Thr Ser Arg Ser Ser Arg Met Leu Ala Val Phe Pro Ala Asn Gly Lys 
625                 630                 635                 640 


Met His Ser Thr Val Asp Cys Asn Gly Val Val Ser Leu Val Gly Gly 
                645                 650                 655     


Pro Ser Val Pro Thr Ser Pro Val Gly Gln Leu Leu Pro Glu Val Ile 
            660                 665                 670         


Ile Asp Lys Pro Ala Thr Asp Asp Asn Gly Thr Thr Thr Glu Thr Glu 
        675                 680                 685             


Met Arg Lys Arg Arg Ser Ser Ser Phe His Val Ser Met Asp Phe Leu 
    690                 695                 700                 


Glu Asp Pro Ser Gln Arg Gln Arg Ala Met Ser Ile Ala Ser Ile Leu 
705                 710                 715                 720 


Thr Asn Thr Val Glu Glu Leu Glu Glu Ser Arg Gln Lys Cys Pro Pro 
                725                 730                 735     


Cys Trp Tyr Lys Phe Ser Asn Ile Phe Leu Ile Trp Asp Cys Ser Pro 
            740                 745                 750         


Tyr Trp Leu Lys Val Lys His Val Val Asn Leu Val Val Met Asp Pro 
        755                 760                 765             


Phe Val Asp Leu Ala Ile Thr Ile Cys Ile Val Leu Asn Thr Leu Phe 
    770                 775                 780                 


Met Ala Met Glu His Tyr Pro Met Thr Asp His Phe Asn Asn Val Leu 
785                 790                 795                 800 


Thr Val Gly Asn Leu Val Phe Thr Gly Ile Phe Thr Ala Glu Met Phe 
                805                 810                 815     


Leu Lys Ile Ile Ala Met Asp Pro Tyr Tyr Tyr Phe Gln Glu Gly Trp 
            820                 825                 830         


Asn Ile Phe Asp Gly Phe Ile Val Thr Leu Ser Leu Val Glu Leu Gly 
        835                 840                 845             


Leu Ala Asn Val Glu Gly Leu Ser Val Leu Arg Ser Phe Arg Leu Leu 
    850                 855                 860                 


Arg Val Phe Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Met Leu Ile 
865                 870                 875                 880 


Lys Ile Ile Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr Leu Val 
                885                 890                 895     


Leu Ala Ile Ile Val Phe Ile Phe Ala Val Val Gly Met Gln Leu Phe 
            900                 905                 910         


Gly Lys Ser Tyr Lys Asp Cys Val Cys Lys Ile Ala Ser Asp Cys Gln 
        915                 920                 925             


Leu Pro Arg Trp His Met Asn Asp Phe Phe His Ser Phe Leu Ile Val 
    930                 935                 940                 


Phe Arg Val Leu Cys Gly Glu Trp Ile Glu Thr Met Trp Asp Cys Met 
945                 950                 955                 960 


Glu Val Ala Gly Gln Ala Met Cys Leu Thr Val Phe Met Met Val Met 
                965                 970                 975     


Val Ile Gly Asn Leu Val Val Leu Asn Leu Phe Leu Ala Leu Leu Leu 
            980                 985                 990         


Ser Ser Phe Ser Ala Asp Asn Leu  Ala Ala Thr Asp Asp  Asp Asn Glu 
        995                 1000                 1005             


Met Asn  Asn Leu Gln Ile Ala  Val Asp Arg Met His  Lys Gly Val 
    1010                 1015                 1020             


Ala Tyr  Val Lys Arg Lys Ile  Tyr Glu Phe Ile Gln  Gln Ser Phe 
    1025                 1030                 1035             


Ile Arg  Lys Gln Lys Ile Leu  Asp Glu Ile Lys Pro  Leu Asp Asp 
    1040                 1045                 1050             


Leu Asn  Asn Lys Lys Asp Ser  Cys Met Ser Asn His  Thr Thr Glu 
    1055                 1060                 1065             


Ile Gly  Lys Asp Leu Asp Tyr  Leu Lys Asp Val Asn  Gly Thr Thr 
    1070                 1075                 1080             


Ser Gly  Ile Gly Thr Gly Ser  Ser Val Glu Lys Tyr  Ile Ile Asp 
    1085                 1090                 1095             


Glu Ser  Asp Tyr Met Ser Phe  Ile Asn Asn Pro Ser  Leu Thr Val 
    1100                 1105                 1110             


Thr Val  Pro Ile Ala Val Gly  Glu Ser Asp Phe Glu  Asn Leu Asn 
    1115                 1120                 1125             


Thr Glu  Asp Phe Ser Ser Glu  Ser Asp Leu Glu Glu  Ser Lys Glu 
    1130                 1135                 1140             


Lys Leu  Asn Glu Ser Ser Ser  Ser Ser Glu Gly Ser  Thr Val Asp 
    1145                 1150                 1155             


Ile Gly  Ala Pro Val Glu Glu  Gln Pro Val Val Glu  Pro Glu Glu 
    1160                 1165                 1170             


Thr Leu  Glu Pro Glu Ala Cys  Phe Thr Glu Gly Cys  Val Gln Arg 
    1175                 1180                 1185             


Phe Lys  Cys Cys Gln Ile Asn  Val Glu Glu Gly Arg  Gly Lys Gln 
    1190                 1195                 1200             


Trp Trp  Asn Leu Arg Arg Thr  Cys Phe Arg Ile Val  Glu His Asn 
    1205                 1210                 1215             


Trp Phe  Glu Thr Phe Ile Val  Phe Met Ile Leu Leu  Ser Ser Gly 
    1220                 1225                 1230             


Ala Leu  Ala Phe Glu Asp Ile  Tyr Ile Asp Gln Arg  Lys Thr Ile 
    1235                 1240                 1245             


Lys Thr  Met Leu Glu Tyr Ala  Asp Lys Val Phe Thr  Tyr Ile Phe 
    1250                 1255                 1260             


Ile Leu  Glu Met Leu Leu Lys  Trp Val Ala Tyr Gly  Tyr Gln Thr 
    1265                 1270                 1275             


Tyr Phe  Thr Asn Ala Trp Cys  Trp Leu Asp Phe Leu  Ile Val Asp 
    1280                 1285                 1290             


Val Ser  Leu Val Ser Leu Thr  Ala Asn Ala Leu Gly  Tyr Ser Glu 
    1295                 1300                 1305             


Leu Gly  Ala Ile Lys Ser Leu  Arg Thr Leu Arg Ala  Leu Arg Pro 
    1310                 1315                 1320             


Leu Arg  Ala Leu Ser Arg Phe  Glu Gly Met Arg Val  Val Val Asn 
    1325                 1330                 1335             


Ala Leu  Leu Gly Ala Ile Pro  Ser Ile Met Asn Val  Leu Leu Val 
    1340                 1345                 1350             


Cys Leu  Ile Phe Trp Leu Ile  Phe Ser Ile Met Gly  Val Asn Leu 
    1355                 1360                 1365             


Phe Ala  Gly Lys Phe Tyr His  Cys Ile Asn Thr Thr  Thr Gly Asp 
    1370                 1375                 1380             


Arg Phe  Asp Ile Glu Asp Val  Asn Asn His Thr Asp  Cys Leu Lys 
    1385                 1390                 1395             


Leu Ile  Glu Arg Asn Glu Thr  Ala Arg Trp Lys Asn  Val Lys Val 
    1400                 1405                 1410             


Asn Phe  Asp Asn Val Gly Phe  Gly Tyr Leu Ser Leu  Leu Gln Val 
    1415                 1420                 1425             


Ala Thr  Phe Lys Gly Trp Met  Asp Ile Met Tyr Ala  Ala Val Asp 
    1430                 1435                 1440             


Ser Arg  Asn Val Glu Leu Gln  Pro Lys Tyr Glu Lys  Ser Leu Tyr 
    1445                 1450                 1455             


Met Tyr  Leu Tyr Phe Val Ile  Phe Ile Ile Phe Gly  Ser Phe Phe 
    1460                 1465                 1470             


Thr Leu  Asn Leu Phe Ile Gly  Val Ile Ile Asp Asn  Phe Asn Gln 
    1475                 1480                 1485             


Gln Lys  Lys Lys Phe Gly Gly  Gln Asp Ile Phe Met  Thr Glu Glu 
    1490                 1495                 1500             


Gln Lys  Lys Tyr Tyr Asn Ala  Met Lys Lys Leu Gly  Ser Lys Lys 
    1505                 1510                 1515             


Pro Gln  Lys Pro Ile Pro Arg  Pro Gly Asn Lys Phe  Gln Gly Met 
    1520                 1525                 1530             


Val Phe  Asp Phe Val Thr Arg  Gln Val Phe Asp Val  Ser Ile Met 
    1535                 1540                 1545             


Ile Leu  Ile Cys Leu Asn Met  Val Thr Met Met Val  Glu Thr Asp 
    1550                 1555                 1560             


Asp Gln  Ser Glu Tyr Val Thr  Thr Ile Leu Ser Arg  Ile Asn Leu 
    1565                 1570                 1575             


Val Phe  Ile Val Leu Phe Thr  Gly Glu Cys Val Leu  Lys Leu Ile 
    1580                 1585                 1590             


Ser Leu  Arg His Tyr Tyr Phe  Thr Ile Gly Trp Asn  Ile Phe Asp 
    1595                 1600                 1605             


Phe Val  Val Val Ile Leu Ser  Ile Val Gly Met Phe  Leu Ala Glu 
    1610                 1615                 1620             


Leu Ile  Glu Lys Tyr Phe Val  Ser Pro Thr Leu Phe  Arg Val Ile 
    1625                 1630                 1635             


Arg Leu  Ala Arg Ile Gly Arg  Ile Leu Arg Leu Ile  Lys Gly Ala 
    1640                 1645                 1650             


Lys Gly  Ile Arg Thr Leu Leu  Phe Ala Leu Met Met  Ser Leu Pro 
    1655                 1660                 1665             


Ala Leu  Phe Asn Ile Gly Leu  Leu Leu Phe Leu Val  Met Phe Ile 
    1670                 1675                 1680             


Tyr Ala  Ile Phe Gly Met Ser  Asn Phe Ala Tyr Val  Lys Arg Glu 
    1685                 1690                 1695             


Val Gly  Ile Asp Asp Met Phe  Asn Phe Glu Thr Phe  Gly Asn Ser 
    1700                 1705                 1710             


Met Ile  Cys Leu Phe Gln Ile  Thr Thr Ser Ala Gly  Trp Asp Gly 
    1715                 1720                 1725             


Leu Leu  Ala Pro Ile Leu Asn  Ser Lys Pro Pro Asp  Cys Asp Pro 
    1730                 1735                 1740             


Asn Lys  Val Asn Pro Gly Ser  Ser Val Lys Gly Asp  Cys Gly Asn 
    1745                 1750                 1755             


Pro Ser  Val Gly Ile Phe Phe  Phe Val Ser Tyr Ile  Ile Ile Ser 
    1760                 1765                 1770             


Phe Leu  Val Val Val Asn Met  Tyr Ile Ala Val Ile  Leu Glu Asn 
    1775                 1780                 1785             


Phe Ser  Val Ala Thr Glu Glu  Ser Ala Glu Pro Leu  Ser Glu Asp 
    1790                 1795                 1800             


Asp Phe  Glu Met Phe Tyr Glu  Val Trp Glu Lys Phe  Asp Pro Asp 
    1805                 1810                 1815             


Ala Thr  Gln Phe Met Glu Phe  Glu Lys Leu Ser Gln  Phe Ala Ala 
    1820                 1825                 1830             


Ala Leu  Glu Pro Pro Leu Asn  Leu Pro Gln Pro Asn  Lys Leu Gln 
    1835                 1840                 1845             


Leu Ile  Ala Met Asp Leu Pro  Met Val Ser Gly Asp  Arg Ile His 
    1850                 1855                 1860             


Cys Leu  Asp Ile Leu Phe Ala  Phe Thr Lys Arg Val  Leu Gly Glu 
    1865                 1870                 1875             


Ser Gly  Glu Met Asp Ala Leu  Arg Ile Gln Met Glu  Glu Arg Phe 
    1880                 1885                 1890             


Met Ala  Ser Asn Pro Ser Lys  Val Ser Tyr Gln Pro  Ile Thr Thr 
    1895                 1900                 1905             


Thr Leu  Lys Arg Lys Gln Glu  Glu Val Ser Ala Val  Ile Ile Gln 
    1910                 1915                 1920             


Arg Ala  Tyr Arg Arg His Leu  Leu Lys Arg Thr Val  Lys Gln Ala 
    1925                 1930                 1935             


Ser Phe  Thr Tyr Asn Lys Asn  Lys Ile Lys Gly Gly  Ala Asn Leu 
    1940                 1945                 1950             


Leu Ile  Lys Glu Asp Met Ile  Ile Asp Arg Ile Asn  Glu Asn Ser 
    1955                 1960                 1965             


Ile Thr  Glu Lys Thr Asp Leu  Thr Met Ser Thr Ala  Ala Cys Pro 
    1970                 1975                 1980             


Pro Ser  Tyr Asp Arg Val Thr  Lys Pro Ile Val Glu  Lys His Glu 
    1985                 1990                 1995             


Gln Glu  Gly Lys Asp Glu Lys  Ala Lys Gly Lys 
    2000                 2005                 


<210>  37
<211>  2009
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Glu Gln Thr Val Leu Val Pro Pro Gly Pro Asp Ser Phe Asn Phe 
1               5                   10                  15      


Phe Thr Arg Glu Ser Leu Ala Ala Ile Glu Arg Arg Ile Ala Glu Glu 
            20                  25                  30          


Lys Ala Lys Asn Pro Lys Pro Asp Lys Lys Asp Asp Asp Glu Asn Gly 
        35                  40                  45              


Pro Lys Pro Asn Ser Asp Leu Glu Ala Gly Lys Asn Leu Pro Phe Ile 
    50                  55                  60                  


Tyr Gly Asp Ile Pro Pro Glu Met Val Ser Glu Pro Leu Glu Asp Leu 
65                  70                  75                  80  


Asp Pro Tyr Tyr Ile Asn Lys Lys Thr Phe Ile Val Leu Asn Lys Leu 
                85                  90                  95      


Lys Ala Ile Phe Arg Phe Ser Ala Thr Ser Ala Leu Tyr Ile Leu Thr 
            100                 105                 110         


Pro Phe Asn Pro Leu Arg Lys Ile Ala Ile Lys Ile Leu Val His Ser 
        115                 120                 125             


Leu Phe Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Val Phe 
    130                 135                 140                 


Met Thr Met Ser Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr Thr 
145                 150                 155                 160 


Phe Thr Gly Ile Tyr Thr Phe Glu Ser Leu Ile Lys Ile Ile Ala Arg 
                165                 170                 175     


Gly Phe Cys Leu Glu Asp Phe Thr Phe Leu Arg Asp Pro Trp Asn Trp 
            180                 185                 190         


Leu Asp Phe Thr Val Ile Thr Phe Ala Tyr Val Thr Glu Phe Val Asp 
        195                 200                 205             


Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala Leu 
    210                 215                 220                 


Lys Thr Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu 
225                 230                 235                 240 


Ile Gln Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val Phe 
                245                 250                 255     


Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly Asn 
            260                 265                 270         


Leu Arg Asn Lys Cys Ile Gln Trp Pro Pro Thr Asn Ala Ser Leu Glu 
        275                 280                 285             


Glu His Ser Ile Glu Lys Asn Ile Thr Val Asn Tyr Asn Gly Thr Leu 
    290                 295                 300                 


Ile Asn Glu Thr Val Phe Glu Phe Asp Trp Lys Ser Tyr Ile Gln Asp 
305                 310                 315                 320 


Ser Arg Tyr His Tyr Phe Leu Glu Gly Phe Leu Asp Ala Leu Leu Cys 
                325                 330                 335     


Gly Asn Ser Ser Asp Ala Gly Gln Cys Pro Glu Gly Tyr Met Cys Val 
            340                 345                 350         


Lys Ala Gly Arg Asn Pro Asn Tyr Gly Tyr Thr Ser Phe Asp Thr Phe 
        355                 360                 365             


Ser Trp Ala Phe Leu Ser Leu Phe Arg Leu Met Thr Gln Asp Phe Trp 
    370                 375                 380                 


Glu Asn Leu Tyr Gln Leu Thr Leu Arg Ala Ala Gly Lys Thr Tyr Met 
385                 390                 395                 400 


Ile Phe Phe Val Leu Val Ile Phe Leu Gly Ser Phe Tyr Leu Ile Asn 
                405                 410                 415     


Leu Ile Leu Ala Val Val Ala Met Ala Tyr Glu Glu Gln Asn Gln Ala 
            420                 425                 430         


Thr Leu Glu Glu Ala Glu Gln Lys Glu Ala Glu Phe Gln Gln Met Ile 
        435                 440                 445             


Glu Gln Leu Lys Lys Gln Gln Glu Ala Ala Gln Gln Ala Ala Thr Ala 
    450                 455                 460                 


Thr Ala Ser Glu His Ser Arg Glu Pro Ser Ala Ala Gly Arg Leu Ser 
465                 470                 475                 480 


Asp Ser Ser Ser Glu Ala Ser Lys Leu Ser Ser Lys Ser Ala Lys Glu 
                485                 490                 495     


Arg Arg Asn Arg Arg Lys Lys Arg Lys Gln Lys Glu Gln Ser Gly Gly 
            500                 505                 510         


Glu Glu Lys Asp Glu Asp Glu Phe Gln Lys Ser Glu Ser Glu Asp Ser 
        515                 520                 525             


Ile Arg Arg Lys Gly Phe Arg Phe Ser Ile Glu Gly Asn Arg Leu Thr 
    530                 535                 540                 


Tyr Glu Lys Arg Tyr Ser Ser Pro His Gln Ser Leu Leu Ser Ile Arg 
545                 550                 555                 560 


Gly Ser Leu Phe Ser Pro Arg Arg Asn Ser Arg Thr Ser Leu Phe Ser 
                565                 570                 575     


Phe Arg Gly Arg Ala Lys Asp Val Gly Ser Glu Asn Asp Phe Ala Asp 
            580                 585                 590         


Asp Glu His Ser Thr Phe Glu Asp Asn Glu Ser Arg Arg Asp Ser Leu 
        595                 600                 605             


Phe Val Pro Arg Arg His Gly Glu Arg Arg Asn Ser Asn Leu Ser Gln 
    610                 615                 620                 


Thr Ser Arg Ser Ser Arg Met Leu Ala Val Phe Pro Ala Asn Gly Lys 
625                 630                 635                 640 


Met His Ser Thr Val Asp Cys Asn Gly Val Val Ser Leu Val Gly Gly 
                645                 650                 655     


Pro Ser Val Pro Thr Ser Pro Val Gly Gln Leu Leu Pro Glu Val Ile 
            660                 665                 670         


Ile Asp Lys Pro Ala Thr Asp Asp Asn Gly Thr Thr Thr Glu Thr Glu 
        675                 680                 685             


Met Arg Lys Arg Arg Ser Ser Ser Phe His Val Ser Met Asp Phe Leu 
    690                 695                 700                 


Glu Asp Pro Ser Gln Arg Gln Arg Ala Met Ser Ile Ala Ser Ile Leu 
705                 710                 715                 720 


Thr Asn Thr Val Glu Glu Leu Glu Glu Ser Arg Gln Lys Cys Pro Pro 
                725                 730                 735     


Cys Trp Tyr Lys Phe Ser Asn Ile Phe Leu Ile Trp Asp Cys Ser Pro 
            740                 745                 750         


Tyr Trp Leu Lys Val Lys His Val Val Asn Leu Val Val Met Asp Pro 
        755                 760                 765             


Phe Val Asp Leu Ala Ile Thr Ile Cys Ile Val Leu Asn Thr Leu Phe 
    770                 775                 780                 


Met Ala Met Glu His Tyr Pro Met Thr Asp His Phe Asn Asn Val Leu 
785                 790                 795                 800 


Thr Val Gly Asn Leu Val Phe Thr Gly Ile Phe Thr Ala Glu Met Phe 
                805                 810                 815     


Leu Lys Ile Ile Ala Met Asp Pro Tyr Tyr Tyr Phe Gln Glu Gly Trp 
            820                 825                 830         


Asn Ile Phe Asp Gly Phe Ile Val Thr Leu Ser Leu Val Glu Leu Gly 
        835                 840                 845             


Leu Ala Asn Val Glu Gly Leu Ser Val Leu Arg Ser Phe Arg Leu Leu 
    850                 855                 860                 


Arg Val Phe Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Met Leu Ile 
865                 870                 875                 880 


Lys Ile Ile Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr Leu Val 
                885                 890                 895     


Leu Ala Ile Ile Val Phe Ile Phe Ala Val Val Gly Met Gln Leu Phe 
            900                 905                 910         


Gly Lys Ser Tyr Lys Asp Cys Val Cys Lys Ile Ala Ser Asp Cys Gln 
        915                 920                 925             


Leu Pro Arg Trp His Met Asn Asp Phe Phe His Ser Phe Leu Ile Val 
    930                 935                 940                 


Phe Arg Val Leu Cys Gly Glu Trp Ile Glu Thr Met Trp Asp Cys Met 
945                 950                 955                 960 


Glu Val Ala Gly Gln Ala Met Cys Leu Thr Val Phe Met Met Val Met 
                965                 970                 975     


Val Ile Gly Asn Leu Val Val Leu Asn Leu Phe Leu Ala Leu Leu Leu 
            980                 985                 990         


Ser Ser Phe Ser Ala Asp Asn Leu  Ala Ala Thr Asp Asp  Asp Asn Glu 
        995                 1000                 1005             


Met Asn  Asn Leu Gln Ile Ala  Val Asp Arg Met His  Lys Gly Val 
    1010                 1015                 1020             


Ala Tyr  Val Lys Arg Lys Ile  Tyr Glu Phe Ile Gln  Gln Ser Phe 
    1025                 1030                 1035             


Ile Arg  Lys Gln Lys Ile Leu  Asp Glu Ile Lys Pro  Leu Asp Asp 
    1040                 1045                 1050             


Leu Asn  Asn Lys Lys Asp Ser  Cys Met Ser Asn His  Thr Thr Glu 
    1055                 1060                 1065             


Ile Gly  Lys Asp Leu Asp Tyr  Leu Lys Asp Val Asn  Gly Thr Thr 
    1070                 1075                 1080             


Ser Gly  Ile Gly Thr Gly Ser  Ser Val Glu Lys Tyr  Ile Ile Asp 
    1085                 1090                 1095             


Glu Ser  Asp Tyr Met Ser Phe  Ile Asn Asn Pro Ser  Leu Thr Val 
    1100                 1105                 1110             


Thr Val  Pro Ile Ala Val Gly  Glu Ser Asp Phe Glu  Asn Leu Asn 
    1115                 1120                 1125             


Thr Glu  Asp Phe Ser Ser Glu  Ser Asp Leu Glu Glu  Ser Lys Glu 
    1130                 1135                 1140             


Lys Leu  Asn Glu Ser Ser Ser  Ser Ser Glu Gly Ser  Thr Val Asp 
    1145                 1150                 1155             


Ile Gly  Ala Pro Val Glu Glu  Gln Pro Val Val Glu  Pro Glu Glu 
    1160                 1165                 1170             


Thr Leu  Glu Pro Glu Ala Cys  Phe Thr Glu Gly Cys  Val Gln Arg 
    1175                 1180                 1185             


Phe Lys  Cys Cys Gln Ile Asn  Val Glu Glu Gly Arg  Gly Lys Gln 
    1190                 1195                 1200             


Trp Trp  Asn Leu Arg Arg Thr  Cys Phe Arg Ile Val  Glu His Asn 
    1205                 1210                 1215             


Trp Phe  Glu Thr Phe Ile Val  Phe Met Ile Leu Leu  Ser Ser Gly 
    1220                 1225                 1230             


Ala Leu  Ala Phe Glu Asp Ile  Tyr Ile Asp Gln Arg  Lys Thr Ile 
    1235                 1240                 1245             


Lys Thr  Met Leu Glu Tyr Ala  Asp Lys Val Phe Thr  Tyr Ile Phe 
    1250                 1255                 1260             


Ile Leu  Glu Met Leu Leu Lys  Trp Val Ala Tyr Gly  Tyr Gln Thr 
    1265                 1270                 1275             


Tyr Phe  Thr Asn Ala Trp Cys  Trp Leu Asp Phe Leu  Ile Val Asp 
    1280                 1285                 1290             


Val Ser  Leu Val Ser Leu Thr  Ala Asn Ala Leu Gly  Tyr Ser Glu 
    1295                 1300                 1305             


Leu Gly  Ala Ile Lys Ser Leu  Arg Thr Leu Arg Ala  Leu Arg Pro 
    1310                 1315                 1320             


Leu Arg  Ala Leu Ser Arg Phe  Glu Gly Met Arg Val  Val Val Asn 
    1325                 1330                 1335             


Ala Leu  Leu Gly Ala Ile Pro  Ser Ile Met Asn Val  Leu Leu Val 
    1340                 1345                 1350             


Cys Leu  Ile Phe Trp Leu Ile  Phe Ser Ile Met Gly  Val Asn Leu 
    1355                 1360                 1365             


Phe Ala  Gly Lys Phe Tyr His  Cys Ile Asn Thr Thr  Thr Gly Asp 
    1370                 1375                 1380             


Arg Phe  Asp Ile Glu Asp Val  Asn Asn His Thr Asp  Cys Leu Lys 
    1385                 1390                 1395             


Leu Ile  Glu Arg Asn Glu Thr  Ala Arg Trp Lys Asn  Val Lys Val 
    1400                 1405                 1410             


Asn Phe  Asp Asn Val Gly Phe  Gly Tyr Leu Ser Leu  Leu Gln Val 
    1415                 1420                 1425             


Ala Thr  Phe Lys Gly Trp Met  Asp Ile Met Tyr Ala  Ala Val Asp 
    1430                 1435                 1440             


Ser Arg  Asn Val Glu Leu Gln  Pro Lys Tyr Glu Lys  Ser Leu Tyr 
    1445                 1450                 1455             


Met Tyr  Leu Tyr Phe Val Ile  Phe Ile Ile Phe Gly  Ser Phe Phe 
    1460                 1465                 1470             


Thr Leu  Asn Leu Phe Ile Gly  Val Ile Ile Asp Asn  Phe Asn Gln 
    1475                 1480                 1485             


Gln Lys  Lys Lys Phe Gly Gly  Gln Asp Ile Phe Met  Thr Glu Glu 
    1490                 1495                 1500             


Gln Lys  Lys Tyr Tyr Asn Ala  Met Lys Lys Leu Gly  Ser Lys Lys 
    1505                 1510                 1515             


Pro Gln  Lys Pro Ile Pro Arg  Pro Gly Asn Lys Phe  Gln Gly Met 
    1520                 1525                 1530             


Val Phe  Asp Phe Val Thr Arg  Gln Val Phe Asp Ile  Ser Ile Met 
    1535                 1540                 1545             


Ile Leu  Ile Cys Leu Asn Met  Val Thr Met Met Val  Glu Thr Asp 
    1550                 1555                 1560             


Asp Gln  Ser Glu Tyr Val Thr  Thr Ile Leu Ser Arg  Ile Asn Leu 
    1565                 1570                 1575             


Val Phe  Ile Val Leu Phe Thr  Gly Glu Cys Val Leu  Lys Leu Ile 
    1580                 1585                 1590             


Ser Leu  Arg His Tyr Tyr Phe  Thr Ile Gly Trp Asn  Ile Phe Asp 
    1595                 1600                 1605             


Phe Val  Val Val Ile Leu Ser  Ile Val Gly Met Phe  Leu Ala Glu 
    1610                 1615                 1620             


Leu Ile  Glu Lys Tyr Phe Val  Ser Pro Thr Leu Phe  Arg Val Ile 
    1625                 1630                 1635             


Arg Leu  Ala Arg Ile Gly Gln  Ile Leu Arg Leu Ile  Lys Gly Ala 
    1640                 1645                 1650             


Lys Gly  Ile Arg Thr Leu Leu  Phe Ala Leu Met Met  Ser Leu Pro 
    1655                 1660                 1665             


Ala Leu  Phe Asn Ile Gly Leu  Leu Leu Phe Leu Val  Met Phe Ile 
    1670                 1675                 1680             


Tyr Ala  Ile Phe Gly Met Ser  Asn Phe Ala Tyr Val  Lys Arg Glu 
    1685                 1690                 1695             


Val Gly  Ile Asp Asp Met Phe  Asn Phe Glu Thr Phe  Gly Asn Ser 
    1700                 1705                 1710             


Met Ile  Cys Leu Phe Gln Ile  Thr Thr Ser Ala Gly  Trp Asp Gly 
    1715                 1720                 1725             


Leu Leu  Ala Pro Ile Leu Asn  Ser Lys Pro Pro Asp  Cys Asp Pro 
    1730                 1735                 1740             


Asn Lys  Val Asn Pro Gly Ser  Ser Val Lys Gly Asp  Cys Gly Asn 
    1745                 1750                 1755             


Pro Ser  Val Gly Ile Phe Phe  Phe Val Ser Tyr Ile  Ile Ile Ser 
    1760                 1765                 1770             


Phe Leu  Val Val Val Asn Met  Tyr Ile Ala Val Ile  Leu Glu Asn 
    1775                 1780                 1785             


Phe Ser  Val Ala Thr Glu Glu  Ser Ala Glu Pro Leu  Ser Glu Asp 
    1790                 1795                 1800             


Asp Phe  Glu Met Phe Tyr Glu  Val Trp Glu Lys Phe  Asp Pro Asp 
    1805                 1810                 1815             


Ala Thr  Gln Phe Met Glu Phe  Glu Lys Leu Ser Gln  Phe Ala Ala 
    1820                 1825                 1830             


Ala Leu  Glu Pro Pro Leu Asn  Leu Pro Gln Pro Asn  Lys Leu Gln 
    1835                 1840                 1845             


Leu Ile  Ala Met Asp Leu Pro  Met Val Ser Gly Asp  Arg Ile His 
    1850                 1855                 1860             


Cys Leu  Asp Ile Leu Phe Ala  Phe Thr Lys Arg Val  Leu Gly Glu 
    1865                 1870                 1875             


Ser Gly  Glu Met Asp Ala Leu  Arg Ile Gln Met Glu  Glu Arg Phe 
    1880                 1885                 1890             


Met Ala  Ser Asn Pro Ser Lys  Val Ser Tyr Gln Pro  Ile Thr Thr 
    1895                 1900                 1905             


Thr Leu  Lys Arg Lys Gln Glu  Glu Val Ser Ala Val  Ile Ile Gln 
    1910                 1915                 1920             


Arg Ala  Tyr Arg Arg His Leu  Leu Lys Arg Thr Val  Lys Gln Ala 
    1925                 1930                 1935             


Ser Phe  Thr Tyr Asn Lys Asn  Lys Ile Lys Gly Gly  Ala Asn Leu 
    1940                 1945                 1950             


Leu Ile  Lys Glu Asp Met Ile  Ile Asp Arg Ile Asn  Glu Asn Ser 
    1955                 1960                 1965             


Ile Thr  Glu Lys Thr Asp Leu  Thr Met Ser Thr Ala  Ala Cys Pro 
    1970                 1975                 1980             


Pro Ser  Tyr Asp Arg Val Thr  Lys Pro Ile Val Glu  Lys His Glu 
    1985                 1990                 1995             


Gln Glu  Gly Lys Asp Glu Lys  Ala Lys Gly Lys 
    2000                 2005                 


<210>  38
<211>  2009
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Glu Gln Thr Val Leu Val Pro Pro Gly Pro Asp Ser Phe Asn Phe 
1               5                   10                  15      


Phe Thr Arg Glu Ser Leu Ala Ala Ile Glu Arg Arg Ile Ala Glu Glu 
            20                  25                  30          


Lys Ala Lys Asn Pro Lys Pro Asp Lys Lys Asp Asp Asp Glu Asn Gly 
        35                  40                  45              


Pro Lys Pro Asn Ser Asp Leu Glu Ala Gly Lys Asn Leu Pro Phe Ile 
    50                  55                  60                  


Tyr Gly Asp Ile Pro Pro Glu Met Val Ser Glu Pro Leu Glu Asp Leu 
65                  70                  75                  80  


Asp Pro Tyr Tyr Ile Asn Lys Lys Thr Phe Ile Val Leu Asn Lys Leu 
                85                  90                  95      


Lys Ala Ile Phe Arg Phe Ser Ala Thr Ser Ala Leu Tyr Ile Leu Thr 
            100                 105                 110         


Pro Phe Asn Pro Leu Arg Lys Ile Ala Ile Lys Ile Leu Val His Ser 
        115                 120                 125             


Leu Phe Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Val Phe 
    130                 135                 140                 


Met Thr Met Ser Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr Thr 
145                 150                 155                 160 


Phe Thr Gly Ile Tyr Thr Phe Glu Ser Leu Ile Lys Ile Ile Ala Arg 
                165                 170                 175     


Gly Phe Cys Leu Glu Asp Phe Thr Phe Leu Arg Asp Pro Trp Asn Trp 
            180                 185                 190         


Leu Asp Phe Thr Val Ile Thr Phe Ala Tyr Val Thr Glu Phe Val Asp 
        195                 200                 205             


Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala Leu 
    210                 215                 220                 


Lys Thr Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu 
225                 230                 235                 240 


Ile Gln Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val Phe 
                245                 250                 255     


Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly Asn 
            260                 265                 270         


Leu Arg Asn Lys Cys Ile Gln Trp Pro Pro Thr Asn Ala Ser Leu Glu 
        275                 280                 285             


Glu His Ser Ile Glu Lys Asn Ile Thr Val Asn Tyr Asn Gly Thr Leu 
    290                 295                 300                 


Ile Asn Glu Thr Val Phe Glu Phe Asp Trp Lys Ser Tyr Ile Gln Asp 
305                 310                 315                 320 


Ser Arg Tyr His Tyr Phe Leu Glu Gly Phe Leu Asp Ala Leu Leu Cys 
                325                 330                 335     


Gly Asn Ser Ser Asp Ala Gly Gln Cys Pro Glu Gly Tyr Met Cys Val 
            340                 345                 350         


Lys Ala Gly Arg Asn Pro Asn Tyr Gly Tyr Thr Ser Phe Asp Thr Phe 
        355                 360                 365             


Ser Trp Ala Phe Leu Ser Leu Phe Arg Leu Met Thr Gln Asp Phe Trp 
    370                 375                 380                 


Glu Asn Leu Tyr Gln Leu Thr Leu Arg Ala Ala Gly Lys Thr Tyr Met 
385                 390                 395                 400 


Ile Phe Phe Val Leu Val Ile Phe Leu Gly Ser Phe Tyr Leu Ile Asn 
                405                 410                 415     


Leu Ile Leu Ala Val Val Ala Met Ala Tyr Glu Glu Gln Asn Gln Ala 
            420                 425                 430         


Thr Leu Glu Glu Ala Glu Gln Lys Glu Ala Glu Phe Gln Gln Met Ile 
        435                 440                 445             


Glu Gln Leu Lys Lys Gln Gln Glu Ala Ala Gln Gln Ala Ala Thr Ala 
    450                 455                 460                 


Thr Ala Ser Glu His Ser Arg Glu Pro Ser Ala Ala Gly Arg Leu Ser 
465                 470                 475                 480 


Asp Ser Ser Ser Glu Ala Ser Lys Leu Ser Ser Lys Ser Ala Lys Glu 
                485                 490                 495     


Arg Arg Asn Arg Arg Lys Lys Arg Lys Gln Lys Glu Gln Ser Gly Gly 
            500                 505                 510         


Glu Glu Lys Asp Glu Asp Glu Phe Gln Lys Ser Glu Ser Glu Asp Ser 
        515                 520                 525             


Ile Arg Arg Lys Gly Phe Arg Phe Ser Ile Glu Gly Asn Arg Leu Thr 
    530                 535                 540                 


Tyr Glu Lys Arg Tyr Ser Ser Pro His Gln Ser Leu Leu Ser Ile Arg 
545                 550                 555                 560 


Gly Ser Leu Phe Ser Pro Arg Arg Asn Ser Arg Thr Ser Leu Phe Ser 
                565                 570                 575     


Phe Arg Gly Arg Ala Lys Asp Val Gly Ser Glu Asn Asp Phe Ala Asp 
            580                 585                 590         


Asp Glu His Ser Thr Phe Glu Asp Asn Glu Ser Arg Arg Asp Ser Leu 
        595                 600                 605             


Phe Val Pro Arg Arg His Gly Glu Arg Arg Asn Ser Asn Leu Ser Gln 
    610                 615                 620                 


Thr Ser Arg Ser Ser Arg Met Leu Ala Val Phe Pro Ala Asn Gly Lys 
625                 630                 635                 640 


Met His Ser Thr Val Asp Cys Asn Gly Val Val Ser Leu Val Gly Gly 
                645                 650                 655     


Pro Ser Val Pro Thr Ser Pro Val Gly Gln Leu Leu Pro Glu Val Ile 
            660                 665                 670         


Ile Asp Lys Pro Ala Thr Asp Asp Asn Gly Thr Thr Thr Glu Thr Glu 
        675                 680                 685             


Met Arg Lys Arg Arg Ser Ser Ser Phe His Val Ser Met Asp Phe Leu 
    690                 695                 700                 


Glu Asp Pro Ser Gln Arg Gln Arg Ala Met Ser Ile Ala Ser Ile Leu 
705                 710                 715                 720 


Thr Asn Thr Val Glu Glu Leu Glu Glu Ser Arg Gln Lys Cys Pro Pro 
                725                 730                 735     


Cys Trp Tyr Lys Phe Ser Asn Ile Phe Leu Ile Trp Asp Cys Ser Pro 
            740                 745                 750         


Tyr Trp Leu Lys Val Lys His Val Val Asn Leu Val Val Met Asp Pro 
        755                 760                 765             


Phe Val Asp Leu Ala Ile Thr Ile Cys Ile Val Leu Asn Thr Leu Phe 
    770                 775                 780                 


Met Ala Met Glu His Tyr Pro Met Thr Asp His Phe Asn Asn Val Leu 
785                 790                 795                 800 


Thr Val Gly Asn Leu Val Phe Thr Gly Ile Phe Thr Ala Glu Met Phe 
                805                 810                 815     


Leu Lys Ile Ile Ala Met Asp Pro Tyr Tyr Tyr Phe Gln Glu Gly Trp 
            820                 825                 830         


Asn Ile Phe Asp Gly Phe Ile Val Thr Leu Ser Leu Val Glu Leu Gly 
        835                 840                 845             


Leu Ala Asn Val Glu Gly Leu Ser Val Leu Arg Ser Phe Arg Leu Leu 
    850                 855                 860                 


Arg Val Phe Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Met Leu Ile 
865                 870                 875                 880 


Lys Ile Ile Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr Leu Val 
                885                 890                 895     


Leu Ala Ile Ile Val Phe Ile Phe Ala Val Val Gly Met Gln Leu Phe 
            900                 905                 910         


Gly Lys Ser Tyr Lys Asp Cys Val Cys Lys Ile Ala Ser Asp Cys Gln 
        915                 920                 925             


Leu Pro Arg Trp His Met Asn Asp Phe Phe His Ser Phe Leu Ile Val 
    930                 935                 940                 


Phe Arg Val Leu Cys Gly Glu Trp Ile Glu Thr Met Trp Asp Cys Met 
945                 950                 955                 960 


Glu Val Ala Gly Gln Ala Met Cys Leu Thr Val Phe Met Met Val Met 
                965                 970                 975     


Val Ile Gly Asn Leu Val Val Leu Asn Leu Phe Leu Ala Leu Leu Leu 
            980                 985                 990         


Ser Ser Phe Ser Ala Asp Asn Leu  Ala Ala Thr Asp Asp  Asp Asn Glu 
        995                 1000                 1005             


Met Asn  Asn Leu Gln Ile Ala  Val Asp Arg Met His  Lys Gly Val 
    1010                 1015                 1020             


Ala Tyr  Val Lys Arg Lys Ile  Tyr Glu Phe Ile Gln  Gln Ser Phe 
    1025                 1030                 1035             


Ile Arg  Lys Gln Lys Ile Leu  Asp Glu Ile Lys Pro  Leu Asp Asp 
    1040                 1045                 1050             


Leu Asn  Asn Lys Lys Asp Ser  Cys Met Ser Asn His  Thr Thr Glu 
    1055                 1060                 1065             


Ile Gly  Lys Asp Leu Asp Tyr  Leu Lys Asp Val Asn  Gly Thr Thr 
    1070                 1075                 1080             


Ser Gly  Ile Gly Thr Gly Ser  Ser Val Glu Lys Tyr  Ile Ile Asp 
    1085                 1090                 1095             


Glu Ser  Asp Tyr Met Ser Phe  Ile Asn Asn Pro Ser  Leu Thr Val 
    1100                 1105                 1110             


Thr Val  Pro Ile Ala Val Gly  Glu Ser Asp Phe Glu  Asn Leu Asn 
    1115                 1120                 1125             


Thr Glu  Asp Phe Ser Ser Glu  Ser Asp Leu Glu Glu  Ser Lys Glu 
    1130                 1135                 1140             


Lys Leu  Asn Glu Ser Ser Ser  Ser Ser Glu Gly Ser  Thr Val Asp 
    1145                 1150                 1155             


Ile Gly  Ala Pro Val Glu Glu  Gln Pro Val Val Glu  Pro Glu Glu 
    1160                 1165                 1170             


Thr Leu  Glu Pro Glu Ala Cys  Phe Thr Glu Gly Cys  Val Gln Arg 
    1175                 1180                 1185             


Phe Lys  Cys Cys Gln Ile Asn  Val Glu Glu Gly Arg  Gly Lys Gln 
    1190                 1195                 1200             


Trp Trp  Asn Leu Arg Arg Thr  Cys Phe Arg Ile Val  Glu His Asn 
    1205                 1210                 1215             


Trp Phe  Glu Thr Phe Ile Val  Phe Met Ile Leu Leu  Ser Ser Gly 
    1220                 1225                 1230             


Ala Leu  Ala Phe Glu Asp Ile  Tyr Ile Asp Gln Arg  Lys Thr Ile 
    1235                 1240                 1245             


Lys Thr  Met Leu Glu Tyr Ala  Asp Lys Val Phe Thr  Tyr Ile Phe 
    1250                 1255                 1260             


Ile Leu  Glu Met Leu Leu Lys  Trp Val Ala Tyr Gly  Tyr Gln Thr 
    1265                 1270                 1275             


Tyr Phe  Thr Asn Ala Trp Cys  Trp Leu Asp Phe Leu  Ile Val Asp 
    1280                 1285                 1290             


Val Ser  Leu Val Ser Leu Thr  Ala Asn Ala Leu Gly  Tyr Ser Glu 
    1295                 1300                 1305             


Leu Gly  Ala Ile Lys Ser Leu  Arg Thr Leu Arg Ala  Leu Arg Pro 
    1310                 1315                 1320             


Leu Arg  Ala Leu Ser Arg Phe  Glu Gly Met Arg Val  Val Val Asn 
    1325                 1330                 1335             


Ala Leu  Leu Gly Ala Ile Pro  Ser Ile Met Asn Val  Leu Leu Val 
    1340                 1345                 1350             


Cys Leu  Ile Phe Trp Leu Ile  Phe Ser Ile Met Gly  Val Asn Leu 
    1355                 1360                 1365             


Phe Ala  Gly Lys Phe Tyr His  Cys Ile Asn Thr Thr  Thr Gly Asp 
    1370                 1375                 1380             


Arg Phe  Asp Ile Glu Asp Val  Asn Asn His Thr Asp  Cys Leu Lys 
    1385                 1390                 1395             


Leu Ile  Glu Arg Asn Glu Thr  Ala Arg Trp Lys Asn  Val Lys Val 
    1400                 1405                 1410             


Asn Phe  Asp Asn Val Gly Phe  Gly Tyr Leu Ser Leu  Leu Gln Val 
    1415                 1420                 1425             


Ala Thr  Phe Lys Gly Trp Met  Asp Ile Met Tyr Ala  Ala Val Asp 
    1430                 1435                 1440             


Ser Arg  Asn Val Glu Leu Gln  Pro Lys Tyr Glu Lys  Ser Leu Tyr 
    1445                 1450                 1455             


Met Tyr  Leu Tyr Phe Val Ile  Phe Ile Ile Phe Gly  Ser Phe Phe 
    1460                 1465                 1470             


Thr Leu  Asn Leu Phe Ile Gly  Val Ile Ile Asp Asn  Phe Asn Gln 
    1475                 1480                 1485             


Gln Lys  Lys Lys Phe Gly Gly  Gln Asp Ile Phe Met  Thr Glu Glu 
    1490                 1495                 1500             


Gln Lys  Lys Tyr Tyr Asn Ala  Met Lys Lys Leu Gly  Ser Lys Lys 
    1505                 1510                 1515             


Pro Gln  Lys Pro Ile Pro Arg  Pro Gly Asn Lys Phe  Gln Gly Met 
    1520                 1525                 1530             


Val Phe  Asp Phe Val Thr Arg  Gln Val Phe Asp Ile  Ser Ile Met 
    1535                 1540                 1545             


Ile Leu  Ile Cys Leu Asn Met  Val Thr Met Met Val  Glu Thr Asp 
    1550                 1555                 1560             


Asp Gln  Ser Glu Tyr Val Thr  Thr Ile Leu Ser Arg  Ile Asn Leu 
    1565                 1570                 1575             


Val Phe  Ile Val Leu Phe Thr  Gly Glu Cys Val Leu  Lys Leu Ile 
    1580                 1585                 1590             


Ser Leu  Arg His Tyr Tyr Phe  Thr Ile Gly Trp Asn  Ile Phe Asp 
    1595                 1600                 1605             


Phe Val  Val Val Ile Leu Ser  Ile Val Gly Met Phe  Leu Ala Glu 
    1610                 1615                 1620             


Leu Ile  Glu Lys Tyr Phe Val  Ser Pro Thr Leu Phe  Arg Val Ile 
    1625                 1630                 1635             


Arg Leu  Ala Arg Ile Gly Arg  Ile Leu Arg Leu Ile  Lys Gly Ala 
    1640                 1645                 1650             


Lys Gly  Ile Arg Thr Leu Leu  Phe Ala Leu Met Met  Ser Leu Pro 
    1655                 1660                 1665             


Ala Leu  Phe Asn Ile Gly Leu  Leu Leu Phe Leu Val  Met Phe Ile 
    1670                 1675                 1680             


Tyr Ala  Ile Phe Gly Met Ser  Asn Phe Ala Tyr Val  Lys Arg Glu 
    1685                 1690                 1695             


Val Gly  Ile Asp Asp Met Phe  Asn Val Glu Thr Phe  Gly Asn Ser 
    1700                 1705                 1710             


Met Ile  Cys Leu Phe Gln Ile  Thr Thr Ser Ala Gly  Trp Asp Gly 
    1715                 1720                 1725             


Leu Leu  Ala Pro Ile Leu Asn  Ser Lys Pro Pro Asp  Cys Asp Pro 
    1730                 1735                 1740             


Asn Lys  Val Asn Pro Gly Ser  Ser Val Lys Gly Asp  Cys Gly Asn 
    1745                 1750                 1755             


Pro Ser  Val Gly Ile Phe Phe  Phe Val Ser Tyr Ile  Ile Ile Ser 
    1760                 1765                 1770             


Phe Leu  Val Val Val Asn Met  Tyr Ile Ala Val Ile  Leu Glu Asn 
    1775                 1780                 1785             


Phe Ser  Val Ala Thr Glu Glu  Ser Ala Glu Pro Leu  Ser Glu Asp 
    1790                 1795                 1800             


Asp Phe  Glu Met Phe Tyr Glu  Val Trp Glu Lys Phe  Asp Pro Asp 
    1805                 1810                 1815             


Ala Thr  Gln Phe Met Glu Phe  Glu Lys Leu Ser Gln  Phe Ala Ala 
    1820                 1825                 1830             


Ala Leu  Glu Pro Pro Leu Asn  Leu Pro Gln Pro Asn  Lys Leu Gln 
    1835                 1840                 1845             


Leu Ile  Ala Met Asp Leu Pro  Met Val Ser Gly Asp  Arg Ile His 
    1850                 1855                 1860             


Cys Leu  Asp Ile Leu Phe Ala  Phe Thr Lys Arg Val  Leu Gly Glu 
    1865                 1870                 1875             


Ser Gly  Glu Met Asp Ala Leu  Arg Ile Gln Met Glu  Glu Arg Phe 
    1880                 1885                 1890             


Met Ala  Ser Asn Pro Ser Lys  Val Ser Tyr Gln Pro  Ile Thr Thr 
    1895                 1900                 1905             


Thr Leu  Lys Arg Lys Gln Glu  Glu Val Ser Ala Val  Ile Ile Gln 
    1910                 1915                 1920             


Arg Ala  Tyr Arg Arg His Leu  Leu Lys Arg Thr Val  Lys Gln Ala 
    1925                 1930                 1935             


Ser Phe  Thr Tyr Asn Lys Asn  Lys Ile Lys Gly Gly  Ala Asn Leu 
    1940                 1945                 1950             


Leu Ile  Lys Glu Asp Met Ile  Ile Asp Arg Ile Asn  Glu Asn Ser 
    1955                 1960                 1965             


Ile Thr  Glu Lys Thr Asp Leu  Thr Met Ser Thr Ala  Ala Cys Pro 
    1970                 1975                 1980             


Pro Ser  Tyr Asp Arg Val Thr  Lys Pro Ile Val Glu  Lys His Glu 
    1985                 1990                 1995             


Gln Glu  Gly Lys Asp Glu Lys  Ala Lys Gly Lys 
    2000                 2005                 


<210>  39
<211>  2009
<212>  PRT
<213>  Homo sapiens

<400>  39

Met Glu Gln Thr Val Leu Val Pro Pro Gly Pro Asp Ser Phe Asn Phe 
1               5                   10                  15      


Phe Thr Arg Glu Ser Leu Ala Ala Ile Glu Arg Arg Ile Ala Glu Glu 
            20                  25                  30          


Lys Ala Lys Asn Pro Lys Pro Asp Lys Lys Asp Asp Asp Glu Asn Gly 
        35                  40                  45              


Pro Lys Pro Asn Ser Asp Leu Glu Ala Gly Lys Asn Leu Pro Phe Ile 
    50                  55                  60                  


Tyr Gly Asp Ile Pro Pro Glu Met Val Ser Glu Pro Leu Glu Asp Leu 
65                  70                  75                  80  


Asp Pro Tyr Tyr Ile Asn Lys Lys Thr Phe Ile Val Leu Asn Lys Leu 
                85                  90                  95      


Lys Ala Ile Phe Arg Phe Ser Ala Thr Ser Ala Leu Tyr Ile Leu Thr 
            100                 105                 110         


Pro Phe Asn Pro Leu Arg Lys Ile Ala Ile Lys Ile Leu Val His Ser 
        115                 120                 125             


Leu Phe Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Val Phe 
    130                 135                 140                 


Met Thr Met Ser Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr Thr 
145                 150                 155                 160 


Phe Thr Gly Ile Tyr Thr Phe Glu Ser Leu Ile Lys Ile Ile Ala Arg 
                165                 170                 175     


Gly Phe Cys Leu Glu Asp Phe Thr Phe Leu Arg Asp Pro Trp Asn Trp 
            180                 185                 190         


Leu Asp Phe Thr Val Ile Thr Phe Ala Tyr Val Thr Glu Phe Val Asp 
        195                 200                 205             


Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala Leu 
    210                 215                 220                 


Lys Thr Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu 
225                 230                 235                 240 


Ile Gln Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val Phe 
                245                 250                 255     


Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly Asn 
            260                 265                 270         


Leu Arg Asn Lys Cys Ile Gln Trp Pro Pro Thr Asn Ala Ser Leu Glu 
        275                 280                 285             


Glu His Ser Ile Glu Lys Asn Ile Thr Val Asn Tyr Asn Gly Thr Leu 
    290                 295                 300                 


Ile Asn Glu Thr Val Phe Glu Phe Asp Trp Lys Ser Tyr Ile Gln Asp 
305                 310                 315                 320 


Ser Arg Tyr His Tyr Phe Leu Glu Gly Phe Leu Asp Ala Leu Leu Cys 
                325                 330                 335     


Gly Asn Ser Ser Asp Ala Gly Gln Cys Pro Glu Gly Tyr Met Cys Val 
            340                 345                 350         


Lys Ala Gly Arg Asn Pro Asn Tyr Gly Tyr Thr Ser Phe Asp Thr Phe 
        355                 360                 365             


Ser Trp Ala Phe Leu Ser Leu Phe Arg Leu Met Thr Gln Asp Phe Trp 
    370                 375                 380                 


Glu Asn Leu Tyr Gln Leu Thr Leu Arg Ala Ala Gly Lys Thr Tyr Met 
385                 390                 395                 400 


Ile Phe Phe Val Leu Val Ile Phe Leu Gly Ser Phe Tyr Leu Ile Asn 
                405                 410                 415     


Leu Ile Leu Ala Val Val Ala Met Ala Tyr Glu Glu Gln Asn Gln Ala 
            420                 425                 430         


Thr Leu Glu Glu Ala Glu Gln Lys Glu Ala Glu Phe Gln Gln Met Ile 
        435                 440                 445             


Glu Gln Leu Lys Lys Gln Gln Glu Ala Ala Gln Gln Ala Ala Thr Ala 
    450                 455                 460                 


Thr Ala Ser Glu His Ser Arg Glu Pro Ser Ala Ala Gly Arg Leu Ser 
465                 470                 475                 480 


Asp Ser Ser Ser Glu Ala Ser Lys Leu Ser Ser Lys Ser Ala Lys Glu 
                485                 490                 495     


Arg Arg Asn Arg Arg Lys Lys Arg Lys Gln Lys Glu Gln Ser Gly Gly 
            500                 505                 510         


Glu Glu Lys Asp Glu Asp Glu Phe Gln Lys Ser Glu Ser Glu Asp Ser 
        515                 520                 525             


Ile Arg Arg Lys Gly Phe Arg Phe Ser Ile Glu Gly Asn Arg Leu Thr 
    530                 535                 540                 


Tyr Glu Lys Arg Tyr Ser Ser Pro His Gln Ser Leu Leu Ser Ile Arg 
545                 550                 555                 560 


Gly Ser Leu Phe Ser Pro Arg Arg Asn Ser Arg Thr Ser Leu Phe Ser 
                565                 570                 575     


Phe Arg Gly Arg Ala Lys Asp Val Gly Ser Glu Asn Asp Phe Ala Asp 
            580                 585                 590         


Asp Glu His Ser Thr Phe Glu Asp Asn Glu Ser Arg Arg Asp Ser Leu 
        595                 600                 605             


Phe Val Pro Arg Arg His Gly Glu Arg Arg Asn Ser Asn Leu Ser Gln 
    610                 615                 620                 


Thr Ser Arg Ser Ser Arg Met Leu Ala Val Phe Pro Ala Asn Gly Lys 
625                 630                 635                 640 


Met His Ser Thr Val Asp Cys Asn Gly Val Val Ser Leu Val Gly Gly 
                645                 650                 655     


Pro Ser Val Pro Thr Ser Pro Val Gly Gln Leu Leu Pro Glu Val Ile 
            660                 665                 670         


Ile Asp Lys Pro Ala Thr Asp Asp Asn Gly Thr Thr Thr Glu Thr Glu 
        675                 680                 685             


Met Arg Lys Arg Arg Ser Ser Ser Phe His Val Ser Met Asp Phe Leu 
    690                 695                 700                 


Glu Asp Pro Ser Gln Arg Gln Arg Ala Met Ser Ile Ala Ser Ile Leu 
705                 710                 715                 720 


Thr Asn Thr Val Glu Glu Leu Glu Glu Ser Arg Gln Lys Cys Pro Pro 
                725                 730                 735     


Cys Trp Tyr Lys Phe Ser Asn Ile Phe Leu Ile Trp Asp Cys Ser Pro 
            740                 745                 750         


Tyr Trp Leu Lys Val Lys His Val Val Asn Leu Val Val Met Asp Pro 
        755                 760                 765             


Phe Val Asp Leu Ala Ile Thr Ile Cys Ile Val Leu Asn Thr Leu Phe 
    770                 775                 780                 


Met Ala Met Glu His Tyr Pro Met Thr Asp His Phe Asn Asn Val Leu 
785                 790                 795                 800 


Thr Val Gly Asn Leu Val Phe Thr Gly Ile Phe Thr Ala Glu Met Phe 
                805                 810                 815     


Leu Lys Ile Ile Ala Met Asp Pro Tyr Tyr Tyr Phe Gln Glu Gly Trp 
            820                 825                 830         


Asn Ile Phe Asp Gly Phe Ile Val Thr Leu Ser Leu Val Glu Leu Gly 
        835                 840                 845             


Leu Ala Asn Val Glu Gly Leu Ser Val Leu Arg Ser Phe Arg Leu Leu 
    850                 855                 860                 


Arg Val Phe Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Met Leu Ile 
865                 870                 875                 880 


Lys Ile Ile Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr Leu Val 
                885                 890                 895     


Leu Ala Ile Ile Val Phe Ile Phe Ala Val Val Gly Met Gln Leu Phe 
            900                 905                 910         


Gly Lys Ser Tyr Lys Asp Cys Val Cys Lys Ile Ala Ser Asp Cys Gln 
        915                 920                 925             


Leu Pro Arg Trp His Met Asn Asp Phe Phe His Ser Phe Leu Ile Val 
    930                 935                 940                 


Phe Arg Val Leu Cys Gly Glu Trp Ile Glu Thr Met Trp Asp Cys Met 
945                 950                 955                 960 


Glu Val Ala Gly Gln Ala Met Cys Leu Thr Val Phe Met Met Val Met 
                965                 970                 975     


Val Ile Gly Asn Leu Val Val Leu Asn Leu Phe Leu Ala Leu Leu Leu 
            980                 985                 990         


Ser Ser Phe Ser Ala Asp Asn Leu  Ala Ala Thr Asp Asp  Asp Asn Glu 
        995                 1000                 1005             


Met Asn  Asn Leu Gln Ile Ala  Val Asp Arg Met His  Lys Gly Val 
    1010                 1015                 1020             


Ala Tyr  Val Lys Arg Lys Ile  Tyr Glu Phe Ile Gln  Gln Ser Phe 
    1025                 1030                 1035             


Ile Arg  Lys Gln Lys Ile Leu  Asp Glu Ile Lys Pro  Leu Asp Asp 
    1040                 1045                 1050             


Leu Asn  Asn Lys Lys Asp Ser  Cys Met Ser Asn His  Thr Thr Glu 
    1055                 1060                 1065             


Ile Gly  Lys Asp Leu Asp Tyr  Leu Lys Asp Val Asn  Gly Thr Thr 
    1070                 1075                 1080             


Ser Gly  Ile Gly Thr Gly Ser  Ser Val Glu Lys Tyr  Ile Ile Asp 
    1085                 1090                 1095             


Glu Ser  Asp Tyr Met Ser Phe  Ile Asn Asn Pro Ser  Leu Thr Val 
    1100                 1105                 1110             


Thr Val  Pro Ile Ala Val Gly  Glu Ser Asp Phe Glu  Asn Leu Asn 
    1115                 1120                 1125             


Thr Glu  Asp Phe Ser Ser Glu  Ser Asp Leu Glu Glu  Ser Lys Glu 
    1130                 1135                 1140             


Lys Leu  Asn Glu Ser Ser Ser  Ser Ser Glu Gly Ser  Thr Val Asp 
    1145                 1150                 1155             


Ile Gly  Ala Pro Val Glu Glu  Gln Pro Val Val Glu  Pro Glu Glu 
    1160                 1165                 1170             


Thr Leu  Glu Pro Glu Ala Cys  Phe Thr Glu Gly Cys  Val Gln Arg 
    1175                 1180                 1185             


Phe Lys  Cys Cys Gln Ile Asn  Val Glu Glu Gly Arg  Gly Lys Gln 
    1190                 1195                 1200             


Trp Trp  Asn Leu Arg Arg Thr  Cys Phe Arg Ile Val  Glu His Asn 
    1205                 1210                 1215             


Trp Phe  Glu Thr Phe Ile Val  Phe Met Ile Leu Leu  Ser Ser Gly 
    1220                 1225                 1230             


Ala Leu  Ala Phe Glu Asp Ile  Tyr Ile Asp Gln Arg  Lys Thr Ile 
    1235                 1240                 1245             


Lys Thr  Met Leu Glu Tyr Ala  Asp Lys Val Phe Thr  Tyr Ile Phe 
    1250                 1255                 1260             


Ile Leu  Glu Met Leu Leu Lys  Trp Val Ala Tyr Gly  Tyr Gln Thr 
    1265                 1270                 1275             


Tyr Phe  Thr Asn Ala Trp Cys  Trp Leu Asp Phe Leu  Ile Val Asp 
    1280                 1285                 1290             


Val Ser  Leu Val Ser Leu Thr  Ala Asn Ala Leu Gly  Tyr Ser Glu 
    1295                 1300                 1305             


Leu Gly  Ala Ile Lys Ser Leu  Arg Thr Leu Arg Ala  Leu Arg Pro 
    1310                 1315                 1320             


Leu Arg  Ala Leu Ser Arg Phe  Glu Gly Met Arg Val  Val Val Asn 
    1325                 1330                 1335             


Ala Leu  Leu Gly Ala Ile Pro  Ser Ile Met Asn Val  Leu Leu Val 
    1340                 1345                 1350             


Cys Leu  Ile Phe Trp Leu Ile  Phe Ser Ile Met Gly  Val Asn Leu 
    1355                 1360                 1365             


Phe Ala  Gly Lys Phe Tyr His  Cys Ile Asn Thr Thr  Thr Gly Asp 
    1370                 1375                 1380             


Arg Phe  Asp Ile Glu Asp Val  Asn Asn His Thr Asp  Cys Leu Lys 
    1385                 1390                 1395             


Leu Ile  Glu Arg Asn Glu Thr  Ala Arg Trp Lys Asn  Val Lys Val 
    1400                 1405                 1410             


Asn Phe  Asp Asn Val Gly Phe  Gly Tyr Leu Ser Leu  Leu Gln Val 
    1415                 1420                 1425             


Ala Thr  Phe Lys Gly Trp Met  Asp Ile Met Tyr Ala  Ala Val Asp 
    1430                 1435                 1440             


Ser Arg  Asn Val Glu Leu Gln  Pro Lys Tyr Glu Lys  Ser Leu Tyr 
    1445                 1450                 1455             


Met Tyr  Leu Tyr Phe Val Ile  Phe Ile Ile Phe Gly  Ser Phe Phe 
    1460                 1465                 1470             


Thr Leu  Asn Leu Phe Ile Gly  Val Ile Ile Asp Asn  Phe Asn Gln 
    1475                 1480                 1485             


Gln Lys  Lys Lys Phe Gly Gly  Gln Asp Ile Phe Met  Thr Glu Glu 
    1490                 1495                 1500             


Gln Lys  Lys Tyr Tyr Asn Ala  Met Lys Lys Leu Gly  Ser Lys Lys 
    1505                 1510                 1515             


Pro Gln  Lys Pro Ile Pro Arg  Pro Gly Asn Lys Phe  Gln Gly Met 
    1520                 1525                 1530             


Val Phe  Asp Phe Val Thr Arg  Gln Val Phe Asp Ile  Ser Ile Met 
    1535                 1540                 1545             


Ile Leu  Ile Cys Leu Asn Met  Val Thr Met Met Val  Glu Thr Asp 
    1550                 1555                 1560             


Asp Gln  Ser Glu Tyr Val Thr  Thr Ile Leu Ser Arg  Ile Asn Leu 
    1565                 1570                 1575             


Val Phe  Ile Val Leu Phe Thr  Gly Glu Cys Val Leu  Lys Leu Ile 
    1580                 1585                 1590             


Ser Leu  Arg His Tyr Tyr Phe  Thr Ile Gly Trp Asn  Ile Phe Asp 
    1595                 1600                 1605             


Phe Val  Val Val Ile Leu Ser  Ile Val Gly Met Phe  Leu Ala Glu 
    1610                 1615                 1620             


Leu Ile  Glu Lys Tyr Phe Val  Ser Pro Thr Leu Phe  Arg Val Ile 
    1625                 1630                 1635             


Arg Leu  Ala Arg Ile Gly Arg  Ile Leu Arg Leu Ile  Lys Gly Ala 
    1640                 1645                 1650             


Lys Gly  Ile Arg Thr Leu Leu  Phe Ala Leu Met Met  Ser Leu Pro 
    1655                 1660                 1665             


Ala Leu  Phe Asn Ile Gly Leu  Leu Leu Phe Leu Val  Met Phe Ile 
    1670                 1675                 1680             


Tyr Ala  Ile Phe Gly Met Ser  Asn Phe Ala Tyr Val  Lys Arg Glu 
    1685                 1690                 1695             


Val Gly  Ile Asp Asp Met Phe  Asn Phe Glu Thr Phe  Gly Asn Ser 
    1700                 1705                 1710             


Met Ile  Cys Leu Phe Gln Ile  Thr Thr Ser Ala Gly  Trp Asp Gly 
    1715                 1720                 1725             


Leu Leu  Ala Pro Ile Leu Asn  Ser Lys Pro Pro Asp  Cys Asp Pro 
    1730                 1735                 1740             


Asn Lys  Val Asn Pro Gly Ser  Ser Val Lys Gly Asp  Cys Gly Asn 
    1745                 1750                 1755             


Pro Ser  Val Gly Ile Phe Phe  Phe Val Ser Tyr Ile  Ile Ile Ser 
    1760                 1765                 1770             


Phe Leu  Val Val Val Asn Met  Tyr Ile Thr Val Ile  Leu Glu Asn 
    1775                 1780                 1785             


Phe Ser  Val Ala Thr Glu Glu  Ser Ala Glu Pro Leu  Ser Glu Asp 
    1790                 1795                 1800             


Asp Phe  Glu Met Phe Tyr Glu  Val Trp Glu Lys Phe  Asp Pro Asp 
    1805                 1810                 1815             


Ala Thr  Gln Phe Met Glu Phe  Glu Lys Leu Ser Gln  Phe Ala Ala 
    1820                 1825                 1830             


Ala Leu  Glu Pro Pro Leu Asn  Leu Pro Gln Pro Asn  Lys Leu Gln 
    1835                 1840                 1845             


Leu Ile  Ala Met Asp Leu Pro  Met Val Ser Gly Asp  Arg Ile His 
    1850                 1855                 1860             


Cys Leu  Asp Ile Leu Phe Ala  Phe Thr Lys Arg Val  Leu Gly Glu 
    1865                 1870                 1875             


Ser Gly  Glu Met Asp Ala Leu  Arg Ile Gln Met Glu  Glu Arg Phe 
    1880                 1885                 1890             


Met Ala  Ser Asn Pro Ser Lys  Val Ser Tyr Gln Pro  Ile Thr Thr 
    1895                 1900                 1905             


Thr Leu  Lys Arg Lys Gln Glu  Glu Val Ser Ala Val  Ile Ile Gln 
    1910                 1915                 1920             


Arg Ala  Tyr Arg Arg His Leu  Leu Lys Arg Thr Val  Lys Gln Ala 
    1925                 1930                 1935             


Ser Phe  Thr Tyr Asn Lys Asn  Lys Ile Lys Gly Gly  Ala Asn Leu 
    1940                 1945                 1950             


Leu Ile  Lys Glu Asp Met Ile  Ile Asp Arg Ile Asn  Glu Asn Ser 
    1955                 1960                 1965             


Ile Thr  Glu Lys Thr Asp Leu  Thr Met Ser Thr Ala  Ala Cys Pro 
    1970                 1975                 1980             


Pro Ser  Tyr Asp Arg Val Thr  Lys Pro Ile Val Glu  Lys His Glu 
    1985                 1990                 1995             


Gln Glu  Gly Lys Asp Glu Lys  Ala Lys Gly Lys 
    2000                 2005                 


<210>  40
<211>  90
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Glu Gln Thr Val Leu Val Pro Pro Gly Pro Asp Ser Ser Thr Ser 
1               5                   10                  15      


Ser Pro Glu Asn Leu Leu Arg Leu Leu Lys Asp Ala Leu Gln Lys Lys 
            20                  25                  30          


Arg Gln Arg Ile Pro Asn Gln Thr Lys Lys Met Thr Thr Lys Met Ala 
        35                  40                  45              


Gln Ser Gln Ile Val Thr Trp Lys Leu Glu Arg Thr Phe His Leu Phe 
    50                  55                  60                  


Met Glu Thr Phe Leu Gln Arg Trp Cys Gln Ser Pro Trp Arg Thr Trp 
65                  70                  75                  80  


Thr Pro Thr Ile Ser Ile Arg Lys Leu Leu 
                85                  90  


<210>  41
<211>  169
<212>  PRT
<213>  Homo sapiens

<400>  41

Met Glu Gln Thr Val Leu Val Pro Pro Gly Pro Asp Ser Phe Asn Phe 
1               5                   10                  15      


Phe Thr Arg Glu Ser Leu Ala Ala Ile Glu Arg Arg Ile Ala Glu Glu 
            20                  25                  30          


Lys Ala Lys Asn Pro Lys Pro Asp Lys Lys Asp Asp Asp Glu Asn Gly 
        35                  40                  45              


Pro Lys Pro Asn Ser Asp Leu Glu Ala Gly Lys Asn Leu Pro Phe Ile 
    50                  55                  60                  


Tyr Gly Asp Ile Pro Pro Glu Met Val Ser Glu Pro Leu Glu Asp Leu 
65                  70                  75                  80  


Asp Pro Tyr Tyr Ile Asn Lys Lys Thr Phe Ile Val Leu Asn Lys Leu 
                85                  90                  95      


Lys Ala Ile Phe Arg Phe Ser Ala Thr Ser Ala Leu Tyr Ile Leu Thr 
            100                 105                 110         


Pro Phe Asn Pro Leu Arg Lys Ile Ala Ile Lys Ile Leu Val His Ser 
        115                 120                 125             


Leu Phe Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Val Phe 
    130                 135                 140                 


Met Thr Met Ser Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr Thr 
145                 150                 155                 160 


Phe Thr Gly Ile Tyr Ser Glu Ser Phe 
                165                 


<210>  42
<211>  621
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Glu Gln Thr Val Leu Val Pro Pro Gly Pro Asp Ser Phe Asn Phe 
1               5                   10                  15      


Phe Thr Arg Glu Ser Leu Ala Ala Ile Glu Arg Arg Ile Ala Glu Glu 
            20                  25                  30          


Lys Ala Lys Asn Pro Lys Pro Asp Lys Lys Asp Asp Asp Glu Asn Gly 
        35                  40                  45              


Pro Lys Pro Asn Ser Asp Leu Glu Ala Gly Lys Asn Leu Pro Phe Ile 
    50                  55                  60                  


Tyr Gly Asp Ile Pro Pro Glu Met Val Ser Glu Pro Leu Glu Asp Leu 
65                  70                  75                  80  


Asp Pro Tyr Tyr Ile Asn Lys Lys Thr Phe Ile Val Leu Asn Lys Leu 
                85                  90                  95      


Lys Ala Ile Phe Arg Phe Ser Ala Thr Ser Ala Leu Tyr Ile Leu Thr 
            100                 105                 110         


Pro Phe Asn Pro Leu Arg Lys Ile Ala Ile Lys Ile Leu Val His Ser 
        115                 120                 125             


Leu Phe Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Val Phe 
    130                 135                 140                 


Met Thr Met Ser Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr Thr 
145                 150                 155                 160 


Phe Thr Gly Ile Tyr Thr Phe Glu Ser Leu Ile Lys Ile Ile Ala Arg 
                165                 170                 175     


Gly Phe Cys Leu Glu Asp Phe Thr Phe Leu Arg Asp Pro Trp Asn Trp 
            180                 185                 190         


Leu Asp Phe Thr Val Ile Thr Phe Ala Tyr Val Thr Glu Phe Val Asp 
        195                 200                 205             


Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala Leu 
    210                 215                 220                 


Lys Thr Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu 
225                 230                 235                 240 


Ile Gln Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val Phe 
                245                 250                 255     


Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly Asn 
            260                 265                 270         


Leu Arg Asn Lys Cys Ile Gln Trp Pro Pro Thr Asn Ala Ser Leu Glu 
        275                 280                 285             


Glu His Ser Ile Glu Lys Asn Ile Thr Val Asn Tyr Asn Gly Thr Leu 
    290                 295                 300                 


Ile Asn Glu Thr Val Phe Glu Phe Asp Trp Lys Ser Tyr Ile Gln Asp 
305                 310                 315                 320 


Ser Arg Tyr His Tyr Phe Leu Glu Gly Phe Leu Asp Ala Leu Leu Cys 
                325                 330                 335     


Gly Asn Ser Ser Asp Ala Gly Gln Cys Pro Glu Gly Tyr Met Cys Val 
            340                 345                 350         


Lys Ala Gly Arg Asn Pro Asn Tyr Gly Tyr Thr Ser Phe Asp Thr Phe 
        355                 360                 365             


Ser Trp Ala Phe Leu Ser Leu Phe Arg Leu Met Thr Gln Asp Phe Trp 
    370                 375                 380                 


Glu Asn Leu Tyr Gln Leu Thr Leu Arg Ala Ala Gly Lys Thr Tyr Met 
385                 390                 395                 400 


Ile Phe Phe Val Leu Val Ile Phe Leu Gly Ser Phe Tyr Leu Ile Asn 
                405                 410                 415     


Leu Ile Leu Ala Val Val Ala Met Ala Tyr Glu Glu Gln Asn Gln Ala 
            420                 425                 430         


Thr Leu Glu Glu Ala Glu Gln Lys Glu Ala Glu Phe Gln Gln Met Ile 
        435                 440                 445             


Glu Gln Leu Lys Lys Gln Gln Glu Ala Ala Gln Gln Ala Ala Thr Ala 
    450                 455                 460                 


Thr Ala Ser Glu His Ser Arg Glu Pro Ser Ala Ala Gly Arg Leu Ser 
465                 470                 475                 480 


Asp Ser Ser Ser Glu Ala Ser Lys Leu Ser Ser Lys Ser Ala Lys Glu 
                485                 490                 495     


Arg Arg Asn Arg Arg Lys Lys Arg Lys Gln Lys Glu Gln Ser Gly Gly 
            500                 505                 510         


Glu Glu Lys Asp Glu Asp Glu Phe Gln Lys Ser Glu Ser Glu Asp Ser 
        515                 520                 525             


Ile Arg Arg Lys Gly Phe Arg Phe Ser Ile Glu Gly Asn Arg Leu Thr 
    530                 535                 540                 


Tyr Glu Lys Arg Tyr Ser Ser Pro His Gln Ser Leu Leu Ser Ile Arg 
545                 550                 555                 560 


Gly Ser Tyr Phe His Gln Gly Glu Ile Ala Glu Gln Ala Phe Ser Ala 
                565                 570                 575     


Leu Glu Gly Glu Gln Arg Met Trp Asp Leu Arg Thr Thr Ser Gln Met 
            580                 585                 590         


Met Ser Thr Ala Pro Leu Arg Ile Thr Arg Ala Val Glu Ile Pro Cys 
        595                 600                 605             


Leu Cys Pro Asp Asp Thr Glu Arg Asp Ala Thr Ala Thr 
    610                 615                 620     


<210>  43
<211>  1078
<212>  PRT
<213>  Homo sapiens

<400>  43

Met Glu Gln Thr Val Leu Val Pro Pro Gly Pro Asp Ser Phe Asn Phe 
1               5                   10                  15      


Phe Thr Arg Glu Ser Leu Ala Ala Ile Glu Arg Arg Ile Ala Glu Glu 
            20                  25                  30          


Lys Ala Lys Asn Pro Lys Pro Asp Lys Lys Asp Asp Asp Glu Asn Gly 
        35                  40                  45              


Pro Lys Pro Asn Ser Asp Leu Glu Ala Gly Lys Asn Leu Pro Phe Ile 
    50                  55                  60                  


Tyr Gly Asp Ile Pro Pro Glu Met Val Ser Glu Pro Leu Glu Asp Leu 
65                  70                  75                  80  


Asp Pro Tyr Tyr Ile Asn Lys Lys Thr Phe Ile Val Leu Asn Lys Leu 
                85                  90                  95      


Lys Ala Ile Phe Arg Phe Ser Ala Thr Ser Ala Leu Tyr Ile Leu Thr 
            100                 105                 110         


Pro Phe Asn Pro Leu Arg Lys Ile Ala Ile Lys Ile Leu Val His Ser 
        115                 120                 125             


Leu Phe Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Val Phe 
    130                 135                 140                 


Met Thr Met Ser Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr Thr 
145                 150                 155                 160 


Phe Thr Gly Ile Tyr Thr Phe Glu Ser Leu Ile Lys Ile Ile Ala Arg 
                165                 170                 175     


Gly Phe Cys Leu Glu Asp Phe Thr Phe Leu Arg Asp Pro Trp Asn Trp 
            180                 185                 190         


Leu Asp Phe Thr Val Ile Thr Phe Ala Tyr Val Thr Glu Phe Val Asp 
        195                 200                 205             


Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala Leu 
    210                 215                 220                 


Lys Thr Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu 
225                 230                 235                 240 


Ile Gln Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val Phe 
                245                 250                 255     


Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly Asn 
            260                 265                 270         


Leu Arg Asn Lys Cys Ile Gln Trp Pro Pro Thr Asn Ala Ser Leu Glu 
        275                 280                 285             


Glu His Ser Ile Glu Lys Asn Ile Thr Val Asn Tyr Asn Gly Thr Leu 
    290                 295                 300                 


Ile Asn Glu Thr Val Phe Glu Phe Asp Trp Lys Ser Tyr Ile Gln Asp 
305                 310                 315                 320 


Ser Arg Tyr His Tyr Phe Leu Glu Gly Phe Leu Asp Ala Leu Leu Cys 
                325                 330                 335     


Gly Asn Ser Ser Asp Ala Gly Gln Cys Pro Glu Gly Tyr Met Cys Val 
            340                 345                 350         


Lys Ala Gly Arg Asn Pro Asn Tyr Gly Tyr Thr Ser Phe Asp Thr Phe 
        355                 360                 365             


Ser Trp Ala Phe Leu Ser Leu Phe Arg Leu Met Thr Gln Asp Phe Trp 
    370                 375                 380                 


Glu Asn Leu Tyr Gln Leu Thr Leu Arg Ala Ala Gly Lys Thr Tyr Met 
385                 390                 395                 400 


Ile Phe Phe Val Leu Val Ile Phe Leu Gly Ser Phe Tyr Leu Ile Asn 
                405                 410                 415     


Leu Ile Leu Ala Val Val Ala Met Ala Tyr Glu Glu Gln Asn Gln Ala 
            420                 425                 430         


Thr Leu Glu Glu Ala Glu Gln Lys Glu Ala Glu Phe Gln Gln Met Ile 
        435                 440                 445             


Glu Gln Leu Lys Lys Gln Gln Glu Ala Ala Gln Gln Ala Ala Thr Ala 
    450                 455                 460                 


Thr Ala Ser Glu His Ser Arg Glu Pro Ser Ala Ala Gly Arg Leu Ser 
465                 470                 475                 480 


Asp Ser Ser Ser Glu Ala Ser Lys Leu Ser Ser Lys Ser Ala Lys Glu 
                485                 490                 495     


Arg Arg Asn Arg Arg Lys Lys Arg Lys Gln Lys Glu Gln Ser Gly Gly 
            500                 505                 510         


Glu Glu Lys Asp Glu Asp Glu Phe Gln Lys Ser Glu Ser Glu Asp Ser 
        515                 520                 525             


Ile Arg Arg Lys Gly Phe Arg Phe Ser Ile Glu Gly Asn Arg Leu Thr 
    530                 535                 540                 


Tyr Glu Lys Arg Tyr Ser Ser Pro His Gln Ser Leu Leu Ser Ile Arg 
545                 550                 555                 560 


Gly Ser Leu Phe Ser Pro Arg Arg Asn Ser Arg Thr Ser Leu Phe Ser 
                565                 570                 575     


Phe Arg Gly Arg Ala Lys Asp Val Gly Ser Glu Asn Asp Phe Ala Asp 
            580                 585                 590         


Asp Glu His Ser Thr Phe Glu Asp Asn Glu Ser Arg Arg Asp Ser Leu 
        595                 600                 605             


Phe Val Pro Arg Arg His Gly Glu Arg Arg Asn Ser Asn Leu Ser Gln 
    610                 615                 620                 


Thr Ser Arg Ser Ser Arg Met Leu Ala Val Phe Pro Ala Asn Gly Lys 
625                 630                 635                 640 


Met His Ser Thr Val Asp Cys Asn Gly Val Val Ser Leu Val Gly Gly 
                645                 650                 655     


Pro Ser Val Pro Thr Ser Pro Val Gly Gln Leu Leu Pro Glu Val Ile 
            660                 665                 670         


Ile Asp Lys Pro Ala Thr Asp Asp Asn Gly Thr Thr Thr Glu Thr Glu 
        675                 680                 685             


Met Arg Lys Arg Arg Ser Ser Ser Phe His Val Ser Met Asp Phe Leu 
    690                 695                 700                 


Glu Asp Pro Ser Gln Arg Gln Arg Ala Met Ser Ile Ala Ser Ile Leu 
705                 710                 715                 720 


Thr Asn Thr Val Glu Glu Leu Glu Glu Ser Arg Gln Lys Cys Pro Pro 
                725                 730                 735     


Cys Trp Tyr Lys Phe Ser Asn Ile Phe Leu Ile Trp Asp Cys Ser Pro 
            740                 745                 750         


Tyr Trp Leu Lys Val Lys His Val Val Asn Leu Val Val Met Asp Pro 
        755                 760                 765             


Phe Val Asp Leu Ala Ile Thr Ile Cys Ile Val Leu Asn Thr Leu Phe 
    770                 775                 780                 


Met Ala Met Glu His Tyr Pro Met Thr Asp His Phe Asn Asn Val Leu 
785                 790                 795                 800 


Thr Val Gly Asn Leu Val Phe Thr Gly Ile Phe Thr Ala Glu Met Phe 
                805                 810                 815     


Leu Lys Ile Ile Ala Met Asp Pro Tyr Tyr Tyr Phe Gln Glu Gly Trp 
            820                 825                 830         


Asn Ile Phe Asp Gly Phe Ile Val Thr Leu Ser Leu Val Glu Leu Gly 
        835                 840                 845             


Leu Ala Asn Val Glu Gly Leu Ser Val Leu Arg Ser Phe Arg Leu Leu 
    850                 855                 860                 


Arg Val Phe Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Met Leu Ile 
865                 870                 875                 880 


Lys Ile Ile Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr Leu Val 
                885                 890                 895     


Leu Ala Ile Ile Val Phe Ile Phe Ala Val Val Gly Met Gln Leu Phe 
            900                 905                 910         


Gly Lys Ser Tyr Lys Asp Cys Val Cys Lys Ile Ala Ser Asp Cys Gln 
        915                 920                 925             


Leu Pro Arg Trp His Met Asn Asp Phe Phe His Ser Phe Leu Ile Val 
    930                 935                 940                 


Phe Arg Val Leu Cys Gly Glu Trp Ile Glu Thr Met Trp Asp Cys Met 
945                 950                 955                 960 


Glu Val Ala Gly Gln Ala Met Cys Leu Thr Val Phe Met Met Val Met 
                965                 970                 975     


Val Ile Gly Asn Leu Val Val Leu Asn Leu Phe Leu Ala Leu Leu Leu 
            980                 985                 990         


Ser Ser Phe Ser Ala Asp Asn Leu  Ala Ala Thr Asp Asp  Asp Asn Glu 
        995                 1000                 1005             


Met Asn  Asn Leu Gln Ile Ala  Val Asp Arg Met His  Lys Gly Val 
    1010                 1015                 1020             


Ala Tyr  Val Lys Arg Lys Ile  Tyr Glu Phe Ile Gln  Gln Ser Phe 
    1025                 1030                 1035             


Ile Arg  Lys Gln Lys Ile Leu  Asp Glu Ile Lys Pro  Leu Asp Asp 
    1040                 1045                 1050             


Leu Asn  Asn Lys Lys Asp Ser  Cys Met Ser Asn His  Thr Thr Glu 
    1055                 1060                 1065             


Ile Gly  Lys Asp Leu Asp Tyr  Leu Lys Met 
    1070                 1075             


<210>  44
<211>  1214
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Glu Gln Thr Val Leu Val Pro Pro Gly Pro Asp Ser Phe Asn Phe 
1               5                   10                  15      


Phe Thr Arg Glu Ser Leu Ala Ala Ile Glu Arg Arg Ile Ala Glu Glu 
            20                  25                  30          


Lys Ala Lys Asn Pro Lys Pro Asp Lys Lys Asp Asp Asp Glu Asn Gly 
        35                  40                  45              


Pro Lys Pro Asn Ser Asp Leu Glu Ala Gly Lys Asn Leu Pro Phe Ile 
    50                  55                  60                  


Tyr Gly Asp Ile Pro Pro Glu Met Val Ser Glu Pro Leu Glu Asp Leu 
65                  70                  75                  80  


Asp Pro Tyr Tyr Ile Asn Lys Lys Thr Phe Ile Val Leu Asn Lys Leu 
                85                  90                  95      


Lys Ala Ile Phe Arg Phe Ser Ala Thr Ser Ala Leu Tyr Ile Leu Thr 
            100                 105                 110         


Pro Phe Asn Pro Leu Arg Lys Ile Ala Ile Lys Ile Leu Val His Ser 
        115                 120                 125             


Leu Phe Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Val Phe 
    130                 135                 140                 


Met Thr Met Ser Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr Thr 
145                 150                 155                 160 


Phe Thr Gly Ile Tyr Thr Phe Glu Ser Leu Ile Lys Ile Ile Ala Arg 
                165                 170                 175     


Gly Phe Cys Leu Glu Asp Phe Thr Phe Leu Arg Asp Pro Trp Asn Trp 
            180                 185                 190         


Leu Asp Phe Thr Val Ile Thr Phe Ala Tyr Val Thr Glu Phe Val Asp 
        195                 200                 205             


Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala Leu 
    210                 215                 220                 


Lys Thr Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu 
225                 230                 235                 240 


Ile Gln Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val Phe 
                245                 250                 255     


Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly Asn 
            260                 265                 270         


Leu Arg Asn Lys Cys Ile Gln Trp Pro Pro Thr Asn Ala Ser Leu Glu 
        275                 280                 285             


Glu His Ser Ile Glu Lys Asn Ile Thr Val Asn Tyr Asn Gly Thr Leu 
    290                 295                 300                 


Ile Asn Glu Thr Val Phe Glu Phe Asp Trp Lys Ser Tyr Ile Gln Asp 
305                 310                 315                 320 


Ser Arg Tyr His Tyr Phe Leu Glu Gly Phe Leu Asp Ala Leu Leu Cys 
                325                 330                 335     


Gly Asn Ser Ser Asp Ala Gly Gln Cys Pro Glu Gly Tyr Met Cys Val 
            340                 345                 350         


Lys Ala Gly Arg Asn Pro Asn Tyr Gly Tyr Thr Ser Phe Asp Thr Phe 
        355                 360                 365             


Ser Trp Ala Phe Leu Ser Leu Phe Arg Leu Met Thr Gln Asp Phe Trp 
    370                 375                 380                 


Glu Asn Leu Tyr Gln Leu Thr Leu Arg Ala Ala Gly Lys Thr Tyr Met 
385                 390                 395                 400 


Ile Phe Phe Val Leu Val Ile Phe Leu Gly Ser Phe Tyr Leu Ile Asn 
                405                 410                 415     


Leu Ile Leu Ala Val Val Ala Met Ala Tyr Glu Glu Gln Asn Gln Ala 
            420                 425                 430         


Thr Leu Glu Glu Ala Glu Gln Lys Glu Ala Glu Phe Gln Gln Met Ile 
        435                 440                 445             


Glu Gln Leu Lys Lys Gln Gln Glu Ala Ala Gln Gln Ala Ala Thr Ala 
    450                 455                 460                 


Thr Ala Ser Glu His Ser Arg Glu Pro Ser Ala Ala Gly Arg Leu Ser 
465                 470                 475                 480 


Asp Ser Ser Ser Glu Ala Ser Lys Leu Ser Ser Lys Ser Ala Lys Glu 
                485                 490                 495     


Arg Arg Asn Arg Arg Lys Lys Arg Lys Gln Lys Glu Gln Ser Gly Gly 
            500                 505                 510         


Glu Glu Lys Asp Glu Asp Glu Phe Gln Lys Ser Glu Ser Glu Asp Ser 
        515                 520                 525             


Ile Arg Arg Lys Gly Phe Arg Phe Ser Ile Glu Gly Asn Arg Leu Thr 
    530                 535                 540                 


Tyr Glu Lys Arg Tyr Ser Ser Pro His Gln Ser Leu Leu Ser Ile Arg 
545                 550                 555                 560 


Gly Ser Leu Phe Ser Pro Arg Arg Asn Ser Arg Thr Ser Leu Phe Ser 
                565                 570                 575     


Phe Arg Gly Arg Ala Lys Asp Val Gly Ser Glu Asn Asp Phe Ala Asp 
            580                 585                 590         


Asp Glu His Ser Thr Phe Glu Asp Asn Glu Ser Arg Arg Asp Ser Leu 
        595                 600                 605             


Phe Val Pro Arg Arg His Gly Glu Arg Arg Asn Ser Asn Leu Ser Gln 
    610                 615                 620                 


Thr Ser Arg Ser Ser Arg Met Leu Ala Val Phe Pro Ala Asn Gly Lys 
625                 630                 635                 640 


Met His Ser Thr Val Asp Cys Asn Gly Val Val Ser Leu Val Gly Gly 
                645                 650                 655     


Pro Ser Val Pro Thr Ser Pro Val Gly Gln Leu Leu Pro Glu Val Ile 
            660                 665                 670         


Ile Asp Lys Pro Ala Thr Asp Asp Asn Gly Thr Thr Thr Glu Thr Glu 
        675                 680                 685             


Met Arg Lys Arg Arg Ser Ser Ser Phe His Val Ser Met Asp Phe Leu 
    690                 695                 700                 


Glu Asp Pro Ser Gln Arg Gln Arg Ala Met Ser Ile Ala Ser Ile Leu 
705                 710                 715                 720 


Thr Asn Thr Val Glu Glu Leu Glu Glu Ser Arg Gln Lys Cys Pro Pro 
                725                 730                 735     


Cys Trp Tyr Lys Phe Ser Asn Ile Phe Leu Ile Trp Asp Cys Ser Pro 
            740                 745                 750         


Tyr Trp Leu Lys Val Lys His Val Val Asn Leu Val Val Met Asp Pro 
        755                 760                 765             


Phe Val Asp Leu Ala Ile Thr Ile Cys Ile Val Leu Asn Thr Leu Phe 
    770                 775                 780                 


Met Ala Met Glu His Tyr Pro Met Thr Asp His Phe Asn Asn Val Leu 
785                 790                 795                 800 


Thr Val Gly Asn Leu Val Phe Thr Gly Ile Phe Thr Ala Glu Met Phe 
                805                 810                 815     


Leu Lys Ile Ile Ala Met Asp Pro Tyr Tyr Tyr Phe Gln Glu Gly Trp 
            820                 825                 830         


Asn Ile Phe Asp Gly Phe Ile Val Thr Leu Ser Leu Val Glu Leu Gly 
        835                 840                 845             


Leu Ala Asn Val Glu Gly Leu Ser Val Leu Arg Ser Phe Arg Leu Leu 
    850                 855                 860                 


Arg Val Phe Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Met Leu Ile 
865                 870                 875                 880 


Lys Ile Ile Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr Leu Val 
                885                 890                 895     


Leu Ala Ile Ile Val Phe Ile Phe Ala Val Val Gly Met Gln Leu Phe 
            900                 905                 910         


Gly Lys Ser Tyr Lys Asp Cys Val Cys Lys Ile Ala Ser Asp Cys Gln 
        915                 920                 925             


Leu Pro Arg Trp His Met Asn Asp Phe Phe His Ser Phe Leu Ile Val 
    930                 935                 940                 


Phe Arg Val Leu Cys Gly Glu Trp Ile Glu Thr Met Trp Asp Cys Met 
945                 950                 955                 960 


Glu Val Ala Gly Gln Ala Met Cys Leu Thr Val Phe Met Met Val Met 
                965                 970                 975     


Val Ile Gly Asn Leu Val Val Leu Asn Leu Phe Leu Ala Leu Leu Leu 
            980                 985                 990         


Ser Ser Phe Ser Ala Asp Asn Leu  Ala Ala Thr Asp Asp  Asp Asn Glu 
        995                 1000                 1005             


Met Asn  Asn Leu Gln Ile Ala  Val Asp Arg Met His  Lys Gly Val 
    1010                 1015                 1020             


Ala Tyr  Val Lys Arg Lys Ile  Tyr Glu Phe Ile Gln  Gln Ser Phe 
    1025                 1030                 1035             


Ile Arg  Lys Gln Lys Ile Leu  Asp Glu Ile Lys Pro  Leu Asp Asp 
    1040                 1045                 1050             


Leu Asn  Asn Lys Lys Asp Ser  Cys Met Ser Asn His  Thr Thr Glu 
    1055                 1060                 1065             


Ile Gly  Lys Asp Leu Asp Tyr  Leu Lys Asp Val Asn  Gly Thr Thr 
    1070                 1075                 1080             


Ser Gly  Ile Gly Thr Gly Ser  Ser Val Glu Lys Tyr  Ile Ile Asp 
    1085                 1090                 1095             


Glu Ser  Asp Tyr Met Ser Phe  Ile Asn Asn Pro Ser  Leu Thr Val 
    1100                 1105                 1110             


Thr Val  Pro Ile Ala Val Gly  Glu Ser Asp Phe Glu  Asn Leu Asn 
    1115                 1120                 1125             


Thr Glu  Asp Phe Ser Ser Glu  Ser Asp Leu Glu Glu  Ser Lys Glu 
    1130                 1135                 1140             


Lys Leu  Asn Glu Ser Ser Ser  Ser Ser Glu Gly Ser  Thr Val Asp 
    1145                 1150                 1155             


Ile Gly  Ala Pro Val Glu Glu  Gln Pro Val Val Glu  Pro Glu Glu 
    1160                 1165                 1170             


Thr Leu  Glu Pro Glu Ala Cys  Phe Thr Glu Gly Cys  Val Gln Ile 
    1175                 1180                 1185             


Gln Val  Leu Ser Asn Gln Cys  Gly Arg Arg Gln Arg  Lys Thr Met 
    1190                 1195                 1200             


Val Glu  Pro Glu Lys Asp Val  Phe Pro Asn Ser 
    1205                 1210                 


<210>  45
<211>  1358
<212>  PRT
<213>  Homo sapiens

<400>  45

Met Glu Gln Thr Val Leu Val Pro Pro Gly Pro Asp Ser Phe Asn Phe 
1               5                   10                  15      


Phe Thr Arg Glu Ser Leu Ala Ala Ile Glu Arg Arg Ile Ala Glu Glu 
            20                  25                  30          


Lys Ala Lys Asn Pro Lys Pro Asp Lys Lys Asp Asp Asp Glu Asn Gly 
        35                  40                  45              


Pro Lys Pro Asn Ser Asp Leu Glu Ala Gly Lys Asn Leu Pro Phe Ile 
    50                  55                  60                  


Tyr Gly Asp Ile Pro Pro Glu Met Val Ser Glu Pro Leu Glu Asp Leu 
65                  70                  75                  80  


Asp Pro Tyr Tyr Ile Asn Lys Lys Thr Phe Ile Val Leu Asn Lys Leu 
                85                  90                  95      


Lys Ala Ile Phe Arg Phe Ser Ala Thr Ser Ala Leu Tyr Ile Leu Thr 
            100                 105                 110         


Pro Phe Asn Pro Leu Arg Lys Ile Ala Ile Lys Ile Leu Val His Ser 
        115                 120                 125             


Leu Phe Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Val Phe 
    130                 135                 140                 


Met Thr Met Ser Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr Thr 
145                 150                 155                 160 


Phe Thr Gly Ile Tyr Thr Phe Glu Ser Leu Ile Lys Ile Ile Ala Arg 
                165                 170                 175     


Gly Phe Cys Leu Glu Asp Phe Thr Phe Leu Arg Asp Pro Trp Asn Trp 
            180                 185                 190         


Leu Asp Phe Thr Val Ile Thr Phe Ala Tyr Val Thr Glu Phe Val Asp 
        195                 200                 205             


Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala Leu 
    210                 215                 220                 


Lys Thr Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu 
225                 230                 235                 240 


Ile Gln Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val Phe 
                245                 250                 255     


Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly Asn 
            260                 265                 270         


Leu Arg Asn Lys Cys Ile Gln Trp Pro Pro Thr Asn Ala Ser Leu Glu 
        275                 280                 285             


Glu His Ser Ile Glu Lys Asn Ile Thr Val Asn Tyr Asn Gly Thr Leu 
    290                 295                 300                 


Ile Asn Glu Thr Val Phe Glu Phe Asp Trp Lys Ser Tyr Ile Gln Asp 
305                 310                 315                 320 


Ser Arg Tyr His Tyr Phe Leu Glu Gly Phe Leu Asp Ala Leu Leu Cys 
                325                 330                 335     


Gly Asn Ser Ser Asp Ala Gly Gln Cys Pro Glu Gly Tyr Met Cys Val 
            340                 345                 350         


Lys Ala Gly Arg Asn Pro Asn Tyr Gly Tyr Thr Ser Phe Asp Thr Phe 
        355                 360                 365             


Ser Trp Ala Phe Leu Ser Leu Phe Arg Leu Met Thr Gln Asp Phe Trp 
    370                 375                 380                 


Glu Asn Leu Tyr Gln Leu Thr Leu Arg Ala Ala Gly Lys Thr Tyr Met 
385                 390                 395                 400 


Ile Phe Phe Val Leu Val Ile Phe Leu Gly Ser Phe Tyr Leu Ile Asn 
                405                 410                 415     


Leu Ile Leu Ala Val Val Ala Met Ala Tyr Glu Glu Gln Asn Gln Ala 
            420                 425                 430         


Thr Leu Glu Glu Ala Glu Gln Lys Glu Ala Glu Phe Gln Gln Met Ile 
        435                 440                 445             


Glu Gln Leu Lys Lys Gln Gln Glu Ala Ala Gln Gln Ala Ala Thr Ala 
    450                 455                 460                 


Thr Ala Ser Glu His Ser Arg Glu Pro Ser Ala Ala Gly Arg Leu Ser 
465                 470                 475                 480 


Asp Ser Ser Ser Glu Ala Ser Lys Leu Ser Ser Lys Ser Ala Lys Glu 
                485                 490                 495     


Arg Arg Asn Arg Arg Lys Lys Arg Lys Gln Lys Glu Gln Ser Gly Gly 
            500                 505                 510         


Glu Glu Lys Asp Glu Asp Glu Phe Gln Lys Ser Glu Ser Glu Asp Ser 
        515                 520                 525             


Ile Arg Arg Lys Gly Phe Arg Phe Ser Ile Glu Gly Asn Arg Leu Thr 
    530                 535                 540                 


Tyr Glu Lys Arg Tyr Ser Ser Pro His Gln Ser Leu Leu Ser Ile Arg 
545                 550                 555                 560 


Gly Ser Leu Phe Ser Pro Arg Arg Asn Ser Arg Thr Ser Leu Phe Ser 
                565                 570                 575     


Phe Arg Gly Arg Ala Lys Asp Val Gly Ser Glu Asn Asp Phe Ala Asp 
            580                 585                 590         


Asp Glu His Ser Thr Phe Glu Asp Asn Glu Ser Arg Arg Asp Ser Leu 
        595                 600                 605             


Phe Val Pro Arg Arg His Gly Glu Arg Arg Asn Ser Asn Leu Ser Gln 
    610                 615                 620                 


Thr Ser Arg Ser Ser Arg Met Leu Ala Val Phe Pro Ala Asn Gly Lys 
625                 630                 635                 640 


Met His Ser Thr Val Asp Cys Asn Gly Val Val Ser Leu Val Gly Gly 
                645                 650                 655     


Pro Ser Val Pro Thr Ser Pro Val Gly Gln Leu Leu Pro Glu Val Ile 
            660                 665                 670         


Ile Asp Lys Pro Ala Thr Asp Asp Asn Gly Thr Thr Thr Glu Thr Glu 
        675                 680                 685             


Met Arg Lys Arg Arg Ser Ser Ser Phe His Val Ser Met Asp Phe Leu 
    690                 695                 700                 


Glu Asp Pro Ser Gln Arg Gln Arg Ala Met Ser Ile Ala Ser Ile Leu 
705                 710                 715                 720 


Thr Asn Thr Val Glu Glu Leu Glu Glu Ser Arg Gln Lys Cys Pro Pro 
                725                 730                 735     


Cys Trp Tyr Lys Phe Ser Asn Ile Phe Leu Ile Trp Asp Cys Ser Pro 
            740                 745                 750         


Tyr Trp Leu Lys Val Lys His Val Val Asn Leu Val Val Met Asp Pro 
        755                 760                 765             


Phe Val Asp Leu Ala Ile Thr Ile Cys Ile Val Leu Asn Thr Leu Phe 
    770                 775                 780                 


Met Ala Met Glu His Tyr Pro Met Thr Asp His Phe Asn Asn Val Leu 
785                 790                 795                 800 


Thr Val Gly Asn Leu Val Phe Thr Gly Ile Phe Thr Ala Glu Met Phe 
                805                 810                 815     


Leu Lys Ile Ile Ala Met Asp Pro Tyr Tyr Tyr Phe Gln Glu Gly Trp 
            820                 825                 830         


Asn Ile Phe Asp Gly Phe Ile Val Thr Leu Ser Leu Val Glu Leu Gly 
        835                 840                 845             


Leu Ala Asn Val Glu Gly Leu Ser Val Leu Arg Ser Phe Arg Leu Leu 
    850                 855                 860                 


Arg Val Phe Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Met Leu Ile 
865                 870                 875                 880 


Lys Ile Ile Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr Leu Val 
                885                 890                 895     


Leu Ala Ile Ile Val Phe Ile Phe Ala Val Val Gly Met Gln Leu Phe 
            900                 905                 910         


Gly Lys Ser Tyr Lys Asp Cys Val Cys Lys Ile Ala Ser Asp Cys Gln 
        915                 920                 925             


Leu Pro Arg Trp His Met Asn Asp Phe Phe His Ser Phe Leu Ile Val 
    930                 935                 940                 


Phe Arg Val Leu Cys Gly Glu Trp Ile Glu Thr Met Trp Asp Cys Met 
945                 950                 955                 960 


Glu Val Ala Gly Gln Ala Met Cys Leu Thr Val Phe Met Met Val Met 
                965                 970                 975     


Val Ile Gly Asn Leu Val Val Leu Asn Leu Phe Leu Ala Leu Leu Leu 
            980                 985                 990         


Ser Ser Phe Ser Ala Asp Asn Leu  Ala Ala Thr Asp Asp  Asp Asn Glu 
        995                 1000                 1005             


Met Asn  Asn Leu Gln Ile Ala  Val Asp Arg Met His  Lys Gly Val 
    1010                 1015                 1020             


Ala Tyr  Val Lys Arg Lys Ile  Tyr Glu Phe Ile Gln  Gln Ser Phe 
    1025                 1030                 1035             


Ile Arg  Lys Gln Lys Ile Leu  Asp Glu Ile Lys Pro  Leu Asp Asp 
    1040                 1045                 1050             


Leu Asn  Asn Lys Lys Asp Ser  Cys Met Ser Asn His  Thr Thr Glu 
    1055                 1060                 1065             


Ile Gly  Lys Asp Leu Asp Tyr  Leu Lys Asp Val Asn  Gly Thr Thr 
    1070                 1075                 1080             


Ser Gly  Ile Gly Thr Gly Ser  Ser Val Glu Lys Tyr  Ile Ile Asp 
    1085                 1090                 1095             


Glu Ser  Asp Tyr Met Ser Phe  Ile Asn Asn Pro Ser  Leu Thr Val 
    1100                 1105                 1110             


Thr Val  Pro Ile Ala Val Gly  Glu Ser Asp Phe Glu  Asn Leu Asn 
    1115                 1120                 1125             


Thr Glu  Asp Phe Ser Ser Glu  Ser Asp Leu Glu Glu  Ser Lys Glu 
    1130                 1135                 1140             


Lys Leu  Asn Glu Ser Ser Ser  Ser Ser Glu Gly Ser  Thr Val Asp 
    1145                 1150                 1155             


Ile Gly  Ala Pro Val Glu Glu  Gln Pro Val Val Glu  Pro Glu Glu 
    1160                 1165                 1170             


Thr Leu  Glu Pro Glu Ala Cys  Phe Thr Glu Gly Cys  Val Gln Arg 
    1175                 1180                 1185             


Phe Lys  Cys Cys Gln Ile Asn  Val Glu Glu Gly Arg  Gly Lys Gln 
    1190                 1195                 1200             


Trp Trp  Asn Leu Arg Arg Thr  Cys Phe Arg Ile Val  Glu His Asn 
    1205                 1210                 1215             


Trp Phe  Glu Thr Phe Ile Val  Phe Met Ile Leu Leu  Ser Ser Gly 
    1220                 1225                 1230             


Ala Leu  Ala Phe Glu Asp Ile  Tyr Ile Asp Gln Arg  Lys Thr Ile 
    1235                 1240                 1245             


Lys Thr  Met Leu Glu Tyr Ala  Asp Lys Val Phe Thr  Tyr Ile Phe 
    1250                 1255                 1260             


Ile Leu  Glu Met Leu Leu Lys  Trp Val Ala Tyr Gly  Tyr Gln Thr 
    1265                 1270                 1275             


Tyr Phe  Thr Asn Ala Trp Cys  Trp Leu Asp Phe Leu  Ile Val Asp 
    1280                 1285                 1290             


Val Ser  Leu Val Ser Leu Thr  Ala Asn Ala Leu Gly  Tyr Ser Glu 
    1295                 1300                 1305             


Leu Gly  Ala Ile Lys Ser Leu  Arg Thr Leu Arg Ala  Leu Arg Pro 
    1310                 1315                 1320             


Leu Arg  Ala Leu Ser Arg Phe  Glu Gly Met Arg Val  Val Val Asn 
    1325                 1330                 1335             


Ala Leu  Leu Gly Ala Ile Pro  Ser Ile Met Asn Val  Leu Leu Val 
    1340                 1345                 1350             


Cys Leu  Tyr Ser Gly 
    1355             


<210>  46
<211>  1510
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Glu Gln Thr Val Leu Val Pro Pro Gly Pro Asp Ser Phe Asn Phe 
1               5                   10                  15      


Phe Thr Arg Glu Ser Leu Ala Ala Ile Glu Arg Arg Ile Ala Glu Glu 
            20                  25                  30          


Lys Ala Lys Asn Pro Lys Pro Asp Lys Lys Asp Asp Asp Glu Asn Gly 
        35                  40                  45              


Pro Lys Pro Asn Ser Asp Leu Glu Ala Gly Lys Asn Leu Pro Phe Ile 
    50                  55                  60                  


Tyr Gly Asp Ile Pro Pro Glu Met Val Ser Glu Pro Leu Glu Asp Leu 
65                  70                  75                  80  


Asp Pro Tyr Tyr Ile Asn Lys Lys Thr Phe Ile Val Leu Asn Lys Leu 
                85                  90                  95      


Lys Ala Ile Phe Arg Phe Ser Ala Thr Ser Ala Leu Tyr Ile Leu Thr 
            100                 105                 110         


Pro Phe Asn Pro Leu Arg Lys Ile Ala Ile Lys Ile Leu Val His Ser 
        115                 120                 125             


Leu Phe Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Val Phe 
    130                 135                 140                 


Met Thr Met Ser Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr Thr 
145                 150                 155                 160 


Phe Thr Gly Ile Tyr Thr Phe Glu Ser Leu Ile Lys Ile Ile Ala Arg 
                165                 170                 175     


Gly Phe Cys Leu Glu Asp Phe Thr Phe Leu Arg Asp Pro Trp Asn Trp 
            180                 185                 190         


Leu Asp Phe Thr Val Ile Thr Phe Ala Tyr Val Thr Glu Phe Val Asp 
        195                 200                 205             


Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala Leu 
    210                 215                 220                 


Lys Thr Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu 
225                 230                 235                 240 


Ile Gln Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val Phe 
                245                 250                 255     


Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly Asn 
            260                 265                 270         


Leu Arg Asn Lys Cys Ile Gln Trp Pro Pro Thr Asn Ala Ser Leu Glu 
        275                 280                 285             


Glu His Ser Ile Glu Lys Asn Ile Thr Val Asn Tyr Asn Gly Thr Leu 
    290                 295                 300                 


Ile Asn Glu Thr Val Phe Glu Phe Asp Trp Lys Ser Tyr Ile Gln Asp 
305                 310                 315                 320 


Ser Arg Tyr His Tyr Phe Leu Glu Gly Phe Leu Asp Ala Leu Leu Cys 
                325                 330                 335     


Gly Asn Ser Ser Asp Ala Gly Gln Cys Pro Glu Gly Tyr Met Cys Val 
            340                 345                 350         


Lys Ala Gly Arg Asn Pro Asn Tyr Gly Tyr Thr Ser Phe Asp Thr Phe 
        355                 360                 365             


Ser Trp Ala Phe Leu Ser Leu Phe Arg Leu Met Thr Gln Asp Phe Trp 
    370                 375                 380                 


Glu Asn Leu Tyr Gln Leu Thr Leu Arg Ala Ala Gly Lys Thr Tyr Met 
385                 390                 395                 400 


Ile Phe Phe Val Leu Val Ile Phe Leu Gly Ser Phe Tyr Leu Ile Asn 
                405                 410                 415     


Leu Ile Leu Ala Val Val Ala Met Ala Tyr Glu Glu Gln Asn Gln Ala 
            420                 425                 430         


Thr Leu Glu Glu Ala Glu Gln Lys Glu Ala Glu Phe Gln Gln Met Ile 
        435                 440                 445             


Glu Gln Leu Lys Lys Gln Gln Glu Ala Ala Gln Gln Ala Ala Thr Ala 
    450                 455                 460                 


Thr Ala Ser Glu His Ser Arg Glu Pro Ser Ala Ala Gly Arg Leu Ser 
465                 470                 475                 480 


Asp Ser Ser Ser Glu Ala Ser Lys Leu Ser Ser Lys Ser Ala Lys Glu 
                485                 490                 495     


Arg Arg Asn Arg Arg Lys Lys Arg Lys Gln Lys Glu Gln Ser Gly Gly 
            500                 505                 510         


Glu Glu Lys Asp Glu Asp Glu Phe Gln Lys Ser Glu Ser Glu Asp Ser 
        515                 520                 525             


Ile Arg Arg Lys Gly Phe Arg Phe Ser Ile Glu Gly Asn Arg Leu Thr 
    530                 535                 540                 


Tyr Glu Lys Arg Tyr Ser Ser Pro His Gln Ser Leu Leu Ser Ile Arg 
545                 550                 555                 560 


Gly Ser Leu Phe Ser Pro Arg Arg Asn Ser Arg Thr Ser Leu Phe Ser 
                565                 570                 575     


Phe Arg Gly Arg Ala Lys Asp Val Gly Ser Glu Asn Asp Phe Ala Asp 
            580                 585                 590         


Asp Glu His Ser Thr Phe Glu Asp Asn Glu Ser Arg Arg Asp Ser Leu 
        595                 600                 605             


Phe Val Pro Arg Arg His Gly Glu Arg Arg Asn Ser Asn Leu Ser Gln 
    610                 615                 620                 


Thr Ser Arg Ser Ser Arg Met Leu Ala Val Phe Pro Ala Asn Gly Lys 
625                 630                 635                 640 


Met His Ser Thr Val Asp Cys Asn Gly Val Val Ser Leu Val Gly Gly 
                645                 650                 655     


Pro Ser Val Pro Thr Ser Pro Val Gly Gln Leu Leu Pro Glu Val Ile 
            660                 665                 670         


Ile Asp Lys Pro Ala Thr Asp Asp Asn Gly Thr Thr Thr Glu Thr Glu 
        675                 680                 685             


Met Arg Lys Arg Arg Ser Ser Ser Phe His Val Ser Met Asp Phe Leu 
    690                 695                 700                 


Glu Asp Pro Ser Gln Arg Gln Arg Ala Met Ser Ile Ala Ser Ile Leu 
705                 710                 715                 720 


Thr Asn Thr Val Glu Glu Leu Glu Glu Ser Arg Gln Lys Cys Pro Pro 
                725                 730                 735     


Cys Trp Tyr Lys Phe Ser Asn Ile Phe Leu Ile Trp Asp Cys Ser Pro 
            740                 745                 750         


Tyr Trp Leu Lys Val Lys His Val Val Asn Leu Val Val Met Asp Pro 
        755                 760                 765             


Phe Val Asp Leu Ala Ile Thr Ile Cys Ile Val Leu Asn Thr Leu Phe 
    770                 775                 780                 


Met Ala Met Glu His Tyr Pro Met Thr Asp His Phe Asn Asn Val Leu 
785                 790                 795                 800 


Thr Val Gly Asn Leu Val Phe Thr Gly Ile Phe Thr Ala Glu Met Phe 
                805                 810                 815     


Leu Lys Ile Ile Ala Met Asp Pro Tyr Tyr Tyr Phe Gln Glu Gly Trp 
            820                 825                 830         


Asn Ile Phe Asp Gly Phe Ile Val Thr Leu Ser Leu Val Glu Leu Gly 
        835                 840                 845             


Leu Ala Asn Val Glu Gly Leu Ser Val Leu Arg Ser Phe Arg Leu Leu 
    850                 855                 860                 


Arg Val Phe Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Met Leu Ile 
865                 870                 875                 880 


Lys Ile Ile Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr Leu Val 
                885                 890                 895     


Leu Ala Ile Ile Val Phe Ile Phe Ala Val Val Gly Met Gln Leu Phe 
            900                 905                 910         


Gly Lys Ser Tyr Lys Asp Cys Val Cys Lys Ile Ala Ser Asp Cys Gln 
        915                 920                 925             


Leu Pro Arg Trp His Met Asn Asp Phe Phe His Ser Phe Leu Ile Val 
    930                 935                 940                 


Phe Arg Val Leu Cys Gly Glu Trp Ile Glu Thr Met Trp Asp Cys Met 
945                 950                 955                 960 


Glu Val Ala Gly Gln Ala Met Cys Leu Thr Val Phe Met Met Val Met 
                965                 970                 975     


Val Ile Gly Asn Leu Val Val Leu Asn Leu Phe Leu Ala Leu Leu Leu 
            980                 985                 990         


Ser Ser Phe Ser Ala Asp Asn Leu  Ala Ala Thr Asp Asp  Asp Asn Glu 
        995                 1000                 1005             


Met Asn  Asn Leu Gln Ile Ala  Val Asp Arg Met His  Lys Gly Val 
    1010                 1015                 1020             


Ala Tyr  Val Lys Arg Lys Ile  Tyr Glu Phe Ile Gln  Gln Ser Phe 
    1025                 1030                 1035             


Ile Arg  Lys Gln Lys Ile Leu  Asp Glu Ile Lys Pro  Leu Asp Asp 
    1040                 1045                 1050             


Leu Asn  Asn Lys Lys Asp Ser  Cys Met Ser Asn His  Thr Thr Glu 
    1055                 1060                 1065             


Ile Gly  Lys Asp Leu Asp Tyr  Leu Lys Asp Val Asn  Gly Thr Thr 
    1070                 1075                 1080             


Ser Gly  Ile Gly Thr Gly Ser  Ser Val Glu Lys Tyr  Ile Ile Asp 
    1085                 1090                 1095             


Glu Ser  Asp Tyr Met Ser Phe  Ile Asn Asn Pro Ser  Leu Thr Val 
    1100                 1105                 1110             


Thr Val  Pro Ile Ala Val Gly  Glu Ser Asp Phe Glu  Asn Leu Asn 
    1115                 1120                 1125             


Thr Glu  Asp Phe Ser Ser Glu  Ser Asp Leu Glu Glu  Ser Lys Glu 
    1130                 1135                 1140             


Lys Leu  Asn Glu Ser Ser Ser  Ser Ser Glu Gly Ser  Thr Val Asp 
    1145                 1150                 1155             


Ile Gly  Ala Pro Val Glu Glu  Gln Pro Val Val Glu  Pro Glu Glu 
    1160                 1165                 1170             


Thr Leu  Glu Pro Glu Ala Cys  Phe Thr Glu Gly Cys  Val Gln Arg 
    1175                 1180                 1185             


Phe Lys  Cys Cys Gln Ile Asn  Val Glu Glu Gly Arg  Gly Lys Gln 
    1190                 1195                 1200             


Trp Trp  Asn Leu Arg Arg Thr  Cys Phe Arg Ile Val  Glu His Asn 
    1205                 1210                 1215             


Trp Phe  Glu Thr Phe Ile Val  Phe Met Ile Leu Leu  Ser Ser Gly 
    1220                 1225                 1230             


Ala Leu  Ala Phe Glu Asp Ile  Tyr Ile Asp Gln Arg  Lys Thr Ile 
    1235                 1240                 1245             


Lys Thr  Met Leu Glu Tyr Ala  Asp Lys Val Phe Thr  Tyr Ile Phe 
    1250                 1255                 1260             


Ile Leu  Glu Met Leu Leu Lys  Trp Val Ala Tyr Gly  Tyr Gln Thr 
    1265                 1270                 1275             


Tyr Phe  Thr Asn Ala Trp Cys  Trp Leu Asp Phe Leu  Ile Val Asp 
    1280                 1285                 1290             


Val Ser  Leu Val Ser Leu Thr  Ala Asn Ala Leu Gly  Tyr Ser Glu 
    1295                 1300                 1305             


Leu Gly  Ala Ile Lys Ser Leu  Arg Thr Leu Arg Ala  Leu Arg Pro 
    1310                 1315                 1320             


Leu Arg  Ala Leu Ser Arg Phe  Glu Gly Met Arg Val  Val Val Asn 
    1325                 1330                 1335             


Ala Leu  Leu Gly Ala Ile Pro  Ser Ile Met Asn Val  Leu Leu Val 
    1340                 1345                 1350             


Cys Leu  Ile Phe Trp Leu Ile  Phe Ser Ile Met Gly  Val Asn Leu 
    1355                 1360                 1365             


Phe Ala  Gly Lys Phe Tyr His  Cys Ile Asn Thr Thr  Thr Gly Asp 
    1370                 1375                 1380             


Arg Phe  Asp Ile Glu Asp Val  Asn Asn His Thr Asp  Cys Leu Lys 
    1385                 1390                 1395             


Leu Ile  Glu Arg Asn Glu Thr  Ala Arg Trp Lys Asn  Val Lys Val 
    1400                 1405                 1410             


Asn Phe  Asp Asn Val Gly Phe  Gly Tyr Leu Ser Leu  Leu Gln Val 
    1415                 1420                 1425             


Ala Thr  Phe Lys Gly Trp Met  Asp Ile Met Tyr Ala  Ala Val Asp 
    1430                 1435                 1440             


Ser Arg  Asn Val Glu Leu Gln  Pro Lys Tyr Glu Lys  Ser Leu Tyr 
    1445                 1450                 1455             


Met Tyr  Leu Tyr Phe Val Ile  Phe Ile Ile Phe Gly  Ser Phe Phe 
    1460                 1465                 1470             


Thr Leu  Asn Leu Phe Ile Gly  Val Ile Ile Asp Asn  Phe Asn Gln 
    1475                 1480                 1485             


Gln Lys  Lys Lys Phe Gly Gly  Gln Asp Ile Phe Met  Thr Glu Glu 
    1490                 1495                 1500             


Gln Lys  Lys Tyr Tyr Met Gln  
    1505                 1510 


<210>  47
<211>  1007
<212>  PRT
<213>  Homo sapiens

<400>  47

Met Glu Gln Thr Val Leu Val Pro Pro Gly Pro Asp Ser Phe Asn Phe 
1               5                   10                  15      


Phe Thr Arg Glu Ser Leu Ala Ala Ile Glu Arg Arg Ile Ala Glu Glu 
            20                  25                  30          


Lys Ala Lys Asn Pro Lys Pro Asp Lys Lys Asp Asp Asp Glu Asn Gly 
        35                  40                  45              


Pro Lys Pro Asn Ser Asp Leu Glu Ala Gly Lys Asn Leu Pro Phe Ile 
    50                  55                  60                  


Tyr Gly Asp Ile Pro Pro Glu Met Val Ser Glu Pro Leu Glu Asp Leu 
65                  70                  75                  80  


Asp Pro Tyr Tyr Ile Asn Lys Lys Thr Phe Ile Val Leu Asn Lys Leu 
                85                  90                  95      


Lys Ala Ile Phe Arg Phe Ser Ala Thr Ser Ala Leu Tyr Ile Leu Thr 
            100                 105                 110         


Pro Phe Asn Pro Leu Arg Lys Ile Ala Ile Lys Ile Leu Val His Ser 
        115                 120                 125             


Leu Phe Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Val Phe 
    130                 135                 140                 


Met Thr Met Ser Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr Thr 
145                 150                 155                 160 


Phe Thr Gly Ile Tyr Thr Phe Glu Ser Leu Ile Lys Ile Ile Ala Arg 
                165                 170                 175     


Gly Phe Cys Leu Glu Asp Phe Thr Phe Leu Arg Asp Pro Trp Asn Trp 
            180                 185                 190         


Leu Asp Phe Thr Val Ile Thr Phe Ala Tyr Val Thr Glu Phe Val Asp 
        195                 200                 205             


Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala Leu 
    210                 215                 220                 


Lys Thr Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu 
225                 230                 235                 240 


Ile Gln Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val Phe 
                245                 250                 255     


Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly Asn 
            260                 265                 270         


Leu Arg Asn Lys Cys Ile Gln Trp Pro Pro Thr Asn Ala Ser Leu Glu 
        275                 280                 285             


Glu His Ser Ile Glu Lys Asn Ile Thr Val Asn Tyr Asn Gly Thr Leu 
    290                 295                 300                 


Ile Asn Glu Thr Val Phe Glu Phe Asp Trp Lys Ser Tyr Ile Gln Asp 
305                 310                 315                 320 


Ser Arg Tyr His Tyr Phe Leu Glu Gly Phe Leu Asp Ala Leu Leu Cys 
                325                 330                 335     


Gly Asn Ser Ser Asp Ala Gly Gln Cys Pro Glu Gly Tyr Met Cys Val 
            340                 345                 350         


Lys Ala Gly Arg Asn Pro Asn Tyr Gly Tyr Thr Ser Phe Asp Thr Phe 
        355                 360                 365             


Ser Trp Ala Phe Leu Ser Leu Phe Arg Leu Met Thr Gln Asp Phe Trp 
    370                 375                 380                 


Glu Asn Leu Tyr Gln Leu Thr Leu Arg Ala Ala Gly Lys Thr Tyr Met 
385                 390                 395                 400 


Ile Phe Phe Val Leu Val Ile Phe Leu Gly Ser Phe Tyr Leu Ile Asn 
                405                 410                 415     


Leu Ile Leu Ala Val Val Ala Met Ala Tyr Glu Glu Gln Asn Gln Ala 
            420                 425                 430         


Thr Leu Glu Glu Ala Glu Gln Lys Glu Ala Glu Phe Gln Gln Met Ile 
        435                 440                 445             


Glu Gln Leu Lys Lys Gln Gln Glu Ala Ala Gln Gln Ala Ala Thr Ala 
    450                 455                 460                 


Thr Ala Ser Glu His Ser Arg Glu Pro Ser Ala Ala Gly Arg Leu Ser 
465                 470                 475                 480 


Asp Ser Ser Ser Glu Ala Ser Lys Leu Ser Ser Lys Ser Ala Lys Glu 
                485                 490                 495     


Arg Arg Asn Arg Arg Lys Lys Arg Lys Gln Lys Glu Gln Ser Gly Gly 
            500                 505                 510         


Glu Glu Lys Asp Glu Asp Glu Phe Gln Lys Ser Glu Ser Glu Asp Ser 
        515                 520                 525             


Ile Arg Arg Lys Gly Phe Arg Phe Ser Ile Glu Gly Asn Arg Leu Thr 
    530                 535                 540                 


Tyr Glu Lys Arg Tyr Ser Ser Pro His Gln Ser Leu Leu Ser Ile Arg 
545                 550                 555                 560 


Gly Ser Leu Phe Ser Pro Arg Arg Asn Ser Arg Thr Ser Leu Phe Ser 
                565                 570                 575     


Phe Arg Gly Arg Ala Lys Asp Val Gly Ser Glu Asn Asp Phe Ala Asp 
            580                 585                 590         


Asp Glu His Ser Thr Phe Glu Asp Asn Glu Ser Arg Arg Asp Ser Leu 
        595                 600                 605             


Phe Val Pro Arg Arg His Gly Glu Arg Arg Asn Ser Asn Leu Ser Gln 
    610                 615                 620                 


Thr Ser Arg Ser Ser Arg Met Leu Ala Val Phe Pro Ala Asn Gly Lys 
625                 630                 635                 640 


Met His Ser Thr Val Asp Cys Asn Gly Val Val Ser Leu Val Gly Gly 
                645                 650                 655     


Pro Ser Val Pro Thr Ser Pro Val Gly Gln Leu Leu Pro Glu Val Ile 
            660                 665                 670         


Ile Asp Lys Pro Ala Thr Asp Asp Asn Gly Thr Thr Thr Glu Thr Glu 
        675                 680                 685             


Met Arg Lys Arg Arg Ser Ser Ser Phe His Val Ser Met Asp Phe Leu 
    690                 695                 700                 


Glu Asp Pro Ser Gln Arg Gln Arg Ala Met Ser Ile Ala Ser Ile Leu 
705                 710                 715                 720 


Thr Asn Thr Val Glu Glu Leu Glu Glu Ser Arg Gln Lys Cys Pro Pro 
                725                 730                 735     


Cys Trp Tyr Lys Phe Ser Asn Ile Phe Leu Ile Trp Asp Cys Ser Pro 
            740                 745                 750         


Tyr Trp Leu Lys Val Lys His Val Val Asn Leu Val Val Met Asp Pro 
        755                 760                 765             


Phe Val Asp Leu Ala Ile Thr Ile Cys Ile Val Leu Asn Thr Leu Phe 
    770                 775                 780                 


Met Ala Met Glu His Tyr Pro Met Thr Asp His Phe Asn Asn Val Leu 
785                 790                 795                 800 


Thr Val Gly Asn Leu Val Phe Thr Gly Ile Phe Thr Ala Glu Met Phe 
                805                 810                 815     


Leu Lys Ile Ile Ala Met Asp Pro Tyr Tyr Tyr Phe Gln Glu Gly Trp 
            820                 825                 830         


Asn Ile Phe Asp Gly Phe Ile Val Thr Leu Ser Leu Val Glu Leu Gly 
        835                 840                 845             


Leu Ala Asn Val Glu Gly Leu Ser Val Leu Arg Ser Phe Arg Leu Leu 
    850                 855                 860                 


Arg Val Phe Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Met Leu Ile 
865                 870                 875                 880 


Lys Ile Ile Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr Leu Val 
                885                 890                 895     


Leu Ala Ile Ile Val Phe Ile Phe Ala Val Val Gly Met Gln Leu Phe 
            900                 905                 910         


Gly Lys Ser Tyr Lys Asp Cys Val Cys Lys Ile Ala Ser Asp Cys Gln 
        915                 920                 925             


Leu Pro Arg Trp His Met Asn Asp Phe Phe His Ser Phe Leu Ile Val 
    930                 935                 940                 


Phe Arg Val Leu Cys Gly Glu Trp Ile Glu Thr Met Trp Asp Cys Met 
945                 950                 955                 960 


Glu Val Ala Gly Gln Ala Met Cys Leu Thr Val Phe Met Met Val Met 
                965                 970                 975     


Val Ile Gly Asn Leu Val Val Leu Asn Leu Phe Leu Ala Leu Leu Leu 
            980                 985                 990         


Ser Ser Phe Ser Ala Asp Asn Leu  Ala Ala Thr Asp Asp  Asp Asn 
        995                 1000                 1005         


<210>  48
<211>  1426
<212>  PRT
<213>  Homo sapiens

<400>  48

Met Glu Gln Thr Val Leu Val Pro Pro Gly Pro Asp Ser Phe Asn Phe 
1               5                   10                  15      


Phe Thr Arg Glu Ser Leu Ala Ala Ile Glu Arg Arg Ile Ala Glu Glu 
            20                  25                  30          


Lys Ala Lys Asn Pro Lys Pro Asp Lys Lys Asp Asp Asp Glu Asn Gly 
        35                  40                  45              


Pro Lys Pro Asn Ser Asp Leu Glu Ala Gly Lys Asn Leu Pro Phe Ile 
    50                  55                  60                  


Tyr Gly Asp Ile Pro Pro Glu Met Val Ser Glu Pro Leu Glu Asp Leu 
65                  70                  75                  80  


Asp Pro Tyr Tyr Ile Asn Lys Lys Thr Phe Ile Val Leu Asn Lys Leu 
                85                  90                  95      


Lys Ala Ile Phe Arg Phe Ser Ala Thr Ser Ala Leu Tyr Ile Leu Thr 
            100                 105                 110         


Pro Phe Asn Pro Leu Arg Lys Ile Ala Ile Lys Ile Leu Val His Ser 
        115                 120                 125             


Leu Phe Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Val Phe 
    130                 135                 140                 


Met Thr Met Ser Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr Thr 
145                 150                 155                 160 


Phe Thr Gly Ile Tyr Thr Phe Glu Ser Leu Ile Lys Ile Ile Ala Arg 
                165                 170                 175     


Gly Phe Cys Leu Glu Asp Phe Thr Phe Leu Arg Asp Pro Trp Asn Trp 
            180                 185                 190         


Leu Asp Phe Thr Val Ile Thr Phe Ala Tyr Val Thr Glu Phe Val Asp 
        195                 200                 205             


Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala Leu 
    210                 215                 220                 


Lys Thr Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu 
225                 230                 235                 240 


Ile Gln Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val Phe 
                245                 250                 255     


Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly Asn 
            260                 265                 270         


Leu Arg Asn Lys Cys Ile Gln Trp Pro Pro Thr Asn Ala Ser Leu Glu 
        275                 280                 285             


Glu His Ser Ile Glu Lys Asn Ile Thr Val Asn Tyr Asn Gly Thr Leu 
    290                 295                 300                 


Ile Asn Glu Thr Val Phe Glu Phe Asp Trp Lys Ser Tyr Ile Gln Asp 
305                 310                 315                 320 


Ser Arg Tyr His Tyr Phe Leu Glu Gly Phe Leu Asp Ala Leu Leu Cys 
                325                 330                 335     


Gly Asn Ser Ser Asp Ala Gly Gln Cys Pro Glu Gly Tyr Met Cys Val 
            340                 345                 350         


Lys Ala Gly Arg Asn Pro Asn Tyr Gly Tyr Thr Ser Phe Asp Thr Phe 
        355                 360                 365             


Ser Trp Ala Phe Leu Ser Leu Phe Arg Leu Met Thr Gln Asp Phe Trp 
    370                 375                 380                 


Glu Asn Leu Tyr Gln Leu Thr Leu Arg Ala Ala Gly Lys Thr Tyr Met 
385                 390                 395                 400 


Ile Phe Phe Val Leu Val Ile Phe Leu Gly Ser Phe Tyr Leu Ile Asn 
                405                 410                 415     


Leu Ile Leu Ala Val Val Ala Met Ala Tyr Glu Glu Gln Asn Gln Ala 
            420                 425                 430         


Thr Leu Glu Glu Ala Glu Gln Lys Glu Ala Glu Phe Gln Gln Met Ile 
        435                 440                 445             


Glu Gln Leu Lys Lys Gln Gln Glu Ala Ala Gln Gln Ala Ala Thr Ala 
    450                 455                 460                 


Thr Ala Ser Glu His Ser Arg Glu Pro Ser Ala Ala Gly Arg Leu Ser 
465                 470                 475                 480 


Asp Ser Ser Ser Glu Ala Ser Lys Leu Ser Ser Lys Ser Ala Lys Glu 
                485                 490                 495     


Arg Arg Asn Arg Arg Lys Lys Arg Lys Gln Lys Glu Gln Ser Gly Gly 
            500                 505                 510         


Glu Glu Lys Asp Glu Asp Glu Phe Gln Lys Ser Glu Ser Glu Asp Ser 
        515                 520                 525             


Ile Arg Arg Lys Gly Phe Arg Phe Ser Ile Glu Gly Asn Arg Leu Thr 
    530                 535                 540                 


Tyr Glu Lys Arg Tyr Ser Ser Pro His Gln Ser Leu Leu Ser Ile Arg 
545                 550                 555                 560 


Gly Ser Leu Phe Ser Pro Arg Arg Asn Ser Arg Thr Ser Leu Phe Ser 
                565                 570                 575     


Phe Arg Gly Arg Ala Lys Asp Val Gly Ser Glu Asn Asp Phe Ala Asp 
            580                 585                 590         


Asp Glu His Ser Thr Phe Glu Asp Asn Glu Ser Arg Arg Asp Ser Leu 
        595                 600                 605             


Phe Val Pro Arg Arg His Gly Glu Arg Arg Asn Ser Asn Leu Ser Gln 
    610                 615                 620                 


Thr Ser Arg Ser Ser Arg Met Leu Ala Val Phe Pro Ala Asn Gly Lys 
625                 630                 635                 640 


Met His Ser Thr Val Asp Cys Asn Gly Val Val Ser Leu Val Gly Gly 
                645                 650                 655     


Pro Ser Val Pro Thr Ser Pro Val Gly Gln Leu Leu Pro Glu Val Ile 
            660                 665                 670         


Ile Asp Lys Pro Ala Thr Asp Asp Asn Gly Thr Thr Thr Glu Thr Glu 
        675                 680                 685             


Met Arg Lys Arg Arg Ser Ser Ser Phe His Val Ser Met Asp Phe Leu 
    690                 695                 700                 


Glu Asp Pro Ser Gln Arg Gln Arg Ala Met Ser Ile Ala Ser Ile Leu 
705                 710                 715                 720 


Thr Asn Thr Val Glu Glu Leu Glu Glu Ser Arg Gln Lys Cys Pro Pro 
                725                 730                 735     


Cys Trp Tyr Lys Phe Ser Asn Ile Phe Leu Ile Trp Asp Cys Ser Pro 
            740                 745                 750         


Tyr Trp Leu Lys Val Lys His Val Val Asn Leu Val Val Met Asp Pro 
        755                 760                 765             


Phe Val Asp Leu Ala Ile Thr Ile Cys Ile Val Leu Asn Thr Leu Phe 
    770                 775                 780                 


Met Ala Met Glu His Tyr Pro Met Thr Asp His Phe Asn Asn Val Leu 
785                 790                 795                 800 


Thr Val Gly Asn Leu Val Phe Thr Gly Ile Phe Thr Ala Glu Met Phe 
                805                 810                 815     


Leu Lys Ile Ile Ala Met Asp Pro Tyr Tyr Tyr Phe Gln Glu Gly Trp 
            820                 825                 830         


Asn Ile Phe Asp Gly Phe Ile Val Thr Leu Ser Leu Val Glu Leu Gly 
        835                 840                 845             


Leu Ala Asn Val Glu Gly Leu Ser Val Leu Arg Ser Phe Arg Leu Leu 
    850                 855                 860                 


Arg Val Phe Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Met Leu Ile 
865                 870                 875                 880 


Lys Ile Ile Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr Leu Val 
                885                 890                 895     


Leu Ala Ile Ile Val Phe Ile Phe Ala Val Val Gly Met Gln Leu Phe 
            900                 905                 910         


Gly Lys Ser Tyr Lys Asp Cys Val Cys Lys Ile Ala Ser Asp Cys Gln 
        915                 920                 925             


Leu Pro Arg Trp His Met Asn Asp Phe Phe His Ser Phe Leu Ile Val 
    930                 935                 940                 


Phe Arg Val Leu Cys Gly Glu Trp Ile Glu Thr Met Trp Asp Cys Met 
945                 950                 955                 960 


Glu Val Ala Gly Gln Ala Met Cys Leu Thr Val Phe Met Met Val Met 
                965                 970                 975     


Val Ile Gly Asn Leu Val Val Leu Asn Leu Phe Leu Ala Leu Leu Leu 
            980                 985                 990         


Ser Ser Phe Ser Ala Asp Asn Leu  Ala Ala Thr Asp Asp  Asp Asn Glu 
        995                 1000                 1005             


Met Asn  Asn Leu Gln Ile Ala  Val Asp Arg Met His  Lys Gly Val 
    1010                 1015                 1020             


Ala Tyr  Val Lys Arg Lys Ile  Tyr Glu Phe Ile Gln  Gln Ser Phe 
    1025                 1030                 1035             


Ile Arg  Lys Gln Lys Ile Leu  Asp Glu Ile Lys Pro  Leu Asp Asp 
    1040                 1045                 1050             


Leu Asn  Asn Lys Lys Asp Ser  Cys Met Ser Asn His  Thr Thr Glu 
    1055                 1060                 1065             


Ile Gly  Lys Asp Leu Asp Tyr  Leu Lys Asp Val Asn  Gly Thr Thr 
    1070                 1075                 1080             


Ser Gly  Ile Gly Thr Gly Ser  Ser Val Glu Lys Tyr  Ile Ile Asp 
    1085                 1090                 1095             


Glu Ser  Asp Tyr Met Ser Phe  Ile Asn Asn Pro Ser  Leu Thr Val 
    1100                 1105                 1110             


Thr Val  Pro Ile Ala Val Gly  Glu Ser Asp Phe Glu  Asn Leu Asn 
    1115                 1120                 1125             


Thr Glu  Asp Phe Ser Ser Glu  Ser Asp Leu Glu Glu  Ser Lys Glu 
    1130                 1135                 1140             


Lys Leu  Asn Glu Ser Ser Ser  Ser Ser Glu Gly Ser  Thr Val Asp 
    1145                 1150                 1155             


Ile Gly  Ala Pro Val Glu Glu  Gln Pro Val Val Glu  Pro Glu Glu 
    1160                 1165                 1170             


Thr Leu  Glu Pro Glu Ala Cys  Phe Thr Glu Gly Cys  Val Gln Arg 
    1175                 1180                 1185             


Phe Lys  Cys Cys Gln Ile Asn  Val Glu Glu Gly Arg  Gly Lys Gln 
    1190                 1195                 1200             


Trp Trp  Asn Leu Arg Arg Thr  Cys Phe Arg Ile Val  Glu His Asn 
    1205                 1210                 1215             


Trp Phe  Glu Thr Phe Ile Val  Phe Met Ile Leu Leu  Ser Ser Gly 
    1220                 1225                 1230             


Ala Leu  Ala Phe Glu Asp Ile  Tyr Ile Asp Gln Arg  Lys Thr Ile 
    1235                 1240                 1245             


Lys Thr  Met Leu Glu Tyr Ala  Asp Lys Val Phe Thr  Tyr Ile Phe 
    1250                 1255                 1260             


Ile Leu  Glu Met Leu Leu Lys  Trp Val Ala Tyr Gly  Tyr Gln Thr 
    1265                 1270                 1275             


Tyr Phe  Thr Asn Ala Trp Cys  Trp Leu Asp Phe Leu  Ile Val Asp 
    1280                 1285                 1290             


Val Ser  Leu Val Ser Leu Thr  Ala Asn Ala Leu Gly  Tyr Ser Glu 
    1295                 1300                 1305             


Leu Gly  Ala Ile Lys Ser Leu  Arg Thr Leu Arg Ala  Leu Arg Pro 
    1310                 1315                 1320             


Leu Arg  Ala Leu Ser Arg Phe  Glu Gly Met Arg Val  Val Val Asn 
    1325                 1330                 1335             


Ala Leu  Leu Gly Ala Ile Pro  Ser Ile Met Asn Val  Leu Leu Val 
    1340                 1345                 1350             


Cys Leu  Ile Phe Trp Leu Ile  Phe Ser Ile Met Gly  Val Asn Leu 
    1355                 1360                 1365             


Phe Ala  Gly Lys Phe Tyr His  Cys Ile Asn Thr Thr  Thr Gly Asp 
    1370                 1375                 1380             


Arg Phe  Asp Ile Glu Asp Val  Asn Asn His Thr Asp  Cys Leu Lys 
    1385                 1390                 1395             


Leu Ile  Glu Arg Asn Glu Thr  Ala Arg Trp Lys Asn  Val Lys Val 
    1400                 1405                 1410             


Asn Phe  Asp Asn Val Gly Phe  Gly Tyr Leu Ser Leu  Leu 
    1415                 1420                 1425     


<210>  49
<211>  8381
<212>  DNA
<213>  Homo sapiens

<400>  49
atactgcaga ggtctctggt gcatgtgtgt atgtgtgcgt ttgtgtgtgt ttgtgtgtct     60

gtgtgttctg ccccagtgag actgcagccc ttgtaaatac tttgacacct tttgcaagaa    120

ggaatctgaa caattgcaac tgaaggcaca ttgttatcat ctcgtctttg ggtgatgctg    180

ttcctcactg cagatggata attttccttt taatcaggaa tttcatatgc agaataaatg    240

gtaattaaaa tgtgcaggat gacaagatgg agcaaacagt gcttgtacca ccaggacctg    300

acagcttcaa cttcttcacc agagaatctc ttgcggctat tgaaagacgc attgcagaag    360

aaaaggcaaa gaatcccaaa ccagacaaaa aagatgacga cgaaaatggc ccaaagccaa    420

atagtgactt ggaagctgga aagaaccttc catttattta tggagacatt cctccagaga    480

tggtgtcaga gcccctggag gacctggacc cctactatat caataagaaa acttttatag    540

tattgaataa attgaaggcc atcttccggt tcagtgccac ctctgccctg tacattttaa    600

ctcccttcaa tcctcttagg aaaatagcta ttaagatttt ggtacattca ttattcagca    660

tgctaattat gtgcactatt ttgacaaact gtgtgtttat gacaatgagt aaccctcctg    720

attggacaaa gaatgtagaa tacaccttca caggaatata tacttttgaa tcacttataa    780

aaattattgc aaggggattc tgtttagaag attttacttt ccttcgggat ccatggaact    840

ggctcaattt cactgtcatt acatttgcgt acgtcacaga gtttgtggac ctgggcaatg    900

tctcggcatt gagaacattc agagttctcc gagcattgaa gacgatttca gtcattccag    960

gcctgaaaac cattgtggga gccctgatcc agtctgtgaa gaagctctca gatgtaatga   1020

tcctgactgt gttctgtctg agcgtatttg ctctaattgg gctgcagctg ttcatgggca   1080

acctgaggaa taaatgtata caatggcctc ccaccaatgc ttccttggag gaacatagta   1140

tagaaaagaa tataactgtg aattataatg gtacacttat aaatgaaact gtctttgagt   1200

ttgactggaa gtcatatatt caagattcaa gatatcatta tttcctggag ggttttttag   1260

atgcactact atgtggaaat agctctgatg caggccaatg tccagaggga tatatgtgtg   1320

tgaaagctgg tagaaatccc aattatggct acacaagctt tgataccttc agttgggctt   1380

ttttgtcctt gtttcgacta atgactcagg acttctggga aaatctttat caactgacat   1440

tacgtgctgc tgggaaaacg tacatgatat tttttgtatt ggtcattttc ttgggctcat   1500

tctacctaat aaatttgatc ctggctgtgg tggccatggc ctacgaggaa cagaatcagg   1560

ccaccttgga agaagcagaa cagaaagagg ccgaatttca gcagatgatt gaacagctta   1620

aaaagcaaca ggaggcagct cagcaggcag caacggcaac tgcctcagaa cattccagag   1680

agcccagtgc agcaggcagg ctctcagaca gctcatctga agcctctaag ttgagttcca   1740

agagtgctaa ggaaagaaga aatcggagga agaaaagaaa acagaaagag cagtctggtg   1800

gggaagagaa agatgaggat gaattccaaa aatctgaatc tgaggacagc atcaggagga   1860

aaggttttcg cttctccatt gaagggaacc gattgacata tgaaaagagg tactcctccc   1920

cacaccagtc tttgttgagc atccgtggct ccctattttc accaaggcga aatagcagaa   1980

caagcctttt cagctttaga gggcgagcaa aggatgtggg atctgagaac gacttcgcag   2040

atgatgagca cagcaccttt gaggataacg agagccgtag agattccttg tttgtgcccc   2100

gacgacacgg agagagacgc aacagcaacc tgagtcagac cagtaggtca tcccggatgc   2160

tggcagtgtt tccagcgaat gggaagatgc acagcactgt ggattgcaat ggtgtggttt   2220

ccttggttgg tggaccttca gttcctacat cgcctgttgg acagcttctg ccagaggtga   2280

taatagataa gccagctact gatgacaatg gaacaaccac tgaaactgaa atgagaaaga   2340

gaaggtcaag ttctttccac gtttccatgg actttctaga agatccttcc caaaggcaac   2400

gagcaatgag tatagccagc attctaacaa atacagtaga agaacttgaa gaatccaggc   2460

agaaatgccc accctgttgg tataaatttt ccaacatatt cttaatctgg gactgttctc   2520

catattggtt aaaagtgaaa catgttgtca acctggttgt gatggaccca tttgttgacc   2580

tggccatcac catctgtatt gtcttaaata ctcttttcat ggccatggag cactatccaa   2640

tgacggacca tttcaataat gtgcttacag taggaaactt ggttttcact gggatcttta   2700

cagcagaaat gtttctgaaa attattgcca tggatcctta ctattatttc caagaaggct   2760

ggaatatctt tgacggtttt attgtgacgc ttagcctggt agaacttgga ctcgccaatg   2820

tggaaggatt atctgttctc cgttcatttc gattgctgcg agttttcaag ttggcaaaat   2880

cttggccaac gttaaatatg ctaataaaga tcatcggcaa ttccgtgggg gctctgggaa   2940

atttaaccct cgtcttggcc atcatcgtct tcatttttgc cgtggtcggc atgcagctct   3000

ttggtaaaag ctacaaagat tgtgtctgca agatcgccag tgattgtcaa ctcccacgct   3060

ggcacatgaa tgacttcttc cactccttcc tgattgtgtt ccgcgtgctg tgtggggagt   3120

ggatagagac catgtgggac tgtatggagg ttgctggtca agccatgtgc cttactgtct   3180

tcatgatggt catggtgatt ggaaacctag tggtcctgaa tctctttctg gccttgcttc   3240

tgagctcatt tagtgcagac aaccttgcag ccactgatga tgataatgaa atgaataatc   3300

tccaaattgc tgtggatagg atgcacaaag gagtagctta tgtgaaaaga aaaatatatg   3360

aatttattca acagtccttc attaggaaac aaaagatttt agatgaaatt aaaccacttg   3420

atgatctaaa caacaagaaa gacagttgta tgtccaatca tacaacagaa attgggaaag   3480

atcttgacta tcttaaagat gtaaatggaa ctacaagtgg tataggaact ggcagcagtg   3540

ttgaaaaata cattattgat gaaagtgatt acatgtcatt cataaacaac cccagtctta   3600

ctgtgactgt accaattgct gtaggagaat ctgactttga aaatttaaac acggaagact   3660

ttagtagtga atcggatctg gaagaaagca aagagaaact gaatgaaagc agtagctcat   3720

cagaaggtag cactgtggac atcggcgcac ctgtagaaga acagcccgta gtggaacctg   3780

aagaaactct tgaaccagaa gcttgtttca ctgaaggctg tgtacaaaga ttcaagtgtt   3840

gtcaaatcaa tgtggaagaa ggcagaggaa aacaatggtg gaacctgaga aggacgtgtt   3900

tccgaatagt tgaacataac tggtttgaga ccttcattgt tttcatgatt ctccttagta   3960

gtggtgctct ggcatttgaa gatatatata ttgatcagcg aaagacgatt aagacgatgt   4020

tggaatatgc tgacaaggtt ttcacttaca ttttcattct ggaaatgctt ctaaaatggg   4080

tggcatatgg ctatcaaaca tatttcacca atgcctggtg ttggctggac ttcttaattg   4140

ttgatgtttc attggtcagt ttaacagcaa atgccttggg ttactcagaa cttggagcca   4200

tcaaatctct caggacacta agagctctga gacctctaag agccttatct cgatttgaag   4260

ggatgagggt ggttgtgaat gcccttttag gagcaattcc atccatcatg aatgtgcttc   4320

tggtttgtct tatattctgg ctaattttca gcatcatggg cgtaaatttg tttgctggca   4380

aattctacca ctgtattaac accacaactg gtgacaggtt tgacatcgaa gacgtgaata   4440

atcatactga ttgcctaaaa ctaatagaaa gaaatgagac tgctcgatgg aaaaatgtga   4500

aagtaaactt tgataatgta ggatttgggt atctctcttt gcttcaagtt gccacattca   4560

aaggatggat ggatataatg tatgcagcag ttgattccag aaatgtggaa ctccagccta   4620

agtatgaaaa aagtctgtac atgtatcttt actttgttat tttcatcatc tttgggtcct   4680

tcttcacctt gaacctgttt attggtgtca tcatagataa tttcaaccag cagaaaaaga   4740

agtttggagg tcaagacatc tttatgacag aagaacagaa gaaatactat aatgcaatga   4800

aaaaattagg atcgaaaaaa ccgcaaaagc ctatacctcg accaggaaac aaatttcaag   4860

gaatggtctt tgacttcgta accagacaag tttttgacat aagcatcatg attctcatct   4920

gtcttaacat ggtcacaatg atggtggaaa cagatgacca gagtgaatat gtgactacca   4980

ttttgtcacg catcaatctg gtgttcattg tgctatttac tggagagtgt gtactgaaac   5040

tcatctctct acgccattat tattttacca ttggatggaa tatttttgat tttgtggttg   5100

tcattctctc cattgtaggt atgtttcttg ccgagctgat agaaaagtat ttcgtgtccc   5160

ctaccctgtt ccgagtgatc cgtcttgcta ggattggccg aatcctacgt ctgatcaaag   5220

gagcaaaggg gatccgcacg ctgctctttg ctttgatgat gtcccttcct gcgttgttta   5280

acatcggcct cctactcttc ctagtcatgt tcatctacgc catctttggg atgtccaact   5340

ttgcctatgt taagagggaa gttgggatcg atgacatgtt caactttgag acctttggca   5400

acagcatgat ctgcctattc caaattacaa cctctgctgg ctgggatgga ttgctagcac   5460

ccattctcaa cagtaagcca cccgactgtg accctaataa agttaaccct ggaagctcag   5520

ttaagggaga ctgtgggaac ccatctgttg gaattttctt ttttgtcagt tacatcatca   5580

tatccttcct ggttgtggtg aacatgtaca tcgcggtcat cctggagaac ttcagtgttg   5640

ctactgaaga aagtgcagag cctctgagtg aggatgactt tgagatgttc tatgaggttt   5700

gggagaagtt tgatcccgat gcaactcagt tcatggaatt tgaaaaatta tctcagtttg   5760

cagctgcgct tgaaccgcct ctcaatctgc cacaaccaaa caaactccag ctcattgcca   5820

tggatttgcc catggtgagt ggtgaccgga tccactgtct tgatatctta tttgctttta   5880

caaagcgggt tctaggagag agtggagaga tggatgctct acgaatacag atggaagagc   5940

gattcatggc ttccaatcct tccaaggtct cctatcagcc aatcactact actttaaaac   6000

gaaaacaaga ggaagtatct gctgtcatta ttcagcgtgc ttacagacgc caccttttaa   6060

agcgaactgt aaaacaagct tcctttacgt acaataaaaa caaaatcaaa ggtggggcta   6120

atcttcttat aaaagaagac atgataattg acagaataaa tgaaaactct attacagaaa   6180

aaactgatct gaccatgtcc actgcagctt gtccaccttc ctatgaccgg gtgacaaagc   6240

caattgtgga aaaacatgag caagaaggca aagatgaaaa agccaaaggg aaataaatga   6300

aaataaataa aaataattgg gtgacaaatt gtttacagcc tgtgaaggtg atgtattttt   6360

atcaacagga ctcctttagg aggtcaatgc caaactgact gtttttacac aaatctcctt   6420

aaggtcagtg cctacaataa gacagtgacc ccttgtcagc aaactgtgac tctgtgtaaa   6480

ggggagatga ccttgacagg aggttactgt tctcactacc agctgacact gctgaagata   6540

agatgcacaa tggctagtca gactgtaggg accagtttca aggggtgcaa acctgtgatt   6600

ttggggttgt ttaacatgaa acactttagt gtagtaattg tatccactgt ttgcatttca   6660

actgccacat ttgtcacatt tttatggaat ctgttagtgg attcatcttt ttgttaatcc   6720

atgtgtttat tatatgtgac tatttttgta aacgaagttt ctgttgagaa ataggctaag   6780

gacctctata acaggtatgc cacctggggg gtatggcaac cacatggccc tcccagctac   6840

acaaagtcgt ggtttgcatg agggcatgct gcacttagag atcatgcatg agaaaaagtc   6900

acaagaaaaa caaattctta aatttcacca tatttctggg aggggtaatt gggtgataag   6960

tggaggtgct ttgttgatct tgttttgcga aatccagccc ctagaccaag tagattattt   7020

gtgggtaggc cagtaaatct tagcaggtgc aaacttcatt caaatgtttg gagtcataaa   7080

tgttatgttt ctttttgttg tattaaaaaa aaaacctgaa tagtgaatat tgcccctcac   7140

cctccaccgc cagaagactg aattgaccaa aattactctt tataaatttc tgctttttcc   7200

tgcactttgt ttagccatct ttgggctctc agcaaggttg acactgtata tgttaatgaa   7260

atgctattta ttatgtaaat agtcatttta ccctgtggtg cacgtttgag caaacaaata   7320

atgacctaag cacagtattt attgcatcaa atatgtacca caagaaatgt agagtgcaag   7380

ctttacacag gtaataaaat gtattctgta ccatttatag atagtttgga tgctatcaat   7440

gcatgtttat attaccatgc tgctgtatct ggtttctctc actgctcaga atctcattta   7500

tgagaaacca tatgtcagtg gtaaagtcaa ggaaattgtt caacagatct catttattta   7560

agtcattaag caatagtttg cagcacttta acagcttttt ggttattttt acattttaag   7620

tggataacat atggtatata gccagactgt acagacatgt ttaaaaaaac acactgctta   7680

acctattaaa tatgtgttta gaattttata agcaaatata aatactgtaa aaagtcactt   7740

tattttattt ttcagcatta tgtacataaa tatgaagagg aaattatctt caggttgata   7800

tcacaatcac ttttcttact ttctgtccat agtacttttt catgaaagaa atttgctaaa   7860

taagacatga aaacaagact gggtagttgt agatttctgc tttttaaatt acatttgcta   7920

attttagatt atttcacaat tttaaggagc aaaataggtt cacgattcat atccaaatta   7980

tgctttgcaa ttggaaaagg gtttaaaatt ttatttatat ttctggtagt acctgtacta   8040

actgaattga aggtagtgct tatgttattt ttgttctttt tttctgactt cggtttatgt   8100

tttcatttct ttggagtaat gctgctctag attgttctaa atagaatgtg ggcttcataa   8160

tttttttttc cacaaaaaca gagtagtcaa cttatatagt caattacatc aggacatttt   8220

gtgtttctta cagaagcaaa ccataggctc ctcttttcct taaaactact tagataaact   8280

gtattcgtga actgcatgct ggaaaatgct actattatgc taaataatgc taaccaacat   8340

ttaaaatgtg caaaactaat aaagattaca ttttttattt t                       8381


<210>  50
<211>  8381
<212>  DNA
<213>  Homo sapiens

<400>  50
atactgcaga ggtctctggt gcatgtgtgt atgtgtgcgt ttgtgtgtgt ttgtgtgtct     60

gtgtgttctg ccccagtgag actgcagccc ttgtaaatac tttgacacct tttgcaagaa    120

ggaatctgaa caattgcaac tgaaggcaca ttgttatcat ctcgtctttg ggtgatgctg    180

ttcctcactg cagatggata attttccttt taatcaggaa tttcatatgc agaataaatg    240

gtaattaaaa tgtgcaggat gacaagatgg agcaaacagt gcttgtacca ccaggacctg    300

acagcttcaa cttcttcacc agagaatctc ttgcggctat tgaaagacgc attgcagaag    360

aaaaggcaaa gaatcccaaa ccagacaaaa aagatgacga cgaaaatggc ccaaagccaa    420

atagtgactt ggaagctgga aagaaccttc catttattta tggagacatt cctccagaga    480

tggtgtcaga gcccctggag gacctggacc cctactatat caataagaaa acttttatag    540

tattgaataa attgaaggcc atcttccggt tcagtgccac ctctgccctg tacattttaa    600

ctcccttcaa tcctcttagg aaaatagcta ttaagatttt ggtacattca ttattcagca    660

tgctaattat gtgcactatt ttgacaaact gtgtgtttat gacaatgagt aaccctcctg    720

attggacaaa gaatgtagaa tacaccttca caggaatata tacttttgaa tcacttataa    780

aaattattgc aaggggattc tgtttagaag attttacttt ccttcgggat ccatggaact    840

ggctcgattt cactgtcatt acatttgcgt acgtcacaga gtttgtggac ctgggcaatg    900

tctcggcatt gagaacattc agagttctcc gagcattgaa gacgatttca gtcattccag    960

gcctgaaaac cattgtggga gccctgatcc agtctgtgaa gaagctctca gatgtaatga   1020

tcctgactgt gttctgtctg agcgtatttg ctctaattgg gctgcagctg ttcatgggca   1080

acctgaggaa taaatgtata caatggcctc ccaccaatgc ttccttggag gaacatagta   1140

tagaaaagaa tataactgtg aattataatg gtacacttat aaatgaaact gtctttgagt   1200

ttgactggaa gtcatatatt caagattcaa gatatcatta tttcctggag ggttttttag   1260

atgcactact atgtggaaat agctctgatg caggccaatg tccagaggga tatatgtgtg   1320

tgaaagctgg tagaaatccc aattatggct acacaagctt tgataccttc agttgggctt   1380

ttttgtcctt gtttcgacta atgactcagg acttctggga aaatctttat caactgacat   1440

tacgtgctgc tgggaaaacg tacatgatat tttttgtatt ggtcattttc ttgggctcat   1500

tctacctaat aaatttgatc ctggctgtgg tggccatggc ctacgaggaa cagaatcagg   1560

ccaccttgga agaagcagaa cagaaagagg ccgaatttca gcagatgatt gaacagctta   1620

aaaagcaaca ggaggcagct cagcaggcag caacggcaac tgcctcagaa cattccagag   1680

agcccagtgc agcaggcagg ctctcagaca gctcatctga agcctctaag ttgagttcca   1740

agagtgctaa ggaaagaaga aatcggagga agaaaagaaa acagaaagag cagtctggtg   1800

gggaagagaa agatgaggat gaattccaaa aatctgaatc tgaggacagc atcaggagga   1860

aaggttttcg cttctccatt gaagggaacc gattgacata tgaaaagagg tactcctccc   1920

cacaccagtc tttgttgagc atccgtggct ccctattttc accaaggcga aatagcagaa   1980

caagcctttt cagctttaga gggcgagcaa aggatgtggg atctgagaac gacttcgcag   2040

atgatgagca cagcaccttt gaggataacg agagccgtag agattccttg tttgtgcccc   2100

gacgacacgg agagagacgc aacagcaacc tgagtcagac cagtaggtca tcccggatgc   2160

tggcagtgtt tccagcgaat gggaagatgc acagcactgt ggattgcaat ggtgtggttt   2220

ccttggttgg tggaccttca gttcctacat cgcctgttgg acagcttctg ccagaggtga   2280

taatagataa gccagctact gatgacaatg gaacaaccac tgaaactgaa atgagaaaga   2340

gaaggtcaag ttctttccac gtttccatgg actttctaga agatccttcc caaaggcaac   2400

gagcaatgag tatagccagc attctaacaa atacagtaga agaacttgaa gaatccaggc   2460

agaaatgccc accctgttgg tataaatttt ccaacatatt cttaatctgg gactgttctc   2520

catattggtt aaaagtgaaa catgttgtca acctggttgt gatggaccca tttgttgacc   2580

tggccatcac catctgtatt gtcttaaata ctcttttcat ggccatggag cactatccaa   2640

tgacggacca tttcaataat gtgcttacag taggaaactt ggttttcact gggatcttta   2700

cagcagaaat gtttctgaaa attattgcca tggatcctta ctattatttc caagaaggct   2760

ggaatatctt tgacggtttt attgtgacgc ttagcctggt agaacttgga ctcgccaatg   2820

tggaaggatt atctgttctc cgttcatttc gattgctgcg agttttcaag ttggcaaaat   2880

cttggccaac gttaaatatg ctaataaaga tcatcggcaa ttccgtgggg gctctgggaa   2940

atttaaccct cgtcttggcc atcatcgtct tcatttttgc cgtggtcggc atgcagctct   3000

ttggtaaaag ctacaaagat tgtgtctgca agatcgccag tgattgtcaa ctcccacgct   3060

ggcacatgaa tgacttcttc cactccttcc tgattgtgtt ccgcgtgctg tgtggggagt   3120

ggatagagac catgtgggac tgtatggagg ttgctggtca agccatgtgc cttactgtct   3180

tcatgatggt catggtgatt ggaaacctag tggtcctgaa tctctttctg gccttgcttc   3240

tgagctcatt tagtgcagac aaccttgcag ccactgatga tgataatgaa atgaataatc   3300

tccaaattgc tgtggatagg atgcacaaag gagtagctta tgtgaaaaga aaaatatatg   3360

aatttattca acagtccttc attaggaaac aaaagatttt agatgaaatt aaaccacttg   3420

atgatctaaa caacaagaaa gacagttgta tgtccaatca tacaacagaa attgggaaag   3480

atcttgacta tcttaaagat gtaaatggaa ctacaagtgg tataggaact ggcagcagtg   3540

ttgaaaaata cattattgat gaaagtgatt acatgtcatt cataaacaac cccagtctta   3600

ctgtgactgt accaattgct gtaggagaat ctgactttga aaatttaaac acggaagact   3660

ttagtagtga atcggatctg gaagaaagca aagagaaact gaatgaaagc agtagctcat   3720

cagaaggtag cactgtggac atcggcgcac ctgtagaaga acagcccgta gtggaacctg   3780

aagaaactct tgaaccagaa gcttgtttca ctgaaggctg tgtacaaaga ttcaagtgtt   3840

gtcaaatcaa tgtggaagaa ggcagaggaa aacaatggtg gaacctgaga aggacgtgtt   3900

tccgaatagt tgaacataac tggtttgaga ccttcattgt tttcatgatt ctccttagta   3960

gtggtgctct ggcatttgaa gatatatata ttgatcagcg aaagacgatt aagacgatgt   4020

tggaatatgc tgacaaggtt ttcacttaca ttttcattct ggaaatgctt ctaaaatggg   4080

tggcatatgg ctatcaaaca tatttcacca atgcctggtg ttggctggac ttcttaattg   4140

ttgatgtttc attggtcagt ttaacagcaa atgccttggg ttactcagaa cttggagcca   4200

tcaaatctct caggacacta agagctctga gacctctaag agccttatct cgatttgaag   4260

ggatgagggt ggttgtgaat gcccttttag gagcaattcc atccatcatg aatgtgcttc   4320

tggtttgtct tatattctgg ctaattttca gcatcatggg cgtaaatttg tttgctggca   4380

aattctacca ctgtattaac accacaactg gtgacaggtt tgacatcgaa gacgtgaata   4440

atcatactga ttgcctaaaa ctaatagaaa gaaatgagac tgctcgatgg aaaaatgtga   4500

aagtaaactt tgataatgta ggatttgggt atctctcttt gcttcaagtt gccacattca   4560

aaggatggat ggatataatg tatgcagcag ttgattccag aaatgtggaa ctccagccta   4620

agtatgaaaa aagtctgtac atgtatcttt actttgttat tttcatcatc tttgggtcct   4680

tcttcacctt gaacctgttt attgttgtca tcatagataa tttcaaccag cagaaaaaga   4740

agtttggagg tcaagacatc tttatgacag aagaacagaa gaaatactat aatgcaatga   4800

aaaaattagg atcgaaaaaa ccgcaaaagc ctatacctcg accaggaaac aaatttcaag   4860

gaatggtctt tgacttcgta accagacaag tttttgacat aagcatcatg attctcatct   4920

gtcttaacat ggtcacaatg atggtggaaa cagatgacca gagtgaatat gtgactacca   4980

ttttgtcacg catcaatctg gtgttcattg tgctatttac tggagagtgt gtactgaaac   5040

tcatctctct acgccattat tattttacca ttggatggaa tatttttgat tttgtggttg   5100

tcattctctc cattgtaggt atgtttcttg ccgagctgat agaaaagtat ttcgtgtccc   5160

ctaccctgtt ccgagtgatc cgtcttgcta ggattggccg aatcctacgt ctgatcaaag   5220

gagcaaaggg gatccgcacg ctgctctttg ctttgatgat gtcccttcct gcgttgttta   5280

acatcggcct cctactcttc ctagtcatgt tcatctacgc catctttggg atgtccaact   5340

ttgcctatgt taagagggaa gttgggatcg atgacatgtt caactttgag acctttggca   5400

acagcatgat ctgcctattc caaattacaa cctctgctgg ctgggatgga ttgctagcac   5460

ccattctcaa cagtaagcca cccgactgtg accctaataa agttaaccct ggaagctcag   5520

ttaagggaga ctgtgggaac ccatctgttg gaattttctt ttttgtcagt tacatcatca   5580

tatccttcct ggttgtggtg aacatgtaca tcgcggtcat cctggagaac ttcagtgttg   5640

ctactgaaga aagtgcagag cctctgagtg aggatgactt tgagatgttc tatgaggttt   5700

gggagaagtt tgatcccgat gcaactcagt tcatggaatt tgaaaaatta tctcagtttg   5760

cagctgcgct tgaaccgcct ctcaatctgc cacaaccaaa caaactccag ctcattgcca   5820

tggatttgcc catggtgagt ggtgaccgga tccactgtct tgatatctta tttgctttta   5880

caaagcgggt tctaggagag agtggagaga tggatgctct acgaatacag atggaagagc   5940

gattcatggc ttccaatcct tccaaggtct cctatcagcc aatcactact actttaaaac   6000

gaaaacaaga ggaagtatct gctgtcatta ttcagcgtgc ttacagacgc caccttttaa   6060

agcgaactgt aaaacaagct tcctttacgt acaataaaaa caaaatcaaa ggtggggcta   6120

atcttcttat aaaagaagac atgataattg acagaataaa tgaaaactct attacagaaa   6180

aaactgatct gaccatgtcc actgcagctt gtccaccttc ctatgaccgg gtgacaaagc   6240

caattgtgga aaaacatgag caagaaggca aagatgaaaa agccaaaggg aaataaatga   6300

aaataaataa aaataattgg gtgacaaatt gtttacagcc tgtgaaggtg atgtattttt   6360

atcaacagga ctcctttagg aggtcaatgc caaactgact gtttttacac aaatctcctt   6420

aaggtcagtg cctacaataa gacagtgacc ccttgtcagc aaactgtgac tctgtgtaaa   6480

ggggagatga ccttgacagg aggttactgt tctcactacc agctgacact gctgaagata   6540

agatgcacaa tggctagtca gactgtaggg accagtttca aggggtgcaa acctgtgatt   6600

ttggggttgt ttaacatgaa acactttagt gtagtaattg tatccactgt ttgcatttca   6660

actgccacat ttgtcacatt tttatggaat ctgttagtgg attcatcttt ttgttaatcc   6720

atgtgtttat tatatgtgac tatttttgta aacgaagttt ctgttgagaa ataggctaag   6780

gacctctata acaggtatgc cacctggggg gtatggcaac cacatggccc tcccagctac   6840

acaaagtcgt ggtttgcatg agggcatgct gcacttagag atcatgcatg agaaaaagtc   6900

acaagaaaaa caaattctta aatttcacca tatttctggg aggggtaatt gggtgataag   6960

tggaggtgct ttgttgatct tgttttgcga aatccagccc ctagaccaag tagattattt   7020

gtgggtaggc cagtaaatct tagcaggtgc aaacttcatt caaatgtttg gagtcataaa   7080

tgttatgttt ctttttgttg tattaaaaaa aaaacctgaa tagtgaatat tgcccctcac   7140

cctccaccgc cagaagactg aattgaccaa aattactctt tataaatttc tgctttttcc   7200

tgcactttgt ttagccatct ttgggctctc agcaaggttg acactgtata tgttaatgaa   7260

atgctattta ttatgtaaat agtcatttta ccctgtggtg cacgtttgag caaacaaata   7320

atgacctaag cacagtattt attgcatcaa atatgtacca caagaaatgt agagtgcaag   7380

ctttacacag gtaataaaat gtattctgta ccatttatag atagtttgga tgctatcaat   7440

gcatgtttat attaccatgc tgctgtatct ggtttctctc actgctcaga atctcattta   7500

tgagaaacca tatgtcagtg gtaaagtcaa ggaaattgtt caacagatct catttattta   7560

agtcattaag caatagtttg cagcacttta acagcttttt ggttattttt acattttaag   7620

tggataacat atggtatata gccagactgt acagacatgt ttaaaaaaac acactgctta   7680

acctattaaa tatgtgttta gaattttata agcaaatata aatactgtaa aaagtcactt   7740

tattttattt ttcagcatta tgtacataaa tatgaagagg aaattatctt caggttgata   7800

tcacaatcac ttttcttact ttctgtccat agtacttttt catgaaagaa atttgctaaa   7860

taagacatga aaacaagact gggtagttgt agatttctgc tttttaaatt acatttgcta   7920

attttagatt atttcacaat tttaaggagc aaaataggtt cacgattcat atccaaatta   7980

tgctttgcaa ttggaaaagg gtttaaaatt ttatttatat ttctggtagt acctgtacta   8040

actgaattga aggtagtgct tatgttattt ttgttctttt tttctgactt cggtttatgt   8100

tttcatttct ttggagtaat gctgctctag attgttctaa atagaatgtg ggcttcataa   8160

tttttttttc cacaaaaaca gagtagtcaa cttatatagt caattacatc aggacatttt   8220

gtgtttctta cagaagcaaa ccataggctc ctcttttcct taaaactact tagataaact   8280

gtattcgtga actgcatgct ggaaaatgct actattatgc taaataatgc taaccaacat   8340

ttaaaatgtg caaaactaat aaagattaca ttttttattt t                       8381


<210>  51
<211>  8381
<212>  DNA
<213>  Homo sapiens

<400>  51
atactgcaga ggtctctggt gcatgtgtgt atgtgtgcgt ttgtgtgtgt ttgtgtgtct     60

gtgtgttctg ccccagtgag actgcagccc ttgtaaatac tttgacacct tttgcaagaa    120

ggaatctgaa caattgcaac tgaaggcaca ttgttatcat ctcgtctttg ggtgatgctg    180

ttcctcactg cagatggata attttccttt taatcaggaa tttcatatgc agaataaatg    240

gtaattaaaa tgtgcaggat gacaagatgg agcaaacagt gcttgtacca ccaggacctg    300

acagcttcaa cttcttcacc agagaatctc ttgcggctat tgaaagacgc attgcagaag    360

aaaaggcaaa gaatcccaaa ccagacaaaa aagatgacga cgaaaatggc ccaaagccaa    420

atagtgactt ggaagctgga aagaaccttc catttattta tggagacatt cctccagaga    480

tggtgtcaga gcccctggag gacctggacc cctactatat caataagaaa acttttatag    540

tattgaataa attgaaggcc atcttccggt tcagtgccac ctctgccctg tacattttaa    600

ctcccttcaa tcctcttagg aaaatagcta ttaagatttt ggtacattca ttattcagca    660

tgctaattat gtgcactatt ttgacaaact gtgtgtttat gacaatgagt aaccctcctg    720

attggacaaa gaatgtagaa tacaccttca caggaatata tacttttgaa tcacttataa    780

aaattattgc aaggggattc tgtttagaag attttacttt ccttcgggat ccatggaact    840

ggctcgattt cactgtcatt acatttgcgt acgtcacaga gtttgtggac ctgggcaatg    900

tctcggcatt gagaacattc agagttctcc gagcattgaa gacgatttca gtcattccag    960

gcctgaaaac cattgtggga gccctgatcc agtctgtgaa gaagctctca gatgtaatga   1020

tcctgactgt gttctgtctg agcgtatttg ctctaattgg gctgcagctg ttcatgggca   1080

acctgaggaa taaatgtata caatggcctc ccaccaatgc ttccttggag gaacatagta   1140

tagaaaagaa tataactgtg aattataatg gtacacttat aaatgaaact gtctttgagt   1200

ttgactggaa gtcatatatt caagattcaa gatatcatta tttcctggag ggttttttag   1260

atgcactact atgtggaaat agctctgatg caggccaatg tccagaggga tatatgtgtg   1320

tgaaagctgg tagaaatccc aattatggct acacaagctt tgataccttc agttgggctt   1380

ttttgtcctt gtttcgacta atgactcagg acttctggga aaatctttat caactgacat   1440

tacgtgctgc tgggaaaacg tacatgatat tttttgtatt ggtcattttc ttgggctcat   1500

tctacctaat aaatttgatc ctggctgtgg tggccatggc ctacgaggaa cagaatcagg   1560

ccaccttgga agaagcagaa cagaaagagg ccgaatttca gcagatgatt gaacagctta   1620

aaaagcaaca ggaggcagct cagcaggcag caacggcaac tgcctcagaa cattccagag   1680

agcccagtgc agcaggcagg ctctcagaca gctcatctga agcctctaag ttgagttcca   1740

agagtgctaa ggaaagaaga aatcggagga agaaaagaaa acagaaagag cagtctggtg   1800

gggaagagaa agatgaggat gaattccaaa aatctgaatc tgaggacagc atcaggagga   1860

aaggttttcg cttctccatt gaagggaacc gattgacata tgaaaagagg tactcctccc   1920

cacaccagtc tttgttgagc atccgtggct ccctattttc accaaggcga aatagcagaa   1980

caagcctttt cagctttaga gggcgagcaa aggatgtggg atctgagaac gacttcgcag   2040

atgatgagca cagcaccttt gaggataacg agagccgtag agattccttg tttgtgcccc   2100

gacgacacgg agagagacgc aacagcaacc tgagtcagac cagtaggtca tcccggatgc   2160

tggcagtgtt tccagcgaat gggaagatgc acagcactgt ggattgcaat ggtgtggttt   2220

ccttggttgg tggaccttca gttcctacat cgcctgttgg acagcttctg ccagaggtga   2280

taatagataa gccagctact gatgacaatg gaacaaccac tgaaactgaa atgagaaaga   2340

gaaggtcaag ttctttccac gtttccatgg actttctaga agatccttcc caaaggcaac   2400

gagcaatgag tatagccagc attctaacaa atacagtaga agaacttgaa gaatccaggc   2460

agaaatgccc accctgttgg tataaatttt ccaacatatt cttaatctgg gactgttctc   2520

catattggtt aaaagtgaaa catgttgtca acctggttgt gatggaccca tttgttgacc   2580

tggccatcac catctgtatt gtcttaaata ctcttttcat ggccatggag cactatccaa   2640

tgacggacca tttcaataat gtgcttacag taggaaactt ggttttcact gggatcttta   2700

cagcagaaat gtttctgaaa attattgcca tggatcctta ctattatttc caagaaggct   2760

ggaatatctt tgacggtttt attgtgacgc ttagcctggt agaacttgga ctcgccaatg   2820

tggaaggatt atctgttctc cgttcatttc gattgctgcg agttttcaag ttggcaaaat   2880

cttggccaac gttaaatatg ctaataaaga tcatcggcaa ttccgtgggg gctctgggaa   2940

atttaaccct cgtcttggcc atcatcgtct tcatttttgc cgtggtcggc atgcagctct   3000

ttggtaaaag ctacaaagat tgtgtctgca agatcgccag tgattgtcaa ctcccacgct   3060

ggcacatgaa tgacttcttc cactccttcc tgattgtgtt ccgcgtgctg tgtggggagt   3120

ggatagagac catgtgggac tgtatggagg ttgctggtca agccatgtgc cttactgtct   3180

tcatgatggt catggtgatt ggaaacctag tggtcctgaa tctctttctg gccttgcttc   3240

tgagctcatt tagtgcagac aaccttgcag ccactgatga tgataatgaa atgaataatc   3300

tccaaattgc tgtggatagg atgcacaaag gagtagctta tgtgaaaaga aaaatatatg   3360

aatttattca acagtccttc attaggaaac aaaagatttt agatgaaatt aaaccacttg   3420

atgatctaaa caacaagaaa gacagttgta tgtccaatca tacaacagaa attgggaaag   3480

atcttgacta tcttaaagat gtaaatggaa ctacaagtgg tataggaact ggcagcagtg   3540

ttgaaaaata cattattgat gaaagtgatt acatgtcatt cataaacaac cccagtctta   3600

ctgtgactgt accaattgct gtaggagaat ctgactttga aaatttaaac acggaagact   3660

ttagtagtga atcggatctg gaagaaagca aagagaaact gaatgaaagc agtagctcat   3720

cagaaggtag cactgtggac atcggcgcac ctgtagaaga acagcccgta gtggaacctg   3780

aagaaactct tgaaccagaa gcttgtttca ctgaaggctg tgtacaaaga ttcaagtgtt   3840

gtcaaatcaa tgtggaagaa ggcagaggaa aacaatggtg gaacctgaga aggacgtgtt   3900

tccgaatagt tgaacataac tggtttgaga ccttcattgt tttcatgatt ctccttagta   3960

gtggtgctct ggcatttgaa gatatatata ttgatcagcg aaagacgatt aagacgatgt   4020

tggaatatgc tgacaaggtt ttcacttaca ttttcattct ggaaatgctt ctaaaatggg   4080

tggcatatgg ctatcaaaca tatttcacca atgcctggtg ttggctggac ttcttaattg   4140

ttgatgtttc attggtcagt ttaacagcaa atgccttggg ttactcagaa cttggagcca   4200

tcaaatctct caggacacta agagctctga gacctctaag agccttatct cgatttgaag   4260

ggatgagggt ggttgtgaat gcccttttag gagcaattcc atccatcatg aatgtgcttc   4320

tggtttgtct tatattctgg ctaattttca gcatcatggg cgtaaatttg tttgctggca   4380

aattctacca ctgtattaac accacaactg gtgacaggtt tgacatcgaa gacgtgaata   4440

atcatactga ttgcctaaaa ctaatagaaa gaaatgagac tgctcgatgg aaaaatgtga   4500

aagtaaactt tgataatgta ggatttgggt atctctcttt gcttcaagtt gccacattca   4560

aaggatggat ggatataatg tatgcagcag ttgattccag aaatgtggaa ctccagccta   4620

agtatgaaaa aagtctgtac atgtatcttt actttgttat tttcatcatc tttgggtcct   4680

tcttcacctt gaacctgttt attggtgtca tcatagataa tttcaaccag cagaaaaaga   4740

agtttggagg tcaagacatc tttatgacag aagaacagaa gaaatactat aatgcaatga   4800

aaaaattagg atcgaaaaaa ccgcaaaagc ctatacctcg accaggaaac aaatttcaag   4860

gaatggtctt tgacttcgta accagacaag tttttgacat aagcatcatg attctcatct   4920

gtcttaacat ggtcacaatg atggtggaaa cagatgacca gagtgaatat gtgactacca   4980

ttttgtcacg catcaatctg gtgttcattg tgctatttac tggagagtgt gtactgaaac   5040

tcatctctct acgccattat tattttacca ttggatggaa tatttttgat tttgtggttg   5100

tcattctctc cattgtaggt atgtttcttg ccgagctgat agaaaagtat ttcgtgtccc   5160

ctaccctgtt ccaagtgatc cgtcttgcta ggattggccg aatcctacgt ctgatcaaag   5220

gagcaaaggg gatccgcacg ctgctctttg ctttgatgat gtcccttcct gcgttgttta   5280

acatcggcct cctactcttc ctagtcatgt tcatctacgc catctttggg atgtccaact   5340

ttgcctatgt taagagggaa gttgggatcg atgacatgtt caactttgag acctttggca   5400

acagcatgat ctgcctattc caaattacaa cctctgctgg ctgggatgga ttgctagcac   5460

ccattctcaa cagtaagcca cccgactgtg accctaataa agttaaccct ggaagctcag   5520

ttaagggaga ctgtgggaac ccatctgttg gaattttctt ttttgtcagt tacatcatca   5580

tatccttcct ggttgtggtg aacatgtaca tcgcggtcat cctggagaac ttcagtgttg   5640

ctactgaaga aagtgcagag cctctgagtg aggatgactt tgagatgttc tatgaggttt   5700

gggagaagtt tgatcccgat gcaactcagt tcatggaatt tgaaaaatta tctcagtttg   5760

cagctgcgct tgaaccgcct ctcaatctgc cacaaccaaa caaactccag ctcattgcca   5820

tggatttgcc catggtgagt ggtgaccgga tccactgtct tgatatctta tttgctttta   5880

caaagcgggt tctaggagag agtggagaga tggatgctct acgaatacag atggaagagc   5940

gattcatggc ttccaatcct tccaaggtct cctatcagcc aatcactact actttaaaac   6000

gaaaacaaga ggaagtatct gctgtcatta ttcagcgtgc ttacagacgc caccttttaa   6060

agcgaactgt aaaacaagct tcctttacgt acaataaaaa caaaatcaaa ggtggggcta   6120

atcttcttat aaaagaagac atgataattg acagaataaa tgaaaactct attacagaaa   6180

aaactgatct gaccatgtcc actgcagctt gtccaccttc ctatgaccgg gtgacaaagc   6240

caattgtgga aaaacatgag caagaaggca aagatgaaaa agccaaaggg aaataaatga   6300

aaataaataa aaataattgg gtgacaaatt gtttacagcc tgtgaaggtg atgtattttt   6360

atcaacagga ctcctttagg aggtcaatgc caaactgact gtttttacac aaatctcctt   6420

aaggtcagtg cctacaataa gacagtgacc ccttgtcagc aaactgtgac tctgtgtaaa   6480

ggggagatga ccttgacagg aggttactgt tctcactacc agctgacact gctgaagata   6540

agatgcacaa tggctagtca gactgtaggg accagtttca aggggtgcaa acctgtgatt   6600

ttggggttgt ttaacatgaa acactttagt gtagtaattg tatccactgt ttgcatttca   6660

actgccacat ttgtcacatt tttatggaat ctgttagtgg attcatcttt ttgttaatcc   6720

atgtgtttat tatatgtgac tatttttgta aacgaagttt ctgttgagaa ataggctaag   6780

gacctctata acaggtatgc cacctggggg gtatggcaac cacatggccc tcccagctac   6840

acaaagtcgt ggtttgcatg agggcatgct gcacttagag atcatgcatg agaaaaagtc   6900

acaagaaaaa caaattctta aatttcacca tatttctggg aggggtaatt gggtgataag   6960

tggaggtgct ttgttgatct tgttttgcga aatccagccc ctagaccaag tagattattt   7020

gtgggtaggc cagtaaatct tagcaggtgc aaacttcatt caaatgtttg gagtcataaa   7080

tgttatgttt ctttttgttg tattaaaaaa aaaacctgaa tagtgaatat tgcccctcac   7140

cctccaccgc cagaagactg aattgaccaa aattactctt tataaatttc tgctttttcc   7200

tgcactttgt ttagccatct ttgggctctc agcaaggttg acactgtata tgttaatgaa   7260

atgctattta ttatgtaaat agtcatttta ccctgtggtg cacgtttgag caaacaaata   7320

atgacctaag cacagtattt attgcatcaa atatgtacca caagaaatgt agagtgcaag   7380

ctttacacag gtaataaaat gtattctgta ccatttatag atagtttgga tgctatcaat   7440

gcatgtttat attaccatgc tgctgtatct ggtttctctc actgctcaga atctcattta   7500

tgagaaacca tatgtcagtg gtaaagtcaa ggaaattgtt caacagatct catttattta   7560

agtcattaag caatagtttg cagcacttta acagcttttt ggttattttt acattttaag   7620

tggataacat atggtatata gccagactgt acagacatgt ttaaaaaaac acactgctta   7680

acctattaaa tatgtgttta gaattttata agcaaatata aatactgtaa aaagtcactt   7740

tattttattt ttcagcatta tgtacataaa tatgaagagg aaattatctt caggttgata   7800

tcacaatcac ttttcttact ttctgtccat agtacttttt catgaaagaa atttgctaaa   7860

taagacatga aaacaagact gggtagttgt agatttctgc tttttaaatt acatttgcta   7920

attttagatt atttcacaat tttaaggagc aaaataggtt cacgattcat atccaaatta   7980

tgctttgcaa ttggaaaagg gtttaaaatt ttatttatat ttctggtagt acctgtacta   8040

actgaattga aggtagtgct tatgttattt ttgttctttt tttctgactt cggtttatgt   8100

tttcatttct ttggagtaat gctgctctag attgttctaa atagaatgtg ggcttcataa   8160

tttttttttc cacaaaaaca gagtagtcaa cttatatagt caattacatc aggacatttt   8220

gtgtttctta cagaagcaaa ccataggctc ctcttttcct taaaactact tagataaact   8280

gtattcgtga actgcatgct ggaaaatgct actattatgc taaataatgc taaccaacat   8340

ttaaaatgtg caaaactaat aaagattaca ttttttattt t                       8381


<210>  52
<211>  8380
<212>  DNA
<213>  Homo sapiens

<400>  52
atactgcaga ggtctctggt gcatgtgtgt atgtgtgcgt ttgtgtgtgt ttgtgtgtct     60

gtgtgttctg ccccagtgag actgcagccc ttgtaaatac tttgacacct tttgcaagaa    120

ggaatctgaa caattgcaac tgaaggcaca ttgttatcat ctcgtctttg ggtgatgctg    180

ttcctcactg cagatggata attttccttt taatcaggaa tttcatatgc agaataaatg    240

gtaattaaaa tgtgcaggat gacaagatgg agcaaacagt gcttgtacca ccaggacctg    300

acagcttcaa cttcttcacc agagaatctc ttgcggctat tgaaagacgc attgcagaag    360

aaaaggcaaa gaatcccaaa ccagacaaaa aagatgacga cgaaaatggc ccaaagccaa    420

atagtgactt ggaagctgga aagaaccttc catttattta tggagacatt cctccagaga    480

tggtgtcaga gcccctggag gacctggacc cctactatat caataagaaa acttttatag    540

tattgaataa attgaaggcc atcttccggt tcagtgccac ctctgccctg tacattttaa    600

ctcccttcaa tcctcttagg aaaatagcta ttaagatttt ggtacattca ttattcagca    660

tgctaattat gtgcactatt ttgacaaact gtgtgtttat gacaatgagt aaccctcctg    720

attggacaaa gaatgtagaa tacaccttca caggaatata tacttttgaa tcacttataa    780

aaattattgc aaggggattc tgtttagaag attttacttt ccttcgggat ccatggaact    840

ggctcgattt cactgtcatt acatttgcgt acgtcacaga gtttgtggac ctgggcaatg    900

tctcggcatt gagaacattc agagttctcc gagcattgaa gacgatttca gtcattccag    960

gcctgaaaac cattgtggga gccctgatcc agtctgtgaa gaagctctca gatgtaatga   1020

tcctgactgt gttctgtctg agcgtatttg ctctaattgg gctgcagctg ttcatgggca   1080

acctgaggaa taaatgtata caatggcctc ccaccaatgc ttccttggag gaacatagta   1140

tagaaaagaa tataactgtg aattataatg gtacacttat aaatgaaact gtctttgagt   1200

ttgactggaa gtcatatatt caagattcaa gatatcatta tttcctggag ggttttttag   1260

atgcactact atgtggaaat agctctgatg caggccaatg tccagaggga tatatgtgtg   1320

tgaaagctgg tagaaatccc aattatggct acacaagctt tgataccttc agttgggctt   1380

ttttgtcctt gtttcgacta atgactcagg acttctggga aaatctttat caactgacat   1440

tacgtgctgc tgggaaaacg tacatgatat tttttgtatt ggtcattttc ttgggctcat   1500

tctacctaat aaatttgatc ctggctgtgg tggccatggc ctacgaggaa cagaatcagg   1560

ccaccttgga agaagcagaa cagaaagagg ccgaatttca gcagatgatt gaacagctta   1620

aaaagcaaca ggaggcagct cagcaggcag caacggcaac tgcctcagaa cattccagag   1680

agcccagtgc agcaggcagg ctctcagaca gctcatctga agcctctaag ttgagttcca   1740

agagtgctaa ggaaagaaga aatcggagga agaaaagaaa acagaaagag cagtctggtg   1800

gggaagagaa agatgaggat gaattccaaa aatctgaatc tgaggacagc atcaggagga   1860

aaggttttcg cttctccatt gaagggaacc gattgacata tgaaaagagg tactcctccc   1920

cacaccagtc tttgttgagc atccgtggct ccctattttc accaaggcga aatagcagaa   1980

caagcctttc agctttagag ggcgagcaaa ggatgtggga tctgagaacg acttcgcaga   2040

tgatgagcac agcacctttg aggataacga gagccgtaga gattccttgt ttgtgccccg   2100

acgacacgga gagagacgca acagcaacct gagtcagacc agtaggtcat cccggatgct   2160

ggcagtgttt ccagcgaatg ggaagatgca cagcactgtg gattgcaatg gtgtggtttc   2220

cttggttggt ggaccttcag ttcctacatc gcctgttgga cagcttctgc cagaggtgat   2280

aatagataag ccagctactg atgacaatgg aacaaccact gaaactgaaa tgagaaagag   2340

aaggtcaagt tctttccacg tttccatgga ctttctagaa gatccttccc aaaggcaacg   2400

agcaatgagt atagccagca ttctaacaaa tacagtagaa gaacttgaag aatccaggca   2460

gaaatgccca ccctgttggt ataaattttc caacatattc ttaatctggg actgttctcc   2520

atattggtta aaagtgaaac atgttgtcaa cctggttgtg atggacccat ttgttgacct   2580

ggccatcacc atctgtattg tcttaaatac tcttttcatg gccatggagc actatccaat   2640

gacggaccat ttcaataatg tgcttacagt aggaaacttg gttttcactg ggatctttac   2700

agcagaaatg tttctgaaaa ttattgccat ggatccttac tattatttcc aagaaggctg   2760

gaatatcttt gacggtttta ttgtgacgct tagcctggta gaacttggac tcgccaatgt   2820

ggaaggatta tctgttctcc gttcatttcg attgctgcga gttttcaagt tggcaaaatc   2880

ttggccaacg ttaaatatgc taataaagat catcggcaat tccgtggggg ctctgggaaa   2940

tttaaccctc gtcttggcca tcatcgtctt catttttgcc gtggtcggca tgcagctctt   3000

tggtaaaagc tacaaagatt gtgtctgcaa gatcgccagt gattgtcaac tcccacgctg   3060

gcacatgaat gacttcttcc actccttcct gattgtgttc cgcgtgctgt gtggggagtg   3120

gatagagacc atgtgggact gtatggaggt tgctggtcaa gccatgtgcc ttactgtctt   3180

catgatggtc atggtgattg gaaacctagt ggtcctgaat ctctttctgg ccttgcttct   3240

gagctcattt agtgcagaca accttgcagc cactgatgat gataatgaaa tgaataatct   3300

ccaaattgct gtggatagga tgcacaaagg agtagcttat gtgaaaagaa aaatatatga   3360

atttattcaa cagtccttca ttaggaaaca aaagatttta gatgaaatta aaccacttga   3420

tgatctaaac aacaagaaag acagttgtat gtccaatcat acaacagaaa ttgggaaaga   3480

tcttgactat cttaaagatg taaatggaac tacaagtggt ataggaactg gcagcagtgt   3540

tgaaaaatac attattgatg aaagtgatta catgtcattc ataaacaacc ccagtcttac   3600

tgtgactgta ccaattgctg taggagaatc tgactttgaa aatttaaaca cggaagactt   3660

tagtagtgaa tcggatctgg aagaaagcaa agagaaactg aatgaaagca gtagctcatc   3720

agaaggtagc actgtggaca tcggcgcacc tgtagaagaa cagcccgtag tggaacctga   3780

agaaactctt gaaccagaag cttgtttcac tgaaggctgt gtacaaagat tcaagtgttg   3840

tcaaatcaat gtggaagaag gcagaggaaa acaatggtgg aacctgagaa ggacgtgttt   3900

ccgaatagtt gaacataact ggtttgagac cttcattgtt ttcatgattc tccttagtag   3960

tggtgctctg gcatttgaag atatatatat tgatcagcga aagacgatta agacgatgtt   4020

ggaatatgct gacaaggttt tcacttacat tttcattctg gaaatgcttc taaaatgggt   4080

ggcatatggc tatcaaacat atttcaccaa tgcctggtgt tggctggact tcttaattgt   4140

tgatgtttca ttggtcagtt taacagcaaa tgccttgggt tactcagaac ttggagccat   4200

caaatctctc aggacactaa gagctctgag acctctaaga gccttatctc gatttgaagg   4260

gatgagggtg gttgtgaatg cccttttagg agcaattcca tccatcatga atgtgcttct   4320

ggtttgtctt atattctggc taattttcag catcatgggc gtaaatttgt ttgctggcaa   4380

attctaccac tgtattaaca ccacaactgg tgacaggttt gacatcgaag acgtgaataa   4440

tcatactgat tgcctaaaac taatagaaag aaatgagact gctcgatgga aaaatgtgaa   4500

agtaaacttt gataatgtag gatttgggta tctctctttg cttcaagttg ccacattcaa   4560

aggatggatg gatataatgt atgcagcagt tgattccaga aatgtggaac tccagcctaa   4620

gtatgaaaaa agtctgtaca tgtatcttta ctttgttatt ttcatcatct ttgggtcctt   4680

cttcaccttg aacctgttta ttggtgtcat catagataat ttcaaccagc agaaaaagaa   4740

gtttggaggt caagacatct ttatgacaga agaacagaag aaatactata atgcaatgaa   4800

aaaattagga tcgaaaaaac cgcaaaagcc tatacctcga ccaggaaaca aatttcaagg   4860

aatggtcttt gacttcgtaa ccagacaagt ttttgacata agcatcatga ttctcatctg   4920

tcttaacatg gtcacaatga tggtggaaac agatgaccag agtgaatatg tgactaccat   4980

tttgtcacgc atcaatctgg tgttcattgt gctatttact ggagagtgtg tactgaaact   5040

catctctcta cgccattatt attttaccat tggatggaat atttttgatt ttgtggttgt   5100

cattctctcc attgtaggta tgtttcttgc cgagctgata gaaaagtatt tcgtgtcccc   5160

taccctgttc cgagtgatcc gtcttgctag gattggccga atcctacgtc tgatcaaagg   5220

agcaaagggg atccgcacgc tgctctttgc tttgatgatg tcccttcctg cgttgtttaa   5280

catcggcctc ctactcttcc tagtcatgtt catctacgcc atctttggga tgtccaactt   5340

tgcctatgtt aagagggaag ttgggatcga tgacatgttc aactttgaga cctttggcaa   5400

cagcatgatc tgcctattcc aaattacaac ctctgctggc tgggatggat tgctagcacc   5460

cattctcaac agtaagccac ccgactgtga ccctaataaa gttaaccctg gaagctcagt   5520

taagggagac tgtgggaacc catctgttgg aattttcttt tttgtcagtt acatcatcat   5580

atccttcctg gttgtggtga acatgtacat cgcggtcatc ctggagaact tcagtgttgc   5640

tactgaagaa agtgcagagc ctctgagtga ggatgacttt gagatgttct atgaggtttg   5700

ggagaagttt gatcccgatg caactcagtt catggaattt gaaaaattat ctcagtttgc   5760

agctgcgctt gaaccgcctc tcaatctgcc acaaccaaac aaactccagc tcattgccat   5820

ggatttgccc atggtgagtg gtgaccggat ccactgtctt gatatcttat ttgcttttac   5880

aaagcgggtt ctaggagaga gtggagagat ggatgctcta cgaatacaga tggaagagcg   5940

attcatggct tccaatcctt ccaaggtctc ctatcagcca atcactacta ctttaaaacg   6000

aaaacaagag gaagtatctg ctgtcattat tcagcgtgct tacagacgcc accttttaaa   6060

gcgaactgta aaacaagctt cctttacgta caataaaaac aaaatcaaag gtggggctaa   6120

tcttcttata aaagaagaca tgataattga cagaataaat gaaaactcta ttacagaaaa   6180

aactgatctg accatgtcca ctgcagcttg tccaccttcc tatgaccggg tgacaaagcc   6240

aattgtggaa aaacatgagc aagaaggcaa agatgaaaaa gccaaaggga aataaatgaa   6300

aataaataaa aataattggg tgacaaattg tttacagcct gtgaaggtga tgtattttta   6360

tcaacaggac tcctttagga ggtcaatgcc aaactgactg tttttacaca aatctcctta   6420

aggtcagtgc ctacaataag acagtgaccc cttgtcagca aactgtgact ctgtgtaaag   6480

gggagatgac cttgacagga ggttactgtt ctcactacca gctgacactg ctgaagataa   6540

gatgcacaat ggctagtcag actgtaggga ccagtttcaa ggggtgcaaa cctgtgattt   6600

tggggttgtt taacatgaaa cactttagtg tagtaattgt atccactgtt tgcatttcaa   6660

ctgccacatt tgtcacattt ttatggaatc tgttagtgga ttcatctttt tgttaatcca   6720

tgtgtttatt atatgtgact atttttgtaa acgaagtttc tgttgagaaa taggctaagg   6780

acctctataa caggtatgcc acctgggggg tatggcaacc acatggccct cccagctaca   6840

caaagtcgtg gtttgcatga gggcatgctg cacttagaga tcatgcatga gaaaaagtca   6900

caagaaaaac aaattcttaa atttcaccat atttctggga ggggtaattg ggtgataagt   6960

ggaggtgctt tgttgatctt gttttgcgaa atccagcccc tagaccaagt agattatttg   7020

tgggtaggcc agtaaatctt agcaggtgca aacttcattc aaatgtttgg agtcataaat   7080

gttatgtttc tttttgttgt attaaaaaaa aaacctgaat agtgaatatt gcccctcacc   7140

ctccaccgcc agaagactga attgaccaaa attactcttt ataaatttct gctttttcct   7200

gcactttgtt tagccatctt tgggctctca gcaaggttga cactgtatat gttaatgaaa   7260

tgctatttat tatgtaaata gtcattttac cctgtggtgc acgtttgagc aaacaaataa   7320

tgacctaagc acagtattta ttgcatcaaa tatgtaccac aagaaatgta gagtgcaagc   7380

tttacacagg taataaaatg tattctgtac catttataga tagtttggat gctatcaatg   7440

catgtttata ttaccatgct gctgtatctg gtttctctca ctgctcagaa tctcatttat   7500

gagaaaccat atgtcagtgg taaagtcaag gaaattgttc aacagatctc atttatttaa   7560

gtcattaagc aatagtttgc agcactttaa cagctttttg gttattttta cattttaagt   7620

ggataacata tggtatatag ccagactgta cagacatgtt taaaaaaaca cactgcttaa   7680

cctattaaat atgtgtttag aattttataa gcaaatataa atactgtaaa aagtcacttt   7740

attttatttt tcagcattat gtacataaat atgaagagga aattatcttc aggttgatat   7800

cacaatcact tttcttactt tctgtccata gtactttttc atgaaagaaa tttgctaaat   7860

aagacatgaa aacaagactg ggtagttgta gatttctgct ttttaaatta catttgctaa   7920

ttttagatta tttcacaatt ttaaggagca aaataggttc acgattcata tccaaattat   7980

gctttgcaat tggaaaaggg tttaaaattt tatttatatt tctggtagta cctgtactaa   8040

ctgaattgaa ggtagtgctt atgttatttt tgttcttttt ttctgacttc ggtttatgtt   8100

ttcatttctt tggagtaatg ctgctctaga ttgttctaaa tagaatgtgg gcttcataat   8160

ttttttttcc acaaaaacag agtagtcaac ttatatagtc aattacatca ggacattttg   8220

tgtttcttac agaagcaaac cataggctcc tcttttcctt aaaactactt agataaactg   8280

tattcgtgaa ctgcatgctg gaaaatgcta ctattatgct aaataatgct aaccaacatt   8340

taaaatgtgc aaaactaata aagattacat tttttatttt                         8380


<210>  53
<211>  8379
<212>  DNA
<213>  Homo sapiens

<400>  53
atactgcaga ggtctctggt gcatgtgtgt atgtgtgcgt ttgtgtgtgt ttgtgtgtct     60

gtgtgttctg ccccagtgag actgcagccc ttgtaaatac tttgacacct tttgcaagaa    120

ggaatctgaa caattgcaac tgaaggcaca ttgttatcat ctcgtctttg ggtgatgctg    180

ttcctcactg cagatggata attttccttt taatcaggaa tttcatatgc agaataaatg    240

gtaattaaaa tgtgcaggat gacaagatgg agcaaacagt gcttgtacca ccaggacctg    300

acagcttcaa cttcttcacc agagaatctc ttgcggctat tgaaagacgc attgcagaag    360

aaaaggcaaa gaatcccaaa ccagacaaaa aagatgacga cgaaaatggc ccaaagccaa    420

atagtgactt ggaagctgga aagaaccttc catttattta tggagacatt cctccagaga    480

tggtgtcaga gcccctggag gacctggacc cctactatat caataagaaa acttttatag    540

tattgaataa attgaaggcc atcttccggt tcagtgccac ctctgccctg tacattttaa    600

ctcccttcaa tcctcttagg aaaatagcta ttaagatttt ggtacattca ttattcagca    660

tgctaattat gtgcactatt ttgacaaact gtgtgtttat gacaatgagt aaccctcctg    720

attggacaaa gaatgtagaa tacaccttca caggaatata tacttttgaa tcacttataa    780

aaattattgc aaggggattc tgtttagaag attttacttt ccttcgggat ccatggaact    840

ggctcgattt cactgtcatt acatttgcgt acgtcacaga gtttgtggac ctgggcaatg    900

tctcggcatt gagaacattc agagttctcc gagcattgaa gacgatttca gtcattccag    960

gcctgaaaac cattgtggga gccctgatcc agtctgtgaa gaagctctca gatgtaatga   1020

tcctgactgt gttctgtctg agcgtatttg ctctaattgg gctgcagctg ttcatgggca   1080

acctgaggaa taaatgtata caatggcctc ccaccaatgc ttccttggag gaacatagta   1140

tagaaaagaa tataactgtg aattataatg gtacacttat aaatgaaact gtctttgagt   1200

ttgactggaa gtcatatatt caagattcaa gatatcatta tttcctggag ggttttttag   1260

atgcactact atgtggaaat agctctgatg caggccaatg tccagaggga tatatgtgtg   1320

tgaaagctgg tagaaatccc aattatggct acacaagctt tgataccttc agttgggctt   1380

ttttgtcctt gtttcgacta atgactcagg acttctggga aaatctttat caactgacat   1440

tacgtgctgc tgggaaaacg tacatgatat tttttgtatt ggtcattttc ttgggctcat   1500

tctacctaat aaatttgatc ctggctgtgg tggccatggc ctacgaggaa cagaatcagg   1560

ccaccttgga agaagcagaa cagaaagagg ccgaatttca gcagatgatt gaacagctta   1620

aaaagcaaca ggaggcagct cagcaggcag caacggcaac tgcctcagaa cattccagag   1680

agcccagtgc agcaggcagg ctctcagaca gctcatctga agcctctaag ttgagttcca   1740

agagtgctaa ggaaagaaga aatcggagga agaaaagaaa acagaaagag cagtctggtg   1800

gggaagagaa agatgaggat gaattccaaa aatctgaatc tgaggacagc atcaggagga   1860

aaggttttcg cttctccatt gaagggaacc gattgacata tgaaaagagg tactcctccc   1920

cacaccagtc tttgttgagc atccgtggct ccctattttc accaaggcga aatagcagaa   1980

caagcctttt cagctttaga gggcgagcaa aggatgtggg atctgagaac gacttcgcag   2040

atgatgagca cagcaccttt gaggataacg agagccgtag agattccttg tttgtgcccc   2100

gacgacacgg agagagacgc aacagcaacc tgagtcagac cagtaggtca tcccggatgc   2160

tggcagtgtt tccagcgaat gggaagatgc acagcactgt ggattgcaat ggtgtggttt   2220

ccttggttgg tggaccttca gttcctacat cgcctgttgg acagcttctg ccagaggtga   2280

taatagataa gccagctact gatgacaatg gaacaaccac tgaaactgaa atgagaaaga   2340

gaaggtcaag ttctttccac gtttccatgg actttctaga agatccttcc caaaggcaac   2400

gagcaatgag tatagccagc attctaacaa atacagtaga agaacttgaa gaatccaggc   2460

agaaatgccc accctgttgg tataaatttt ccaacatatt cttaatctgg gactgttctc   2520

catattggtt aaaagtgaaa catgttgtca acctggttgt gatggaccca tttgttgacc   2580

tggccatcac catctgtatt gtcttaaata ctcttttcat ggccatggag cactatccaa   2640

tgacggacca tttcaataat gtgcttacag taggaaactt ggttttcact gggatcttta   2700

cagcagaaat gtttctgaaa attattgcca tggatcctta ctattatttc caagaaggct   2760

ggaatatctt tgacggtttt attgtgacgc ttagcctggt agaacttgga ctcgccaatg   2820

tggaaggatt atctgttctc cgttcatttc gattgctgcg agttttcaag ttggcaaaat   2880

cttggccaac gttaaatatg ctaataaaga tcatcggcaa ttccgtgggg gctctgggaa   2940

atttaaccct cgtcttggcc atcatcgtct tcatttttgc cgtggtcggc atgcagctct   3000

ttggtaaaag ctacaaagat tgtgtctgca agatcgccag tgattgtcaa ctcccacgct   3060

ggcacatgaa tgacttcttc cactccttcc tgattgtgtt ccgcgtgctg tgtggggagt   3120

ggatagagac catgtgggac tgtatggagg ttgctggtca agccatgtgc cttactgtct   3180

tcatgatggt catggtgatt ggaaacctag tggtcctgaa tctctttctg gccttgcttc   3240

tgagctcatt tagtgcagac aaccttgcag ccactgatga tgataatgaa atgaataatc   3300

tccaaattgc tgtggatagg atgcacaaag gagtagctta tgtgaaaaga aaaatatatg   3360

aatttattca acagtccttc attaggaaac aaaagatttt agatgaaatt aaaccacttg   3420

atgatctaaa caacaagaaa gacagttgta tgtccaatca tacaacagaa attgggaaag   3480

atcttgacta tcttaaagat gtaaatggaa ctacaagtgg tataggaact ggcagcagtg   3540

ttgaaaaata cattattgat gaaagtgatt acatgtcatt cataaacaac cccagtctta   3600

ctgtgactgt accaattgct gtaggagaat ctgactttga aaatttaaac acggaagact   3660

ttagtagtga atcggatctg gaagaaagca aagagaaact gaatgaaagc agtagctcat   3720

cagaaggtag cactgtggac atcggcgcac ctgtagaaga acagcccgta gtggaacctg   3780

aagaaactct tgaaccagaa gcttgtttca ctgaaggctg tgtacaaaga ttcaagtgtt   3840

gtcaaatcaa tgtggaagaa ggcagaggaa aacaatggtg gaacctgaga aggacgtgtt   3900

tccgaatagt tgaacataac tggtttgaga ccttcattgt tttcatgatt ctccttagta   3960

gtggtgctct ggcatttgaa gatatatata ttgatcagcg aaagacgatt aagacgatgt   4020

tggaatatgc tgacaaggtt ttcacttaca ttttcattct ggaaatgctt ctaaaatggg   4080

tggcatatgg ctatcaaaca tatttcacca atgcctggtg ttggctggac ttcttaattg   4140

ttgatgtttc attggtcagt ttaacagcaa atgccttggg ttactcagaa cttggagcca   4200

tcaaatctct caggacacta agagctctga gacctctaag agccttatct cgatttgaag   4260

ggatgagggt ggttgtgaat gcccttttag gagcaattcc atccatcatg aatgtgcttc   4320

tggtttgtct tatattctgg ctaattttca gcatcatggg cgtaaatttg tttgctggca   4380

aattctacca ctgtattaac accacaactg gtgacaggtt tgacatcgaa gacgtgaata   4440

atcatactga ttgcctaaaa ctaatagaaa gaaatgagac tgctcgatgg aaaaatgtga   4500

aagtaaactt tgataatgta ggatttgggt atctctcttt gcttcaagtt gccacattca   4560

aaggatggat ggatataatg tatgcagcag ttgattccag aaatgtggaa ctccagccta   4620

agtatgaaaa aagtctgtac atgtatcttt actttgttat tttcatcatc tttgggtcct   4680

tcttcacctt gaacctgttt attggtgtca tcatagataa tttcaaccag cagaaaaaga   4740

agtttggagg tcaagacatc tttatgacag aagaacagaa gaaatactat aatgcaatga   4800

aaaaattagg atcgaaaaaa ccgcaaaagc ctatacctcg accaggaaac aaatttcaag   4860

gaatggtctt tgacttcgta accagacaag tttttgacat aagcatcatg attctcatct   4920

gtcttaacat ggtcacaatg atggtggaaa cagatgacca gagtgaatat gtgactacca   4980

ttttgtcacg catcaatctg gtgttcattg tgctatttac tggagagtgt gtactgaaac   5040

tcatctctct acgccattat tattttacca ttggatggaa tatttttgat tttgtggttg   5100

tcattctctc cattgtaggt atgtttcttg ccgagctgat agaaaagtat ttcgtgtccc   5160

ctaccctgtt ccgagtgatc cgtcttgcta ggattggccg aatcctacgt ctgatcaaag   5220

gagcaaaggg gatccgcacg ctgctctttg ctttgatgat gtcccttcct gcgttgttta   5280

acatcggcct cctactcttc ctagtcatgt tcatctacgc catctttggg atgtccaact   5340

ttgcctatgt taagagggaa gttgggatcg atgacatgtt caactttgag acctttggca   5400

acagcatgat ctgcctattc caaattacaa cctctgctgg ctgggatgga ttgctagcac   5460

ccattctcaa cagtaagcca cccgactgtg accctaataa agttaaccct ggaagctcag   5520

ttaagggaga ctgtgggaac ccatctgttg gaattttctt ttttgtcagt tacatcatca   5580

tatccttcct ggttgtggtg aacatgtaca tcgcggtcat cctggagaac ttcagtgttg   5640

ctactgaaga aagtgcagag cctctgagtg aggatgactt tgagatgttc tatgaggttt   5700

gggagaagtt tgatcccgat gcaactcagt tcatggaatt tgaaaaatta tctcagtttg   5760

cagctgcgct tgaaccgcct ctcaatctgc cacaaccaaa caaactccag ctcattgcca   5820

tggatttgcc catggtgagt ggtgaccgga tccactgtct tgatatctta tttgctttta   5880

caaagcgggt tctaggagag agtggagaga tggatgctct acgaatacag atggaagagc   5940

gattcatggc ttccaatcct tccaaggtct cctatcagcc aatcactact actttaaaac   6000

gaaaacgagg aagtatctgc tgtcattatt cagcgtgctt acagacgcca ccttttaaag   6060

cgaactgtaa aacaagcttc ctttacgtac aataaaaaca aaatcaaagg tggggctaat   6120

cttcttataa aagaagacat gataattgac agaataaatg aaaactctat tacagaaaaa   6180

actgatctga ccatgtccac tgcagcttgt ccaccttcct atgaccgggt gacaaagcca   6240

attgtggaaa aacatgagca agaaggcaaa gatgaaaaag ccaaagggaa ataaatgaaa   6300

ataaataaaa ataattgggt gacaaattgt ttacagcctg tgaaggtgat gtatttttat   6360

caacaggact cctttaggag gtcaatgcca aactgactgt ttttacacaa atctccttaa   6420

ggtcagtgcc tacaataaga cagtgacccc ttgtcagcaa actgtgactc tgtgtaaagg   6480

ggagatgacc ttgacaggag gttactgttc tcactaccag ctgacactgc tgaagataag   6540

atgcacaatg gctagtcaga ctgtagggac cagtttcaag gggtgcaaac ctgtgatttt   6600

ggggttgttt aacatgaaac actttagtgt agtaattgta tccactgttt gcatttcaac   6660

tgccacattt gtcacatttt tatggaatct gttagtggat tcatcttttt gttaatccat   6720

gtgtttatta tatgtgacta tttttgtaaa cgaagtttct gttgagaaat aggctaagga   6780

cctctataac aggtatgcca cctggggggt atggcaacca catggccctc ccagctacac   6840

aaagtcgtgg tttgcatgag ggcatgctgc acttagagat catgcatgag aaaaagtcac   6900

aagaaaaaca aattcttaaa tttcaccata tttctgggag gggtaattgg gtgataagtg   6960

gaggtgcttt gttgatcttg ttttgcgaaa tccagcccct agaccaagta gattatttgt   7020

gggtaggcca gtaaatctta gcaggtgcaa acttcattca aatgtttgga gtcataaatg   7080

ttatgtttct ttttgttgta ttaaaaaaaa aacctgaata gtgaatattg cccctcaccc   7140

tccaccgcca gaagactgaa ttgaccaaaa ttactcttta taaatttctg ctttttcctg   7200

cactttgttt agccatcttt gggctctcag caaggttgac actgtatatg ttaatgaaat   7260

gctatttatt atgtaaatag tcattttacc ctgtggtgca cgtttgagca aacaaataat   7320

gacctaagca cagtatttat tgcatcaaat atgtaccaca agaaatgtag agtgcaagct   7380

ttacacaggt aataaaatgt attctgtacc atttatagat agtttggatg ctatcaatgc   7440

atgtttatat taccatgctg ctgtatctgg tttctctcac tgctcagaat ctcatttatg   7500

agaaaccata tgtcagtggt aaagtcaagg aaattgttca acagatctca tttatttaag   7560

tcattaagca atagtttgca gcactttaac agctttttgg ttatttttac attttaagtg   7620

gataacatat ggtatatagc cagactgtac agacatgttt aaaaaaacac actgcttaac   7680

ctattaaata tgtgtttaga attttataag caaatataaa tactgtaaaa agtcacttta   7740

ttttattttt cagcattatg tacataaata tgaagaggaa attatcttca ggttgatatc   7800

acaatcactt ttcttacttt ctgtccatag tactttttca tgaaagaaat ttgctaaata   7860

agacatgaaa acaagactgg gtagttgtag atttctgctt tttaaattac atttgctaat   7920

tttagattat ttcacaattt taaggagcaa aataggttca cgattcatat ccaaattatg   7980

ctttgcaatt ggaaaagggt ttaaaatttt atttatattt ctggtagtac ctgtactaac   8040

tgaattgaag gtagtgctta tgttattttt gttctttttt tctgacttcg gtttatgttt   8100

tcatttcttt ggagtaatgc tgctctagat tgttctaaat agaatgtggg cttcataatt   8160

tttttttcca caaaaacaga gtagtcaact tatatagtca attacatcag gacattttgt   8220

gtttcttaca gaagcaaacc ataggctcct cttttcctta aaactactta gataaactgt   8280

attcgtgaac tgcatgctgg aaaatgctac tattatgcta aataatgcta accaacattt   8340

aaaatgtgca aaactaataa agattacatt ttttatttt                          8379


<210>  54
<211>  2009
<212>  PRT
<213>  Homo sapiens

<400>  54

Met Glu Gln Thr Val Leu Val Pro Pro Gly Pro Asp Ser Phe Asn Phe 
1               5                   10                  15      


Phe Thr Arg Glu Ser Leu Ala Ala Ile Glu Arg Arg Ile Ala Glu Glu 
            20                  25                  30          


Lys Ala Lys Asn Pro Lys Pro Asp Lys Lys Asp Asp Asp Glu Asn Gly 
        35                  40                  45              


Pro Lys Pro Asn Ser Asp Leu Glu Ala Gly Lys Asn Leu Pro Phe Ile 
    50                  55                  60                  


Tyr Gly Asp Ile Pro Pro Glu Met Val Ser Glu Pro Leu Glu Asp Leu 
65                  70                  75                  80  


Asp Pro Tyr Tyr Ile Asn Lys Lys Thr Phe Ile Val Leu Asn Lys Leu 
                85                  90                  95      


Lys Ala Ile Phe Arg Phe Ser Ala Thr Ser Ala Leu Tyr Ile Leu Thr 
            100                 105                 110         


Pro Phe Asn Pro Leu Arg Lys Ile Ala Ile Lys Ile Leu Val His Ser 
        115                 120                 125             


Leu Phe Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Val Phe 
    130                 135                 140                 


Met Thr Met Ser Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr Thr 
145                 150                 155                 160 


Phe Thr Gly Ile Tyr Thr Phe Glu Ser Leu Ile Lys Ile Ile Ala Arg 
                165                 170                 175     


Gly Phe Cys Leu Glu Asp Phe Thr Phe Leu Arg Asp Pro Trp Asn Trp 
            180                 185                 190         


Leu Asn Phe Thr Val Ile Thr Phe Ala Tyr Val Thr Glu Phe Val Asp 
        195                 200                 205             


Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala Leu 
    210                 215                 220                 


Lys Thr Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu 
225                 230                 235                 240 


Ile Gln Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val Phe 
                245                 250                 255     


Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly Asn 
            260                 265                 270         


Leu Arg Asn Lys Cys Ile Gln Trp Pro Pro Thr Asn Ala Ser Leu Glu 
        275                 280                 285             


Glu His Ser Ile Glu Lys Asn Ile Thr Val Asn Tyr Asn Gly Thr Leu 
    290                 295                 300                 


Ile Asn Glu Thr Val Phe Glu Phe Asp Trp Lys Ser Tyr Ile Gln Asp 
305                 310                 315                 320 


Ser Arg Tyr His Tyr Phe Leu Glu Gly Phe Leu Asp Ala Leu Leu Cys 
                325                 330                 335     


Gly Asn Ser Ser Asp Ala Gly Gln Cys Pro Glu Gly Tyr Met Cys Val 
            340                 345                 350         


Lys Ala Gly Arg Asn Pro Asn Tyr Gly Tyr Thr Ser Phe Asp Thr Phe 
        355                 360                 365             


Ser Trp Ala Phe Leu Ser Leu Phe Arg Leu Met Thr Gln Asp Phe Trp 
    370                 375                 380                 


Glu Asn Leu Tyr Gln Leu Thr Leu Arg Ala Ala Gly Lys Thr Tyr Met 
385                 390                 395                 400 


Ile Phe Phe Val Leu Val Ile Phe Leu Gly Ser Phe Tyr Leu Ile Asn 
                405                 410                 415     


Leu Ile Leu Ala Val Val Ala Met Ala Tyr Glu Glu Gln Asn Gln Ala 
            420                 425                 430         


Thr Leu Glu Glu Ala Glu Gln Lys Glu Ala Glu Phe Gln Gln Met Ile 
        435                 440                 445             


Glu Gln Leu Lys Lys Gln Gln Glu Ala Ala Gln Gln Ala Ala Thr Ala 
    450                 455                 460                 


Thr Ala Ser Glu His Ser Arg Glu Pro Ser Ala Ala Gly Arg Leu Ser 
465                 470                 475                 480 


Asp Ser Ser Ser Glu Ala Ser Lys Leu Ser Ser Lys Ser Ala Lys Glu 
                485                 490                 495     


Arg Arg Asn Arg Arg Lys Lys Arg Lys Gln Lys Glu Gln Ser Gly Gly 
            500                 505                 510         


Glu Glu Lys Asp Glu Asp Glu Phe Gln Lys Ser Glu Ser Glu Asp Ser 
        515                 520                 525             


Ile Arg Arg Lys Gly Phe Arg Phe Ser Ile Glu Gly Asn Arg Leu Thr 
    530                 535                 540                 


Tyr Glu Lys Arg Tyr Ser Ser Pro His Gln Ser Leu Leu Ser Ile Arg 
545                 550                 555                 560 


Gly Ser Leu Phe Ser Pro Arg Arg Asn Ser Arg Thr Ser Leu Phe Ser 
                565                 570                 575     


Phe Arg Gly Arg Ala Lys Asp Val Gly Ser Glu Asn Asp Phe Ala Asp 
            580                 585                 590         


Asp Glu His Ser Thr Phe Glu Asp Asn Glu Ser Arg Arg Asp Ser Leu 
        595                 600                 605             


Phe Val Pro Arg Arg His Gly Glu Arg Arg Asn Ser Asn Leu Ser Gln 
    610                 615                 620                 


Thr Ser Arg Ser Ser Arg Met Leu Ala Val Phe Pro Ala Asn Gly Lys 
625                 630                 635                 640 


Met His Ser Thr Val Asp Cys Asn Gly Val Val Ser Leu Val Gly Gly 
                645                 650                 655     


Pro Ser Val Pro Thr Ser Pro Val Gly Gln Leu Leu Pro Glu Val Ile 
            660                 665                 670         


Ile Asp Lys Pro Ala Thr Asp Asp Asn Gly Thr Thr Thr Glu Thr Glu 
        675                 680                 685             


Met Arg Lys Arg Arg Ser Ser Ser Phe His Val Ser Met Asp Phe Leu 
    690                 695                 700                 


Glu Asp Pro Ser Gln Arg Gln Arg Ala Met Ser Ile Ala Ser Ile Leu 
705                 710                 715                 720 


Thr Asn Thr Val Glu Glu Leu Glu Glu Ser Arg Gln Lys Cys Pro Pro 
                725                 730                 735     


Cys Trp Tyr Lys Phe Ser Asn Ile Phe Leu Ile Trp Asp Cys Ser Pro 
            740                 745                 750         


Tyr Trp Leu Lys Val Lys His Val Val Asn Leu Val Val Met Asp Pro 
        755                 760                 765             


Phe Val Asp Leu Ala Ile Thr Ile Cys Ile Val Leu Asn Thr Leu Phe 
    770                 775                 780                 


Met Ala Met Glu His Tyr Pro Met Thr Asp His Phe Asn Asn Val Leu 
785                 790                 795                 800 


Thr Val Gly Asn Leu Val Phe Thr Gly Ile Phe Thr Ala Glu Met Phe 
                805                 810                 815     


Leu Lys Ile Ile Ala Met Asp Pro Tyr Tyr Tyr Phe Gln Glu Gly Trp 
            820                 825                 830         


Asn Ile Phe Asp Gly Phe Ile Val Thr Leu Ser Leu Val Glu Leu Gly 
        835                 840                 845             


Leu Ala Asn Val Glu Gly Leu Ser Val Leu Arg Ser Phe Arg Leu Leu 
    850                 855                 860                 


Arg Val Phe Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Met Leu Ile 
865                 870                 875                 880 


Lys Ile Ile Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr Leu Val 
                885                 890                 895     


Leu Ala Ile Ile Val Phe Ile Phe Ala Val Val Gly Met Gln Leu Phe 
            900                 905                 910         


Gly Lys Ser Tyr Lys Asp Cys Val Cys Lys Ile Ala Ser Asp Cys Gln 
        915                 920                 925             


Leu Pro Arg Trp His Met Asn Asp Phe Phe His Ser Phe Leu Ile Val 
    930                 935                 940                 


Phe Arg Val Leu Cys Gly Glu Trp Ile Glu Thr Met Trp Asp Cys Met 
945                 950                 955                 960 


Glu Val Ala Gly Gln Ala Met Cys Leu Thr Val Phe Met Met Val Met 
                965                 970                 975     


Val Ile Gly Asn Leu Val Val Leu Asn Leu Phe Leu Ala Leu Leu Leu 
            980                 985                 990         


Ser Ser Phe Ser Ala Asp Asn Leu  Ala Ala Thr Asp Asp  Asp Asn Glu 
        995                 1000                 1005             


Met Asn  Asn Leu Gln Ile Ala  Val Asp Arg Met His  Lys Gly Val 
    1010                 1015                 1020             


Ala Tyr  Val Lys Arg Lys Ile  Tyr Glu Phe Ile Gln  Gln Ser Phe 
    1025                 1030                 1035             


Ile Arg  Lys Gln Lys Ile Leu  Asp Glu Ile Lys Pro  Leu Asp Asp 
    1040                 1045                 1050             


Leu Asn  Asn Lys Lys Asp Ser  Cys Met Ser Asn His  Thr Thr Glu 
    1055                 1060                 1065             


Ile Gly  Lys Asp Leu Asp Tyr  Leu Lys Asp Val Asn  Gly Thr Thr 
    1070                 1075                 1080             


Ser Gly  Ile Gly Thr Gly Ser  Ser Val Glu Lys Tyr  Ile Ile Asp 
    1085                 1090                 1095             


Glu Ser  Asp Tyr Met Ser Phe  Ile Asn Asn Pro Ser  Leu Thr Val 
    1100                 1105                 1110             


Thr Val  Pro Ile Ala Val Gly  Glu Ser Asp Phe Glu  Asn Leu Asn 
    1115                 1120                 1125             


Thr Glu  Asp Phe Ser Ser Glu  Ser Asp Leu Glu Glu  Ser Lys Glu 
    1130                 1135                 1140             


Lys Leu  Asn Glu Ser Ser Ser  Ser Ser Glu Gly Ser  Thr Val Asp 
    1145                 1150                 1155             


Ile Gly  Ala Pro Val Glu Glu  Gln Pro Val Val Glu  Pro Glu Glu 
    1160                 1165                 1170             


Thr Leu  Glu Pro Glu Ala Cys  Phe Thr Glu Gly Cys  Val Gln Arg 
    1175                 1180                 1185             


Phe Lys  Cys Cys Gln Ile Asn  Val Glu Glu Gly Arg  Gly Lys Gln 
    1190                 1195                 1200             


Trp Trp  Asn Leu Arg Arg Thr  Cys Phe Arg Ile Val  Glu His Asn 
    1205                 1210                 1215             


Trp Phe  Glu Thr Phe Ile Val  Phe Met Ile Leu Leu  Ser Ser Gly 
    1220                 1225                 1230             


Ala Leu  Ala Phe Glu Asp Ile  Tyr Ile Asp Gln Arg  Lys Thr Ile 
    1235                 1240                 1245             


Lys Thr  Met Leu Glu Tyr Ala  Asp Lys Val Phe Thr  Tyr Ile Phe 
    1250                 1255                 1260             


Ile Leu  Glu Met Leu Leu Lys  Trp Val Ala Tyr Gly  Tyr Gln Thr 
    1265                 1270                 1275             


Tyr Phe  Thr Asn Ala Trp Cys  Trp Leu Asp Phe Leu  Ile Val Asp 
    1280                 1285                 1290             


Val Ser  Leu Val Ser Leu Thr  Ala Asn Ala Leu Gly  Tyr Ser Glu 
    1295                 1300                 1305             


Leu Gly  Ala Ile Lys Ser Leu  Arg Thr Leu Arg Ala  Leu Arg Pro 
    1310                 1315                 1320             


Leu Arg  Ala Leu Ser Arg Phe  Glu Gly Met Arg Val  Val Val Asn 
    1325                 1330                 1335             


Ala Leu  Leu Gly Ala Ile Pro  Ser Ile Met Asn Val  Leu Leu Val 
    1340                 1345                 1350             


Cys Leu  Ile Phe Trp Leu Ile  Phe Ser Ile Met Gly  Val Asn Leu 
    1355                 1360                 1365             


Phe Ala  Gly Lys Phe Tyr His  Cys Ile Asn Thr Thr  Thr Gly Asp 
    1370                 1375                 1380             


Arg Phe  Asp Ile Glu Asp Val  Asn Asn His Thr Asp  Cys Leu Lys 
    1385                 1390                 1395             


Leu Ile  Glu Arg Asn Glu Thr  Ala Arg Trp Lys Asn  Val Lys Val 
    1400                 1405                 1410             


Asn Phe  Asp Asn Val Gly Phe  Gly Tyr Leu Ser Leu  Leu Gln Val 
    1415                 1420                 1425             


Ala Thr  Phe Lys Gly Trp Met  Asp Ile Met Tyr Ala  Ala Val Asp 
    1430                 1435                 1440             


Ser Arg  Asn Val Glu Leu Gln  Pro Lys Tyr Glu Lys  Ser Leu Tyr 
    1445                 1450                 1455             


Met Tyr  Leu Tyr Phe Val Ile  Phe Ile Ile Phe Gly  Ser Phe Phe 
    1460                 1465                 1470             


Thr Leu  Asn Leu Phe Ile Gly  Val Ile Ile Asp Asn  Phe Asn Gln 
    1475                 1480                 1485             


Gln Lys  Lys Lys Phe Gly Gly  Gln Asp Ile Phe Met  Thr Glu Glu 
    1490                 1495                 1500             


Gln Lys  Lys Tyr Tyr Asn Ala  Met Lys Lys Leu Gly  Ser Lys Lys 
    1505                 1510                 1515             


Pro Gln  Lys Pro Ile Pro Arg  Pro Gly Asn Lys Phe  Gln Gly Met 
    1520                 1525                 1530             


Val Phe  Asp Phe Val Thr Arg  Gln Val Phe Asp Ile  Ser Ile Met 
    1535                 1540                 1545             


Ile Leu  Ile Cys Leu Asn Met  Val Thr Met Met Val  Glu Thr Asp 
    1550                 1555                 1560             


Asp Gln  Ser Glu Tyr Val Thr  Thr Ile Leu Ser Arg  Ile Asn Leu 
    1565                 1570                 1575             


Val Phe  Ile Val Leu Phe Thr  Gly Glu Cys Val Leu  Lys Leu Ile 
    1580                 1585                 1590             


Ser Leu  Arg His Tyr Tyr Phe  Thr Ile Gly Trp Asn  Ile Phe Asp 
    1595                 1600                 1605             


Phe Val  Val Val Ile Leu Ser  Ile Val Gly Met Phe  Leu Ala Glu 
    1610                 1615                 1620             


Leu Ile  Glu Lys Tyr Phe Val  Ser Pro Thr Leu Phe  Arg Val Ile 
    1625                 1630                 1635             


Arg Leu  Ala Arg Ile Gly Arg  Ile Leu Arg Leu Ile  Lys Gly Ala 
    1640                 1645                 1650             


Lys Gly  Ile Arg Thr Leu Leu  Phe Ala Leu Met Met  Ser Leu Pro 
    1655                 1660                 1665             


Ala Leu  Phe Asn Ile Gly Leu  Leu Leu Phe Leu Val  Met Phe Ile 
    1670                 1675                 1680             


Tyr Ala  Ile Phe Gly Met Ser  Asn Phe Ala Tyr Val  Lys Arg Glu 
    1685                 1690                 1695             


Val Gly  Ile Asp Asp Met Phe  Asn Phe Glu Thr Phe  Gly Asn Ser 
    1700                 1705                 1710             


Met Ile  Cys Leu Phe Gln Ile  Thr Thr Ser Ala Gly  Trp Asp Gly 
    1715                 1720                 1725             


Leu Leu  Ala Pro Ile Leu Asn  Ser Lys Pro Pro Asp  Cys Asp Pro 
    1730                 1735                 1740             


Asn Lys  Val Asn Pro Gly Ser  Ser Val Lys Gly Asp  Cys Gly Asn 
    1745                 1750                 1755             


Pro Ser  Val Gly Ile Phe Phe  Phe Val Ser Tyr Ile  Ile Ile Ser 
    1760                 1765                 1770             


Phe Leu  Val Val Val Asn Met  Tyr Ile Ala Val Ile  Leu Glu Asn 
    1775                 1780                 1785             


Phe Ser  Val Ala Thr Glu Glu  Ser Ala Glu Pro Leu  Ser Glu Asp 
    1790                 1795                 1800             


Asp Phe  Glu Met Phe Tyr Glu  Val Trp Glu Lys Phe  Asp Pro Asp 
    1805                 1810                 1815             


Ala Thr  Gln Phe Met Glu Phe  Glu Lys Leu Ser Gln  Phe Ala Ala 
    1820                 1825                 1830             


Ala Leu  Glu Pro Pro Leu Asn  Leu Pro Gln Pro Asn  Lys Leu Gln 
    1835                 1840                 1845             


Leu Ile  Ala Met Asp Leu Pro  Met Val Ser Gly Asp  Arg Ile His 
    1850                 1855                 1860             


Cys Leu  Asp Ile Leu Phe Ala  Phe Thr Lys Arg Val  Leu Gly Glu 
    1865                 1870                 1875             


Ser Gly  Glu Met Asp Ala Leu  Arg Ile Gln Met Glu  Glu Arg Phe 
    1880                 1885                 1890             


Met Ala  Ser Asn Pro Ser Lys  Val Ser Tyr Gln Pro  Ile Thr Thr 
    1895                 1900                 1905             


Thr Leu  Lys Arg Lys Gln Glu  Glu Val Ser Ala Val  Ile Ile Gln 
    1910                 1915                 1920             


Arg Ala  Tyr Arg Arg His Leu  Leu Lys Arg Thr Val  Lys Gln Ala 
    1925                 1930                 1935             


Ser Phe  Thr Tyr Asn Lys Asn  Lys Ile Lys Gly Gly  Ala Asn Leu 
    1940                 1945                 1950             


Leu Ile  Lys Glu Asp Met Ile  Ile Asp Arg Ile Asn  Glu Asn Ser 
    1955                 1960                 1965             


Ile Thr  Glu Lys Thr Asp Leu  Thr Met Ser Thr Ala  Ala Cys Pro 
    1970                 1975                 1980             


Pro Ser  Tyr Asp Arg Val Thr  Lys Pro Ile Val Glu  Lys His Glu 
    1985                 1990                 1995             


Gln Glu  Gly Lys Asp Glu Lys  Ala Lys Gly Lys 
    2000                 2005                 


<210>  55
<211>  2009
<212>  PRT
<213>  Homo sapiens

<400>  55

Met Glu Gln Thr Val Leu Val Pro Pro Gly Pro Asp Ser Phe Asn Phe 
1               5                   10                  15      


Phe Thr Arg Glu Ser Leu Ala Ala Ile Glu Arg Arg Ile Ala Glu Glu 
            20                  25                  30          


Lys Ala Lys Asn Pro Lys Pro Asp Lys Lys Asp Asp Asp Glu Asn Gly 
        35                  40                  45              


Pro Lys Pro Asn Ser Asp Leu Glu Ala Gly Lys Asn Leu Pro Phe Ile 
    50                  55                  60                  


Tyr Gly Asp Ile Pro Pro Glu Met Val Ser Glu Pro Leu Glu Asp Leu 
65                  70                  75                  80  


Asp Pro Tyr Tyr Ile Asn Lys Lys Thr Phe Ile Val Leu Asn Lys Leu 
                85                  90                  95      


Lys Ala Ile Phe Arg Phe Ser Ala Thr Ser Ala Leu Tyr Ile Leu Thr 
            100                 105                 110         


Pro Phe Asn Pro Leu Arg Lys Ile Ala Ile Lys Ile Leu Val His Ser 
        115                 120                 125             


Leu Phe Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Val Phe 
    130                 135                 140                 


Met Thr Met Ser Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr Thr 
145                 150                 155                 160 


Phe Thr Gly Ile Tyr Thr Phe Glu Ser Leu Ile Lys Ile Ile Ala Arg 
                165                 170                 175     


Gly Phe Cys Leu Glu Asp Phe Thr Phe Leu Arg Asp Pro Trp Asn Trp 
            180                 185                 190         


Leu Asp Phe Thr Val Ile Thr Phe Ala Tyr Val Thr Glu Phe Val Asp 
        195                 200                 205             


Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala Leu 
    210                 215                 220                 


Lys Thr Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu 
225                 230                 235                 240 


Ile Gln Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val Phe 
                245                 250                 255     


Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly Asn 
            260                 265                 270         


Leu Arg Asn Lys Cys Ile Gln Trp Pro Pro Thr Asn Ala Ser Leu Glu 
        275                 280                 285             


Glu His Ser Ile Glu Lys Asn Ile Thr Val Asn Tyr Asn Gly Thr Leu 
    290                 295                 300                 


Ile Asn Glu Thr Val Phe Glu Phe Asp Trp Lys Ser Tyr Ile Gln Asp 
305                 310                 315                 320 


Ser Arg Tyr His Tyr Phe Leu Glu Gly Phe Leu Asp Ala Leu Leu Cys 
                325                 330                 335     


Gly Asn Ser Ser Asp Ala Gly Gln Cys Pro Glu Gly Tyr Met Cys Val 
            340                 345                 350         


Lys Ala Gly Arg Asn Pro Asn Tyr Gly Tyr Thr Ser Phe Asp Thr Phe 
        355                 360                 365             


Ser Trp Ala Phe Leu Ser Leu Phe Arg Leu Met Thr Gln Asp Phe Trp 
    370                 375                 380                 


Glu Asn Leu Tyr Gln Leu Thr Leu Arg Ala Ala Gly Lys Thr Tyr Met 
385                 390                 395                 400 


Ile Phe Phe Val Leu Val Ile Phe Leu Gly Ser Phe Tyr Leu Ile Asn 
                405                 410                 415     


Leu Ile Leu Ala Val Val Ala Met Ala Tyr Glu Glu Gln Asn Gln Ala 
            420                 425                 430         


Thr Leu Glu Glu Ala Glu Gln Lys Glu Ala Glu Phe Gln Gln Met Ile 
        435                 440                 445             


Glu Gln Leu Lys Lys Gln Gln Glu Ala Ala Gln Gln Ala Ala Thr Ala 
    450                 455                 460                 


Thr Ala Ser Glu His Ser Arg Glu Pro Ser Ala Ala Gly Arg Leu Ser 
465                 470                 475                 480 


Asp Ser Ser Ser Glu Ala Ser Lys Leu Ser Ser Lys Ser Ala Lys Glu 
                485                 490                 495     


Arg Arg Asn Arg Arg Lys Lys Arg Lys Gln Lys Glu Gln Ser Gly Gly 
            500                 505                 510         


Glu Glu Lys Asp Glu Asp Glu Phe Gln Lys Ser Glu Ser Glu Asp Ser 
        515                 520                 525             


Ile Arg Arg Lys Gly Phe Arg Phe Ser Ile Glu Gly Asn Arg Leu Thr 
    530                 535                 540                 


Tyr Glu Lys Arg Tyr Ser Ser Pro His Gln Ser Leu Leu Ser Ile Arg 
545                 550                 555                 560 


Gly Ser Leu Phe Ser Pro Arg Arg Asn Ser Arg Thr Ser Leu Phe Ser 
                565                 570                 575     


Phe Arg Gly Arg Ala Lys Asp Val Gly Ser Glu Asn Asp Phe Ala Asp 
            580                 585                 590         


Asp Glu His Ser Thr Phe Glu Asp Asn Glu Ser Arg Arg Asp Ser Leu 
        595                 600                 605             


Phe Val Pro Arg Arg His Gly Glu Arg Arg Asn Ser Asn Leu Ser Gln 
    610                 615                 620                 


Thr Ser Arg Ser Ser Arg Met Leu Ala Val Phe Pro Ala Asn Gly Lys 
625                 630                 635                 640 


Met His Ser Thr Val Asp Cys Asn Gly Val Val Ser Leu Val Gly Gly 
                645                 650                 655     


Pro Ser Val Pro Thr Ser Pro Val Gly Gln Leu Leu Pro Glu Val Ile 
            660                 665                 670         


Ile Asp Lys Pro Ala Thr Asp Asp Asn Gly Thr Thr Thr Glu Thr Glu 
        675                 680                 685             


Met Arg Lys Arg Arg Ser Ser Ser Phe His Val Ser Met Asp Phe Leu 
    690                 695                 700                 


Glu Asp Pro Ser Gln Arg Gln Arg Ala Met Ser Ile Ala Ser Ile Leu 
705                 710                 715                 720 


Thr Asn Thr Val Glu Glu Leu Glu Glu Ser Arg Gln Lys Cys Pro Pro 
                725                 730                 735     


Cys Trp Tyr Lys Phe Ser Asn Ile Phe Leu Ile Trp Asp Cys Ser Pro 
            740                 745                 750         


Tyr Trp Leu Lys Val Lys His Val Val Asn Leu Val Val Met Asp Pro 
        755                 760                 765             


Phe Val Asp Leu Ala Ile Thr Ile Cys Ile Val Leu Asn Thr Leu Phe 
    770                 775                 780                 


Met Ala Met Glu His Tyr Pro Met Thr Asp His Phe Asn Asn Val Leu 
785                 790                 795                 800 


Thr Val Gly Asn Leu Val Phe Thr Gly Ile Phe Thr Ala Glu Met Phe 
                805                 810                 815     


Leu Lys Ile Ile Ala Met Asp Pro Tyr Tyr Tyr Phe Gln Glu Gly Trp 
            820                 825                 830         


Asn Ile Phe Asp Gly Phe Ile Val Thr Leu Ser Leu Val Glu Leu Gly 
        835                 840                 845             


Leu Ala Asn Val Glu Gly Leu Ser Val Leu Arg Ser Phe Arg Leu Leu 
    850                 855                 860                 


Arg Val Phe Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Met Leu Ile 
865                 870                 875                 880 


Lys Ile Ile Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr Leu Val 
                885                 890                 895     


Leu Ala Ile Ile Val Phe Ile Phe Ala Val Val Gly Met Gln Leu Phe 
            900                 905                 910         


Gly Lys Ser Tyr Lys Asp Cys Val Cys Lys Ile Ala Ser Asp Cys Gln 
        915                 920                 925             


Leu Pro Arg Trp His Met Asn Asp Phe Phe His Ser Phe Leu Ile Val 
    930                 935                 940                 


Phe Arg Val Leu Cys Gly Glu Trp Ile Glu Thr Met Trp Asp Cys Met 
945                 950                 955                 960 


Glu Val Ala Gly Gln Ala Met Cys Leu Thr Val Phe Met Met Val Met 
                965                 970                 975     


Val Ile Gly Asn Leu Val Val Leu Asn Leu Phe Leu Ala Leu Leu Leu 
            980                 985                 990         


Ser Ser Phe Ser Ala Asp Asn Leu  Ala Ala Thr Asp Asp  Asp Asn Glu 
        995                 1000                 1005             


Met Asn  Asn Leu Gln Ile Ala  Val Asp Arg Met His  Lys Gly Val 
    1010                 1015                 1020             


Ala Tyr  Val Lys Arg Lys Ile  Tyr Glu Phe Ile Gln  Gln Ser Phe 
    1025                 1030                 1035             


Ile Arg  Lys Gln Lys Ile Leu  Asp Glu Ile Lys Pro  Leu Asp Asp 
    1040                 1045                 1050             


Leu Asn  Asn Lys Lys Asp Ser  Cys Met Ser Asn His  Thr Thr Glu 
    1055                 1060                 1065             


Ile Gly  Lys Asp Leu Asp Tyr  Leu Lys Asp Val Asn  Gly Thr Thr 
    1070                 1075                 1080             


Ser Gly  Ile Gly Thr Gly Ser  Ser Val Glu Lys Tyr  Ile Ile Asp 
    1085                 1090                 1095             


Glu Ser  Asp Tyr Met Ser Phe  Ile Asn Asn Pro Ser  Leu Thr Val 
    1100                 1105                 1110             


Thr Val  Pro Ile Ala Val Gly  Glu Ser Asp Phe Glu  Asn Leu Asn 
    1115                 1120                 1125             


Thr Glu  Asp Phe Ser Ser Glu  Ser Asp Leu Glu Glu  Ser Lys Glu 
    1130                 1135                 1140             


Lys Leu  Asn Glu Ser Ser Ser  Ser Ser Glu Gly Ser  Thr Val Asp 
    1145                 1150                 1155             


Ile Gly  Ala Pro Val Glu Glu  Gln Pro Val Val Glu  Pro Glu Glu 
    1160                 1165                 1170             


Thr Leu  Glu Pro Glu Ala Cys  Phe Thr Glu Gly Cys  Val Gln Arg 
    1175                 1180                 1185             


Phe Lys  Cys Cys Gln Ile Asn  Val Glu Glu Gly Arg  Gly Lys Gln 
    1190                 1195                 1200             


Trp Trp  Asn Leu Arg Arg Thr  Cys Phe Arg Ile Val  Glu His Asn 
    1205                 1210                 1215             


Trp Phe  Glu Thr Phe Ile Val  Phe Met Ile Leu Leu  Ser Ser Gly 
    1220                 1225                 1230             


Ala Leu  Ala Phe Glu Asp Ile  Tyr Ile Asp Gln Arg  Lys Thr Ile 
    1235                 1240                 1245             


Lys Thr  Met Leu Glu Tyr Ala  Asp Lys Val Phe Thr  Tyr Ile Phe 
    1250                 1255                 1260             


Ile Leu  Glu Met Leu Leu Lys  Trp Val Ala Tyr Gly  Tyr Gln Thr 
    1265                 1270                 1275             


Tyr Phe  Thr Asn Ala Trp Cys  Trp Leu Asp Phe Leu  Ile Val Asp 
    1280                 1285                 1290             


Val Ser  Leu Val Ser Leu Thr  Ala Asn Ala Leu Gly  Tyr Ser Glu 
    1295                 1300                 1305             


Leu Gly  Ala Ile Lys Ser Leu  Arg Thr Leu Arg Ala  Leu Arg Pro 
    1310                 1315                 1320             


Leu Arg  Ala Leu Ser Arg Phe  Glu Gly Met Arg Val  Val Val Asn 
    1325                 1330                 1335             


Ala Leu  Leu Gly Ala Ile Pro  Ser Ile Met Asn Val  Leu Leu Val 
    1340                 1345                 1350             


Cys Leu  Ile Phe Trp Leu Ile  Phe Ser Ile Met Gly  Val Asn Leu 
    1355                 1360                 1365             


Phe Ala  Gly Lys Phe Tyr His  Cys Ile Asn Thr Thr  Thr Gly Asp 
    1370                 1375                 1380             


Arg Phe  Asp Ile Glu Asp Val  Asn Asn His Thr Asp  Cys Leu Lys 
    1385                 1390                 1395             


Leu Ile  Glu Arg Asn Glu Thr  Ala Arg Trp Lys Asn  Val Lys Val 
    1400                 1405                 1410             


Asn Phe  Asp Asn Val Gly Phe  Gly Tyr Leu Ser Leu  Leu Gln Val 
    1415                 1420                 1425             


Ala Thr  Phe Lys Gly Trp Met  Asp Ile Met Tyr Ala  Ala Val Asp 
    1430                 1435                 1440             


Ser Arg  Asn Val Glu Leu Gln  Pro Lys Tyr Glu Lys  Ser Leu Tyr 
    1445                 1450                 1455             


Met Tyr  Leu Tyr Phe Val Ile  Phe Ile Ile Phe Gly  Ser Phe Phe 
    1460                 1465                 1470             


Thr Leu  Asn Leu Phe Ile Val  Val Ile Ile Asp Asn  Phe Asn Gln 
    1475                 1480                 1485             


Gln Lys  Lys Lys Phe Gly Gly  Gln Asp Ile Phe Met  Thr Glu Glu 
    1490                 1495                 1500             


Gln Lys  Lys Tyr Tyr Asn Ala  Met Lys Lys Leu Gly  Ser Lys Lys 
    1505                 1510                 1515             


Pro Gln  Lys Pro Ile Pro Arg  Pro Gly Asn Lys Phe  Gln Gly Met 
    1520                 1525                 1530             


Val Phe  Asp Phe Val Thr Arg  Gln Val Phe Asp Ile  Ser Ile Met 
    1535                 1540                 1545             


Ile Leu  Ile Cys Leu Asn Met  Val Thr Met Met Val  Glu Thr Asp 
    1550                 1555                 1560             


Asp Gln  Ser Glu Tyr Val Thr  Thr Ile Leu Ser Arg  Ile Asn Leu 
    1565                 1570                 1575             


Val Phe  Ile Val Leu Phe Thr  Gly Glu Cys Val Leu  Lys Leu Ile 
    1580                 1585                 1590             


Ser Leu  Arg His Tyr Tyr Phe  Thr Ile Gly Trp Asn  Ile Phe Asp 
    1595                 1600                 1605             


Phe Val  Val Val Ile Leu Ser  Ile Val Gly Met Phe  Leu Ala Glu 
    1610                 1615                 1620             


Leu Ile  Glu Lys Tyr Phe Val  Ser Pro Thr Leu Phe  Arg Val Ile 
    1625                 1630                 1635             


Arg Leu  Ala Arg Ile Gly Arg  Ile Leu Arg Leu Ile  Lys Gly Ala 
    1640                 1645                 1650             


Lys Gly  Ile Arg Thr Leu Leu  Phe Ala Leu Met Met  Ser Leu Pro 
    1655                 1660                 1665             


Ala Leu  Phe Asn Ile Gly Leu  Leu Leu Phe Leu Val  Met Phe Ile 
    1670                 1675                 1680             


Tyr Ala  Ile Phe Gly Met Ser  Asn Phe Ala Tyr Val  Lys Arg Glu 
    1685                 1690                 1695             


Val Gly  Ile Asp Asp Met Phe  Asn Phe Glu Thr Phe  Gly Asn Ser 
    1700                 1705                 1710             


Met Ile  Cys Leu Phe Gln Ile  Thr Thr Ser Ala Gly  Trp Asp Gly 
    1715                 1720                 1725             


Leu Leu  Ala Pro Ile Leu Asn  Ser Lys Pro Pro Asp  Cys Asp Pro 
    1730                 1735                 1740             


Asn Lys  Val Asn Pro Gly Ser  Ser Val Lys Gly Asp  Cys Gly Asn 
    1745                 1750                 1755             


Pro Ser  Val Gly Ile Phe Phe  Phe Val Ser Tyr Ile  Ile Ile Ser 
    1760                 1765                 1770             


Phe Leu  Val Val Val Asn Met  Tyr Ile Ala Val Ile  Leu Glu Asn 
    1775                 1780                 1785             


Phe Ser  Val Ala Thr Glu Glu  Ser Ala Glu Pro Leu  Ser Glu Asp 
    1790                 1795                 1800             


Asp Phe  Glu Met Phe Tyr Glu  Val Trp Glu Lys Phe  Asp Pro Asp 
    1805                 1810                 1815             


Ala Thr  Gln Phe Met Glu Phe  Glu Lys Leu Ser Gln  Phe Ala Ala 
    1820                 1825                 1830             


Ala Leu  Glu Pro Pro Leu Asn  Leu Pro Gln Pro Asn  Lys Leu Gln 
    1835                 1840                 1845             


Leu Ile  Ala Met Asp Leu Pro  Met Val Ser Gly Asp  Arg Ile His 
    1850                 1855                 1860             


Cys Leu  Asp Ile Leu Phe Ala  Phe Thr Lys Arg Val  Leu Gly Glu 
    1865                 1870                 1875             


Ser Gly  Glu Met Asp Ala Leu  Arg Ile Gln Met Glu  Glu Arg Phe 
    1880                 1885                 1890             


Met Ala  Ser Asn Pro Ser Lys  Val Ser Tyr Gln Pro  Ile Thr Thr 
    1895                 1900                 1905             


Thr Leu  Lys Arg Lys Gln Glu  Glu Val Ser Ala Val  Ile Ile Gln 
    1910                 1915                 1920             


Arg Ala  Tyr Arg Arg His Leu  Leu Lys Arg Thr Val  Lys Gln Ala 
    1925                 1930                 1935             


Ser Phe  Thr Tyr Asn Lys Asn  Lys Ile Lys Gly Gly  Ala Asn Leu 
    1940                 1945                 1950             


Leu Ile  Lys Glu Asp Met Ile  Ile Asp Arg Ile Asn  Glu Asn Ser 
    1955                 1960                 1965             


Ile Thr  Glu Lys Thr Asp Leu  Thr Met Ser Thr Ala  Ala Cys Pro 
    1970                 1975                 1980             


Pro Ser  Tyr Asp Arg Val Thr  Lys Pro Ile Val Glu  Lys His Glu 
    1985                 1990                 1995             


Gln Glu  Gly Lys Asp Glu Lys  Ala Lys Gly Lys 
    2000                 2005                 


<210>  56
<211>  2009
<212>  PRT
<213>  Homo sapiens

<400>  56

Met Glu Gln Thr Val Leu Val Pro Pro Gly Pro Asp Ser Phe Asn Phe 
1               5                   10                  15      


Phe Thr Arg Glu Ser Leu Ala Ala Ile Glu Arg Arg Ile Ala Glu Glu 
            20                  25                  30          


Lys Ala Lys Asn Pro Lys Pro Asp Lys Lys Asp Asp Asp Glu Asn Gly 
        35                  40                  45              


Pro Lys Pro Asn Ser Asp Leu Glu Ala Gly Lys Asn Leu Pro Phe Ile 
    50                  55                  60                  


Tyr Gly Asp Ile Pro Pro Glu Met Val Ser Glu Pro Leu Glu Asp Leu 
65                  70                  75                  80  


Asp Pro Tyr Tyr Ile Asn Lys Lys Thr Phe Ile Val Leu Asn Lys Leu 
                85                  90                  95      


Lys Ala Ile Phe Arg Phe Ser Ala Thr Ser Ala Leu Tyr Ile Leu Thr 
            100                 105                 110         


Pro Phe Asn Pro Leu Arg Lys Ile Ala Ile Lys Ile Leu Val His Ser 
        115                 120                 125             


Leu Phe Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Val Phe 
    130                 135                 140                 


Met Thr Met Ser Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr Thr 
145                 150                 155                 160 


Phe Thr Gly Ile Tyr Thr Phe Glu Ser Leu Ile Lys Ile Ile Ala Arg 
                165                 170                 175     


Gly Phe Cys Leu Glu Asp Phe Thr Phe Leu Arg Asp Pro Trp Asn Trp 
            180                 185                 190         


Leu Asp Phe Thr Val Ile Thr Phe Ala Tyr Val Thr Glu Phe Val Asp 
        195                 200                 205             


Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala Leu 
    210                 215                 220                 


Lys Thr Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu 
225                 230                 235                 240 


Ile Gln Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val Phe 
                245                 250                 255     


Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly Asn 
            260                 265                 270         


Leu Arg Asn Lys Cys Ile Gln Trp Pro Pro Thr Asn Ala Ser Leu Glu 
        275                 280                 285             


Glu His Ser Ile Glu Lys Asn Ile Thr Val Asn Tyr Asn Gly Thr Leu 
    290                 295                 300                 


Ile Asn Glu Thr Val Phe Glu Phe Asp Trp Lys Ser Tyr Ile Gln Asp 
305                 310                 315                 320 


Ser Arg Tyr His Tyr Phe Leu Glu Gly Phe Leu Asp Ala Leu Leu Cys 
                325                 330                 335     


Gly Asn Ser Ser Asp Ala Gly Gln Cys Pro Glu Gly Tyr Met Cys Val 
            340                 345                 350         


Lys Ala Gly Arg Asn Pro Asn Tyr Gly Tyr Thr Ser Phe Asp Thr Phe 
        355                 360                 365             


Ser Trp Ala Phe Leu Ser Leu Phe Arg Leu Met Thr Gln Asp Phe Trp 
    370                 375                 380                 


Glu Asn Leu Tyr Gln Leu Thr Leu Arg Ala Ala Gly Lys Thr Tyr Met 
385                 390                 395                 400 


Ile Phe Phe Val Leu Val Ile Phe Leu Gly Ser Phe Tyr Leu Ile Asn 
                405                 410                 415     


Leu Ile Leu Ala Val Val Ala Met Ala Tyr Glu Glu Gln Asn Gln Ala 
            420                 425                 430         


Thr Leu Glu Glu Ala Glu Gln Lys Glu Ala Glu Phe Gln Gln Met Ile 
        435                 440                 445             


Glu Gln Leu Lys Lys Gln Gln Glu Ala Ala Gln Gln Ala Ala Thr Ala 
    450                 455                 460                 


Thr Ala Ser Glu His Ser Arg Glu Pro Ser Ala Ala Gly Arg Leu Ser 
465                 470                 475                 480 


Asp Ser Ser Ser Glu Ala Ser Lys Leu Ser Ser Lys Ser Ala Lys Glu 
                485                 490                 495     


Arg Arg Asn Arg Arg Lys Lys Arg Lys Gln Lys Glu Gln Ser Gly Gly 
            500                 505                 510         


Glu Glu Lys Asp Glu Asp Glu Phe Gln Lys Ser Glu Ser Glu Asp Ser 
        515                 520                 525             


Ile Arg Arg Lys Gly Phe Arg Phe Ser Ile Glu Gly Asn Arg Leu Thr 
    530                 535                 540                 


Tyr Glu Lys Arg Tyr Ser Ser Pro His Gln Ser Leu Leu Ser Ile Arg 
545                 550                 555                 560 


Gly Ser Leu Phe Ser Pro Arg Arg Asn Ser Arg Thr Ser Leu Phe Ser 
                565                 570                 575     


Phe Arg Gly Arg Ala Lys Asp Val Gly Ser Glu Asn Asp Phe Ala Asp 
            580                 585                 590         


Asp Glu His Ser Thr Phe Glu Asp Asn Glu Ser Arg Arg Asp Ser Leu 
        595                 600                 605             


Phe Val Pro Arg Arg His Gly Glu Arg Arg Asn Ser Asn Leu Ser Gln 
    610                 615                 620                 


Thr Ser Arg Ser Ser Arg Met Leu Ala Val Phe Pro Ala Asn Gly Lys 
625                 630                 635                 640 


Met His Ser Thr Val Asp Cys Asn Gly Val Val Ser Leu Val Gly Gly 
                645                 650                 655     


Pro Ser Val Pro Thr Ser Pro Val Gly Gln Leu Leu Pro Glu Val Ile 
            660                 665                 670         


Ile Asp Lys Pro Ala Thr Asp Asp Asn Gly Thr Thr Thr Glu Thr Glu 
        675                 680                 685             


Met Arg Lys Arg Arg Ser Ser Ser Phe His Val Ser Met Asp Phe Leu 
    690                 695                 700                 


Glu Asp Pro Ser Gln Arg Gln Arg Ala Met Ser Ile Ala Ser Ile Leu 
705                 710                 715                 720 


Thr Asn Thr Val Glu Glu Leu Glu Glu Ser Arg Gln Lys Cys Pro Pro 
                725                 730                 735     


Cys Trp Tyr Lys Phe Ser Asn Ile Phe Leu Ile Trp Asp Cys Ser Pro 
            740                 745                 750         


Tyr Trp Leu Lys Val Lys His Val Val Asn Leu Val Val Met Asp Pro 
        755                 760                 765             


Phe Val Asp Leu Ala Ile Thr Ile Cys Ile Val Leu Asn Thr Leu Phe 
    770                 775                 780                 


Met Ala Met Glu His Tyr Pro Met Thr Asp His Phe Asn Asn Val Leu 
785                 790                 795                 800 


Thr Val Gly Asn Leu Val Phe Thr Gly Ile Phe Thr Ala Glu Met Phe 
                805                 810                 815     


Leu Lys Ile Ile Ala Met Asp Pro Tyr Tyr Tyr Phe Gln Glu Gly Trp 
            820                 825                 830         


Asn Ile Phe Asp Gly Phe Ile Val Thr Leu Ser Leu Val Glu Leu Gly 
        835                 840                 845             


Leu Ala Asn Val Glu Gly Leu Ser Val Leu Arg Ser Phe Arg Leu Leu 
    850                 855                 860                 


Arg Val Phe Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Met Leu Ile 
865                 870                 875                 880 


Lys Ile Ile Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr Leu Val 
                885                 890                 895     


Leu Ala Ile Ile Val Phe Ile Phe Ala Val Val Gly Met Gln Leu Phe 
            900                 905                 910         


Gly Lys Ser Tyr Lys Asp Cys Val Cys Lys Ile Ala Ser Asp Cys Gln 
        915                 920                 925             


Leu Pro Arg Trp His Met Asn Asp Phe Phe His Ser Phe Leu Ile Val 
    930                 935                 940                 


Phe Arg Val Leu Cys Gly Glu Trp Ile Glu Thr Met Trp Asp Cys Met 
945                 950                 955                 960 


Glu Val Ala Gly Gln Ala Met Cys Leu Thr Val Phe Met Met Val Met 
                965                 970                 975     


Val Ile Gly Asn Leu Val Val Leu Asn Leu Phe Leu Ala Leu Leu Leu 
            980                 985                 990         


Ser Ser Phe Ser Ala Asp Asn Leu  Ala Ala Thr Asp Asp  Asp Asn Glu 
        995                 1000                 1005             


Met Asn  Asn Leu Gln Ile Ala  Val Asp Arg Met His  Lys Gly Val 
    1010                 1015                 1020             


Ala Tyr  Val Lys Arg Lys Ile  Tyr Glu Phe Ile Gln  Gln Ser Phe 
    1025                 1030                 1035             


Ile Arg  Lys Gln Lys Ile Leu  Asp Glu Ile Lys Pro  Leu Asp Asp 
    1040                 1045                 1050             


Leu Asn  Asn Lys Lys Asp Ser  Cys Met Ser Asn His  Thr Thr Glu 
    1055                 1060                 1065             


Ile Gly  Lys Asp Leu Asp Tyr  Leu Lys Asp Val Asn  Gly Thr Thr 
    1070                 1075                 1080             


Ser Gly  Ile Gly Thr Gly Ser  Ser Val Glu Lys Tyr  Ile Ile Asp 
    1085                 1090                 1095             


Glu Ser  Asp Tyr Met Ser Phe  Ile Asn Asn Pro Ser  Leu Thr Val 
    1100                 1105                 1110             


Thr Val  Pro Ile Ala Val Gly  Glu Ser Asp Phe Glu  Asn Leu Asn 
    1115                 1120                 1125             


Thr Glu  Asp Phe Ser Ser Glu  Ser Asp Leu Glu Glu  Ser Lys Glu 
    1130                 1135                 1140             


Lys Leu  Asn Glu Ser Ser Ser  Ser Ser Glu Gly Ser  Thr Val Asp 
    1145                 1150                 1155             


Ile Gly  Ala Pro Val Glu Glu  Gln Pro Val Val Glu  Pro Glu Glu 
    1160                 1165                 1170             


Thr Leu  Glu Pro Glu Ala Cys  Phe Thr Glu Gly Cys  Val Gln Arg 
    1175                 1180                 1185             


Phe Lys  Cys Cys Gln Ile Asn  Val Glu Glu Gly Arg  Gly Lys Gln 
    1190                 1195                 1200             


Trp Trp  Asn Leu Arg Arg Thr  Cys Phe Arg Ile Val  Glu His Asn 
    1205                 1210                 1215             


Trp Phe  Glu Thr Phe Ile Val  Phe Met Ile Leu Leu  Ser Ser Gly 
    1220                 1225                 1230             


Ala Leu  Ala Phe Glu Asp Ile  Tyr Ile Asp Gln Arg  Lys Thr Ile 
    1235                 1240                 1245             


Lys Thr  Met Leu Glu Tyr Ala  Asp Lys Val Phe Thr  Tyr Ile Phe 
    1250                 1255                 1260             


Ile Leu  Glu Met Leu Leu Lys  Trp Val Ala Tyr Gly  Tyr Gln Thr 
    1265                 1270                 1275             


Tyr Phe  Thr Asn Ala Trp Cys  Trp Leu Asp Phe Leu  Ile Val Asp 
    1280                 1285                 1290             


Val Ser  Leu Val Ser Leu Thr  Ala Asn Ala Leu Gly  Tyr Ser Glu 
    1295                 1300                 1305             


Leu Gly  Ala Ile Lys Ser Leu  Arg Thr Leu Arg Ala  Leu Arg Pro 
    1310                 1315                 1320             


Leu Arg  Ala Leu Ser Arg Phe  Glu Gly Met Arg Val  Val Val Asn 
    1325                 1330                 1335             


Ala Leu  Leu Gly Ala Ile Pro  Ser Ile Met Asn Val  Leu Leu Val 
    1340                 1345                 1350             


Cys Leu  Ile Phe Trp Leu Ile  Phe Ser Ile Met Gly  Val Asn Leu 
    1355                 1360                 1365             


Phe Ala  Gly Lys Phe Tyr His  Cys Ile Asn Thr Thr  Thr Gly Asp 
    1370                 1375                 1380             


Arg Phe  Asp Ile Glu Asp Val  Asn Asn His Thr Asp  Cys Leu Lys 
    1385                 1390                 1395             


Leu Ile  Glu Arg Asn Glu Thr  Ala Arg Trp Lys Asn  Val Lys Val 
    1400                 1405                 1410             


Asn Phe  Asp Asn Val Gly Phe  Gly Tyr Leu Ser Leu  Leu Gln Val 
    1415                 1420                 1425             


Ala Thr  Phe Lys Gly Trp Met  Asp Ile Met Tyr Ala  Ala Val Asp 
    1430                 1435                 1440             


Ser Arg  Asn Val Glu Leu Gln  Pro Lys Tyr Glu Lys  Ser Leu Tyr 
    1445                 1450                 1455             


Met Tyr  Leu Tyr Phe Val Ile  Phe Ile Ile Phe Gly  Ser Phe Phe 
    1460                 1465                 1470             


Thr Leu  Asn Leu Phe Ile Gly  Val Ile Ile Asp Asn  Phe Asn Gln 
    1475                 1480                 1485             


Gln Lys  Lys Lys Phe Gly Gly  Gln Asp Ile Phe Met  Thr Glu Glu 
    1490                 1495                 1500             


Gln Lys  Lys Tyr Tyr Asn Ala  Met Lys Lys Leu Gly  Ser Lys Lys 
    1505                 1510                 1515             


Pro Gln  Lys Pro Ile Pro Arg  Pro Gly Asn Lys Phe  Gln Gly Met 
    1520                 1525                 1530             


Val Phe  Asp Phe Val Thr Arg  Gln Val Phe Asp Ile  Ser Ile Met 
    1535                 1540                 1545             


Ile Leu  Ile Cys Leu Asn Met  Val Thr Met Met Val  Glu Thr Asp 
    1550                 1555                 1560             


Asp Gln  Ser Glu Tyr Val Thr  Thr Ile Leu Ser Arg  Ile Asn Leu 
    1565                 1570                 1575             


Val Phe  Ile Val Leu Phe Thr  Gly Glu Cys Val Leu  Lys Leu Ile 
    1580                 1585                 1590             


Ser Leu  Arg His Tyr Tyr Phe  Thr Ile Gly Trp Asn  Ile Phe Asp 
    1595                 1600                 1605             


Phe Val  Val Val Ile Leu Ser  Ile Val Gly Met Phe  Leu Ala Glu 
    1610                 1615                 1620             


Leu Ile  Glu Lys Tyr Phe Val  Ser Pro Thr Leu Phe  Gln Val Ile 
    1625                 1630                 1635             


Arg Leu  Ala Arg Ile Gly Arg  Ile Leu Arg Leu Ile  Lys Gly Ala 
    1640                 1645                 1650             


Lys Gly  Ile Arg Thr Leu Leu  Phe Ala Leu Met Met  Ser Leu Pro 
    1655                 1660                 1665             


Ala Leu  Phe Asn Ile Gly Leu  Leu Leu Phe Leu Val  Met Phe Ile 
    1670                 1675                 1680             


Tyr Ala  Ile Phe Gly Met Ser  Asn Phe Ala Tyr Val  Lys Arg Glu 
    1685                 1690                 1695             


Val Gly  Ile Asp Asp Met Phe  Asn Phe Glu Thr Phe  Gly Asn Ser 
    1700                 1705                 1710             


Met Ile  Cys Leu Phe Gln Ile  Thr Thr Ser Ala Gly  Trp Asp Gly 
    1715                 1720                 1725             


Leu Leu  Ala Pro Ile Leu Asn  Ser Lys Pro Pro Asp  Cys Asp Pro 
    1730                 1735                 1740             


Asn Lys  Val Asn Pro Gly Ser  Ser Val Lys Gly Asp  Cys Gly Asn 
    1745                 1750                 1755             


Pro Ser  Val Gly Ile Phe Phe  Phe Val Ser Tyr Ile  Ile Ile Ser 
    1760                 1765                 1770             


Phe Leu  Val Val Val Asn Met  Tyr Ile Ala Val Ile  Leu Glu Asn 
    1775                 1780                 1785             


Phe Ser  Val Ala Thr Glu Glu  Ser Ala Glu Pro Leu  Ser Glu Asp 
    1790                 1795                 1800             


Asp Phe  Glu Met Phe Tyr Glu  Val Trp Glu Lys Phe  Asp Pro Asp 
    1805                 1810                 1815             


Ala Thr  Gln Phe Met Glu Phe  Glu Lys Leu Ser Gln  Phe Ala Ala 
    1820                 1825                 1830             


Ala Leu  Glu Pro Pro Leu Asn  Leu Pro Gln Pro Asn  Lys Leu Gln 
    1835                 1840                 1845             


Leu Ile  Ala Met Asp Leu Pro  Met Val Ser Gly Asp  Arg Ile His 
    1850                 1855                 1860             


Cys Leu  Asp Ile Leu Phe Ala  Phe Thr Lys Arg Val  Leu Gly Glu 
    1865                 1870                 1875             


Ser Gly  Glu Met Asp Ala Leu  Arg Ile Gln Met Glu  Glu Arg Phe 
    1880                 1885                 1890             


Met Ala  Ser Asn Pro Ser Lys  Val Ser Tyr Gln Pro  Ile Thr Thr 
    1895                 1900                 1905             


Thr Leu  Lys Arg Lys Gln Glu  Glu Val Ser Ala Val  Ile Ile Gln 
    1910                 1915                 1920             


Arg Ala  Tyr Arg Arg His Leu  Leu Lys Arg Thr Val  Lys Gln Ala 
    1925                 1930                 1935             


Ser Phe  Thr Tyr Asn Lys Asn  Lys Ile Lys Gly Gly  Ala Asn Leu 
    1940                 1945                 1950             


Leu Ile  Lys Glu Asp Met Ile  Ile Asp Arg Ile Asn  Glu Asn Ser 
    1955                 1960                 1965             


Ile Thr  Glu Lys Thr Asp Leu  Thr Met Ser Thr Ala  Ala Cys Pro 
    1970                 1975                 1980             


Pro Ser  Tyr Asp Arg Val Thr  Lys Pro Ile Val Glu  Lys His Glu 
    1985                 1990                 1995             


Gln Glu  Gly Lys Asp Glu Lys  Ala Lys Gly Lys 
    2000                 2005                 


<210>  57
<211>  621
<212>  PRT
<213>  Homo sapiens

<400>  57

Met Glu Gln Thr Val Leu Val Pro Pro Gly Pro Asp Ser Phe Asn Phe 
1               5                   10                  15      


Phe Thr Arg Glu Ser Leu Ala Ala Ile Glu Arg Arg Ile Ala Glu Glu 
            20                  25                  30          


Lys Ala Lys Asn Pro Lys Pro Asp Lys Lys Asp Asp Asp Glu Asn Gly 
        35                  40                  45              


Pro Lys Pro Asn Ser Asp Leu Glu Ala Gly Lys Asn Leu Pro Phe Ile 
    50                  55                  60                  


Tyr Gly Asp Ile Pro Pro Glu Met Val Ser Glu Pro Leu Glu Asp Leu 
65                  70                  75                  80  


Asp Pro Tyr Tyr Ile Asn Lys Lys Thr Phe Ile Val Leu Asn Lys Leu 
                85                  90                  95      


Lys Ala Ile Phe Arg Phe Ser Ala Thr Ser Ala Leu Tyr Ile Leu Thr 
            100                 105                 110         


Pro Phe Asn Pro Leu Arg Lys Ile Ala Ile Lys Ile Leu Val His Ser 
        115                 120                 125             


Leu Phe Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Val Phe 
    130                 135                 140                 


Met Thr Met Ser Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr Thr 
145                 150                 155                 160 


Phe Thr Gly Ile Tyr Thr Phe Glu Ser Leu Ile Lys Ile Ile Ala Arg 
                165                 170                 175     


Gly Phe Cys Leu Glu Asp Phe Thr Phe Leu Arg Asp Pro Trp Asn Trp 
            180                 185                 190         


Leu Asp Phe Thr Val Ile Thr Phe Ala Tyr Val Thr Glu Phe Val Asp 
        195                 200                 205             


Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala Leu 
    210                 215                 220                 


Lys Thr Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu 
225                 230                 235                 240 


Ile Gln Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val Phe 
                245                 250                 255     


Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly Asn 
            260                 265                 270         


Leu Arg Asn Lys Cys Ile Gln Trp Pro Pro Thr Asn Ala Ser Leu Glu 
        275                 280                 285             


Glu His Ser Ile Glu Lys Asn Ile Thr Val Asn Tyr Asn Gly Thr Leu 
    290                 295                 300                 


Ile Asn Glu Thr Val Phe Glu Phe Asp Trp Lys Ser Tyr Ile Gln Asp 
305                 310                 315                 320 


Ser Arg Tyr His Tyr Phe Leu Glu Gly Phe Leu Asp Ala Leu Leu Cys 
                325                 330                 335     


Gly Asn Ser Ser Asp Ala Gly Gln Cys Pro Glu Gly Tyr Met Cys Val 
            340                 345                 350         


Lys Ala Gly Arg Asn Pro Asn Tyr Gly Tyr Thr Ser Phe Asp Thr Phe 
        355                 360                 365             


Ser Trp Ala Phe Leu Ser Leu Phe Arg Leu Met Thr Gln Asp Phe Trp 
    370                 375                 380                 


Glu Asn Leu Tyr Gln Leu Thr Leu Arg Ala Ala Gly Lys Thr Tyr Met 
385                 390                 395                 400 


Ile Phe Phe Val Leu Val Ile Phe Leu Gly Ser Phe Tyr Leu Ile Asn 
                405                 410                 415     


Leu Ile Leu Ala Val Val Ala Met Ala Tyr Glu Glu Gln Asn Gln Ala 
            420                 425                 430         


Thr Leu Glu Glu Ala Glu Gln Lys Glu Ala Glu Phe Gln Gln Met Ile 
        435                 440                 445             


Glu Gln Leu Lys Lys Gln Gln Glu Ala Ala Gln Gln Ala Ala Thr Ala 
    450                 455                 460                 


Thr Ala Ser Glu His Ser Arg Glu Pro Ser Ala Ala Gly Arg Leu Ser 
465                 470                 475                 480 


Asp Ser Ser Ser Glu Ala Ser Lys Leu Ser Ser Lys Ser Ala Lys Glu 
                485                 490                 495     


Arg Arg Asn Arg Arg Lys Lys Arg Lys Gln Lys Glu Gln Ser Gly Gly 
            500                 505                 510         


Glu Glu Lys Asp Glu Asp Glu Phe Gln Lys Ser Glu Ser Glu Asp Ser 
        515                 520                 525             


Ile Arg Arg Lys Gly Phe Arg Phe Ser Ile Glu Gly Asn Arg Leu Thr 
    530                 535                 540                 


Tyr Glu Lys Arg Tyr Ser Ser Pro His Gln Ser Leu Leu Ser Ile Arg 
545                 550                 555                 560 


Gly Ser Leu Phe Ser Pro Arg Arg Asn Ser Arg Thr Ser Leu Ser Ala 
                565                 570                 575     


Leu Glu Gly Glu Gln Arg Met Trp Asp Leu Arg Thr Thr Ser Gln Met 
            580                 585                 590         


Met Ser Thr Ala Pro Leu Arg Ile Thr Arg Ala Val Glu Ile Pro Cys 
        595                 600                 605             


Leu Cys Pro Asp Asp Thr Glu Arg Asp Ala Thr Ala Thr 
    610                 615                 620     


<210>  58
<211>  1942
<212>  PRT
<213>  Homo sapiens

<400>  58

Met Glu Gln Thr Val Leu Val Pro Pro Gly Pro Asp Ser Phe Asn Phe 
1               5                   10                  15      


Phe Thr Arg Glu Ser Leu Ala Ala Ile Glu Arg Arg Ile Ala Glu Glu 
            20                  25                  30          


Lys Ala Lys Asn Pro Lys Pro Asp Lys Lys Asp Asp Asp Glu Asn Gly 
        35                  40                  45              


Pro Lys Pro Asn Ser Asp Leu Glu Ala Gly Lys Asn Leu Pro Phe Ile 
    50                  55                  60                  


Tyr Gly Asp Ile Pro Pro Glu Met Val Ser Glu Pro Leu Glu Asp Leu 
65                  70                  75                  80  


Asp Pro Tyr Tyr Ile Asn Lys Lys Thr Phe Ile Val Leu Asn Lys Leu 
                85                  90                  95      


Lys Ala Ile Phe Arg Phe Ser Ala Thr Ser Ala Leu Tyr Ile Leu Thr 
            100                 105                 110         


Pro Phe Asn Pro Leu Arg Lys Ile Ala Ile Lys Ile Leu Val His Ser 
        115                 120                 125             


Leu Phe Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Val Phe 
    130                 135                 140                 


Met Thr Met Ser Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr Thr 
145                 150                 155                 160 


Phe Thr Gly Ile Tyr Thr Phe Glu Ser Leu Ile Lys Ile Ile Ala Arg 
                165                 170                 175     


Gly Phe Cys Leu Glu Asp Phe Thr Phe Leu Arg Asp Pro Trp Asn Trp 
            180                 185                 190         


Leu Asp Phe Thr Val Ile Thr Phe Ala Tyr Val Thr Glu Phe Val Asp 
        195                 200                 205             


Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala Leu 
    210                 215                 220                 


Lys Thr Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu 
225                 230                 235                 240 


Ile Gln Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val Phe 
                245                 250                 255     


Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly Asn 
            260                 265                 270         


Leu Arg Asn Lys Cys Ile Gln Trp Pro Pro Thr Asn Ala Ser Leu Glu 
        275                 280                 285             


Glu His Ser Ile Glu Lys Asn Ile Thr Val Asn Tyr Asn Gly Thr Leu 
    290                 295                 300                 


Ile Asn Glu Thr Val Phe Glu Phe Asp Trp Lys Ser Tyr Ile Gln Asp 
305                 310                 315                 320 


Ser Arg Tyr His Tyr Phe Leu Glu Gly Phe Leu Asp Ala Leu Leu Cys 
                325                 330                 335     


Gly Asn Ser Ser Asp Ala Gly Gln Cys Pro Glu Gly Tyr Met Cys Val 
            340                 345                 350         


Lys Ala Gly Arg Asn Pro Asn Tyr Gly Tyr Thr Ser Phe Asp Thr Phe 
        355                 360                 365             


Ser Trp Ala Phe Leu Ser Leu Phe Arg Leu Met Thr Gln Asp Phe Trp 
    370                 375                 380                 


Glu Asn Leu Tyr Gln Leu Thr Leu Arg Ala Ala Gly Lys Thr Tyr Met 
385                 390                 395                 400 


Ile Phe Phe Val Leu Val Ile Phe Leu Gly Ser Phe Tyr Leu Ile Asn 
                405                 410                 415     


Leu Ile Leu Ala Val Val Ala Met Ala Tyr Glu Glu Gln Asn Gln Ala 
            420                 425                 430         


Thr Leu Glu Glu Ala Glu Gln Lys Glu Ala Glu Phe Gln Gln Met Ile 
        435                 440                 445             


Glu Gln Leu Lys Lys Gln Gln Glu Ala Ala Gln Gln Ala Ala Thr Ala 
    450                 455                 460                 


Thr Ala Ser Glu His Ser Arg Glu Pro Ser Ala Ala Gly Arg Leu Ser 
465                 470                 475                 480 


Asp Ser Ser Ser Glu Ala Ser Lys Leu Ser Ser Lys Ser Ala Lys Glu 
                485                 490                 495     


Arg Arg Asn Arg Arg Lys Lys Arg Lys Gln Lys Glu Gln Ser Gly Gly 
            500                 505                 510         


Glu Glu Lys Asp Glu Asp Glu Phe Gln Lys Ser Glu Ser Glu Asp Ser 
        515                 520                 525             


Ile Arg Arg Lys Gly Phe Arg Phe Ser Ile Glu Gly Asn Arg Leu Thr 
    530                 535                 540                 


Tyr Glu Lys Arg Tyr Ser Ser Pro His Gln Ser Leu Leu Ser Ile Arg 
545                 550                 555                 560 


Gly Ser Leu Phe Ser Pro Arg Arg Asn Ser Arg Thr Ser Leu Phe Ser 
                565                 570                 575     


Phe Arg Gly Arg Ala Lys Asp Val Gly Ser Glu Asn Asp Phe Ala Asp 
            580                 585                 590         


Asp Glu His Ser Thr Phe Glu Asp Asn Glu Ser Arg Arg Asp Ser Leu 
        595                 600                 605             


Phe Val Pro Arg Arg His Gly Glu Arg Arg Asn Ser Asn Leu Ser Gln 
    610                 615                 620                 


Thr Ser Arg Ser Ser Arg Met Leu Ala Val Phe Pro Ala Asn Gly Lys 
625                 630                 635                 640 


Met His Ser Thr Val Asp Cys Asn Gly Val Val Ser Leu Val Gly Gly 
                645                 650                 655     


Pro Ser Val Pro Thr Ser Pro Val Gly Gln Leu Leu Pro Glu Val Ile 
            660                 665                 670         


Ile Asp Lys Pro Ala Thr Asp Asp Asn Gly Thr Thr Thr Glu Thr Glu 
        675                 680                 685             


Met Arg Lys Arg Arg Ser Ser Ser Phe His Val Ser Met Asp Phe Leu 
    690                 695                 700                 


Glu Asp Pro Ser Gln Arg Gln Arg Ala Met Ser Ile Ala Ser Ile Leu 
705                 710                 715                 720 


Thr Asn Thr Val Glu Glu Leu Glu Glu Ser Arg Gln Lys Cys Pro Pro 
                725                 730                 735     


Cys Trp Tyr Lys Phe Ser Asn Ile Phe Leu Ile Trp Asp Cys Ser Pro 
            740                 745                 750         


Tyr Trp Leu Lys Val Lys His Val Val Asn Leu Val Val Met Asp Pro 
        755                 760                 765             


Phe Val Asp Leu Ala Ile Thr Ile Cys Ile Val Leu Asn Thr Leu Phe 
    770                 775                 780                 


Met Ala Met Glu His Tyr Pro Met Thr Asp His Phe Asn Asn Val Leu 
785                 790                 795                 800 


Thr Val Gly Asn Leu Val Phe Thr Gly Ile Phe Thr Ala Glu Met Phe 
                805                 810                 815     


Leu Lys Ile Ile Ala Met Asp Pro Tyr Tyr Tyr Phe Gln Glu Gly Trp 
            820                 825                 830         


Asn Ile Phe Asp Gly Phe Ile Val Thr Leu Ser Leu Val Glu Leu Gly 
        835                 840                 845             


Leu Ala Asn Val Glu Gly Leu Ser Val Leu Arg Ser Phe Arg Leu Leu 
    850                 855                 860                 


Arg Val Phe Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Met Leu Ile 
865                 870                 875                 880 


Lys Ile Ile Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr Leu Val 
                885                 890                 895     


Leu Ala Ile Ile Val Phe Ile Phe Ala Val Val Gly Met Gln Leu Phe 
            900                 905                 910         


Gly Lys Ser Tyr Lys Asp Cys Val Cys Lys Ile Ala Ser Asp Cys Gln 
        915                 920                 925             


Leu Pro Arg Trp His Met Asn Asp Phe Phe His Ser Phe Leu Ile Val 
    930                 935                 940                 


Phe Arg Val Leu Cys Gly Glu Trp Ile Glu Thr Met Trp Asp Cys Met 
945                 950                 955                 960 


Glu Val Ala Gly Gln Ala Met Cys Leu Thr Val Phe Met Met Val Met 
                965                 970                 975     


Val Ile Gly Asn Leu Val Val Leu Asn Leu Phe Leu Ala Leu Leu Leu 
            980                 985                 990         


Ser Ser Phe Ser Ala Asp Asn Leu  Ala Ala Thr Asp Asp  Asp Asn Glu 
        995                 1000                 1005             


Met Asn  Asn Leu Gln Ile Ala  Val Asp Arg Met His  Lys Gly Val 
    1010                 1015                 1020             


Ala Tyr  Val Lys Arg Lys Ile  Tyr Glu Phe Ile Gln  Gln Ser Phe 
    1025                 1030                 1035             


Ile Arg  Lys Gln Lys Ile Leu  Asp Glu Ile Lys Pro  Leu Asp Asp 
    1040                 1045                 1050             


Leu Asn  Asn Lys Lys Asp Ser  Cys Met Ser Asn His  Thr Thr Glu 
    1055                 1060                 1065             


Ile Gly  Lys Asp Leu Asp Tyr  Leu Lys Asp Val Asn  Gly Thr Thr 
    1070                 1075                 1080             


Ser Gly  Ile Gly Thr Gly Ser  Ser Val Glu Lys Tyr  Ile Ile Asp 
    1085                 1090                 1095             


Glu Ser  Asp Tyr Met Ser Phe  Ile Asn Asn Pro Ser  Leu Thr Val 
    1100                 1105                 1110             


Thr Val  Pro Ile Ala Val Gly  Glu Ser Asp Phe Glu  Asn Leu Asn 
    1115                 1120                 1125             


Thr Glu  Asp Phe Ser Ser Glu  Ser Asp Leu Glu Glu  Ser Lys Glu 
    1130                 1135                 1140             


Lys Leu  Asn Glu Ser Ser Ser  Ser Ser Glu Gly Ser  Thr Val Asp 
    1145                 1150                 1155             


Ile Gly  Ala Pro Val Glu Glu  Gln Pro Val Val Glu  Pro Glu Glu 
    1160                 1165                 1170             


Thr Leu  Glu Pro Glu Ala Cys  Phe Thr Glu Gly Cys  Val Gln Arg 
    1175                 1180                 1185             


Phe Lys  Cys Cys Gln Ile Asn  Val Glu Glu Gly Arg  Gly Lys Gln 
    1190                 1195                 1200             


Trp Trp  Asn Leu Arg Arg Thr  Cys Phe Arg Ile Val  Glu His Asn 
    1205                 1210                 1215             


Trp Phe  Glu Thr Phe Ile Val  Phe Met Ile Leu Leu  Ser Ser Gly 
    1220                 1225                 1230             


Ala Leu  Ala Phe Glu Asp Ile  Tyr Ile Asp Gln Arg  Lys Thr Ile 
    1235                 1240                 1245             


Lys Thr  Met Leu Glu Tyr Ala  Asp Lys Val Phe Thr  Tyr Ile Phe 
    1250                 1255                 1260             


Ile Leu  Glu Met Leu Leu Lys  Trp Val Ala Tyr Gly  Tyr Gln Thr 
    1265                 1270                 1275             


Tyr Phe  Thr Asn Ala Trp Cys  Trp Leu Asp Phe Leu  Ile Val Asp 
    1280                 1285                 1290             


Val Ser  Leu Val Ser Leu Thr  Ala Asn Ala Leu Gly  Tyr Ser Glu 
    1295                 1300                 1305             


Leu Gly  Ala Ile Lys Ser Leu  Arg Thr Leu Arg Ala  Leu Arg Pro 
    1310                 1315                 1320             


Leu Arg  Ala Leu Ser Arg Phe  Glu Gly Met Arg Val  Val Val Asn 
    1325                 1330                 1335             


Ala Leu  Leu Gly Ala Ile Pro  Ser Ile Met Asn Val  Leu Leu Val 
    1340                 1345                 1350             


Cys Leu  Ile Phe Trp Leu Ile  Phe Ser Ile Met Gly  Val Asn Leu 
    1355                 1360                 1365             


Phe Ala  Gly Lys Phe Tyr His  Cys Ile Asn Thr Thr  Thr Gly Asp 
    1370                 1375                 1380             


Arg Phe  Asp Ile Glu Asp Val  Asn Asn His Thr Asp  Cys Leu Lys 
    1385                 1390                 1395             


Leu Ile  Glu Arg Asn Glu Thr  Ala Arg Trp Lys Asn  Val Lys Val 
    1400                 1405                 1410             


Asn Phe  Asp Asn Val Gly Phe  Gly Tyr Leu Ser Leu  Leu Gln Val 
    1415                 1420                 1425             


Ala Thr  Phe Lys Gly Trp Met  Asp Ile Met Tyr Ala  Ala Val Asp 
    1430                 1435                 1440             


Ser Arg  Asn Val Glu Leu Gln  Pro Lys Tyr Glu Lys  Ser Leu Tyr 
    1445                 1450                 1455             


Met Tyr  Leu Tyr Phe Val Ile  Phe Ile Ile Phe Gly  Ser Phe Phe 
    1460                 1465                 1470             


Thr Leu  Asn Leu Phe Ile Gly  Val Ile Ile Asp Asn  Phe Asn Gln 
    1475                 1480                 1485             


Gln Lys  Lys Lys Phe Gly Gly  Gln Asp Ile Phe Met  Thr Glu Glu 
    1490                 1495                 1500             


Gln Lys  Lys Tyr Tyr Asn Ala  Met Lys Lys Leu Gly  Ser Lys Lys 
    1505                 1510                 1515             


Pro Gln  Lys Pro Ile Pro Arg  Pro Gly Asn Lys Phe  Gln Gly Met 
    1520                 1525                 1530             


Val Phe  Asp Phe Val Thr Arg  Gln Val Phe Asp Ile  Ser Ile Met 
    1535                 1540                 1545             


Ile Leu  Ile Cys Leu Asn Met  Val Thr Met Met Val  Glu Thr Asp 
    1550                 1555                 1560             


Asp Gln  Ser Glu Tyr Val Thr  Thr Ile Leu Ser Arg  Ile Asn Leu 
    1565                 1570                 1575             


Val Phe  Ile Val Leu Phe Thr  Gly Glu Cys Val Leu  Lys Leu Ile 
    1580                 1585                 1590             


Ser Leu  Arg His Tyr Tyr Phe  Thr Ile Gly Trp Asn  Ile Phe Asp 
    1595                 1600                 1605             


Phe Val  Val Val Ile Leu Ser  Ile Val Gly Met Phe  Leu Ala Glu 
    1610                 1615                 1620             


Leu Ile  Glu Lys Tyr Phe Val  Ser Pro Thr Leu Phe  Arg Val Ile 
    1625                 1630                 1635             


Arg Leu  Ala Arg Ile Gly Arg  Ile Leu Arg Leu Ile  Lys Gly Ala 
    1640                 1645                 1650             


Lys Gly  Ile Arg Thr Leu Leu  Phe Ala Leu Met Met  Ser Leu Pro 
    1655                 1660                 1665             


Ala Leu  Phe Asn Ile Gly Leu  Leu Leu Phe Leu Val  Met Phe Ile 
    1670                 1675                 1680             


Tyr Ala  Ile Phe Gly Met Ser  Asn Phe Ala Tyr Val  Lys Arg Glu 
    1685                 1690                 1695             


Val Gly  Ile Asp Asp Met Phe  Asn Phe Glu Thr Phe  Gly Asn Ser 
    1700                 1705                 1710             


Met Ile  Cys Leu Phe Gln Ile  Thr Thr Ser Ala Gly  Trp Asp Gly 
    1715                 1720                 1725             


Leu Leu  Ala Pro Ile Leu Asn  Ser Lys Pro Pro Asp  Cys Asp Pro 
    1730                 1735                 1740             


Asn Lys  Val Asn Pro Gly Ser  Ser Val Lys Gly Asp  Cys Gly Asn 
    1745                 1750                 1755             


Pro Ser  Val Gly Ile Phe Phe  Phe Val Ser Tyr Ile  Ile Ile Ser 
    1760                 1765                 1770             


Phe Leu  Val Val Val Asn Met  Tyr Ile Ala Val Ile  Leu Glu Asn 
    1775                 1780                 1785             


Phe Ser  Val Ala Thr Glu Glu  Ser Ala Glu Pro Leu  Ser Glu Asp 
    1790                 1795                 1800             


Asp Phe  Glu Met Phe Tyr Glu  Val Trp Glu Lys Phe  Asp Pro Asp 
    1805                 1810                 1815             


Ala Thr  Gln Phe Met Glu Phe  Glu Lys Leu Ser Gln  Phe Ala Ala 
    1820                 1825                 1830             


Ala Leu  Glu Pro Pro Leu Asn  Leu Pro Gln Pro Asn  Lys Leu Gln 
    1835                 1840                 1845             


Leu Ile  Ala Met Asp Leu Pro  Met Val Ser Gly Asp  Arg Ile His 
    1850                 1855                 1860             


Cys Leu  Asp Ile Leu Phe Ala  Phe Thr Lys Arg Val  Leu Gly Glu 
    1865                 1870                 1875             


Ser Gly  Glu Met Asp Ala Leu  Arg Ile Gln Met Glu  Glu Arg Phe 
    1880                 1885                 1890             


Met Ala  Ser Asn Pro Ser Lys  Val Ser Tyr Gln Pro  Ile Thr Thr 
    1895                 1900                 1905             


Thr Leu  Lys Arg Lys Arg Gly  Ser Ile Cys Cys His  Tyr Ser Ala 
    1910                 1915                 1920             


Cys Leu  Gln Thr Pro Pro Phe  Lys Ala Asn Cys Lys  Thr Ser Phe 
    1925                 1930                 1935             


Leu Tyr  Val Gln 
    1940         


